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"Red fruit (Pandanus conoideous Lam.) has been known by public as a medicine for any kind of diseases, among of them is for cancer. To determine the carcinogenesis inhibition effect of red fruit extract , we have examined the effect on 7,12-dimethylbenz[a]anthrasene (DMBA)-induced rat lungs cancer model in female Sprague-Dawley rats. The extract was tested at 0.21 ml/200 g bw; 0.43 ml/200 g bwand 0.88 ml/ 200 g bw. The experiment was terminated at day 120. Lung histology was used to evaluate carcinogenesis inhibition. The result showed that the extract at 0.21 ml/200g bw improved lung carcinogenesis inhibition than other dose."

"Latar Belakang: Mutasi Epidermal Growth Factor Receptor (EGFR) merupakan prediktor keberhasilan terapi TKI pada non-small cell lung cancer (NSCLC). Ras Asia, perempuan, bukan perokok, tipe histologis adenokarsinoma adalah karakteristik klinikopatologis yang diketahui memiliki asosiasi dengan mutasi EGFR pada NSCLC. Di Indonesia belum pernah dilakukan penelitian yang membuktikan asosiasi tersebut di tengah keterbatasan sumber daya dan fasilitas pemeriksaan biomolekuler untuk medeteksi mutasi EGFR.Metode: Desain studi adalah potong lintang. Subjek dikumpulkan secara konsekutif dari pasien adenokarsinoma paru stadium lanjut Rumah Sakit Umum Pusat Nasional Cipto Mangunkusumo dan Rumah Sakit Dharmais Pusat Kanker Nasional yang memeriksakan status mutasi EGFR di Laboratorium Kalbe Genomics dalam kurun waktu Januari 2010 hingga Desember 2013. Dari rekam medis pasien ditelusuri data umur, jenis kelamin, status merokok, diagnosis dan status mutasi EGFR. Uji chi-square dilanjutkan regresi logistik digunakan untuk menilai asosiasi jenis kelamin dan status merokok terhadap status mutasi EGFR.Hasil: Studi melibatkan 51 subjek dan didapatkan proporsi mutasi EGFR sebesar 47,1% (IK 95% = 33,4% – 60,8%). Uji bivariat menunjukkan perempuan (RO=4,80; IK 95%=1,12-20,61) dan bukan perokok (RO=4,00; IK 95%=1,23-13,06) memiliki asosiasi dengan mutasi EGFR, namun pada uji multivariat hanya status bukan perokok yang masih bermakna (RO=4,00; IK 95%=1,22-13,06).Simpulan: Proporsi mutasi EGFR pada kelompok pasien adenokarsinoma paru stadium lanjut 47,1%. Hanya status bukan perokok yang memiliki asosiasi independen dengan mutasi EGFR.

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Background: Epidermal Growth Factor Receptor (EGFR) mutation is predictor for successful TKI therapy in non-small cell lung cancer (NSCLC) patient. Asian, women, non-smoker, and histology of adenocarcinoma are the clinicopathological characteristics associated with EGFR mutation in NSCLC patient. In Indonesia, no research has been performed to confirm association between those characteristics while the resources and facilities to detect EGFR mutation are lacking.

Method: A cross sectional study was performed in Cipto Mangunkusumo National Referral Hospital and Dharmais Hospital National Cancer Center from January 2010 to December 2013. Subjects were collected consecutively from advanced lung adenocarcinoma patients who underwent examination for EGFR mutation in Kalbe Genomics Laboratory during study period. From medical records, information about age, gender, smoking status, diagnosis, and EGFR mutation status were collected. Chi square and logistic regression analysis were performed to assess association between variables.

Results: From 51 subjects participated in this study, proportion of EGFR mutation was 47.1% (CI 95% = 33,4% – 60,8%). Bivariate analysis revealed that women (OR=4,80; CI 95%=1,12-20,61) and non-smoker (OR=4,00; CI 95%=1,23-13,06) were associated with EGFR mutation. While in multivariate analysis, non-smoker status was the only significant clinical factor associated with EGFR mutation (OR=4.00; CI 95%=1.22-13.06).

Conclusion: Proportion of EGFR mutation in advanced lung adenocarcinoma patients is 47,1%. Non-smoker status is the only clinical factor associated with EGFR mutation."

"Kanker paru merupakan penyakit kanker yang paling mematikan dan sering terjadi pada laki-laki. Dalam melakukan asuhan keperawatan kanker perlu dilakukan pendekatan teori. Karya ilmiah akhir yang dibuat saat melakukan residensi keperawatan medikal bedah kekhususan onkologi dilakukan di rumah sakit kanker Dharmais Jakarta meliputi analisis residensi kanker paru dengan pendekatan teori Self Care Orem, penerapan Evidence Based Nursing efektifitas pemberian aromaterapi lavender fleur oil terhadap penurunan kecemasan pada pasien kanker payudara yang akan dilakukan pembedahan dan kegiatan proyek inovasi tentang format pengkjian khusus pada luka kanker dengan menggunakan Malignant Wound Assesment Tools MWAT. Kesimpulan teori Self Care Orem mampu dilakukan pada pasien kanker paru. Intervensi lavender fleur oil dapat menurunkan kecemasan sembelum dilakuakan pembedahan payudara dan format pengkajian MWAT dapat diterapkan dalam pengkajian pasien dengan luka kanker.

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Lung Cancer is the most deadly cancers, and often occurs in men. In doing cancer nursing care necessary theoretical approach. The scientific work of late made while doing a residency medical surgical nursing specificity oncology conducted in a cancer hospital Dharmais Jakarta include analysis residency lung cancer with the theoretical approach of Self Care Orem, application of Evidence Based Nursing effectiveness of aromatherapy lavender fleur oil to decrease anxiety in patients with breast cancer will do the surgery and about the innovation project activity pengkjian format specifically on cancer by using Malignant wounds wound Assessment Tools MWAT. Conclusions Self Care Orem theory capable performed in patients with lung cancer. Intervention fleur lavender oil can reduce anxiety sembelum dilakuakan breast surgery and format MWAT assessment can be applied in the assessment of patients with cancer sores."

"Latar belakang: Pandemi COVID-19 membawa perubahan yang besar terhadap sistem pelayanan kesehatan, salah satunya pada terapi kanker paru. Berbagai keterbatasan yang dihadapi tenaga kesehatan dan risiko COVID-19 yang tinggi pada pasien kanker paru menyebabkan terjadinya perubahan terapi pada pasien kanker paru. Penelitian ini bertujuan untuk mengetahui perubahan terapi dan tingkat kekhawatiran pada pasien kanker paru. Metode: Penelitian potong lintang yang melibatkan pasien rawat jalan kanker paru dilakukan di Poli Onkologi RSUP Persahabatan. Pemilihan sampel dilakukan menggunakan metode consecutive sampling. Perubahan terapi pasien kanker paru selama pandemi dinilai menggunakan survei daring yang disusun oleh Dutch Federation of Cancer Patients Organisations dan Dutch Multidisiplinary Oncology Foundation yang dimodifikasi dan diterjemahkan dalam Bahasa Indonesia. Karakteristik subjek yang meliputi karakteristik demografi, karakteristik kanker paru, jenis terapi, dan riwayat infeksi COVID-19 turut dinilai dalam penelitian ini. Hasil: Sebanyak 68,2% pasien kanker paru mengalami perubahan terapi selama pandemi COVID-19. Tidak ditemukan adanya korelasi antara karakteristik dan tingkat kekhawatiran subjek dengan perubahan terapi selama pandemi COVID-19. Kekhawatiran terhadap perubahan terapi ditemukan pada 77,3% subjek penelitian. Kesimpulan: Penelitian ini menemukan tingginya proporsi pasien kanker paru yang mengalami perubahan selama pandemi COVID-19. Perubahan terapi selama pandemi sebaiknya mempertimbangkan dampak psikologis pasien dan efektivitas terapi. Diperlukan penelitian lebih lanjut untuk mengetahui faktor-faktor yang memengaruhi perubahan terapi selama pandemi COVID-19.

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Introduction: The COVID-19 pandemic has brought major changes to the health care system, one of which is lung cancer treatment. Various limitations faced by health workers and the high risk of COVID-19 in lung cancer patients led to changes in lung cancer treatment. This study aims to assess changes in therapy and level of concern in lung cancer patients.

Method: A cross-sectional study involving lung cancer outpatients was conducted in Thoracic Oncology Outpatient Clinic in Persahabatan National Respiratory Referral Hospital Jakarta, Indonesia. Sample recruitment was done using consecutive sampling method. Changes in therapy for lung cancer patients during the pandemic were assessed using an online survey by the Dutch Federation of Cancer Patients Organizations and the Dutch Multidisciplinary Oncology Foundation which was modified and translated into Bahasa. Patients characteristics, including demographic characteristics, lung cancer characteristics, type of therapy, and history of COVID-19 infection were also assessed in this study.

Result: A total of 68.2% of lung cancer patients reported changes in therapy during the COVID-19 pandemic and 77,3% were concerned about treatment changes. No correlation was found between the characteristics and level of concern of the subjects with changes in treatment during the COVID-19 pandemic.

Conclusion: This study found a high proportion of lung cancer patients who experienced changes during the COVID-19 pandemic. Changes in therapy during a pandemic should take into account the psychological impact of the patient and the effectiveness of therapy. Further research is needed to determine the factors that influence the changes during the COVID-19 pandemic."