Hasil Pencarian

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Hasil Pencarian

Ditemukan 4 dokumen yang sesuai dengan query
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Arnadi
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2002
T58808
UI - Tesis Membership  Universitas Indonesia Library
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Ade Martinus
"Latar belakang: Cidera saraf perifer sebagai keluaran dari post operatif hingga saat ini belum ditangani dengan maksimal. Penelitian ini ditujukan untuk menentukan potensi dari sekretom pada regenerasi cidera saraf perifer.
Metode: Cidera saraf perifer buatan dilakukan pada tikus dengan melakukan diseksi pada saraf sciatic. Evaluasi perbaikan motorik dilakukan mengunakan Sciatic Functional Index (SFI) pada minggu ke enam (SFI 1), minggu ke sembilan (SFI 2), dan minggu ke dua belas (SFI 3). Rasio berat basah antara otot gastrocnemius kanan dan kiri dibandingkan serta dilakukan histomorphometry saraf sciatic pada tiap kelompok.
Hasil: Kelompok III menunjukan SFI 1 yang lebih baik dibandingkan kelompok I (p=0.017). Kelompok I dan III menunjukan perbedaan SF2 yang signifikan dibandingkan dengan kelompok II dan IV (p<0.001). Rasio tertinggi dari otot gastrocnemius ditemukan pada kelompok I dan III, yang bernilai 0.65 ± 0.059 dan 0.67 ± 0.179 (p<0.001). Pada histomorphometry, akson termyelinisasi paling banyak ditemukan pada kelompok I dan III, yang bernilai p<0.001.
Kesimpulan: Sekretom sel punca mesenkimal korda umbilikalis dapat digunakan sebagai terapi baru untuk menggantikan autograf pada penanganan kerusakan saraf perifer.

Background: Currently, the post-surgical outcome of peripheral nerve injury has not been optimal. The purpose of this research is to determine the potency of secretome in peripheral nerve injury regeneration.
Method: The mice had artificially-induced peripheral nerve injury, which was created by dissecting the sciatic nerve. Sciatic Functional Index (SFI) was used to evaluate the motoric recovery on week six (SFI 1), week nine (SFI 2), and week twelve (SFI 3). The mice was sacrificed on week twelve. The wet mass ratios of the right and left gastrocnemius muscle were compared, then the sciatic nerve histomorphometry evaluation was performed on each group.
Results: Group III showed a better SFI 1 result than Group I (p=0.017). Group I and III showed significantly better SFI 2 than group II and IV (p<0.001). The highest ratio of gastrocnemius muscle was found in group I and III, which were 0.65 ± 0.059 and 0.67 ± 0.179 (p<0.001). On histomorphometry, the highest number of myelinated axons were found in group I and III, which were p<0.001.
Conclusion: Umbilical cord mesenchymal stem cell secretome can be used as a new therapy to replace the autograft in peripheral nerve defect management.
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Lengkap +
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2019
SP-pdf
UI - Tugas Akhir  Universitas Indonesia Library
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Nabila Maudy Salma
"Berdasarkan data dari WHO masih terdapatnya peningkatan angka disabilitas yang disebabkan karena cedera pada sistem saraf tepi. Setelah terjadinya cedera saraf tepi, maka akan terjadi serangkaian proses seluler maupun molekuler sebagai respon terhadap adanya cedera. Salah satu respon molekuler yang penting yaitu aktivasi jalur persinyalan balik, menyebabkan terinduksinya sintesis berbagai protein, salah satunya adalah HSP 70, berperan sebagai neuro proteksi dan mencegah terjadinya apoptosis neuron lebih lanjut. Tujuan penelitian ini yaitu untuk menilai pengaruh pemberian PRP terhadap proses regenerasi saraf tepi dengan melihat hubungan ekspresi HSP 70 terhadap fungsi berjalan (TFI & PFI). Penelitian ini menggunakan sampel bahan biologis tersimpan yaitu Medulla Spinalis tikus berjumlah 36, terbagi menjadi dua kelompok besar berdasarkan hari terminasi nya yaitu H-7 dan H-42. Hasil penelitian ini menunjukan bahwa tidak terdapatnya hubungan (p>0,05) antara ekspresi HSP 70 terhadap fungsi berjalan melalui pemeriksaan TFI dan PFI pada kelompok skiatika yang diberi PRP maupun yang tidak diberi PRP, berarti bahwa tidak adanya hubungan secara langsung antara ekspresi HSP 70 dengan perbaikan fungsi motorik.

According to WHO data, the number of disabilities brought on by damage to the peripheral nervous system is continually rising. Following a peripheral nerve damage, a number of cellular and molecular reactions will take place. One significant biological reaction is the activation of the reverse signaling pathway, which triggers the creation of several proteins, including HSP 70, which serves as neuroprotection and stops more neuronal apoptosis. The aim of this study was to assess the effect of PRP administration on the process of peripheral nerve regeneration by examined the correlation between HSP 70 expression with the motoric function (TFI & PFI). This research used samples of stored biological material, namely 36 rat spinal cords, divided into two large groups based on termination day, namely H-7 and H-42. The results of this study showed that there was no correlation (p>0.05) between HSP 70 expression and walking function through TFI and PFI examinations in the sciatica group who were given PRP and those who were not given PRP, indicating that there is no direct correlation between HSP 70 expression with motor function improvement."
Lengkap +
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2023
T-pdf
UI - Tesis Membership  Universitas Indonesia Library
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"This updatable book provides an accessible informative overview of the current state of the art in nerve repair research.
The introduction includes history of nerve repair research and establishes key concepts and terminology and will be followed by sections that represent the main areas of interest in the field: (1) Biomaterials, (2) Therapeutic Cells, (3) Drug, Gene and Extracellular Vesicle Therapies, (4) Research Models and (5) Clinical Translation. Each section will contain 3 - 6 chapters, capturing the full breadth of relevant technology. Bringing together diverse disciplines under one overarching theme echoes the multidisciplinary approach that underpins modern tissue engineering and regenerative medicine. Each chapter will be written in an accessible manner that will facilitate interest and understanding, providing a comprehensive single reference source. The updatable nature of the work will ensure that it can evolve to accommodate future changes and new technologies.
The main readership for this work will be researchers and clinicians based in academic, industrial and healthcare settings all over the world."
Lengkap +
Switzerland: Springer Cham, 2019
e20503311
eBooks  Universitas Indonesia Library