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Abstrak :

Latar Belakang: Salah satu faktor utama yang terlibat dalam gangguan mineral tulang dan muskuloskeletal pada pasien penyakit ginjal kronik (PGK) adalah Fibroblast Growth Factor-23 (FGF-23). Peningkatan kadar FGF-23 terjadi pada awal PGK dan semakin meningkat pada PGK tahap akhir terutama yang menjalani dialisis. FGF-23 mendapat perhatian khusus karena perannya terhadap otot skeletal pada pasien PGK yang menjalani hemodialisis belum diketahui secara pasti. 

Tujuan: Mengetahui korelasi antara kekuatan genggam tangan(KGT) dengan kadar FGF-23 pada pasien yang menjalani hemodialisis kronis.

Metode: Penelitianinimerupakanstudipotong lintang. Penelitian ini dilaksanakan di unit Hemodialisis Divisi Ginjal-Hipertensi Departemen Ilmu Penyakit Dalam RSCM Jakarta, pada 74 pasien dialisis 2 kali seminggu. Pengukuran FGF dengan pemeriksaan intactFibroblast Growth Factor-23 (iFGF-23) dan menilai KGT dengan dinamometer hidraulik tangan merek Jamar. Pemilihansubjekdilakukansecaraconsecutivesamplingsampaijumlah subyekyangdiperlukanterpenuhi.

Hasil: Subjek pada penelitian ini sebanyak 74 subjek dengan kadar pemeriksaan iFGF-23 pada laki-laki lebih tinggi dibandingkan dengan perempuan, (3276 [ min-maks; 41-6613]pg/ml dan1585 pg/ml, [min-maks; 21-4820])dan nilai KGT pasien laki-laki adalah 25 kg (min-maks; 11-48) dan perempuan adalah 20 kg (min-maks; 8-26). Setelah dilakukan penyesuaian dengan indeks komorbid charlson modifikasidan indeks massa tubuh, maka tidak didapatkan korelasi antara FGF-23 dengan KGT pada subjek laki-laki (r=-0.053, p=0.7) akan tetapi terdapat korelasi negatif bermakna pada subjek perempuan (r=-0.4, p=0.02). 

Kesimpulan: Kadar iFGF-23 memiliki korelasi negatif bermakna dengan KGT pada perempuan dan hal tersebut tidak ditemukan pada subjek penelitian laki-laki.

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Background: Patients with chronic kidney disease (CKD) face with muscle atrophy, low muscle strength, and low physical activity. One of the main factors involved in bone mineral and skeletal muscle dysfunction in patients with chronic kidney disease (CKD) is Fibroblast Growth Factor-23 (FGF-23). Despite FGF-23 associated left ventricular hypertrophy, there are no prior studies assessing whether FGF-23 level is associated with skeletal muscle strength in hemodialysis patient. 

Objective: To determine the correlation between hand-grip strength (HGS) and FGF-23 levels in patients undergoing twice-weekly hemodialysis patients.

Patient and Method: This is a cross-sectional study, which was conducted on 74 twice-weekly hemodialysis patient at the Hemodialysis Unit at Rumah Sakit Cipto Mangunkusumo, Jakarta. Before dialysis session, intact Fibroblast Growth Factor-23 (iFGF-23) were measured in singlicate from plasma samples and han-grip strength that measured by Jamar hydraulic hand dynamometer. Subject selection was done by consecutive sampling until the required number of subjects was fulfilled. 

Results: There were 74 subjects recruited in this study, which included 7 (18.9%) male and 3 (8.1%) female subject had body mass index (BMI) < 18.5 kg/m2. Level of iFGF23 were significantly higher in males than in females (3276 pg/ml [ min-max, 41-6613] and 1585 pg/ml, [min-max 21-4820], respectively). According to the Asian Working Group for Sarcopenia, the HGS value of male patients was lower than in females (25 kg [min-max; 11-48], (20 kg [min-max; 8-26], respectively). After adjusting to Modified Charlson Comorbidity index (mCCI) and BMI, we found a significant correlation iFGF-23 and HGS in the female subject (r = -0.4, p = 0.02 and no correlation between iFGF-23 and HGS in male subject (r = -0,053, p = 0.7). 

 

Conclusion: In twice-weekly hemodialysis patients, iFGF-23 has a significant correlation with HGS in women and this was not found in male subject.

Abstrak :
Latar Belakang: Ameloblastoma merupakan tumor yang berasal dari jaringan epitel odontogenik pembentuk gigi. Umumnya ameloblastoma jinak, tapi bersifat agresif secara lokal dengan tingkat rekurensi yang tinggi. MMP-2 merupakan salah satu yang paling berkaitan dengan invasi ameloblastoma. Matrix metalloproteinase-2 (MMP-2) merupakan enzim proteolitik yang diproduksi dalam sel-sel di seluruh tubuh dan menjadi bagian dari matriks ekstraselular, yang merupakan rangkaian rumit protein dan molekul lain yang terbentuk diruang antara sel-sel. Tujuan: Mengetahui sifat invasi lokal ameloblastoma dari sisi molekular. Metode Penelitian: 30 sampel ameloblastoma terdiri dari 8 sampel tipe pleksiform, 5 sampel tipe folikuler, dan 17 sampel tipe campuran. Sampel dipulas secara immunohistokimia dengan antibodi MMP-2. Hasil: Terdapat perbedaan ekpresi MMP-2 dari sel epitel pada berbagai tipe ameloblastoma. Terdapat perbedaan ekspresi MMP-2 dari sel fibroblast pada berbagai macam tipe ameloblastoma. Tipe campuran memiliki tingkat invasif yang paling tinggi dari ketiga tipe ameloblastoma dan memiliki sifat yang lebih infiltratif. Kesimpulan :Terdapat perbedaan ekspresi immunohistokimia matriks metalloproteinase (MMP-2) terhadap sel epitel dan fibroblast ameloblastoma tipe folikular, pleksiform, dan campuran. ......Background : Ameloblastoma is a tumor which originate from odontogenic epithelial tissue. Mostly ameloblastoma is benign, but can be locally aggressive with high recurrence level. MMP- 2 is one that connected with ameloblastoma invasion. Matrix metalloproteinase-2 (MMP-2) is proteolitic enzim that produce in body cells and become part of extracellular matrix. Objective: Understanding ameloblastoma local invasion from molecular side. Methods: 30 samples plexiform type ameloblastoma (n = 8), 5 samples folicullar type, and 17 samples mixed type. Samples are smeared by antibody MMP-2 immunochemistry. Results: There are differences in MMP-2 expression from any kind ameloblastoma epithelial cells. There are differences in MMP- 2 expression from any kind ameloblastoma fibroblast cells. Mixed type has highest invasion level from another three types of ameloblastoma and more infiltrative. Conclusion: There are immunochemistry Matriks Metalloproteinase (MMP-2) differences at epitel cell and fibroblast of folicullar, plexiform, and mixed type of ameloblastomas.

Abstrak :
Fibroblast growth factors (FGFs) have been recognized primarily as autocrine/paracrine factors that regulate embryonic development and organogenesis. However, recent studies have revealed that some FGFs function as endocrine factors and regulate various metabolic processes in adulthood. Such FGFs, collectively called endocrine FGFs, are comprised of three members (FGF15/19, FGF21, and FGF23: FGF15 is the mouse ortholog of human FGF19). These endocrine FGFs share a common structural feature that enables the endocrine mode of action at the expense of the affinity to FGF receptors. To restore the affinity to FGF receptors in their target organs, the endocrine FGFs have designated the Klotho family of transmembrane proteins as obligate co-receptors. By expressing Klothos in a tissue-specific manner, this unique co-receptor system also enables the endocrine FGFs to specify their target organs among many tissues that express FGF receptors.