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"Latar Belakang: Giant Cell Tumor (GCT) adalah tumor yang sering mengenai individu berusia 20-45 tahun. Penatalaksanaan GCT radius distal adalah untuk menghilangkan massa tumor sepenuhnya dan mempertahankan pergelangan tangan. Beberapa metode rekonstruksi dapat dilakukan seperti arthrodesis total, Free Vascularized Fibular Graft (FVFG) atau Non-Vascularized Fibular Graft (NVFG), dengan prosedur rekonstruksi terutama melibatkan artroplasti atau arthrodesis pergelangan tangan parsial. Penelitian ini disusun untuk mengetahui perbandingan luaran fungsional pasien rekonstruksi GCT radius distal menggunakan teknik FVFG, NVFG, dan arthrodesis. Metode: Penelitian ini merupakan penelitian analitik dengan desain studi potong lintang yang menilai keluaran. post operasi dan tidak pada subjek tidak terdapat perlakuan khusus pada pasien. Pengambilan data akan dilakukan di RSUPN Cipto Mangunkusumo, Jakara, dan dilaksanakan pada bulan Juli 2020 – Juli 2021. Populasi target pada penelitian ini yaitu pasien yang telah didiagnosis dengan GCT tulang distal radius dan telah dilakukan operasi penyelamatan ekstrimitas beserta prosedur rekonstruksi berupa NVFG atau FVFG atau arthrodesis. Hasil : Terdapat 21 pasien GCT radius distal di RSCM pada penelitian ini yang termasuk kriteria inklusi dan di ikutkan dalam proses analisis data. Jumlah subjek laki-laki adalah 12 orang dan perempuan 9 orang (rasio 4:3). Golongan usia yang paling banyak adalah 21-30 tahun (33,3%). Tidak didapatkan hubungan yang bermakna di antara ketiga prosedur tersebut dengan luaran fungsional pasien (p = 0,49). Namun apabila dilihat dari rerata skor MSTS yang terbaik adalah metode FVFG dengan skor 24,4. Rerata FVFG lebih baik bila dibandingkan dengan arthrodesis 23,2 dan NVFG 23,18. Kesimpulan: Tidak terdapat perbedaan luaran fungsional dari tatalaksana operasi penyelamatan ekstremitas pada pasien dengan GCT tulang distal radius yang dilakukan prosedur NVFG, FVFG, dan arthrodesis.

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Background: Giant Cell Tumor (GCT) is a tumor that often affects individuals aged 20- 45 years. Management of the distal radius GCT is to completely remove the tumor mass and preserve the wrist. Several reconstruction methods can be performed such as total arthrodesis, Free Vascularized Fibular Graft (FVFG) or Non-Vascularized Fibular Graft (NVFG), with the reconstructive procedure primarily involving arthroplasty or partial wrist arthrodesis. This study was structured to compare the functional outcomes of patients with distal radius GCT reconstruction using FVFG, NVFG, and arthrodesis techniques. Method: This study is an analytic study with a cross-sectional design that assesses outcomes. postoperatively and not on the subject there is no special treatment for the patient. Data collection will be carried out at Cipto Mangunkusumo General Hospital, Jakarta, and will be held in July 2020 – July 2021. The target population in this study are patients who have been diagnosed with GCT of the distal radius and have undergone extremity rescue surgery along with reconstruction procedures in the form of NVFG or FVFG or arthrodesis. Result: There were 21 distal radius GCT patients at the RSCM in this study which included the inclusion criteria and were included in the data analysis process. The number of male subjects was 12 people and 9 female subjects (4:3). The most common age group is 21-30 years (33.3%). There was no significant relationship between the three procedures and the patient's functional outcome (p = 0.49). However, when viewed from the average MSTS score, the best is the FVFG method with a score of 24.4. The mean FVFG was better when compared to arthrodesis 23.2 and NVFG 23.18. Conclusion: There was no difference in the functional outcome of limb salvage surgical management in patients with GCT of the distal radius who underwent NVFG, FVFG, and arthrodesis procedures."

"Pendahuluan: Osteosarkoma adalah tumor ganas tulang paling sering ditemukan di RS Cipto Mangunkusumo (RSCM). Penatalaksanaan osteosarkoma dengan limb-salvage surgery (LSS) makin berkembang disamping tindakan amputasi. Penelitian ini bertujuan untuk mengetahui perbandingan luaran hasil LSS dan amputasi pada pasien osteosarkoma di RSCM. Metode: Studi ini menggunakan desain kohort retrospektif pada pasien osteosarkoma periode tahun 1995-2014 di RSCM. Dilakukan evaluasi angka kesintasan, rekurensi lokal, metastasis, komplikasi, skor fungsional menurut Musculoskeletal Tumor Society Scoring system (MSTS) pada pasien yang dilakukan LSS dan amputasi. Metode Kaplan-Meier digunakan untuk mendeskripsikan kesintasan, sintasan bebas rekurensi lokal antara LSS dan amputasi. Hubungan karakteristik pasien dianalisis dengan uji log rank. Uji Kai kuadrat, Eksak Fischer dan Mann-Whitney U digunakan untuk menganalisis hubungan antara skor MSTS dan karakteristik pasien, angka rekurensi, metastasis serta komplikasi. Untuk melihat pengaruh katakteristik terhadap sintasan dilakukan analisis regresi Cox dan uji Wald serta analisis multivariat backward stepwise. Temuan: Penelitian dan Diskusi Kesintasan 5 tahun pasien osteosarkoma 14,6%. Kesintasan 5 tahun LSS 34,8%, kesintasan 5 tahun amputasi 15,9%. Kesintasan bebas rekurensi lokal 5 tahun untuk LSS 96,2% dan untuk amputasi 86,5%. Kesintasan dipengaruhi metastasis, tipe operasi dan ukuran tumor. Metastasis merupakan faktor paling berpengaruh berdasarkan analisis multivariat. Metastasis terbanyak ditemukan di paru. Gejala awal dan staging Enneking mempengaruhi metastasis (p=0,02 dan 0,007). Infeksi adalah komplikasi tersering. Tipe biopsi FNAB memberi komplikasi yang paling sedikit. LSS memberi skor fungsional yang lebih tinggi (83,3%) daripada amputasi (61,7%). Pasien dengan rekurensi lokal cenderung mempunyai skor fungsional buruk (p=0,023). Kesimpulan: Kesintasan paling tinggi pada pasien osteosarkoma RSCM yang dilakukan LSS. Luaran fungsional dengan skor MSTS baik (83,3%) didapatkan pada pasien yang dilakukan LSS dan bebas rekurensi lokal. Skor MSTS buruk dijumpai pada pasien amputasi dengan rekurensi lokal, komplikasi dan metastasis.

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Introduction: Osteosarcoma is the most common malignant bone tumor seen in Cipto Mangunkusumo Hospital (CMH). Treatment for osteosarcoma includes limb-salvage surgery (LSS), and it is increasingly more frequently performed compared to amputation. This study aims to analyze the outcome of LSS compared to amputation for osteosarcoma patients in CMH.

Methods: This is a retrospective cohort study to review osteosarcoma patients during 1995-2014 period in CMH. Analysis was performed on survival rate, local recurrence, metastasis, complication, and functional score according to Musculoskeletal Tumor Scoring System (MSTS) for patients underwent LSS or amputation. Kaplan-Meier method was used to determine survival rate, and disease-free survival rate between LSS and amputation. Log-rank analysis was used to determine relationship between patients characteristic. Chi-Square, Exact-Fischer, and Mann-Whitney U tests were used to analyze the correlation between MSTS score and patient characteristics, rate of recurrence, metastasis, and complication. To determine the influence of patient characteristics to survival, Cox regression analysis, Wald Test and backward stepwise multivariate analysis were performed.

Results: and discussion 5-year survival rate osteosarcoma patients was 14.6%, 5-year survival rate for LSS was 34.8% compared to 15.9% for amputation. Disease-free survival for LSS was 96,2%, while amputation was 86,5%. Survival were influenced by metastasis, type of surgical intervention, and tumor size. According to multivariate analysis, survival was most influenced by metastasis. Metastasis were found predominantly in lungs. Initial symptoms and Enneking stage were correlated to metastasis (p=0.02 and 0.007, respectively). Infection was the most common complication. FNAB gave the least complication compared to other types of biopsy. LSS gave the highest functional score (83.3%) compared to amputation (61.7%). Patients with local recurrence tend to have poor functional score (p=0.023).

Conclusion: The highest survival rate for osteosarcoma patients in CMH was found on patients who underwent LSS. Good functional outcome according to MSTS score (83.3%) were found on patients who underwent LSS and free of local recurrence. Poor MSTS score were seen on patients undergone amputation, patients who had had local recurrence, complication and metastasis"