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Abstrak :
Infeksi soil-transmitted helminths STH di Indonesia masih tinggi terutama di daerah miskin, berpendidikan rendah, dan higiene buruk seperti di Desa Pero Konda, Sumba Barat Daya. Sayangnya, Desa Pero Konda tidak pernah mendapatkan survey prevalensi serta program pemberantasan STH dari puskesmas setempat. Untuk memberantas STH di daerah berisiko tinggi, WHO menganjurkan albendazol 400mg dosis tunggal untuk pengobatan masal. Meski demikian angka kesembuhan STH setelah pemberian albendazol 400mg bervariasi di tiap-tiap daerah. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian albendazol dosis tunggal 400mg terhadap prevalensi STH di Desa Pero Konda. Penelitian eksperimental semu ini menggunakan desain pre-post study. Subjek diwawancara dan dilakukan pemeriksaan feses sebelum dan sesudah pemberian albendazol 400mg dosis tunggal. Pengambilan data sebelum pemberian albendazol dilakukan pada bulan Agustus 2015. Evaluasi dilakukan pada bulan Januari 2016. Hasil penelitian menunjukan prevalensi Ascaris lumbricoides menurun signifikan

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Soil transmitted helminthes STH infection prevalence is high in Indonesia rsquo s low educated and deprived area with poor hygiene like Pero Konda Village, South West Sumba District. Unfortunately, local community health center had never conducted STH prevalence survey and elimination program in Pero Konda Village. To eliminate STH in high risk area, WHO recommends the use of single dose albendazole 400mg mass treatment. However, the cure rate after single dose albendazole 400mg treatment varies from one place to another. The aim of this study was to assess the effect of single dose albendazole 400mg treatment towards STH infection in Pero Konda Village. This study was a quasi experimental with pre post design. Subjects were interviewed and their feces were collected before and after treatment with single dose albendazole 400mg. Pre treatment data collection and treatment were done on August 2015 and the post treatment data collection was conducted on January 2016. STH infections were assessed using fecal examination with light microscope. Result showed that Ascaris lumbricoides infection significantly.

Abstrak :
Albendazol 400mg dosis tunggal adalah antelmintik yang direkomendasikan WHO untuk memberantas STH, namun obat tersebut hanya efektif untuk memberantas Ascaris lumbricoides dan tidak efektif terhadap trikuriasis sehingga dosis perlu ditingkatkan. Penelitian ini bertujuan untuk mengetahui efektivitas albendazol 400mg triple dose dalam pengobatan infeksi cacing usus pada anak berusia 1-15 tahun di desa Perobatang, Sumba Barat Daya. Desain penelitian adalah pre-post study. Data diambil dua kali, yaitu pada 12 Juli 2016 dan 26 Juli 2016. Orang tua subjek/subjek diminta untuk mengumpulkan feses, kemudian dibuat sediaan kato katz dan sampel feses diperiksa secara mikroskopis. Subjek yang positif diberikan albendazol triple dose dan sampel feses diperiksa kembali untuk mengetahui cure rate CR dan egg reduction rate ERR dua minggu setelah intervensi. Hasil penelitian menunjukkan dari 246 sampel, didapatkan 192 anak 78 positif STH dan turun menjadi 66 anak 27 setelah intervensi. Pengobatan albendazol triple dose efektif untuk mengobati infeksi cacing tambang sebanyak 24 anak yang terinfeksi cacing tambang seluruhnya sembuh dan A.lumbricoides CR = 97 ; ERR = 100 , tetapi kurang efektif untuk infeksi T.trichiura CR=61 dan ERR= 91 . Meskipun demikian, rerata hitung telur T.trichiura sebelum dan dua minggu setelah pengobatan menurun secara bermakna uji Wilcoxon.

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Single dose albendazole 400 mg is an anthelmintic which is recommended by WHO to eliminate the STH infection. However, it is only effective to eliminate Ascaris lumbricoides, but ineffective against trichuriasis thus, the dosage needs to be increased. This research aimed to determine the effectiveness of triple dose albendazole 400mg in eliminating the intestinal helminth infections on children aged 1 ndash 15 years in Perobatang village, Southwest Sumba. This study was designed as a pre post study. Data were collected twice on 12th July 2016 and 26th July 2016. Subjects or their parents were asked to collect the stool, then the stool samples were examined using the Kato Katz method for microscopic examination. Subjects infected with STH were given albendazole triple dose and their stool samples were collected again to determine the cure rate CR and egg reduction rate ERR at 2 week post treatment. As much as 246 subjects were conducted, 192 of them 78 were positive with STH infections and decrease to 66 subjects 27 after treatment. Treatment with albendazole triple dose was effective against hookworm all the 24 samples with hookworm infection was entirely cured and A. lumbricoides CR 97 ERR 99.98 , while albendazole triple dose was still ineffective against T.trichiura CR 61 and ERR 90.87 although the wilcoxon test for T.trichiura showed a significant reduction egg count epg before and 2 week after treatment p 0.001 . Overall, the infection rate at 2 week after treatment decreased significantly McNemar test, p 0,001 . It can be concluded that the triple dose albendazole 400mg is effective against ascariasis, but ineffective against trichuriasis. Further research is required to adjust the dosage or to consider using another anthelmintic to enhance the effectiveness in eliminating trichuriasis.