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Abstrak :
Atherosclerosis is a degenerative disease of large and medium arteries which loss their elasticity and the arterial walls are thickened which may cause coronary heart disease. Atherosclerosis is related to hyperlipidemia and concentration of serum lipoprotein cholesterol which are influenced by the intake of certain dietary lipids.

The polyunsaturated fatty acid (PUFA), particularly linoleic acid is believed to have a lowering effect, saturated fatty acid (SAFA) increase, and mono-unsaturated fatty acid (MUFA) is neutral or has no effect on serum triglyceride that PUFA especially when given ia a large amount besides HDL-c. MUFA seems to have a similar effect as PUFA but without lowering effect on HDL-c. Low LDL-c and high HDL-c levels have positive effect on preventing and curing atherosclerosis and contrary of high LDL-c and low HDL-c.

In this study, 60 albino, 2 month old male rats were put in separate cages and divides randomly into 6 groups. Each group received proportionally the first phase diet rich in margarine (40% of total energy) and cholesterol (10% w/w) for 3 months with additional oralforced feeding of proplythiouracil treated with the second phase diet with additional different types of fat source. The control group receieved normal diet. Determination of serum TG, total cholesterol, LDL-c, HDL-c and microscopic pathological examination of the aorta were carried out after treatment with the first and second phase diets.

Analysis of variance showed that there were significant differences in serum TG, total cholesterol and LDL-c levels, the amount of diet consumed and the body weight changes between the treatment serum TG, total cholesterol and LDL-c as peanut oil. Serum HDL-c appeared not to be influenced by the different types of dietary fat. Pathological examination did not reveal any identifiable atherosclerosis signs in the aorta of the rats.

Abstrak :
Penelitian telah dilakukan untuk mengetahui pengaruh pemberian madu PS (Pollen Substitute) terhadap konsentrasi High-Density Lipoprotein (HDL) dan Low-Density Lipoprotein (LDL) dalam plasma darah tikus yang diberi diet tinggi lemak. Dua puluh empat ekor tikus dibagi dalam 4 kelompok, terdiri atas kelompok kontrol normal yang diberi pakan standar (KK1), kelompok kontrol perlakuan yang diberi diet tinggi lemak (KK2), dan kelompok perlakuan yang diberi diet tinggi lemak serta larutan madu PS dengan dua konsentrasi larutan berturut-turut yaitu 10% dan 20% (KP1 dan KP2). Bahan uji diberikan setiap hari selama 14 hari berturut-turut. Pengambilan darah dilakukan pada hari ke-0 (T0) dan ke-14 (T14), kemudian dilakukan analisis konsentrasi HDL-LDL berdasarkan metode Cholesterol Oxidase-Phenol Amino Phenazone (CHOD-PAP). Hasil uji Kruskal-Wallis (P > 0,05) untuk konsentrasi HDL menunjukkan bahwa tidak ada perbedaan nyata antar rerata kelompok perlakuan. Sedangkan, hasil uji Anava (P< 0,05) untuk konsentrasi LDL menunjukkan terdapat perbedaan yang nyata. Hasil penelitian menunjukkan efek pemberian madu PS terhadap penurunakonsentrasi LDL dan peningkatan konsentrasi HDL plasma. ......The present study was conducted to investigate the effects of PS Honey intake on plasma High Density Lipoprotein (HDL) and Low-Density Lipoprotein (LDL) concentrations in male Sprague-Dawley rats fed with hyperlipidemic diets. Twenty-four male rats were divided into 4 groups, consisting of normal control group (KK1) fed with standard diets, treatment control group fed with high fat diets (KK2), and treatment group fed with high fat diets and PS honey solution in different concentration, 10% and 20% (KP1 and KP2) respectively. Treatment was given orally and administered daily for 14 consecutive days. HDL and LDL levels were measured at day 0 (T0) and day 14 (T14) using Cholesterol Oxidase- Phenol Amino Phenazone (CHOD-PAP) method. Kruskal-Wallis test results (P >0,05) showed no significant effect of treatment on HDL concentration. Anova test results (P < 0,05) showed a significant effect of treatment on LDL. The results demonstrated the potential beneficiary effect of dietary PS Honey in lowering LDL and increasing HDL plasma consentrations.

Abstrak :
Dislipidemia atau abnormalitas kadar lipid dalam darah yang merupakan penyebab utama terjadinya penyakit kardiovaskular dapat diprediksi dengan melihat rasio total kolesterol/K-HDL. Penelitian ini merupakan penelitian cross sectional dengan pendekatan kuantitatif dan bertujuan untuk mengetahui faktorfaktor risiko yang berhubungan dengan rasio total kolesterol/K-HDL pada guru Sekolah Dasar di Kecamatan Cilandak Jakarta Selatan tahun 2013. Hasil penelitian menunjukkan 21,7% responden memiliki rasio total kolesterol/K-HDL berisiko (≥ 5). Hasil analisis bivariat menunjukkan jenis kelamin, lingkar pinggang, frekuensi makan sayur, dan kebiasaan merokok berhubungan secara signifikan dengan rasio total kolesterol/K-HDL. Hasil analisis multivariat menunjukkan bahwa jenis kelamin, lingkar pinggang, dan frekuensi makan sayur dapat menjelaskan 17,7% variasi variabel rasio total kolesterol/K-HDL. Jenis kelamin dan frekuensi makan sayur merupakan faktor predominan terhadap rasio total kolesterol/K-HDL. Peneliti menyarankan untuk dilakukan program Komunikasi Informasi dan Edukasi (KIE), sehingga dapat menambah wawasan untuk mencapai rasio total kolesterol/K-HDL yang optimal. ......Dyslipidemia or abnormality of lipid levels in the blood, which is the major cause of cardiovascular disease, can be predicted by the ratio of total cholesterol/HDL-C. This study is a cross-sectional quantitative approach and aims to explore the risk factors associated with the ratio of total cholesterol/HDL-C among primary school teachers in Cilandak District, South Jakarta in 2013. The results show 21.7% of respondents were high risk ratio (≥ 5). Bivariate analysis shows that sex, waist circumference, frequency of vegetable consumption, and smoking habits are significantly associated with the ratio. Multivariate analysis shows that sex, waist circumference, and frequency of vegetable consumption explain 17.7% of variation in the ratio. Sex and frequency of vegetable consumption are relatively more predominant factors to the ratio. Researcher suggests Communication Information and Education (CIE) program to be held as an insight to achieve an optimal total cholesterol/HDL-C ratio.

Abstrak :
ABSTRAK
Aterosklerosis merupakan inflamasi akibat OxLDL yang berhubungan dengan lipoprotein associated phospholipase A2 LpPLA2 , sehingga menarik mengetahui lebih jauh peran LpPLA2 dalam patogenesis awal aterosklerosis, Penelitian eksperimental ini menggunakan metode post-test with control group secara invivo 50 ekor tikus Sprague Dawley SD yang dikelompokkan dalam kelompok normal, dislipidemia DL , DM tipe 2 DMT2 dan DL serta DMT2 yang diberikan Darapladib DP dengan dosis 30 mg/kg berat badan/hari. Terdiri dari 2 serial waktu perlakuan yaitu 8 dan 16 minggu. Uji statistik menunjukkan kondisi DL, ekspresi protein Lp-PLA2 di jaringan aorta signifikan dengan peningkatan jumlah sel busa. Pada kondisi DMT2, ekspresi relatif mRNA Lp-PLA2 darah signifikan dengan peningkatan jumlah sel busa. Pemberian DP menekan ekspresi Lp-PLA2 dan LisoPC di jaringan aorta tetapi DP tidak menekan ekspresi mRNA Lp-PLA2 jaringan aorta dan darah baik pada kondisi DMT2 maupun DL. DP mampu menekan inflamasi baik di jaringan aorta maupun plasma kondisi DL maupun DMT2. Ekspresi protein Lp-PLA2 jaringan aorta sesuai dengan perubahan kadar LisoPC jaringan aorta. Namun, profil ekspresi mRNA Lp-PLA2 tidak sesuai dengan profil perubahan kadar LisoPC. Protein Lp-PLA2 tidak dapat menggambarkan ekspresi Lp-PLA2 di aorta. Terdapat perbedaan jalur patomekanisme Lp-PLA2 dalam mengaktivasi respons inflamasi diantara kondisi DMT2 dan DL. Keywords : Aterosklerosis, Dislipidemia, DM Tipe 2, LP-PLA2, LisoPC

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ABSTRACT
Athrosclerosis in an inflamation caused by OxLDL which has corellation with lipoprotein associated phospholipase A2 LpPLA2 . Then, it is interesting to do a deeper exploration about LpPLA2 rsquo s role in atherosclerosis patogenesis. These experimental reseacrh use an invivo post test with control group in 50 Sprague Dawley rats SD that will be grouped in a normal, dyslipidemia DL , type 2 diabetes DMT2 or DL and DMT2 group with Darapladib DP administration 30 mg kg body weight daily, each group consisted of 2 serials treatment time, which are 8 weeks and 16 weeks treatment groups. Statistics result showed that in DL condition Lp PLA2 protein expression in aortic tissue correlate significantly with the increase of foam cells, while in DMT2 condition mRNA Lp PLA2 blood expression correlate significantly with the increase of foam cells. DP decreases Lp PLA2 protein expression and LysoPC in aortic tissue, but DP failed to decrease blood and aorta tissue mRNA Lp PLA2 expression both in DL and DMT2 condition. DP is able to decrease inflammation marker both in aortic tissue and plasma both in DMT2 and DL condition. The pattern of Lp PLA2 protein expression in aorta is similar to LysoPC level. However, mRNA Lp PLA2 expression pattern is different from lisoPC level pattern. mRNA Lp PLA2 and Lp PLA2 protein expressions in aorta is different from the blood. Therefore, Lp PLA2 expression in blood does not represent the expression of Lp PLA2 in the aorta. There is a different pattern of Lp PLA2 pathomechanism in activating inflammation response between DMT2 and DL conditions. Keywords Atherosclerosis, Dyslipidemia, type 2 DM, LP PLA2, LisoPC

Abstrak :
PCSK9 (Proprotein Convertase Substisilin Kexin 9) diketahui berfungsi dalam memetabolisme lipid dalam mendegradasi LDLR (Low Density Lipoprotein Receptor). Penelitian ini dilakukan untuk mengembangkan model hewan tinggi PCSK9 karena terbatasnya model in vivo PCSK9 yang menggambarkan fisiologis manusia. Pada pankreas diketahui memiliki PCSK9, yang berfungsi dapat mempengaruhi sekresi insulin. Insulin merupakan hormon yang diproduksi di beta sel yang terdapat di pankreas dan berfungsi dalam meregulasi gula darah. Pada penelitian ini dilakukan evaluasi efek pemberian HFD (High-Fructose Diet) terhadap peningkatan kadar PCSK9 pada plasma dan pankreas, menggunakan metode uji ELISA dan Western Blot, Kadar PCSK9 pada plasma tikus Wistar (Rattus Novergicus) jantan pada durasi induksi 3 minggu dan 4 minggu terdapat perbedaan yang signifikan (p>0,005), sedangkan kadar PCSK9 pada pankreas berkorelasi positif antara durasi induksi fruktosa dan kadar PCSK9, dimana terjadi peningkatan bersamaan dengan lamanya pemberian HFD berdasarkan analisis statistik peningkatan tersebut tidak signifikan, dengan kadar rata-rata tertinggi pada plasma sebesar 1195,01 ng/ml pada durasi 4 minggu dan pada pankreas memiliki kadar 1029,88 ng/ml pada durasi 5 minggu setelah pemberian HFD. Hasil western blot yang dilakukan pada sampel pankreas tidak dapat dilakukan metode kuantifikasi lebih lanjut, meskipun demikian hasil kualifikasi β-actin memberikan hasil dengan absorbansi tertinggi pada HFD 1 (A= 433,45). ......PCSK9 (Proprotein Convertase Substicilin Kexin 9) is known to function in lipid metabolism in degrading LDLR (Low Density Lipoprotein Receptor). This research was conducted to develop a tall animal model for PCSK9 due to the limited in vivo PCSK9 model that describes human physiology. The pancreas is known to have PCSK9, which functions to affect insulin secretion. Insulin is a hormone produced in beta cells in the pancreas and functions to regulate blood sugar. In this study, we evaluated the effect of HFD (High-Fructose Diet) administration on increasing PCSK9 levels in plasma and pancreas, using the ELISA and Western Blot test methods. PCSK9 levels in plasma of male Wistar rats (Rattus novergicus) at induction duration of 3 weeks and 4 weeks showed a significant difference (p>0.005), while PCSK9 levels in the pancreas positively correlated between the duration of fructose induction and PCSK9 levels, where there was an increase along with the duration of HFD administration based on statistical analysis the increase was not significant, with the highest average plasma level of 1195.01 ng/ml for 4 weeks duration and in the pancreas having levels of 1029, 88 ng/ml for a duration of 5 weeks after HFD administration. The results of the western blot performed on the pancreas sample could not be carried out by further quantification methods, even though the results of the qualification of β-actin gave the result with the highest absorbance in HFD 1 (A = 433.45).

Abstrak :
Tujuan: Membuat kriteria tipe HDL proaterogenik/antiaterogenik berdasarkan konsentrasi Apolipoprotein A-I (ApoA-I), Paraoxonase-1 (PON-1), Neopterin dan HDL-cholesterol. Metode: Penelitian dilakukan secara kontrol-kasus pada 52 subjek dengan sindrom koroner akut (SKA) dan 30 subjek kontrol sehat. Tipe HDL proaterogenik dan antiaterogenik ditentukan berdasarkan konsentrasi ApoA-I, PON-1, Neopterin dan HDL-cholesterol. Konsentrasi ApoA-I diukur menggunakan metode imunoturbidimetri, PON-1 diukur dengan metode kolorimetri, Neopterin diukur dengan metode ELISA dan HDL-cholesterol diukur dengan metode homogenous. Analisis regresi logistik univariat dilakukan dengan SKA sebagai variabel tergantung dan konsentrasi ApoA-I, PON-1, Neopterin dan HDL-cholesterol sebagai variabel tidak tergantung. Tipe HDL proaterogenik dan antiaterogenik ditentukan dengan menggunakan nilai cut off dan odd ratio ApoA-I, PON-1, Neopterin dan HDL-cholesterol. Hasil: Umur subjek penelitian adalah 50,89 + 12,63 tahun, konsentrasi HDL-cholesterol : 39,82 + 9,84 mg/dL, Apo A-1 : 119,77 + 32,05 mg/dL, PON-1 : 41,26 + 18,19 kU/L, Neopterin : 16,22 + 38,10 nmol/L. Cut off ApoA-I, PON-1 dan Neopterin secara berturut-turut adalah 124,5 mg/dL, 40,8 kU/L, and 7,016 nmol/L. Hasil analisis regresi logistik univariat didapatkan OR untuk ApoA-I, PON-1 dan Neopterin secara berturut-turut 29,759 (95% CI : 4,074 ? 217,382), 1,647 (95% CI : 0,412 ? 6,586), 4,317 (95% CI : 1,098 ? 16,977). Dengan sistem scoring, kami menyimpulkan total score > 18 menunjukkan tipe HDL proaterogenik, dan total score < 18 merupakan tipe HDL antiaterogenik. Dengan sistem scoring ini kami menemukan 78,85% populasi SKA termasuk ke dalam tipe HDL proaterogenik. Kesimpulan: Disfungsi HDL atau tipe HDL proaterogenik/antiaterogenik dapat diperkirakan dengan menggunakan sistem scoring ApoA-I ? PON-1 ? Neopterin ? HDL-cholesterol. Subjek dengan total score < 18 dikelompokkan ke dalam tipe HDL antiaterogenik, sedangkan subjek dengan total score >18 memiliki tipe HDL proaterogenik.

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Abstract
Aim: To make proatherogenic/antiatherogenic HDL type criteria using Apolipoprotein A-I (ApoA-I), Paraoxonase-1 (PON-1), Neopterin and HDL-cholesterol levels, which may be useful in clinical practice. Methods: This was a case control study recruiting 52 subjects with Acute Coronary Syndrome (ACS) and 30 control healthy subjects. HDL type was classifi ed into antiatherogenic and proatherogenic based on the levels of ApoA-I, PON-1, Neopterin and HDL-cholesterol. Concentrations of ApoA-I was measured by immunoturbidimetry method, PON-1 was measured by colorimetric method, Neopterin was measured by ELISA, and HDL-C was determined by homogenous method. Univariate logistic regression analysis was done using ACS as a dependent variable and levels of ApoA-I, PON-1, Neopterin and HDL-cholesterol as independent variables. Proatherogenic/antiatherogenic HDL type was determined by using ApoA-I, PON-1, Neopterin and HDL-cholesterol cut off and odd ratios. Results: Patient?s age was 50.89 + 12.63 year, HDL-C was 39.82 + 9.84 mg/dL, Apo A-1 was 119.77 + 32.05 mg/ dL, PON-1 was 41.26 + 18.19 kU/L, Neopterin was 16.22 + 38.10 nmol/L. Cut offs of ApoA-I, PON-1 and Neopterin successively were 124.5 mg/dL, 40.8 kU/L, and 7.016 nmol/L. On univariate logistic regression analysis showed that OR of ApoA-I, PON-1 and Neopterin respectively were 29.759 (95% CI : 4.074 ? 217.382), 1.647 (95% CI : 0.412 ? 6.586), 4.317 (95% CI : 1.098 ? 16.977). Using scoring system, we concluded that total score > 18 was proatherogenic HDL type, and total score < 18 was antiatherogenic HDL type. With this scoring we found 78.85% had proatherogenic HDL type in ACS population. Conclusions: Dysfunctional HDL or proatherogenic/antiatherogenic HDL type can be predicted by using ApoA-I ? PON-1 ? Neopterin ? HDL-cholesterol scoring system. Those with score of 18 are supposed to have antiatherogenic HDL type, and those with score of > 18 were having proatherogenic HDL type.

Abstrak :
Stroke ialah salah satu penyebab kematian dan kecacatan neurologis utama di Indonesia. Stroke merupakan penyakit serebrovaskular yang setiap tahun meningkat jumlahnya. Penelitian ini bertujuan untuk mengetahui pengaruh rasio Low Density Lipoprotein LDL terhadap High Density Lipoprotein HDL dengan kejadian stroke pada penduduk usia dewasa. Penelitian ini menggunakan data dari studi kohort PTM penyakit tidak menular tahun 2011. Sampel dalam penelitian ini ialah penduduk usia dewasa yang menjadi responden penelitian studi kohort faktor risiko PTM di kota Bogor tahun 2011 yang berjumlah 1506 dan dianalisis menggunakan uji regresi logistik dengan signifikansi statistik di lihat berdasarkan interval kepercayaan 95. Prevalensi sampel pada penduduk usia dewasa di kota Bogor yang menderita stroke sebesar 1,26, responden dengan rasio LDL terhadap HDL yang tinggi sebesar 35,66. Responden dengan usia 46 tahun sebesar 34,26 dengan prevalensi jenis kelamin terbanyak pada perempuan sebesar 53,45 dan yang berpendidikan rendah sebesar 54,58, responden yang obesitas sebesar 27,42, responden dengan kadar kolesterol total tinggi sebesar 38,45 serta responden dengan kadar trigliserida tinggi sebesar 17,07. Hasil penelitian menunjukkan terdapat hubungan yang signifikan antara rasio LDL terhadap HDL dengan kejadian stroke dengan adjusted prevalens odds rasio 3,909 95 CI 1,346-11,354. Rasio LDL terhadap HDL yang tinggi berisiko terhadap kejadian stroke pada penduduk usia dewasa.

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Stroke is one of the main causes of death and neurological disability in Indonesia. Stroke is a cerebrovascular disease which increases in number every year. This study aims to determine the effect of the ratio of Low Density Lipoprotein LDL to High Density Lipoprotein HDL with the incidence of stroke in the adult population. This study used data from the PTM (non-communicable disease) cohort study risk factor in 2011. The sample in this study was adult population 25-65 years who were respondents to the PTM cohort study in Bogor in 2011 which numbered 1506 and analyzed using regression tests logistics with statistical significance are seen based on 95 confidence intervals. Sample prevalence in adult population in the city of Bogor who suffered a stroke of 1.26, respondents with a high ratio of LDL to HDL were 35.66. Respondents with a age of sebesar46 years were 34.26 with the highest prevalence of sex in women amounting to 53.45 and those with low education were 54.58, respondents who were obese were 27.42, respondents with high total cholesterol levels were 38, 45 and respondents with high triglyceride levels of 17.07. The results showed that there was a significant relationship between the ratio of LDL to HDL and the incidence of stroke with an adjusted prevalence odds ratio of 3.909 95 CI 1.346-11.354. The high ratio of LDL to HDL is at risk for the incidence of stroke in the adult population.

Abstrak :
Penelitian ini merupakan penelitian kuantitatif yang menggunakan desain cross sectional dan bertujuan untuk mengetahui faktor-faktor yang berhubungan dengan rasio total kolesterol/K-HDL dan rasio K-LDL/K-HDL. Penelitian ini memanfaatkan data penelitian Strategi Nasional yang dilakukan Sartika (2010) mengenai Faktor Resiko Dislipidemia pada Dewasa Urban (Kota Depok, Jawa Barat) dan Dewasa Rural (Kecamatan Rumbia, Kabupaten Lampung Tengah). Populasi penelitian ini adalah semua orang dewasa laki-laki maupun perempuan yang berusia 35-60 tahun yang menetap/tinggal di wilayah rural. Hasil penelitian menunjukkan 27,3% responden memiliki rasio total kolesterol/K-HDL yang tinggi dan 13,1% responden memiliki rasio K-LDL/K-HDL yang tinggi. Hasil analisis bivariat menunjukkan bahwa terdapat hubungan yang bermakna antara Indeks Massa Tubuh (IMT) dengan rasio total kolesterol/K-HDL dan rasio KLDL/K-HDL. Hasil analisis multivariat menunjukan bahwa tingkat stress, pengetahuan, sikap, asupan protein, asupan lemak, asupan sayuran hijau, gula darah puasa dan IMT secara signifikan dapat memprediksi rasio total kolesterol/K-HDL. Hasil analisis multivariat juga menunjukan bahwa asupan sayuran hijau, gula darah puasa, dan IMT secara signifikan dapat memprediksi rasio K-LDL/K-HDL. Peneliti menyarankan kepada petugas kesehatan setempat melakukan pengecekan profil lipid darah secara rutin dan membuat program KIE sehingga dapat menambah wawasan mengenai faktor resiko terjadinya dislipidemia.

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This study is a quantitative study using cross sectional design and aims to determine the factors related to ratio of total cholesterol / HDL ratio and KLDL/ K-HDL. The study relied on National Strategy data conducted by Sartika (2010) on Risk Factors for Dyslipidemia in Adults Urban (City of Depok, West Java) and Adult Rural (District thatch, Central Lampung regency). This study population is all adult men and women aged 35-60 years who lived / live in rural areas. The results showed 27.3% of respondents have a ratio of total cholesterol / HDL high-K and 13.1% of respondents have a high ratio K-LDL/K-HDL. The results of bivariate analysis showed that there was a significant association between body mass index (BMI) with the ratio of total cholesterol / HDL ratio and K-K-LDL/K-HDL. The results of multivariate analysis showed that levels of stress, knowledge, attitudes, intake of protein, fat intake, intake of green vegetables, fasting blood sugar and BMI significantly predicted the ratio of total cholesterol / HDL-C. The results of multivariate analysis also showed that intake of green vegetables, fasting blood glucose, and BMI significantly predicted KLDL/K-HDL ratio. Researchers suggested that local health officers to check the blood lipid profile regularly and make IEC program that can add insight into the risk factors of dyslipidemia.

Abstrak :

 

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Abstrak :
Durian merupakan salah satu jenis buah yang terkenal dikalanagn masyarakat, termasuk di Indonesia. Banyak rumor yang berkembang dikalangan masyarakat bahwa konsumsi buah durian dapat meningkatkan level trigliserida dalam darah. Trigliserida sendiri adalah salah satu jenis lemak yang sangat penting badi tubuh dan berperan dalam berbagai sistem fisiologi dalam tubuh seperti pembentukan membrane sel, sumber energy, penyerapan vitamin A, D, E, K dan juga menjaga panas tubuh. Penelitian ini bertujuan untuk membuktikan rumor tersebut dan memberikan informasi kepada masyarakat tentag pengaruh konsumsi durian terhadap kadar trigliserida darah. Penelitian ini menggunaka metode experimental kepada tikus sebagai subjek. Data diambil pada bulan Juli 2012. Durian yang telah diencerkan diberikan kepada tikus melalui injeksi oral dengan 3 perlakuan berbeda, yaitu tikus diberi makan durian selama 1 minggu, 2 minggu dan 3 minggu, ditambah dengan sekelompok tikus yang diberi makan pelet biasa sebagai kontrol. Data diolah menggunakan SPSS . Hasil menunjukan pada kelompok tikus kontrol mean trigliserida darah sebesar 184,073. Pada kelompk tikus yang diberikan makan durian hasilnya menunjukan pada tikus mingu 1 memiliki mean kadar trigliserida darah sebesar 138,423, pada tikus minggu 2 memiliki mean trigliserida darah sebesar 126,962, dan pada tikus minggu 3 memiliki mean kadar trigliserida darah sebesar 633,447. Dari hasil analisis SPSS hasil menunjukan bahwa data tidak signifikan. Sebagai kesimpulan, terjadi penurunan kadar trigliserida darah pada tikus yang diberi makan hanya durian pada minggu 1 dan 2, sedangkan terjadi peningkatan kadar trigliserida darah pada tikus yang hanya diberi makan durian pada minngu 3, dengan korelasi positif. ...... Durian is one of popular fruits among people including in Indonesia. There is rumor spreading in societythat by consuming durian it can raise the blood triglyceride level. Triglyceride itself is a type of fat that very important which is very important for human body and has important roles in physiology system of our body like in cell membrane construction, energy sources, absorption of vitamin A, D, E, K and keep heat in our body. This research's purpose is to prove that rumor and give the information to society about the effect of durian consumption on the blood triglyceride level. This research uses experimental method with rats as subjects. These data was taken on July 2012. The diluted durian is given through oral injection to rats with 3 different variables, which are given durian for 1 week, 2 weeks, and 3 weeks, plus with a group of rats that was feed with ordinary rats food as a control group. The data is processed using SPSS. The results show that from the control group rats the mean of blood triglyceride level is 184,073. In a group of rats that was fed with durian for 1 week the mean of blood triglyceride level is 138,423, in group of rats which was fed with durian for 2 weeks the mean of blood triglyceride level is 126,962, while in group of rats fed with durian for three weeks the mean of blood triglyceride level is 633,447. From the analyzing process using SPSS it shows that the results data is not significant. In conclusion, there is a reduction of blood triglyceride level in groups of rats fed only by durian for 1 week and 2 weeks, while there is an elevation of blood triglyceride level of a group of rats fed only by durian for 3 weeks, with positive correlation.