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"Paparan terhadap polutan, terutama asap rokok merupakan penyebab peradangan saluran napas kronis pada PPOK. Pada penelitian sebelumnya, piroksikam terbukti menghambat aktivasi neutrofil dan mengurangi pelepasan anion superoksida dari neutrofil melalui ikatannya dengan formyl peptide receptor (FPR) secara in vitro. Penelitian ini dilakukan untuk menganalisis efek antagonis FPR1 piroksikam secara in vivo terhadap parameter hematologi dan red blood’s cell distribution width (RDW). Penelitian ini menggunakan mencit betina ddY. Mencit diinduksi dengan asap rokok selama delapan minggu. Mencit yang sudah mengalami PPOK dibagi menjadi enam kelompok. Kelompok negatif diberi CMC-Na 0,5% secara oral, kelompok positif diberikan inhalasi budesonid 0,002mg/20gBB mencit/hari, serta tiga kelompok variasi dosis piroksikam dengan D1 0,026mg/20gBB mencit/hari; D2 0,052mg/20gBB mencit/hari; dan D3 0,104mg/20gBB mencit/hari secara oral. Mencit diinduksi selama delapan minggu, lalu diberikan perlakuan selama 21 hari. Parameter yang dinilai adalah hematologi serta red blood cell’s distribution width (RDW) yang diukur menggunakan hematology analyzer. Dosis 0,026mg/20gBB dan 0,104mg/20gBB memiliki efek terhadap parameter hematologi. Dosis 0,026mg/20gBB, 0,052mg/20gBB, dan 0,104mg/20gBB dapat menurunkan RDW. Berdasarkan penelitian, piroksikam memiliki efek terhadap parameter hematologi dan dapat menurunkan red blood cell’s distribution width (RDW).

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Exposure to pollutants, especially cigarette smoke, is a cause of chronic airway inflammation in COPD. In a previous study, piroxicam was found to inhibit neutrophil activation and reduce the release of superoxide anion from neutrophils by binding to formyl peptide receptor (FPR) in vitro. This study was conducted to analyze the effect of the FPR1 antagonist piroxicam in vivo on hematological parameters and red blood's cell distribution width (RDW). This study used female DDY mice. Mice were induced with cigarette smoke for eight weeks. COPD Mice were divided into six groups. The negative group was given CMC-Na 0,5% orally, the positive group was given inhaled budesonide 0,002mg/20gBW mice/day, and the three variation dose groups of piroxicam with D1 0.026mg/20gBW mice/day; D2 0,052mg/20gBW mice/day; and D3 0,104mg/20gBW mice/day orally. Mice were induced for eight weeks, then given treatment for 21 days. The parameters assessed were hematology and red blood cell's distribution width (RDW) which was measured using a hematology analyzer. Doses 0.026mg/20gBW and 0.104mg/20gBW of piroxicam affect hematological parameters. Doses 0.026mg/20gBW, 0.052mg/20gBW, and 0.104mg/20gBW of piroxicam are able to reduce RDW. The results showed that piroxicam affects hematological parameters and reduces red blood cell’s distribution width (RDW).

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"[Particulate Matter (PM) terutama partikel <2,5 μg/m3 atau PM2.5, adalahkomponen utama yang terkandung dalam asap dari bahan bakar biomassa. Efekyang terkait dengan paparan jangka panjang PM2,5 meliputi peningkatan gejalapernapasan bagian bawah, penyakit paru obstruktif kronik dan penurunan fungsiparu. Salah satu pengguna bahan bakar biomassa yang cukup tinggi di SumateraBarat adalah usaha rumah makan, tujuan dari penelitian ini menganalisis asosiasifaktor lingkungan dengan konsentrasi PM2,5 pada waktu masak di dapur rumahmakan Kota Solok dan menganalisis konsentrasi PM2,5 pada waktu masak denganfungsi paru pekerja dapur rumah makan. Penelitian ini adalah penelitian dekriptifanalitik dengan menggunakan desain studi cross-sectional, dengan jumlah sampeladalah 71 orang (total sampling). Analisis multivariat hubungan faktor lingkungandengan PM2,5 pada waktu masak didapatkan hubungan signifikan ventilasi OR:5,655 (95% CI: 0,780 ? 40,994) dan lama waktu masak OR: 12,013, (CI: 1,113 ?129,714). Analisis multivariat hubungan PM2,5 pada waktu masak dengangangguan fungsi paru, yaitu PM2,5 OR: 3,60 (CI: 95%, 0,921 ? 14,072), UmurOR: 1,443, (CI 95%, 0,380 ? 5,477), dan masa kerja OR: 13,854, (95% CI: 3,283? 58,388). Terdapat hubungan bermakna antara faktor lingkungan dengankonsentrasi PM2,5 pada waktu masak yaitu variabel lama masak dan ventilasi.Sedangkan untuk konsentrasi PM2,5 pada waktu masak ada hubungan yangbermakna dengan gangguan fungsi paru pekerja dapur dengan dikontrol olehumur dan masa kerja;Particulate Matter (PM), particularly inhalable particulate ( <2,5 μm), isthe main components in biomass emission. Long term exopusre of PM2,5 hadbeen proved to increase lower respiratory disorder, chronic obtructive pulmonarydisease (COPD), and decrease lung function. Padang Restaurant is one of themain user of biomass fuel in west sumatera. The aim of this research was toanalize the association of PM2,5 concentration during cooking and lung functiondisorder among restaurant kitchen workers. This was a cross-sectional study with71 workers were included. There was a significant association between PM2,5and ventilation OR: 5,655 (95% CI: 0,780 ? 40,994) and cooking duration OR:12,013, (CI: 1,113 ? 129,714). Multivariate analysis between PM2,5 and lungfunction disorder showed significant association, PM2,5 OR: 3,60 (CI: 95%, 0,921? 14,072), age OR: 1,443, (CI 95%, 0,380 ? 5,477), and working durationOR: 13,854, (95% CI: 3,283 ? 58,388). There was a significant associationbetween environmental factors (ventilation and cooking duration) and PM2,5concentration during cooking. Meanwhile PM2,5 concentration and lung fuctionshowed significant association after controled by age and working duration., Particulate Matter (PM), particularly inhalable particulate ( <2,5 μm), isthe main components in biomass emission. Long term exopusre of PM2,5 hadbeen proved to increase lower respiratory disorder, chronic obtructive pulmonarydisease (COPD), and decrease lung function. Padang Restaurant is one of themain user of biomass fuel in west sumatera. The aim of this research was toanalize the association of PM2,5 concentration during cooking and lung functiondisorder among restaurant kitchen workers. This was a cross-sectional study with71 workers were included. There was a significant association between PM2,5and ventilation OR: 5,655 (95% CI: 0,780 – 40,994) and cooking duration OR:12,013, (CI: 1,113 – 129,714). Multivariate analysis between PM2,5 and lungfunction disorder showed significant association, PM2,5 OR: 3,60 (CI: 95%, 0,921– 14,072), age OR: 1,443, (CI 95%, 0,380 – 5,477), and working durationOR: 13,854, (95% CI: 3,283 – 58,388). There was a significant associationbetween environmental factors (ventilation and cooking duration) and PM2,5concentration during cooking. Meanwhile PM2,5 concentration and lung fuctionshowed significant association after controled by age and working duration.]"

"Diagnostic imaging is an essential component in the evaluation of the patient with known or suspected respiratory tract disease. While chest radiography continues to serve as the primary tool for imaging the chest, advances in computed tomography (CT) have led to a variety of applications such as high-resolution CT (HRCT), advanced 3-D airway imaging, and image-guided procedures.The aim of this book is to deliver a clinically-oriented approach to pulmonary imaging. Each chapter of the book will provide an organized approach to the different facets of imaging of specific clinical scenarios, focusing on strengths and weaknesses of available imaging tests. High quality examples of typical imaging findings of specific conditions will supplement the text.The target readers include practicing internists, pulmonologists, thoracic surgeons, and primary care practitioners. Other readers will include respiratory care therapists and medical students. The proposed cohort of authors represents experts in the field of thoracic radiology. These authors have experience in thoracic radiology and medical writing, each will deliver a high-quality chapter meeting the aims and scope of this book while addressing the target audience. Aside from the first three chapters, which are introductory materials, each author will be invited to select a clinician with whom they work closely to serve as a co-author in order to provide a chapter that maintains the clinical orientation of this book."

"Latar belakang: Aspergilosis Paru Invasif merupakan penyakit yang berbahaya dan berisiko tinggi kematian. Penelitian mengenai skoring sebelumnya berdasarkan parameter risiko klinis dan biomarker baru untuk memprediksi API. Pada penelitian ini peneliti menggunakan parameter sederhana untuk mendiagnosa API. Tujuan: Studi ini bertujuan untuk mengembangkan model diagnosis API berdasarkan karakteristik klinis, laboratorium, foto toraks dan komorbid. Metode: Penelitian ini dilaksanakan dengan desain potong lintang, secara retrospeksif, menggunakan data rekam medis di RS Dr. Cipto Mangunkusumo (RSCM) sejak Januari 2018 hingga Desember 2022. Model determinan diagnosis Aspergilosis Paru Invasif dikembangkan dari analisis multivariat dengan regresi logistik kemudian diuji performa dan validitas internalnya. Hasil: Total sampel sebanyak 227 pasien dengan eksklusi sebanyak 20 pasien dan yang dilakukan analisis sebanyak 207 pasien. Dua ratus tujuh subjek terdiri dari 110 pasien API dan 97 pasien non-API. Pada penelitian ini demam memiliki skor 2, konsolidasi memiliki skor 2, fibrosis memiliki skor 1, jumlah neutrofil absolut memiliki skor 1, penggunaan steroid memiliki skor 2, Neutrophil Lymphocyte Ratio (NLR) memiliki skor 1. AUC =0.771, p< 0.05 yang menunjukkan hasil performa skor sedang untuk membedakan faktor determinan API. Kesimpulan: Penelitian ini menghasilkan diagnosis API,demam skor 2, konsolidasi skor 2, fibrosis skor 1, jumlah neutrofil absolut skor 1, penggunaan steroid skor 2, NLR skor 1. Skor 0-4 memiliki probabilitas 43,67% atau risiko rendah dan skor 5-8 memliki probabilitas 83,67% atau risiko tinggi faktor-faktor determinan API.

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Background: The diagnosis of IPA is complex because it relies on clinical, radiological, and microbiological criteria. Microbiology is at the core of most diagnostic tests/criteria; however, the results take a lot of time. Researchers use a combination of clinical, radiological, laboratory, and comorbid characteristics to diagnose IPA. Objective : This study aims developed IPA diagnosis model based on clinical characteristics, chest X Ray and patients comorbid. Method: This research was carried out with cross sectional design, retrospectively, using medical record data at Dr. Cipto Mangunkusumo (RSCM) from January 2018 to December 2022. The determinant model for the diagnosis of Invasive Pulmonary Aspergillosis was developed from multivariate analysis with logistic regression and then tested for performance and internal validity. Results: The total sample was 227 patients with the exclusion of 20 patients and 207 patients were analyzed. Two hundred seven subjects consisted of 115 IPA patients and 92 non-IPA patients. In the multivariate analysis this study involved fever, consolidation, fibrosis, absolute neutrophil count, Neutrophil Lymphocyte Ratio (NLR), and steroid used. In this study, fever had a score of 2, consolidation had a score of 2, fibrosis had a score of 1, absolute neutrophil count had a score of 1, steroid had a score of 2. AUC = 0.771, p< 0.05. Conclusion: This study resulted in a diagnosis of API, fever score 2, consolidation score 2, fibrosis score 1, absolute neutrophil count score 1, steroid score 2. A score of 0-4 has a probability of 43.67% or low risk and a score of 5-8 has a probability of 83.67% or high risk API determinant factors."