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Abstrak :
Bromelain yang diisolasi dari nanas (Ananas comosus [L.] Merr) dapat menjadi agen fitoterapi yang sangat baik untuk pengobatan penyakit kardiovaskular karena dapat menghambat agregasi platelet. Namun jika digunakan secara oral, bromelain dapat dengan mudah terdegradasi dalam lingkungan pH asam. Ketidakstabilan dalam kondisi tertentu akan menurunkan aktivitas farmakologisnya dan menurunkan manfaatnya bagi kesehatan. Oleh karena itu, bromelain perlu dienkapsulasi dalam matriks seperti nanosfer alginat-karboksimetil selulosa (CMC) melalui metode gelasi ionik menggunakan ion kalsium sebagai agen pengikat silang. Formula nanosfer dievaluasi rasio swelling, ukuran partikel, dan efisiensi enkapsulasinya. Karakterisasi juga dilakukan dengan menggunakan spektrofotometer infra merah (FTIR) dan mikroskop elektron (SEM). Hasil penelitian menunjukkan bahwa formula nanosfer terbaik (611,05 ± 0,35 nm) memiliki rasio swelling sebesar 177,27% dan 2119,17% pada pH 1,2 dan pH 7,4. Uji efisiensi enkapsulasi menunjukkan bahwa nanosfer Alginate-CMC dapat mengenkapsulasi bromelain sebesar 32,2%. Pelepasan bromelain dari nanosfer alginat-CMC diamati masing-masing 14,09% dan 31,14% di lingkungan lambung dan usus buatan setelah 8 jam. Bromelain dalam nanosfer alginat-CMC mempertahankan identitasnya seperti yang diamati dalam studi FTIR. Bromelain yang dienkapsulasi memiliki aktivitas proteolitik hingga 0,60 U/mL dan aktivitas antiplatelet sebesar 73,95%. Dari penelitian tersebut, dapat disimpulkan bahwa nanosfer alginat-CMC berhasil melindungi bromelain dari lingkungan asam di lambung dan memiliki karakteristik lepas lambat di lingkungan usus buatan. Hasil ini juga menunjukkan bahwa nanosfer alginat-CMC bisa menjadi sistem pengiriman yang menjanjikan untuk pengiriman enzim ......Bromelain isolated from pineapple (Ananas comosus [L.] Merr) can be an excellent phytotherapeutic agent for cardiovascular treatment as it can inhibit platelet aggregation. However, if it is used orally, it can be easily degraded in the acidic pH environment due to enzymes secreted during the digestion process. Its instability under a certain condition will reduce its pharmacological activity and as a result, will reduce its health benefit. Therefore, bromelain needs to be encapsulated in a matrix such as alginate-carboxymethyl cellulose (CMC) nanospheres by ionic gelation method using calcium ion as a crosslinking agent. The alginate-CMC nanospheres were evaluated for their swelling ratio, particle size, and drug encapsulation efficiency. Characterization was also carried out using fourier transform infrared spectrophotometer (FTIR) and scanning electron microscope. The results showed that the best nanosphere (611.05±0,35 nm) has swelling ratios of 177.27% and 2119.17% at pH 1.2 and pH 7.4, respectively. The encapsulation test revealed that the Alginate-CMC nanospheres can encapsulate the bromelain with encapsulation efficiency of 32.2%. The release of bromelain from the nanospheres was observed 14.09% and 31.14% respectively in the artificial gastric and intestinal environment after 8 hours. Bromelain in the nanospheres retains its identity after nanospheres formation as observed in FTIR studies. The encapsulated bromelain has a proteolitic activity up to 0.60 U/mL and antiplatelet activity of 73.95%. From these studies, it can be concluded that the alginate-CMC nanospheres can successfully protect bromelain from the acidic environment in the stomach and have slow-release characteristics. These results also suggest that alginate-CMC nanospheres could be a promising delivery system for enzyme delivery

Abstrak :
Herbal medicine has had a terrible 20th century. An evolving relationship between humans and plants ground to a shuddering halt in the industrial world somewhere around the end of the 19th century. This was astonishing: humans had for millennia been articulating and finessing a primal co-evolution with the plant world and all sentient beings. The insights and benefits for health that had emerged were rich and real. However, while suited to living close to the land, these had become increasingly inadequate to meet the needs of urban life, often involving squalor and pandemic diseases, and when the principles of science and engineering became applicable to medicine the old ways were rudely thrown aside.

Abstrak :
Contents: The European legislation (directive 2004/24/EC) brings clarification and recognition to herbal medicinal products / Giuseppe NisticoÌ? and Dagmar Roth-Behrendt -- Taxonomy, morphology, and ecology of medicinal plants: a botanical perspective / Simon Pierce, Alessandra Luzzaro, and Bruno E.L. Cerabolini -- Ethnopharmacological approaches used to identify medicinal plants / Tsukasa Sakurada ... [et al.] -- Medicinal plants : molecular biology/biotechnology approach -- Candida Vannini ... [et al.] -- Breeding and cultivation of medicinal plants / Christoph Carlen -- Sample preparation, analytical methods, and chemical standardization of medicinal plants -- Angela Perrone ... [et al.] -- The role of zebrafish in the future of natural product discovery -- Alexander D. Crawford, Camila V. Esguerra, and Peter A.M. de Witte -- Phytocomplexes versus single-entity drugs : the never-ending dilemma in herbal medicine / Elizabeth M. Williamson -- Molecular modes of action of drugs used in phytomedicine / Michael Wink -- Bioavailability issues of nonnutrient plant and fruit constituents / Mariusz Konrad Piskula and Junji Terao -- From identification to clinical translation of medicinal plants / Gian Franco Gensini ... [et al.] -- Recommendations for reporting randomized controlled trials of herbal medicine interventions / Joel J. Gagnier ... [et al.] -- Pharmacovigilance methods and systems in herbal medicines / Gioacchino Calapai -- Mechanisms and clinical relevance of herb drug interactions from the perspectives of pharmacokinetics / Laura Berliocchi ... [et al.] -- Nature?s gift to photodynamic medicine : hypericin, a herbal photosensitizer is a component of hypericum perforatum / Heinrich Walt -- Plants and plant-derived products as cancer chemopreventive agents / Douglas M. Noonan, Ilaria Sogno, and Adriana Albini -- From standard tanacetum parthenium extract to a stabilized derivative of parthenolide : studies in animal models of pain / Rosaria Greco ... [et al.] -- Antiviral effects of essential oils used traditionally in phytomedicine / JuÌ?rgen Reichling and Paul Schnitzler -- The neuroprotective capacity of achyrocline satureioides (Lam) D.C. and its flavonoids : mechanisms of action / Federico Dajas ... [et al.] -- Recent progress in echinacea research / Karin Woelkart and Rudolf Bauer -- Contribution of herbal medicine to human health : a brief history / Luigi Antonio Morrone ... [et al.] -- Quality issues of current herbal medicines / Paola Montoro, Sonia Piacente, and Cosimo Pizza -- Herbal medicines in the developing world : South America / Federico Dajas and Felicia Rivera-Megret -- Herbal medicines : epidemiology of their utilization, a perspective on the industrialized world / Anna Loraschi and Marco Cosentino.

Abstrak :
This handbook paves the way to success in plant-based drug development, systematically addressing the issues facing a pharmaceutical scientist who wants to turn a plant compound into a safe and effective drug. Plant pharmacologists from around the world demonstrate the potentials and pitfalls involved, with many of the studies and experiments reported here.

Abstrak :
Il termine panax ginseng evoca la panacea, nome dato dagli antichi a piante dalle grandi proprietà terapeutiche. Mentre il nome cinese si traduce all’incirca come “uomo dalle gambe allargate”, il mistero circa le le sue origini lo avvicinano storicamente alla celebre radice di mandragora dalle forme antropomorfe. Questa pianta dall’effetto rinforzante ha molte altre virtù e proprietà biologiche, di cui il potenziale terapeutico e immunostimolante è notevole. Come tutta una serie di piante denominate adattogene, è la diretta concorrente di un’altra tra le araliaceae, il ginseng americano o panax quinquefolium. Cosa sappiamo del Ginseng? Rari sono i casi di piante così ampiamente studiate dal punto di vista medico e scientifico. Questa opera fornisce un’ampia panoramica delle conoscenze a disposizione, dagli studi classici ai dati scientifici più aggiornati, proponendo una definizione della parola adattogena, fino ad oggi mancante. Il volume cataloga inoltre le altre piante dette adattogene precisando in cosa esse si differenziano dal ginseng.