Hasil Pencarian  ::  Simpan CSV :: Kembali

Abstrak :
Senyawa turunan pirimidin telah berhasil disintesis dari dimedon, aldehida aromatis (Benzaldehid dan vanilin) dan kelompok urea (urea dan tiourea) melalui reaksi kondensasi Biginelli. Produk yang dihasilkan dianalisis dengan menggunakan instrumentasi spektroskopi UV-Vis, FTIR, GC-MS dan 1H-NMR. Pada reaksi tersebut digunakan katalis Fe3O4@asam sitrat yang telah dikonfirmasi dengan instrumentasi FTIR, XRD, SEM-EDX dan PSA. Berdasarkan optimasi reaksi yang dilakukan pada 4-fenil-7,7-dimetil-5-oxo-1,2,3,4,5,6,7,8-oktahidroquinazolin-2-tion (senyawa 1) adalah pelarut etanol, suhu refluks etanol, waktu reaksi 60 menit dan jumlah katalis 7,5 %wt sebesar 57 %.

---

Pyrimidin derivatives were successfully synthesized by reacting dimedone, aromatic aldehyde (benzaldehyde and vanilin) and urea group (urea and thiourea) through Biginelli condensation. The characterization of three product were performed by FTIR, UV-Vis, GC-MS and 1H-NMR instrumentations. In addition, Fe3O4@citric acid catalyst was characterized using FT-IR, XRD, SEM-EDX and PSA. The optimum condition for 4-phenil-7,7-dimethyl-5-oxo-1,2,3,4,5,6,7,8-octahydro-quinazolin-2- tion (compound 1) were in ethanol solvent, reflux temperature, 60 minutes of time reaction and 7,5 % wt of catalyst with yield amount 57 %.

Abstrak :
ABSTRAK
Senyawa turunan pirimidin telah berhasil disintesis dengan mereaksikan benzaldehida, etil asetoasetat, dan urea melalui reaksi kondensasi Biginelli. Produk yang terbentuk dikarakterisasi menggunakan alat FTIR, UV-Vis, dan GC-MS. Pada sintesis senyawa ini digunakan nanokatalis CuFe2O4 yang berhasil disintesis dengan metode kopresipitasi dan dikonfirmasi dengan FTIR, XRD, TEM dan PSA. Berdasarkan optimasi (senyawa 1) dengan nama IUPAC 5-(ethoxy carbonyl)-4-(phenyl)-6-methyl-3,4-dihydropyrimidin2(1-)one diperoleh kondisi optimum dengan waktu 4 jam reaksi, suhu 70°C, dan 7,5% berat katalis dengan yield sebesar 71,57%, untuk (senyawa 2) 5-(ethoxy carbonyl)-4- (phenyl)-6-methyl-3,4-dihydropyrimidin-2(1H)thione diperoleh kondisi optimum selama waktu 4 jam reaksi, suhu 50°C, dan 7,5% berat katalis dihasilkan yield sebesar 76,84% sedangkan untuk (senyawa 3) pada waktu 4 jam reaksi, suhu 70°C, dan 7,5% berat katalis dengan yield sebesar 73,69% belum berhasil membentuk senyawa 5-(ethoxy carbonyl)-4-(phenyl)-6-methyl-3,4-dihydropyrimidin-2(1H)imine dari reaktan benzaldehida, etil asetoasetat dan guanidin.

---

ABSTRACT
Pyrimidine derivatives have been synthesized by reacting benzaldehyde, ethyl acetoacetate, urea through Biginelli condensation reaction using CuFe2O4 nanocatalyst . Characterization of the three of product were performed by using FTIR, UV-Vis and GC-MS. In the synthesis of these compounds using CuFe2O4 nanocatalyst were successfully synthesized by coprecipitation method and characterized by FTIR, XRD, PSA, TEM. Optimum conditions for producing (compound 1) 5-(ethoxy carbonyl)-4- (phenyl)-6-methyl-3,4-dihydropyrimidin-2(1H)one were 4 hours reaction, temperature 70° C and 7.5% weight catalyst with yield 71.57% , (compound 2) 5-(ethoxy carbonyl)- 4-(phenyl)-6-methyl-3,4-dihydropyrimidin-2(1H)thione was at 4 hours reaction, 50° C and 7.5% weight catalyst with yield 76.84% and compound 3 were 4 hours reaction, temperature 70° C and 7.5% weight catalyst with yield 73.69% has not succeeded in forming a 5-(ethoxy carbonyl)-4-(phenyl)-6-methyl-3,4-dihydropyrimidin-2(1H)imine.