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"ABSTRACTLatar Belakang: Serotonin merupakan monoamine yang berperan sebagai neurotransmitter di sistem saraf pusat dan perifer. Penelitian terbaru menyatakan bahwa serotonin juga mempengaruhi fungsi sel T dan sel B. Serotonin transporter merupakan pusat regulasi sistem serotonergic dan menyebar diekspresikan pada sel-sel di sistem imun. Polimorfisme pada promotor gen serotonin transporter (5-HTTLPR) menunjukkan aspek genetic pada terjadinya depresi. Cheilitis angularis merupakan penyakit kompleks dengan keterlibatan faktor geneti. Adanya polimorfisme ini menyebabkan inflamasi pada penyakit cheilitis angularis yang dimediasi oleh sel T dan meningkatnya prevalensi depresi pada pasien cheilitis angularis. Tujuan: Mendeteksi adanya polimorfisme gen Serotonin transporter SLC6A4 (5-HTTLPR) pada penderita cheilitis angulari. Metode: Analisis polimorfisme gen Serotonin transporter SLC6A4 (5-HTTLPR) dilakukan dengan metode PCR-VNTR. Analisis statistic dilakukan dengan uji Chi-square. Hasil: Dalam penelitian ini, pada kelompok cheilitis angularis ditemukan 24 sampel dengan genotip SS, 23 sampel dengan genotip LS, dan 3 sampel dengan genotip LL. Sedangkan pada kelompok non-cheilitis angularis, ditemukan 5 sampel dengan genotip SS, 18 sampel dengan genotip LS, dan 27 sample dengan genotip LL. Pada kelompok cheilitis angularis ditemukan 71 alel S dan 29 alel L, dan pada kelompok non-cheilitis angularis ditemukan 28 alel S dan 72  alel L. Kesimpulan: Terdapat perbedaan bermakna pada distribusi polimorfisme gen Serotonin transporter SLC6A4 (5-HTTLPR)cheilitis angularis dengan non-cheilitis angularis (p = 0.001).

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ABSTRACTSerotonin is a monoamine acting as a neuromediator in the central and peripheral nervous system. Recently, serotonin has also been shown to influence T- and B-cell function. The serotonin transporter is central in the regulation of the serotonergic system and widely expressed on cells of the immune system. A functional length polymorphism in the promoter of the serotonin transporter gene (5-HTTLPR) has been implicated in the genetic background of depression. Cheilitis angularis is a complex disease with a polygenetic inheritance. This polymorphism cause inflammation in cheilitis angularis mediated by the role of T cell and increased prevalence of depression in cheilitis angularis patients. To determine the relationship between the Serotonin transporter SLC6A4 (5-HTTLPR) gene polymorphism in cheilitis angularis patients in Indonesia. Analysis of the Serotonin transporter SLC6A4 (5-HTTLPR) gene polymorphism was observed by carrying out PCR method followed by electrophoresis for the analysis, without the usage of restriction enzyme. The chi-square test was used for statistical analysis. In this study, in the cheilitis angularis group there were 24 samples with SS genotype, 23 samples with LS genotype, and 3 samples with LL genotype. Whereas in the non-cheilitis angularis group, there were 5 samples with SS genotype, 18 samples with LS genotype, and 27 samples with LL genotype. In the cheilitis angularis group found 71 S alleles and 29 L alleles, and in the non-cheilitis angularis group 28 S alleles and 72 L alleles were found. There were significant differences in the distribution of the Serotonin transporter SLC6A4 (5-HTTLPR) gene polymorphism between cheilitis angularis and non-cheilitis angularis groups (p = 0.001). "

"In this book, the author summarizes the latest findings regarding the role of serotonin in modulating the activity of brain regions which organize behavioral patterns associated with fear, anxiety and stress. "

"Latar Belakang: Peningkatan serotonin plasma dan kortisol saliva yang terjadi pada sindrom koroner akut juga terjadi pada gejala ansietas. Dan kedua penanda biologis tersebut digunakan untuk mengetahui adanya gejala ansietas. Tujuan: Mengetahui perbedaan rerata serotonin plasma dan kortisol saliva pada sindrom koroner akut dengan gejala ansietas di RSUPN dr. Cipto Mangunkusumo. Metode: Dilakukan penelitian klinis poong lintang. Hasil: Kadar serotonin plasma dengan gejala ansietas dan tanpa gejala ansietas dibandingkan nilai normal yaitu 194,83 (142,00-892,04) ng/mL dan 167,16 (150,40-225,96) ng/ml. Kadar kortisol saliva pada subjek dengan gejala ansietas dan tanpa gejala ansietas adalah 2,75 (1,28-4,91) µg/dL dan 2,69 (0,91-7,09) µg/dL. Simpulan: Ada peningkatan kadar serotonin plasma dan kortisol saliva pada gejala ansietas walaupun tidak terdapat hubungan antara serotonin plasma dan kortisol saliva dengan gejala ansietas pada pasien SKA.

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Background: Increases in plasma serotonin and salivary cortisol that occur in acute coronary syndrome also occur in symptoms of anxiety. And the two biological markers are used to determine the presence of anxiety symptoms.

Objective: To determine the difference in mean plasma serotonin and salivary cortisol in acute coronary syndrome with anxiety symptoms at RSUPN dr. Cipto Mangunkusumo.

Methods: Poong Lintang clinical research was conducted.

Results: Compared to normal values, plasma serotonin levels with anxiety symptoms and without anxiety symptoms ​​were 194.83 (142.00-892.04) ng/mL and 167.16 (150.40-225.96) ng/ml. Salivary cortisol levels in subjects with anxiety symptoms and without anxiety symptoms were 2.75 (1.28-4.91) µg/dL and 2.69 (0.91-7.09) µg/dL.

Conclusion: There is an increase in plasma serotonin and salivary cortisol levels in anxiety symptoms although there is no relationship between plasma serotonin and salivary cortisol with anxiety symptoms in ACS patients."