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Abstrak :
ABSTRAK Pengelolaan perbekalan farmasi sebagai suatu sistem memegang peranan yang cukup penting dalam meningkatkan pelayanan di rumah sakit, baik dilihat dari sudut kepentingan pasien maupun kepentingan rumah sakit sendiri. Perencanaan pengelolaan perbekalan farmasi perlu dibentuk dengan baik, karena penggunaan perbekalan farmasi di rumah sakit memerlukan biaya yang besar oleh karena itu perlu adanya sistem yang tepat dan koordinasi yang baik oleh instalasi farmasi dan unit-unit pemakai. Hasil penelitian menunjukkan bahwa pengelolaan perbekalan farmasi di RSUP H. Adam Malik sudah dapat dilaksanakan secara baik, meskipun masih ditemukannya beberapa keterbatasan-keterbatasan, antara lain, struktur organisasi yang belum berjalan sesuai standard pelayanan, ketenagaan, dana yang belum mencukupi untuk melayani resep baik untuk rawat jalan maupun rawat inap, prosedur kerja yang belum sesuai dengan standard pelayanan rumah sakit. Disimpulkan bahwa untuk meningkatkan perbekalan farmasi di RSUP Haji Adam Malik perlunya peningkatan proses dalam fungsi logistik, pengawasan yang baik, peningkatan perbekalan farmasi ini juga tergantung kepada peningkatan komponen input. Upaya peningkatan yang disarankan meliputi : - Mengeluarkan surat keputusan untuk struktur organisasi yang dipakai. - Penambahan pelaksana untuk melakukan administrasi - Penggunaan komputer sehingga data yang diperlukan dapat dilihat secara cepat - Menjadikan RSUP H.Adam Malik menjadi RSUP Swadana agar pengelolaan dana yang diterima dapat dipergunakan langsung oleh rumah sakit. - Menggunakan standard therapy dan formularium dalam pengadaan perbekalan farmasi serta menggunakan stok gudang dalam perencanaan perbekalan farmasi. - Meningkatkan farmasi klinis melalui peran serta dari seluruh Apoteker yang ada sehingga pemantauan penggunaan obat, informasi obat, pelaksanaan unit dose dapat dilaksanakan dengan baik. Diharapkan dengan meningkatkan sistem pengelolaan perbekalan farmasi di RSUP H Adam Malik ini dapat meningkatkan fungsi lnstalasi Farmasi sebagai pengelola perbekalan Farmasi di RS.

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ABSTRACT Managing Pharmaceutical stock as a system plays a significant role in an effort to improve service in a hospital both from the patients' and the hospital's perspective. Due to the high expense inherent in stock maintenance and usage in a hospital's pharmacy it is imperative to establish an appropriate system and effective coordination between the pharmacy installation and the user units. A study on the management of pharmaceutical stock at the H. Adam Malik hospital shows that there still are shortcoming to work on. The organization structure is not conducive to meeting the service standard. Other problems include shortage in manpower, shortage in funds to buy supply for the in and out patient's needs, and the work procedures in the unit, which does not the service standard of the hospital. In summation, in order to improve the pharmaceutical stock at the H. Adam Malik General Hospital, it is imperative to improve the process and function of logistic to apply good supervision, and to increase the input component. In order to realize on improvement in the stock management system in the hospital's pharmacy, 1 can recommend the following measures: - Issuing decree on a new organization structure. - Recruiting administration staff. - Making use of computer for data management. - Turning the H. Adam Malik hospital into a self-funding institution. - Making use of the Therapy and Formulation standard in the procurement of pharmaceutical stock and making use of a warehouse. - Increasing clinical pharmacy through the action participation of all pharmacists, so that the supervision of drugs usage and information, the implementation of dose unit can be carried out effectively. It is our hope that improvement in the pharmaceutical stock management system at the H. Adam Malik General Hospital will increase the function of the pharmacy installation of the hospital.

Abstrak :
Summary: The quantitative structure-activity relationships (QSAR) continue to evolve quickly with an explosion of various tools and techniques. This book addresses the scope and limitations of different modeling techniques using case studies from pharmacology, toxicology, and ecotoxicology to demonstrate the utility of each technique

Abstrak :
The only reference on current methods to generate pharmacokinetic and safety profiles of drug candidates, as well as how they must be balanced against one other for the best selection of candidates for further development. Following a brief introduction to the necessities of filtering and risk assessment of potential new drug molecules before actual drug development, the two equally important aspects of pharmacological (ADME) and safety (toxicity) profiling are covered in separate parts. The ADME section covers the profiling of basic physicochemical parameters, such as solubility and permeability, as well as more complex traits, such as the likelihood of drug-drug interactions, metabolic clearance and protein binding properties. The toxicology part addresses, among others, recent advances in early genetic toxicity testing, bioactivation screening, organ-specific toxicity assays for liver, heart, kidney and blood, as well as profiling for autoimmune reactions. By addressing both drug efficiency and drug safety, this modern practical reference shows readers how each individual aspect figures in shaping the key decisions on which the entire drug development process hinges. In short, this is a complete toolbox for assessing the risk/benefit ratio for any novel compound during the early drug development stages, using both in vitro and in silico methods.

Abstrak :
This thesis presents the first report of the comprehensive and quantitative analysis of the effects of tumor-derived mutations on the tetrameric structure of tumor suppressor protein p53, which plays a central role in maintaining genomic integrity. Inactivation of p53 via mutation of its gene is a key step in tumorigenesis. Biophysical analyses revealed that the stability of the mutant peptides varied widely. Formation of a tetrameric structure is to be critical for protein–protein interactions, DNA binding, and the post-translational modification of p53. A small destabilization of the tetrameric structure therefore could result in dysfunction of tumor suppressor activity. This work suggests that the threshold for loss of tumor suppressor activity, in terms of the disruption of p53’s tetrameric structure, could be extremely low. Furthermore, functional control of p53 via tetramer formation was demonstrated, based on the structure–function analysis of mutant p53. The results disclosed that relatively small changes in tetramer formation, induced by the stabilization or inhibition of homo-tetramerization, could control p53 function.

Abstrak :
This practice-oriented handbook surveys current knowledge on the prediction and prevention of adverse drug reactions related to off-target activity of small molecule drugs. It is unique in collating the current approaches into a single source, and includes several highly instructive case studies that may be used as guidelines on how to improve drug development projects. With its large section on ADME-related effects, this is key knowledge for every drug developer.

Abstrak :
Barrier, reservoir, target site, those are but some of the possible functions of biological lipid membranes in the complex interplay of drugs with the organism. A detailed knowledge of lipid membranes and of the various modes of drug-membrane interaction is therefore the prerequisite for a better understanding of drug action. Many of today's pharmaceuticals are amphiphilic or catamphiphilic, enabling them to interact with biological membranes. Crucial membrane properties are surveyed and techniques to elucidate drug-membrane interactions presented, including computer-aided predictions. Effects of membrane interaction on drug action and drug distribution are discussed, and numerous examples are given. This unique reference volume builds on the authors' long experience in the study of drug-membrane interaction.

Abstrak :
This first systematic overview for more than a decade is tailor-made for the medicinal chemist. All the chapters are written by experienced drug developers and include practical examples from real drug candidates. Following an introduction to global drug properties and their impact on drug research, screening and combinatorial chemistry libraries, this handbook demonstrates the best and fastest way to estimate those properties most relevant for the efficiency and pharmacokinetic performance of a drug molecule: lipophilicity,solubility, electronic properties and conformation.