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Abstrak :
Kerusakan target organ tersering pada hipertensi adalah left ventricular hypertrophy LVH dan mikroalbuminuria Radiografi toraks merupakan pemeriksaan non invasif untuk mengevaluasi LVH terutama proyeksi lateral dengan Hoffman Rigler sign. Penelitian bertujuan mengetahui hubungan antara LVH berdasarkan modalitas radiografi toraks dengan mikroalbuminuria pada pasien hipertensi. Sampel merupakan pasien hipertensi yang telah diberikan terapi dan dilakukan radiografi toraks PA dan lateral. Dari 66 pasien hipertensi 19 28 8 dengan mikroalbuminuria positif. Dari 35 pasien hipertensi dengan LVH 12 34 3 dengan mikroalbuminuria positif. Pada penelitian ini radiografi toraks PA dan lateral dapat digunakan untuk menilai tanda LVH.

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Common target organ damage in hypertension is left ventricular hypertrophy LVH and microalbuminuria Chest x ray is a non invasive examination to evaluate LVH especially lateral projection with Hoffman Rigler sign methode. The research aims to investigate the relationship between LVH based modalities PA and lateral chest x ray with microalbuminuria in hypertensive patients. Samples taken were hypertensive patients who have been given therapy and do PA and lateral chest x ray Of 66 hypertensive patients 19 28 8 with positive microalbuminuria Of 35 hypertensive patients with LVH 12 34 3 with positive microalbuminuria In this study PA and lateral chest x ray can be used to assess the sign of LVH.

Abstrak :
Penyakit kardiovaskular merupakan penyakit dengan angka kematian tertinggi di dunia. Fungsi jantung perlu diperiksa secara akurat dan efisien agar penyakit kardiovaskular dapat terdeteksi dengan baik. Penilaian fungsi jantung umumnya dilakukan dengan memberi tanda ventrikel kiri secara manual. Hal tersebut memiliki kekurangan karena dapat memakan waktu, rawan kesalahan karena resolusi citra yang rendah, dan memiliki perbedaan hasil yang bervariasi antar pemeriksa. Oleh karena itu, penandaan ventrikel kiri secara otomatis dengan segmentasi sangat penting agar pemeriksaan fungsi jantung dapat dilakukan lebih efektif dan efisien. Dalam penelitian ini, dilakukan pengembangan model deep learning untuk pekerjaan segmentasi ventrikel kiri pada citra ekokardiografi menggunakan encoder yang dimiliki U-Net, ditambahkan dengan modul Atrous Spatial Pyramid Pooling dan decoder yang dimiliki DeeplabV3+. Selanjutnya, ditambahkan Coordinate Attention pada tahap akhir dalam encoder untuk penyempurnaan fitur. Dilakukan uji pada dataset Echonet-Dynamic, Hasil penelitian menunjukkan bahwa melakukan penggabungan antara encoder yang dimiliki U-Net dan decoder yang dimiliki DeeplabV3+ mampu memberikan peningkatan performa dibandingkan model U-Net dan DeeplabV3+, juga memberikan hasil yang lebih baik dibandingkan penelitian sebelumnya, dengan menghasilkan nilai dice similiarity coefficient sebesar 92.91%. ......Cardiovascular disease is a disease with the highest mortality rate in the world. Heart function needs to be checked accurately and efficiently so that cardiovascular disease can be detected properly. Assessment of cardiac function is generally done by marking the left ventricle manually. This has the drawbacks of being time-consuming, error-prone due to low image resolution, and have inter-observer variability. So that automatic marking of the left ventricle with segmentation is very important so that the examination of cardiac function can be carried out more effectively and efficiently. In this study, a deep learning model was developed for left ventricle segmentation on echocardiographic images using an encoder in U-Net, added with the Atrous Spatial Pyramid Pooling module and an decoder in DeeplabV3+. Furthermore, the Coordinate Attention Module was added at the final stage in the encoder for feature enhancements. Tests were carried out using the Echonet-Dynamic dataset. The results showed that combining the encoder in U-Net and the decoder in DeeplabV3+ was able to provide increased performance compared to the U-Net and DeeplabV3+ models, also gives better results than previous research, by producing a dice similarity coefficient of 92.91%.

Abstrak :
ABSTRAK Latar belakang: latihan fisik aerobik teratur dapat menyebabkan perubahan morfometrik, peningkatan ukuran miosit dengan peningkatan ekspresi connexin43 (Cx43) tanpa lateralisasi, serta peningkatan deposisi matriks ekstraseluler. Latihan fisik sebaiknya dimulai sejak masa anak-anak, guna mencapai kesehatan kardiovaskular di masa dewasa. Metode: Tikus usia juvenile dan dewasa muda dibagi secara acak dalam 7 kelompok, yaitu: kelompok latihan fisik onset juvenile durasi 4 minggu dan kontrol, kelompok latihan fisik onset juvenile durasi 8 minggu dan kontrol, kelompok latihan fisik onset juvenile durasi 12 minggu, kelompok latihan fisik onset usia dewasa muda durasi 8 minggu dan kontrol. Latihan fisik disesuaikan dengan usia tikus dan dipertahankan pada kecepatan 20 m/menit selama 20 menit intermitten, 5x seminggu. Analisis morfometrik jantung, peningkatan ukuran miosit, deposisi matriks ekstraseluler, serta ekspresi serta distribusi Cx43. Hasil: Tikus terlatih (5, 8, dan 12 minggu) pada kedua kelompok usia menunjukkan nilai berat jantung, berat ventrikel kiri, diameter rongga ventrikel, ketebalan otot jantung yang lebih tinggi dibandingkan dengan kelompok kontrolnya. Peningkatan ukuran panjang miosit juga meningkat kelompok latihan dibanding kontrol. Deposisi matriks ekstraseluler meningkat pada kelompok latihan dibandingkan kontrol. Ekspresi Cx43 juga meningkat pada sisi lateral. Kesimpulan: Latihan fisik aerobik dapat meningkatkan ukuran jantung dengan peningkatan ukuran sel, peningkatan deposisi matriks ekstraseluler, peningkatan Cx43 pada sisi lateral. Peningkatan matriks ekstraseluler dan peningkatan lateralisasi menunjukkan peningkatan risiko aritmia.

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ABSTRACT Background: Regular aerobic exercise can improve morphometric changes, an increase in the size of myocytes with increased expression of connexin43 (Cx43) without lateralization, and increase extracellular matrix deposition. Exercise should be started since childhood, in order to achieve cardiovascular health in adulthood. Methods: Juvenile and young adult Rats randomly divided into 7 groups: juvenile onset 4 weeks exercise duration and control group, juvenile onset 8 weeks exercise duration and control group, exercise juvenile onset 12 weeks exercise duration, young adult onset 8 weeks exercise duration and control group. Physical exercise adapted to the age of rats and maintained at speed of 20 m/minute for 20 minutes intermittent, 5 times a week. Morphometric analysis of the heart, increase the size of myocytes, extracellular matrix deposition, expression and distribution of Cx43. Results: Trained rats (5, 8, and 12 weeks) in both age groups showed values of heart weight, left ventricle weight, ventricular cavity diameter, heart muscle thickness is higher than control group. Increased length of myocytes also increased in exercise group compared to the control. Increased deposition of extracellular matrix in exercise group than control. Cx43 expression was also increased in the lateral side. Conclusions: Aerobic exercise can increase the size of the heart with increased cell size, increased extracellular matrix, increased Cx43 lateralization. Increased extracellular matrix deposition and increased lateralization showed an increased risk of arrhythmia.

Abstrak :
Latar Belakang: Statin (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors) melalui efek pleiotrofiknya telah terbukti menurunkan angka kejadian kardiovaskular mayor (KKM) setelah intervensi perkutan pada pasien angina pektoris stabil maupun pasien sindroma koroner akut. Namun masih banyak perdebatan mengenai manfaat statin segera sebelum dilakukan intervensi perkutan primer (IKPP) pada pasien IMA-EST. Tujuan: Untuk mengetahui pengaruh pemberian terapi akut atorvastatin dosis tinggi (80 mg) dan plasebo sebelum IKPP terhadap perfusi mikrovaskular pada pasien IMA-EST yang dinilai dengan teknik IRM (indeks resistensi mikrovaskular). IRM merupakan pemeriksaan mikrovaskular yang spesifik dan bersifat kuantitatif, dapat memberikan nilai prognostik dan prediktor perbaikan fungsi ventrikel kiri setelah dilakukannya IKPP. Metode: Penelitian ini merupakan studi eksperimental acak yang tersamar ganda. Diberikan atorvastatin dosis 80 mg atau plasebo. Sampel diambil secara consecutive dari populasi terjangkau IMA-EST yang menjalani IKPP dan memenuhi kriteria inklusi dan eksklusi. Reperfusi miokardium dinilai dengan parameter IRM dengan menggunakan kawat dengan sensor tekanan dan suhu setelah IKPP selesai dilakukan. Hasil Penelitian: Terdapat 66 sampel yang terbagi dalam 2 kelompok yakni 32 orang mendapatkan atorvastatin 80 mg dan 34 orang mendapatkan plasebo. Tidak didapatkan perbedaan yang signifikan pada kelompok yang mendapatkan atorvastatin 80 mg dan plasebo dalam hal parameter fractional flow reserve (FFR) (0.94 vs. 0.96, p = 0.39), coronary flow reserve (CFR) (1.1 vs. 1.2, p = 0.09) dan IRM (41.54 [12.8-198.2] vs. 41.60 [10.4 ? 200.3], p = 0.61). Kesimpulan: Pemberian terapi atorvastatin dosis tinggi 80 mg sebelum tindakan IKPP pada pasien IMA-EST tidak memberikan pengaruh terhadap perfusi mikrovaskular yang dinilai dengan parameter IMR. ......Background: Statin (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors), given before percutaneous coronary intervention (PCI) was proven to reduce Major Cardiovascular Events (MACE) in patient with stable angina as well as acute coronary syndromes through its pleiotropic effect. Nevertheless, the debate regarding statin administration before primary PCI (PPCI) in STEMI patients is still on the rise. Objective: To establish therapeutic effect of high dose atorvastatin (80 mg) and placebo before primary PCI on microvascular perfusion in STEMI patient using index of microcirculatory resistance (IMR). IMR are specific and quantitative assessment of coronary microvascular dysfunction, reliable on-site predictors of short-term myocardial viability and left ventricle functional recovery of patients undergoing primary PCI for STEMI. Methods: This study is a double blind randomized controlled trial. A high loading dose of atorvastatin (80 mg) or placebo was administered before PPCI. Samples were taken from the population of STEMI patients which underwent PPCI and meet the inclusion and exclusion criteria. The primary end point of this study is IMR. After successful primary percutaneous coronary intervention, IMR was measured using a pressure-temperature sensor-tipped coronary guidewire. Result: Total of 66 patients was divided into 2 groups, atorvastatin group (32 patients) and placebo group (34 patients). There were no significant differences between both groups in regard of fractional flow reserve (FFR) (0.94 vs. 0.96, p = 0.39), coronary flow reserve (CFR) (1.1 vs. 1.2, p = 0.09) and also IMR (41.54 [12.8-198.2] vs. 41.60 [10.4 ? 200.3], p = 0.61). Conclusion: Administration of high loading dose of atorvastatin (80 mg) before primary PCI in STEMI patients didn?t have effect on microvascular perfusion measured by index of microcirculatory resistance.

Abstrak :
Latar belakang. Nekrosis miokardium menginduksi reaksi inflamasi yang hebat dan penempelan netrofil melalui Intercellular Adhesion Molecule (ICAM). Hasil studi ARMYDA-CAMS menunjukkan bahwa pemberian Atorvastatin secara kontinyu pra-Intervensi Koroner Perkutan (IKP) dapat menurunkan kadar ICAM pasca-tindakan pada pasien dengan Angina Pektoris Stabil (APS). Hingga saat ini belum ada penelitian yang melihat efek akut pemberian Atorvastatin 80 mg pada pasien Infark Miokardum Akut dengan Elevasi Segmen ST (IMA-ST) yang menjalani Intervensi Koroner Perkutan Primer (IKPP). Metode. Penelitian ini merupakan suatu uji klinis acak tersamar ganda. Evaluasi dilakukan pada 76 pasien IMA-ST yang menjalani IKPP di Pusat Jantung Nasional Harapan Kita dari bulan Februari hingga bulan Agustus 2014. Pasien dibagi secara acak tersamar ganda menjadi dua kelompok (Atorvastatin 80 mg dan Plasebo). Pemeriksaan ICAM diambil dua kali (0 dan 24 jam pasca-IKPP). Dilakukan analisis statistik untuk menilai efek pemberian Atorvastatin yang dinilai dengan delta ICAM. Hasil. Tidak terdapat perbedaan bermakna pada data dasar kedua kelompok dalam hal klinis, pemeriksaan penunjang, dan angiografik. Nilai delta ICAM menunjukkan perbedaan yang signifikan, yaitu pada kelompok Atorvastatin 80 mg (-13,0±38,5 ng/mL) dan Plasebo (26,1±67,0 ng/mL, p 0,003). Analisa regresi linear (adjusted analysis; sesuai usia, jenis kelamin, diabetes, dan insufisiensi renal) menunjukkan koefisiensi -31,17 ng/mL dengan p 0,037. Kesimpulan. Pemberian Atorvastatin 80 mg secara akut pada pasien IMA-ST menurunkan respon inflamasi endotelium yang dinilai dengan kadar ICAM. ......Background. Myocardial necrosis triggers complement activation and neutrophyl adhesion which is mediated by Intercellular Adhesion Molecule (ICAM). Results from ARMYDA-CAMS, showed that Atorvastatin continuous treatment reduced ICAM value in patients with stable angina pectoris. To date, there are no study yet which investigates the effect of acute Atorvastatin 80 mg treatment in patients with ST Segment Elevation Myocardial Infarction (STEMI) post Primary Percutaneous Coronary Intervention (PPCI). Methods. This is a randomized, double-blinded, controlled trial. Evaluations were performed on 76 STEMI patients who underwent PPCI at National Cardiac Center Harapan Kita (NCCHK) from February 2014 to August 2014. Patients were randomly classified into two groups (Atorvastatin 80 mg and Placebo). Laboratory data on ICAM were taken twice (0-hour and 24-hour post PPCI) and examined at Prodia?s Laboratorium. Statistical analyses using SPSS were performed to evaluate the effect of Atorvastatin treatment, which was measured by delta ICAM. Results. There were no difference between two groups (Atorvastatin vs. Placebo) in terms of clinical, supporting data, and angiographic findings. Delta ICAM values showed significant difference between two groups, which are Atorvastatin 80 mg (-13,0±38,5 ng/mL) and Plasebo (26,1±67,0 ng/mL, p 0,003). Linear regression analysis (adjusted analysis; according to age, sex, diabetes, and renal insufficiency) showed coefficient of -31,17 ng/mL with p 0,037. Conclusion. This study showed that acute Atorvastatin 80 mg treatment pre-PPCI reduces endothelial inflammatory response which was measured by ICAM.

Abstrak :
Latar belakang : Pasien gagal jantung kronik memerlukan evaluasi pemeriksaan ekokardiografi. Berbagai metode pemeriksaan digunakan dalam pemeriksaan ekokardiografi, diantaranya pemeriksaan LAEF, LAVI, dan LVEF yang terkait dengan penelitian ini. Metode pemeriksaan LAEF dan LAVI memiliki peran dalam menilai remodelling atrium kiri, sedang LVEF terkait dengan fungsi sistolik ventrikel kiri. Tujuan : Penelitian ini bertujuan menilai korelasi nilai LAEF dan LAVI dengan nilai LVEF pada < 40% dan ≥ 40%. Metode : Studi potong lintang pada 150 pasien gagal jantung kronik yang dilakukan pemeriksaan ekokardiografi trans-torakal di eko-lab PJT RSCM.Pemeriksaan ekokardiografi metode LAEF dengan metode area length (2 dimensi) pada minimal 2 view eko, sedangkan LAVI dengan metode 2 dimensi. Pemeriksaan LVEF dengan metode Simpson. Hasil : Pada penelitian didapatkan 150 subjek dengan nilai median LAVI 30,9mL/m2 (RIK 22,08-40,80), nilai median LVEF 55,75 % (RIK 40,75-61,85), nilai LAEF median 31,8 % (RIK 23,98-38,30). Korelasi nilai LAEF dengan nilai LVEF pada LVEF < 40% dengan hasil korelasi positif sedang bermakna (r = 0,614; p <0,001), pada LVEF ≥ 40% dengan hasil korelasi positif sedang bermakna (r =0,580 ; p < 0,001). Korelasi nilai LAVI dengan nilai LVEF pada LVEF < 40% dengan hasil berkorelasi negatif lemah dan tidak bermakna (r = -0,093; p = 0,722), sedangkan pada LVEF ≥ 40% dengan hasil berkorelasi negatif lemah bermakna (r = -0,299; p < 0,001). Dilakukan sub-analisis pada LVEF 40-50%, didapatkan nilai LAEF dan nilai LVEF berkorelasi positif lemah bermakna (r = 0,492; p <0,001). Lalu sub-analisis pada LVEF ≥ 50%, didapatkan korelasi nilai LAEF dan nilai LVEF positif lemah tidak bermakna (r = 0,205; p = 0,063). Kesimpulan : Terdapat korelasi positif nilai LAEF dengan nilai LVEF pada pasien gagal jantung kronik baik pada HFrEF (LVEF < 40%) dan LVEF ≥ 40%, sehingga nilai LAEF pada cut-off nilai LVEF 40% dapat menjadi salah satu marker menilai proses remodelling atrium kiri. Sedangkan nilai LAVI dengan LVEF pada pasien gagal jantung kronik ditemukan korelasi lemah atau tidak adanya korelasi. ......Background : Patients with chronic heart failure require echocardiographic evaluation. Various examination methods were used in echocardiographic examinations, including LAEF, LAVI, and LVEF examinations related to this study. LAEF and LAVI examination methods have a role in assessing left atrial remodeling, while LVEF is related to left ventricular systolic function. Objective : This study aims to assess the correlation between LAEF and LAVI values with LVEF values at LVEF < 40% and LVEF 40%. Methods : A cross-sectional study of 150 patients with chronic heart failure who underwent transthoracic echocardiography at the RSCM PJT eco-lab. Echocardiographic examination using the LAEF method with the area length method (2 dimensions), in at least 2 eco views, while the LAVI using the 2-dimensional method. LVEF examination by the Simpson method. Results : The study found 150 subjects with a median LAVI value of 30.9 mL/m2 (IQR 22.08-40.80), a median LVEF value of 55.75% (IQR 40.75-61.85), a median LAEF value of 31 ,8% (IQR 23.98-38.30). The correlation between the LAEF value and the LVEF value at LVEF < 40% has a moderately significant positive correlation (r = 0.614; p < 0.001), while at LVEF ≥ 40% has a moderately significant positive correlation (r = 0.580 ; p < 0.001). The correlation between the LAVI value and the LVEF value at LVEF < 40% has a weak and insignificant negative correlation (r = -0.093; p = 0.722), while at LVEF ≥ 40% has a weak negative significant correlation (r = -0.299; p < 0.001). Sub-analysis was performed on LVEF 40-50%, and the LAEF value and LVEF value were positively and significantly correlated (r = 0.492; p < 0.001). Then the sub-analysis at LVEF > 50%, it was found that the correlation between the LAEF value and LVEF value were weak positive and not significant correlated (r = 0.205; p = 0.063). Conclusion : There is a positive correlation between LAEF values and LVEF values in chronic heart failure patients both at HFrEF (LVEF < 40%) and LVEF ≥ 40%, so that the LAEF value at the cut-off LVEF 40% can be one of the markers to assess the left atrial remodeling process. While the value of LAVI with LVEF in patients with chronic heart failure found a weak correlation or no correlation.

Abstrak :
This project represents a concise review of normal and abnormal cardiac anatomy and physiology, the evolution of SVR to EVLPP with validation of near normal ventricular restoration, plus act as a reference guide for cardiac surgeons with interest in SVR. The authors review normal and abnormal cardiac anatomy following post myocardial infarction and physiology, with focus on the evolution of surgical techniques aimed at establishing an ellipsoid ventricular shape, resulting in near-normal physiological hemodynamics evident at long term.

Abstrak :
Hipertrofi ventrikel kiri atau Left ventricle hypertrophy (LVH) adalah faktor risiko independen terjadinya gagal jantung pada pasien hipertensi. Diagnosis dini LVH diperlukan untuk mencegah kerusakan lebih lanjut pada otot jantung. Cardiotropin-1 (CT-1) diproduksi oleh kardiomiosit dan fibroblas, yang kadarnya dilaporkan meningkat pada pasien hipertensi primer. Tujuan : Membuktikan manfaat CT-1 serum untuk mendeteksi LVH pada pasien hipertensi primer. Metode : Penelitian uji diagnostik dilaksanakan di RSCM Jakarta periode Februari s/d Maret 2013. Subyek penelitian adalah 75 pasien hipertensi primer dengan atau tanpa LVH. Diagnosis LVH dilakukan dengan ekokardiografi sebagai baku emas dan elektrokardiografi/EKG (kriteria Sokolow Lyon voltage, Cornell voltage dan Cornell product). Kadar CT-1 serum diperiksa dari sampel darah vena dengan metode ELISA. Hasil : Berdasarkan ekokardiografi 46 orang (61,3%) LVH dan 29 orang (38,7%) tidak LVH. Kadar CT-1 subyek LVH adalah 82,96 ± 351,843 pg/mL dan subyek tanpa LVH 4,55 ± 1,281 pg/mL (p=0,01). Korelasi CT-1 dengan LVMI adalah tidak bermakna (p=0,1). Luas area dibawah kurva ROC CT-1 untuk diagnosis LVH adalah 0,67 (p=0,01). Nilai cut-off CT-1 adalah 4,45 pg/mL. Uji diagnostik CT-1: Sensitifitas 54,4%, spesifisitas 75,9, NDP 78,1%, NDN 51,2 dan akurasi 61,3%. Uji diagnostik kombinasi CT-1 dan EKG (salah satu kriteria positif LVH): sensitifitas 67,4%, spesifisitas 72,4% , NDP 79,5%, NDN 58,3% dan akurasi 69,3%. Simpulan. CT-1 kurang sensitif namun cukup spesifik untuk diagnosis hipertrofi ventrikel kiri (LVH). Kombinasi CT-1 dengan EKG meningkatkan nilai diagnostik pemeriksaan untuk deteksi LVH pada pasien hipertensi primer.

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Left ventricle hypertrophy (LVH) is independent risk factor of heart failure on hypertension patients. Early detection of LVH is necessary to prevent extensive damage of heart muscle. Cardiotropin-1 (CT-1) is produce by cardiomyosite and fibroblast, that the level of CT-1 has been reported increase on primary hypertension patients. Aim : To prove the benefit of CT-1 serum to detect LVH on primary hypertension patients. Methods : A diagnostic study has been conducted on RSCM Jakarta on the periode of February to March 2013. Research subjects were 75 primary hypertension patients with and without LVH. LVH diagnosis was performed by echocardiography examination as gold standard and electrocardiography/ECG (Sokolow Lyon voltage, Cornell Voltage and Cornell product criterias). CT-1 level was measured by ELISA method from vein blood sample. Results : Based on echocardiography examination 46 patients (61.3%) were diagnosed as LVH and 29 patients (38.7%) without LVH. The level of CT-1 of patients with LVH was 82.96 ± 351.843 pg/mL and 4.55 ± 1.,281 pg/mL on patients without LVH (p=0.01). Correlation between CT-1 and Left Ventricular Mass Index was not significant (p=0.1). Area under the ROC curve was 0.67 (p=0.01). The cut-off of CT-1 level for diagnosis of LVH was 4.45 pg/mL. Diagnostic test yield the sensitivity of CT-1 for diagnosis of LVH was 54.4%, specificity 75.9%, PPV 78.1%, NPV 51.2% and accuracy was 61.3%. Diagnostic test of combination CT-1 and ECG (positive LVH by one or more ECG’s criteria) yield sensitivity 67.4%, specificity 72.4% , PPV 79,5%, NPV 58.3% and accuracy 69.3%. Conclusion. CT-1 examination was not sensitive but specific for LVH diagnosis. Combination of CT-1 and ECG examination was improve diagnostic value of CT-1 for detection of LVH on primary hypertension patients.

Abstrak :
Latar Belakang: Beban penyakit gagal jantung semakin meningkat dan sekitar 50% kasus adalah HFrEF. Penyakit jantung koroner merupakan penyebab utama HFrEF. Pada kasus ini, pemulihan fungsi ventrikel kiri merupakan tujuan utama terapi karena berhubungan dengan penurunan risiko kejadian kardiovaskular. 1 Populasi dengan pemulihan FEVK dikategorikan sebagai HFrecEF dimana populasi ini memiliki karakteristik yang berbeda. 2 Belum terdapat suatu studi yang melihat prediktor pemulihan FEVK sesuai kriteria HFrecEF JACC pada populasi kardiomiopati iskemik setelah revaskularisasi lengkap. Tujuan: Mengetahui faktor-faktor yang mempengaruhi terjadinya pemulihan FEVK pasca revaskularisasi lengkap operasi bedah pintas arteri koroner pada populasi kardiomiopati iskemik. Metode: Sebuah penelitian kohort retrospektif dengan populasi penelitian kardiomiopati iskemik yang menjalani revaskularisasi lengkap dengan BPAK selama periode Januari 2019 sampai dengan Juli 2022 di Rumah Sakit Jantung dan Pembuluh Darah Harapan Kita. Hasil: Terdapat 105 subjek yang memenuhi kriteria inklusi, dengan 72 (68,5%) subjek pada kelompok nonHFrecEF dan 33 (31,5%) subjek pada kelompok HFrecEF. Pada analisis multivariat, LVESD (OR 0,87; p=0,018)) merupakan prediktor independen HFrecEF. Penggunaan RAAS Inhibitor postoperatif menurunkan risiko mortalitas dalam 1 tahun secara signifikan (HR 0,036; p=0,07). Follow up kesintasan 1 tahun menunjukkan tidak ada perbedaan bermakna antara kelompok HFrecEF (95%) dan nonHFrecEF (96%) dengan nilai p=0,999. Terdapat perbedaan kesintasan yang signifikan antara pengguna RAAS Inhibitor dan bukan pengguna RAAS Inhibitor pada populasi penelitian (p<0,0001). Kesimpulan: Nilai LVESD adalah prediktor independen pemulihan FEVK. Angka kesintasan 1 tahun pada seluruh populasi cukup baik yaitu lebih dari 90%. Penggunaan  RAAS Inhibitor pada penelitian ini tidak menunjukkan dampak pemulihan FEVK, namun pengaruhnya pada kesintasan 1 tahun menekankan pentingnya pemberian terapi optimal gagal jantung pada populasi ini. ......It is estimated that the disease burden of heart failure has increased and about 50% of cases are HFrEF. Coronary heart disease is the main risk for heart failure. Left ventricular function recovery is the most important goals of heart failure therapy. It is associated with a reduced risk of cardiovascular events. These population is categorized as patients with HFrecEF where they have unique characteristics. There has not been a study looking at predictors of recovery of EF according to the JACC HFrecEF criteria in the ischemic cardiomyopathy population after complete revascularization. Objectives: To evaluate the factors that predicts the recovery of FEVK after complete revascularization by coronary artery bypass surgery in the ischemic cardiomyopathy population. Methods: This retrospective cohort study used secondary data. Basic data was obtained through medical record and registry of ischemic cardiomyopathy patients underwent complete revascularization with CABG during the period January 2019 to July 2022 at Harapan Kita Cardiovascular Hospital. Results: A total of 105 subjects were obtained, there were 72 (68.5%) subjects in the nonHFrecEF group and 33 (31.5%) subjects in the HFrecEF group. In multivariate analysis, LVESD (OR 0.87; p=0.018)) was an independent predictor of HFrecEF. Postoperative use of RAAS Inhibitors reduced the risk of mortality within 1 year significantly (HR 0.036; p=0.07). No significant difference in 1 year survival follow-up between the HFrecEF (95%) and non-HFrecEF (96%) groups with p = 0.999. There was a significant difference in survival between RAAS Inhibitor users and non-RAAS Inhibitor users in the entire study population (p<0.0001). Conclusion: In ischemic cardiomyopathy patients undergoing CABG, LVESD score is an independent predictor of recovery of LVEF. The 1-year survival rate in the entire population was >90%. Although the use of RAAS inhibitors in this study did not show an impact on recovery of LVEF, its effect on 1-year survival emphasizes the importance of providing optimal therapy for heart failure in this population.