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Hasil Pencarian

Ditemukan 6 dokumen yang sesuai dengan query
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Oky Hermansyah
Virtual Screening Inhibitor DPP-4 Menggunakan QSAR Berbasis Artificial Intelligence = Virtual Screening of DPP-4 Inhibitors Using QSAR-Based Artificial Intelligence.
" ABSTRAK
Inhibitor Dipeptidyl Peptidase-4 (DPP-4) menjadi obat yang semakin penting dalam pengobatan diabetes melitus tipe-2, namun beberapa golongan obat ini memiliki efek samping seperti nyeri sendi yang bisa menjadi parah hingga pankreatitis, diperkirakan efek samping ini muncul terkait dengan penghambatannya terhadap enzim DPP-8 dan DPP-9. Untuk mengembangankan inhibitor DPP-4 baru yang memiliki aktivitas penghambatan yang tinggi terhadap DPP-4 dan penghambatan yang rendah terhadap DPP-8 dan DPP-9 maka dilakukan virtual screening pada lebih dari 10 juta molekul, ... "
2019
T54807
UI - Tesis Membership  Universitas Indonesia Library
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Steric aspects of biomolecular interactions / editors, Gabor Naray-Szabo
Boca Raton: CRC press, 1987
574.192 83 STE
Buku Teks  Universitas Indonesia Library
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Hit and lead profiling identification and optimization of drug like molecules
Weinheim: Wiley VCH, 2009
615.19 HIT
Buku Teks  Universitas Indonesia Library
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Structure-based drug discovery
" Summary: This book describes some of the most exciting developments for the discovery of new drugs, such as Fragment-based methods. This book includes experimental approaches using X-ray crystallography and NMR for Fragment-based screening as well as other biophysical methods for studying protein/ligand interaction ... "
Dordrecht: Springer Science+Business Media, 2007
615.19 STR
Buku Teks  Universitas Indonesia Library
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Lin, Guo-Qiang
Chiral drugs : chemistry and biological action
" Presenting an overview of chiral drugs and their impact on the pharmaceutical industry, Chiral drugs : chemistry and biological action provides an integrated perspective of chiral drugs from concept, synthesis, and pharmaceutical properties. The book includes important chiral technologies and reviews of 200 chiral drugs that have either been approved or made it to advanced trials. It's interdisciplinary approach combines synthetic organic chemistry, medicinal chemistry, and pharmacology in a way that fosters cooperation among interdisciplinary ... "
Hoboken: John Wiley & Sons, 2011
e20376590
eBooks  Universitas Indonesia Library
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Sotriffer, Christoph.
Virtual screening : principles, challenges, and practical guidelines
" Drug discovery is all about finding small molecules that interact in a desired way with larger molecules, namely proteins and other macromolecules in the human body. If the three-dimensional structures of both the small and large molecule are known, their interaction can be tested by computer simulation with a reasonable degree of accuracy. Alternatively, if active ligands are already available, molecular similarity searches can be used to find new molecules. This virtual screening can even ... "
Weinheim: Wiley-VCH, 2011
e20395196
eBooks  Universitas Indonesia Library