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"ABSTRAKRuang Iingkup dan Cara Penelitian : Mesin amplas yang dipakai pada perusahaan mebel ratan " RR " sangat membantu dan mempermudah pekerjaan tenaga kerja, namun dapat menimbulkan Sindrom Getaran Tangan dan Lengan.Telah dilakukan identifikasi penyakit akibat kerja Sindrom Getaran Tangan dan Lengan pada karyawan perusahaan tersebut dengan menggunakan test Allen, test Lewis Prusik, tes rasa raba, tes rasa nyeri dan tes rasa suhu. Selanjutnya dilakukan studi intervensi dan penatalaksanaan Sindrom Getaran Tangan dan Lengan terhadap 3 ( tiga ) orang tenaga kerja dengan masa kerja lebih dari 1 ( satu ) tahun pada bagian amplas. Pengumpulan data telah dilakukan dengan cara pengamatan, anamnesis, pemeriksaan fisik, kuesioner dan alai pengukur getaran.Kesimpulan dan Saran : Didapatkan 3 (tiga) orang tenaga kerja menderita Sindrom Getaran Tangan dan Lengan derajat berat. Studi intervensi selama ± 2 bulan berupa penggunaan sarung tangan belum menghasilkan temuan yang konklusif, diperlukan penanganan yang bersifat komprehensif untuk keberhasilannya.

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ABSTRACT

Hand and Arm Vibration Syndrome on Labours of Rattan Furniture Company " RR "Material and Method : The fig tree machine which was used in rattan furniture company " RR " has been very helpful to the worker.

However it may cause hand and arm vibration syndrome. There was an intervention study of three workers with fig tree work exprience more than one year in the company. Data were collected by means of observation, anamnesis, physical examination, questionare and vibration examination.

Conclusion and Suggestion : Three workers were identified as patients suffer with severe hand and arm vibration syndrome. No conclusive results found from the intervention study a comprehensive management should be taken to produce a successful result."

"Latar Belakang: Sindroma ovarium polikistik (SOPK) merupakan sebuah penyakti dengan prevalensi yang tinggi dan beban kesehatan yang besar. Hingga saat ini, penyebab SOPK masih belum jelas. Penelitian sebelumnya mengenai ekspresi reseptor vitamin D (VDR) pada pasien SOPK menunjukkan hasil yang menjanjikan namun belum terbukti secara jelas. Oleh sebab itu, diduga bahwa polimorfisme VDR berperan penting dalam kejadian dan beratnya gejala SOPK.Metode: Penelitian potong lintang dilakukan pada pasien SOPK dan wanita usia reproduktif non-SOPK sebagai kontrol pada November 2019 hingga 2021. Pasien hamil, menyusui, memiliki riwayat gangguan hormon adrenal, tiroid, maupun prolaktin, atau mengonsumsi obat hormonal dalam 6 bulan terakhir dieksklusi dari penelitian. Subjek penelitian direkrut secara konsekutif. Ekspresi VDR dinilai dari ekspresi mRNA VDR yang dinilai dengan pemeriksaan PCR. Polimorfisme VDR dinilai pada tiga titik regio penyandi gen, yakni rs7975232, rs11574113, dan rs11574114.Hasil: Sebanyak 80 pasien SOPK dan 80 pasien kontrol diikutsertakan dalam penelitian. genotip A/A pada regio rs7975232 dan genotip C/C pada regio rs11574113 lebih banyak didapatkan pada pasien dengan SOPK. Di sisi lain, genotip A/C pada regio rs7975232 dan genotip C/G pada regio rs11574114 lebih banyak didapatkan pada kelompok kontrol (p < 0,05). Tidak terdapat perbedaan ekspresi VDR pada pasien dengan polimorfisme yang berbeda (p > 0,05).Kesimpulan: Didapatkan polimorfisme gen penyandi VDR yang berbeda antara pasien SOPK dan non-SOPK. Tidak didapatkan perbedaan ekspresi VDR yang bermakna antara pasien SOPK dan non-SOPK.

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Background: Polycystic ovary syndrome (SOPK) is a disease with a high prevalence and a large health burden. Until now, the cause of SOPK is still unclear. Previous studies on vitamin D receptor (VDR) expression in PCOS patients have shown promising results but have not been clearly proven. Therefore, it is suspected that the VDR polymorphism plays an important role in the incidence and severity of PCOS symptoms.

Methods: A cross-sectional study was conducted on PCOS patients and non-SOPK women of reproductive age as controls from November 2019 to 2021. Patients who were pregnant, breastfeeding, had a history of adrenal, thyroid, or prolactin hormone disorders, or had taken hormonal drugs in the last 6 months were excluded from the study. study. Research subjects were recruited consecutively. VDR expression was assessed from VDR mRNA expression assessed by PCR examination. VDR polymorphism was assessed at three points in the gene encoding region, namely rs7975232, rs11574113, and rs11574114.

Results: A total of 80 PCOS patients and 80 control patients were included in the study. A/A genotypes in the rs7975232 region and C/C genotypes in the rs11574113 region were more common in patients with PCOS. On the other hand, the A/C genotype in the rs7975232 region and the C/G genotype in the rs11574114 region were more common in the control group (p < 0.05). There was no difference in VDR expression in patients with different polymorphisms (p > 0.05).

Conclusions: Different polymorphisms of the VDR coding gene were found between PCOS and non-SOPK patients. There was no significant difference in VDR expression between PCOS and non-SOPK patients."

"Latar Belakang : Penggunaan VDT merupakan salah satu faktor risiko sindroma dry eye pada pekerja. Faktor risiko lainnya adalah faktor pekerja dan lingkungan kerja. Penelitian dilakukan untuk mengetahui hubungan penggunaan VDT, faktor pekerja dan lingkungan kerja dengan sindroma dry eye pada karyawan Universitas X Jakarta. Metoda Penelitian : Desain penelitian cross sectional. Pengumpulan data dilakukan menggunakan kuesioner, sedangkan untuk data lingkungan kerja dilakukan dengan pengukuran. Diagnosis sindroma dry eye ditegakkan dengan pemeriksaan tes Schirmer dan Break-up Time (BUT).Hasil : Prevalensi sindroma dry eye pada karyawan Universitas X Jakarta sebesar 48,61%. Tidak didapatkan hubungan bermakna penggunaan VDT, faktor pekerja dan lingkungan kerja dengan sindroma dry eye pada karyawan Universitas X. Faktor yang berhubungan dengan sindroma dry eye pada karyawan pengguna VDT di Universitas X Jakarta adalah usia.Kesimpulan dan saran : Perlunya upaya pencegahan sindroma dry eye melalui pemeriksaan kesehatan mata secara berkala terutama kemampuan akomodasi mata yang menurun seiring dengan meningkatnya usia.

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Association Between Visual Display Terminal (VDT) Work, Worker And Workplace Environment Factors With Dry Eye .Syndrome In Universitas X JakartaBackground : VDT work is risk factor for dry eye syndrome. The other risk factor of thy eye syndrome are worker and workplace environment _factors. To find out association between VDT work, worker and workplace environment factors with thy eye syndrome a study was done in X University Jakarta.

Methods : A cross sectional study was used. Data of VDT work was collected by questionnaire, while for workplace environment was collected by measurement. Dry eye syndrome was determined using Schirmer test and Break-up Time (BUT) test.

Results' : The prevalence of dry eye syndrome among workers in X University Jakarta is 48,61%. There was no association between VDT work, worker and workplace environment factors with dry eye syndrome. The risk factor that associated with dry eye syndrome among VDT worker was age.

Conclusions : Periodical medical check up was needed to prevent dry eye syndrome especially eye accommodation examination that related with age."

"Tujuan: Menilai efektifitas dan efek samping fluorometolon (full) 0,1% dalam penatalaksanaan dry eye tipe defisiensi akuosMetode: Penelitian ini merupakan studi uji Minis prospektif, randomisasi dan tersamar ganda di sebuah panti wredha. Sebanyak 35 subjek yang diikutsertakan dalam penelitian ini merupakan dry eye defisiensi akuos tipe non-Sjogren. Subjek diacak ke dalam 2 kelompok yaitu kelompok I mendapatkan fluorometolon 0,1% dan kelompok 2 mendapatkan hidroksipropil metilselulosa 0,3% (kontrol). Penilaian efektifitas berdasarkan skor gejala, tes Schirmer tanpa anestesi, fluorescein break up time (FBUT), pewarnaan fluoresein dan sensitivitas kornea dilakukan pada hari 0, 14 dan 28. Pemeriksaan derajat metaplasia skuamosa dilakukan 2 kali yaitu pada hari 0 dan 28. Penilaian efek samping dilihat dari tekanan intraokular dan katarak. Analisis statistik dilakukan di dalam dan antar kelompok.Hasil: Kedua kelompok mengalami perbaikan gejala, tanda klinis dan derajat metaplasia yang bermakna dari data dasar. Namun tidak didapatkan perbaikan bermakna antara hari 14 dan 28 pada kelompok kontrol. Hasil tes Schirmer dan FBUT lebih baik secara bermakna di kelompok fluorometolon dibanding kelompok kontrol pada hari 14 dan 28. Perbaikan pewarnaan fluoresein lebih berkurang secara bermakna pada kelompok fluorometolon dibanding kelompok kontrol pada hari 28. Skor gejala, sensitivitas kornea dan perbaikan derajat metaplasia tidak berbeda bermakna antar kelompok namun cenderung lebih balk pada kelompok fluorometolon. Efek samping berupa rasa Iengket dan gatal pada ke dua kelompok tidak berbeda bermakna. Tekanan intraokular cenderung stabil dan tidak didapatkan progresifitas katarak selama penelitian.Kesimpulan: Fluorometolon 0,1% topikal memberikan perbaikan gejala dan tanda Minis yang bermakna pada dry eye defisiensi akuos tipe non-Sjogren.

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Purpose: To evaluate the effectiveness and safety of fluorometholone (fml) 0.1% in non-Surgery dry eye syndrome.

Methods: A prospective, randomized, double-masked, clinical trial was conducted in a nursing home. Thirty-five non-Sjogren dry 'eye subjects were included in the study. The subjects were randomized into two groups. Group 1 subjects received fluorometholone 0.1% and group 2 received hydroxypropyl methylcellulose (control). The eye symptom severity score, Schirmer test without anesthesia values, fluorescein break up time (FBUT), fluoresecein staining scores and corneal sensitivity were evaluated before treatment, 14 and 28 days after start the treatment. The degree of squamous metaplasia was evaluated before treatment and day 28. Intraocular pressure, cataract formation and other side effects were recorded to evaluate the safety in both groups. Statistical analyses were performed within and between groups.

Results: Both groups had significant differences compared with their baseline measurements in all of the parameters. However, subjects in the control group showed no significantly improvements between day 14 and day 30. There were no significant differences between groups on symptom severity score and corneal sensitivity on day 14 and 28. The degree of squamous metaplasia was not significantly different between groups on day 28. The FML group had significantly better Schirmer test value and FBUT on days 14 and 28 compared to control group. The fml group subjects also had significantly lower fluorescein staining on days 28. The side effects detected in fml group were sticky and itchy, comparable to control group. Intraocular pressure was stable and no progression of cataract formation.

Conclusion: Topical fluorometholone 0.1% had a clearly beneficial effect both on subjective and objective clinical parameters of non-Sjogren dry eye patients."

"Latar Belakang. Multipel sklerosis merupakan penyakit kronik progresif dimana selain dari berbagai gejala neurologis yang ada, gangguan tidur merupakan masalah yang juga memiliki dampak terhadap penyandang penyakit multipel skeloris. Beberapa penelitian telah menunjukkan bahwa prevalensi gangguan tidur ditemukan lebih tinggi pada penyandang penyakit multipel skeloris dibandingkan populasi normal. Penelitian ini bertujuan untuk mengetahui prevalensi serta pola gangguan tidur pada penyandang penyakit multipel sklerosis di Indonesia.Metode. Penelitian ini merupakan studi deskritptif potong lintang. Populasi penelitian merupakan pasien dengan penyakit multiple sklerosis yang berobat di RSCM Jakarta yang memenuhi kriteria inklusi, dan dilakukan pengambilan data klinis dan pengambilan sampel dengan mengisi kuesioner Pittsburgh Sleep Quality Assessment (PSQI) dan STOP-BANG Sleep Apnea Questionnaire, serta The Mini International Neuropsychiatric Interview ICD-10 (MINI ICD-10). Data yang didapat kemudian dilakukan pengolahan dan analisis data.Hasil. Dari empat puluh dua subjek MS yang diikutsertakan pada penelitian ini, 32 (76,2%) subjek berusia kurang dari 35 tahun, 34 (81,0%) berjenis kelamin perempuan, 23 (54,8%) subjek tidak bekerja, 9 (21,4%) mengalami depresi, dan 9 (21,4%) memiliki EDSS 6 ke atas. Insomnia ditemukan pada 32 (76,2%) subjek, dengan proporsi yang lebih besar ditemukan pada subjek berusia 35 tahun ke atas (80% vs 75%, p=0,556), berjenis kelamin laki-laki (87,5% vs 73,5%, p=0,374), kelompok yang tidak bekerja (78,3% vs 73,7%, p=0,504), kelompok dengan depresi (77,8% vs 75,8%, p=0,638), dan kelompok dengan EDSS lebih dari sama dengan 6 (77,8% vs 75,8%, p=0,638). Seluruh subjek memiliki risiko OSA dengan 39 (92,9%) subjek memiliki risiko ringan-sedang dan 3 (7,1%) subjek memiliki risiko berat. Hanya laki-laki yang memiliki risiko terhadap kejadian OSA (37,5% vs 0%, p=0,005), tetapi tidak berkaitan terhadap kejadian insomnia.Kesimpulan. Prevalensi gangguan tidur pada penyandang penyakit multipel skeloris di Indonesia sangat tingi. Untuk itu perlu dilakukan evaluasi dan pemeriksaan lebih lanjut guna menunjang diagnosis.

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Background. Multiple sclerosis (MS) is a chronic progressive disease in which sleep disorder, besides various neurologic manifestations, highly impacts the patients but is often neglected in clinical settings. Several studies had discovered that sleep disorder was more prevalent in MS than general population. This study aimed to investigate the prevalence and characteristics of sleep disorder in MS patients in Indonesia.Methods. A descriptive cross-sectional study involving MS patients was conducted at Dr. Cipto Mangunkusumo National General Hospital Jakarta. In addition to clinicodemographic data collection, data regarding sleep quality, obstructive sleep apnea (OSA), and depression state were assessed using Indonesian previously-validated Pittsburgh Sleep Quality Index, STOP-BANG Sleep Apnea Questionnaire, and The Mini International Neuropsychiatric Interview ICD-10, respectively.Results. Of forty MS participants included in this study, 29 (72.5%) aged less than 35 years, 32 (80.0%) were women, 20 (50.0%) were unemployed, 10 (25.0%) had depression, and 10 (25.0%) had Expanded Disability Scoring Scale (EDSS) of ≥6. Insomnia was found in 33 (82.5%) participants, of which larger proportion were male (100.0% vs 78.1%, p=0.309. Three (7,1%) participants had moderate risk of OSA. Only male had significant risk of OSA (moderate risk 25.0% vs 0%, p=0.036), but it did not associate with insomnia.Conclusion. Sleep disorder in MS patients in Indonesia is prevalent. There was potencies of the risk of OSA in MS, especially in male. Detection of insomnia and risk OSA is important in MS comprehensive care."

"[ABSTRAKLatar Belakang Lemak merupakan sumber energi penting, komponen utama struktur membran sel dan media penyerapan vitamin larut lemak A, D, E, dan K. Lemak adalah nutrisi utama perkembangan otak anak, penting untuk memeriksa malabsorpsi lemak secara akurat dan tepat. RSCM merupakan rujukan pemeriksaan analisis feses, dengan sekitar 840 pemeriksaan mikroskopik lemak per tahun. Pemeriksaan mikroskopik lemak merupakan satu-satunya yang tersedia di laboratorium RSCM untuk pemeriksaan lemak feses.Tujuan Mengetahui kehandalan pemeriksaan mikroskopik lemak pada analisis feses dalam menggambarkan malabsorpsi lemak pada anak.Metode Uji diagnostik kehandalan pemeriksaan mikroskopik lemak menggunakan Sudan III dibandingkan dengan steatokrit dalam mendiagnosis malabsorpsi lemak pada anak usia 6-60 bulan.Hasil Didapatkan 68 sampel yang terdiri dari 41 laki-laki dan 27 perempuan, median usia 14,3 bulan. Konsistensi feses terbanyak adalah lembek (50,0%). Dengan metode mikroskopik didapatkan lemak terbanyak adalah positif satu pada 29 sampel (42,6%). Sensitivitas pemeriksaan mikroskopik lemak didapatkan sebesar 49,15%, spesifisitas sebesar 66,67%, dengan nilai prediksi positif 90,63% dan nilai prediksi negatif 16,67%.Kesimpulan Pemeriksaan mikroskopik lemak memiliki sensitivitas yang tidak terlalu tinggi dalam mendiagnosis malabsorpsi lemak dan perlu dilengkapi dengan metode lain seperti steatokrit.

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ABSTRACTBackground Lipid is a very important source of energy, major component of cell membrane structure and media for absorption of lipid-soluble vitamins A, D, E, and K. Lipid is the major nutrition for brain development, and thus it is important to test lipid malabsorption accurately. RSCM is the referral hospital for fecal analysis, with 840 lipid microscopic examination done each year. This microscopic test is the only method currently available for fecal lipid malabsorption at RSCM laboratory.Objective To know whether the lipid microscopid test as a part of fecal analysis that have been done so far is effective in representing lipid malabsorption in children.Methods Diagnostic test for effectivity of lipid microscopic test using Sudan III compared to steatocrit test in diagnosing lipid malabsorption in children 6-60 months old suspected to have lipid malabsorption.Results Sixty-eight children consisting of 41 boys and 27 girls were included in the study, with median age 14,3 months. The most common stool consistency was mushy (50,0%). Using microscopic method the most frequent group was positive one in 29 subjects (42,6%). Sensitivity of lipid microscopic test was found to be 49,15% with specificity 66,67%, PPV 90,63% and NPV 16,67%.Conclusion The lipid microscopic test has a moderate sensitivity in diagnosing fat malabsorption, and needs to be complemented with other method such as steatocrit., Background Lipid is a very important source of energy, major component of cell membranestructure and media for absorption of lipid-soluble vitamins A, D, E, and K. Lipid is themajor nutrition for brain development, and thus it is important to test lipid malabsorptionaccurately. Cipto Mangunkusumo Hospital (CMH) is a referral hospital for fecal analysis,with 840 lipid microscopic examination done each year. This microscopic test is the onlymethod currently available for fecal lipid malabsorption at CMH laboratory.Objective To know whether the lipid microscopic test as a part of fecal analysis that isperformed routinely so far is effective in representing lipid malabsorption in children.Methods Diagnostic test for effectivity of lipid microscopic test using Sudan III compared tosteatocrit test in diagnosing lipid malabsorption in children 6-60 months old suspected tohave lipid malabsorption.Results Sixty-nine children consisting of 41 boys and 27 girls were included in the study,with median age 14,3 months. The most common stool consistency was mushy (50,0%).Using microscopic method the most frequent group was positive one in 29 subjects (42,6%).Sensitivity of lipid microscopic test was found to be 49,15% with specificity 66,67%, PPV90,63% and NPV 16,67%.Conclusion Lipid microscopic test has a moderate sensitivity in diagnosing fat malabsorption, and needs to be complemented with other method such as steatocrit.]"

"ABSTRAKObstructive sleep apnea (OSA) is a disease with recurrent episodic of partial or total upper airway collapse during sleep. Snoring is a main symptom of OSA because it may be caused by upper airway collapse during sleep. Several risk factors has been identified as risk factors for OSA. They are male gender, increased of age, overweight or obesity, big neck, craniofacial abnormality, upper airway disease or abnormality, smoking, gene, menopause, nasal congestion, and alcohol consumption. Overweight or obesity are major risk factor of OSA. Obesity also increased progressivity of OSA. "

"ABSTRAK Latar belakang: Identifikasi faktor-faktor risiko sangat penting dalam memprediksi kasus yang mungkin berkembang menjadi sindrom syok dengue SSD dan expanded dengue syndrome EDS . Alasan penelitian ini dilakukan adalah karena masih terdapat perbedaan dari beberapa hasil penelitian sebelumnya mengenai faktor risiko status nutrisi terhadap terjadinya SSD, angka kematian SSD yang masih cukup tinggi 7,81 , dan menggunakan klasifikasi infeksi virus dengue terbaru menurut pedoman WHO terbaru tahun 2011 dengan kelompok EDS.Tujuan: Mengetahui hubungan faktor risiko status nutrisi dan faktor risiko lain terhadap terjadinya SSD dan hubungan status nutrisi terhadap terjadinya EDS. Metode: Studi retrospektif menggunakan data rekam medik pasien anak usia 0 sampai 200 IU . Kata kunci: anak, status nutrisi, demam berdarah dengue, risiko, syok, expanded dengue syndrome. ABSTRACT Background Identifying risk factors is critical in predicting possible cases of dengue shock syndrome DSS and expanded dengue syndrome EDS . The reasons for this research are because there are still some differences from previous research on the risk factors of nutritional status on the occurrence of DSS, high mortality rate of DSS 7.81 , and using the latest dengue virus classification according to the latest WHO guidelines 2011 with the EDS group.Aim To know the correlation between risk factors of nutritional status and other risk factors on the occurrence of DSS and the relationship of nutritional status to the occurrence of EDS. Methods This retrospective study used medical record data of children ages 0 to 200 IU . Key words children, nutritional status, dengue hemorrhagic fever, risk, shock, expanded dengue syndrome. "