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Hasil Pencarian

Ditemukan 2 dokumen yang sesuai dengan query
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Abstrak :
The challenge remains to find the proper combination of these techniques in view of their respective potential, limitations, and costs, in order to pick up the right compounds quickly while keeping the risk of eliminating ‘good’ candidates as low as possible. Potential and limitations of a number of approaches to get early information on solubility and permeability, the main factors governing absorption via passive diffusion, will be discussed with practical examples. It aims at offering longlasting knowledge and stimulating food for thought. This is why its three main parts (biological, physicochemical, and computational strategies) are accompanied by two chapters which set the scene, four others which review the molecular and biological background of pharmacokinetic lead optimization, and finally two which conclude the book.
Weinheim, Germany: Wiley-VCH, 2001
e20394491
eBooks  Universitas Indonesia Library
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Abstrak :
The profiling of ADME properties (absorption, distribution, metabolism, and excretion) is the topic of this book. In this unique work, international authorities and practicing experts from academia and industry offer state-of-the-art presentations of concepts, methods and technologies now in use or development in drug research. The biological strategies emphasized in the book include cell cultures, drug-metabolizing enzymes, transporters and plasma protein binding. The physicochemical strategies focus on artificial membrane-permeability assays, on solubility and lipophilicity and related molecular properties as factors and predictors of pharmacokinetic behavior, and on stability and solid-state properties. Computational strategies comprize the exploration of property spaces, pharmacophore searching to predict biotransformation and enzyme inhibition, and expert systems to process biopharmaceutical profiling data.
Weinheim, Germany: Wiley-VCH, 2006
e20395901
eBooks  Universitas Indonesia Library