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Sitti Syabariah
"Ruang Lingkup dan Cara Penelitian : Implant Levonorgestrel dan Depo medroksiprogesteron asetat (DMPA) merupakan 2 jenis kontrasepsi hormonal jangka panjang yang hanya berisi derivat hormon progestogen. Penggunaan jangka panjang kontrasepsi tersebut dapat menimbulkan gangguan pola menstruasi (pendarahan endometrium). Salah satu teori mengatakan bahwa gangguan tersebut disebabkan kerapuhan kapiler endometrium, karena tergangguannya keseimbangan metabolisme asam arakidonat. Progestogen meningkatkan metabolisme asam arakidonat jalur epoksigenase yang menghasilkan radikal bebas yang kemungkinan meningkatkan kadar peroksida lipid (oksidan). Di lain pihak, vitamin E diketahui merupakan zat antioksi dan utama dalam tubuh. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian kontrasepsi progestogen (Implant Levonorgestrel dan DMPA) terhadap keseimbangan oksidan dan antioksidan tubuh melalui pengukuran kadar peroksida lipid dan kadar vitamin E plasma.
Pada penelitian ini diukur dan dibandingkan antara kadar peroksida lipid dan kadar vitamin E plasma sebelum dan sesudah 3 bulan penggunaan kontrasepsi Implant Levonorgestrel, DMPA dan kontrol. Pengukuran kadar peroksida lipid plasma dengan spektrofotometri sedangkan pengukuran kadar vitamin E dengan kromatografi cair kecepatan tinggi (KCKT). Masing-masing tujuh orang wanita calon pengguna kontrasepsi Implant Levonorgestrel dan tujuh orang wanita calon pengguna DMPAdan tujuh orang kontrol diukur kadar peroksida lipid dan kadar vitamin E plasmanya dan pengukuran diulangi setelah 3 bulan penggunaan kontrasepsi. Data dianalisa dengan analisis varians, uji perbandingan lebih dari dua kelompok, setelah sebelumnya diuji normalitas dengan uji Koimogorov-Smirnov dan uji variansi dengan uji Levene statistic.
Hasil dan Kesimpulan : Dari penelitian diperoleh (1) Kadar peroksida lipid plasma baik sesudah penggunaan kontrasepsi Implant Levonorgestrel maupun DMPA lebih tinggi secant bermakna (p < 0,05), dibandingkan sebelum penggunaan kontrasepsi, (2) Kadar vitamin E plasma sesudah 3 bulan penggunaan kontrasepsi DMPA lebih rendah secara bermakna (p<0,05) dan pada pengguna kontrasepsi Implant cenderung lebih rendah dibandingkan sebelum penggunaan (3) Perubahan peningkatan kadar peroksida lipid plasma pada perlakuan dan kontrol secara statistik tidak berbeda beimakna, dan (4) Perubahan penurunan kadar vitamin E plasma pada perlakuaan dan kontrol juga secara statistik tidak berbeda bermakna (p > 0.05)."
Jakarta: Fakultas Kedokteran Universitas Indonesia, 1999
T-Pdf
UI - Tesis Membership  Universitas Indonesia Library
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Azwan Nurdin
"Ruang lingkup dan cara penelitian : Penggunaan kontrasepsi hormonal dapat menyebabkan beberapa efek samping, salah satunya adalah tromboemboli. Penetapan kadar F 1.2 dapat dipergunakan untuk menentukan resiko terjadinya tromboemboli karena kadar yang tinggi dari senyawa peptida ini menunjukkan adanya aktivasi sistem koagulasi.
Tujuan utama penelitian ini adalah mengukur kadar F 1.2 pada akseptor implan levonorgestre yang telah menggunakannya > 4 tahun dengan menggunakan metode ELISA. Tujuan lain dari penelitian ini adalah untuk mengetahui apakah ada hubungan antara kadar F 1.2 dengan umur, lama pemakaian implan levonorgestrel dan besarnya paritas pada akseptor.
Penelitian Cross Sectional ini dilakukan pada 100 akseptor yang telah memakai implan selama 4 tahun atau lebih. Subjek penelitian diambil dari Klinik Keluarga Berencana Pulogadung-Jakarta. Sebelum pengambilan darah tidak diperlukan persiapan khusus atau puasa yang dilakukan pada akseptor.
Hasil dan Kesimpulan : Rentang kadar F 1.2 dari seluruh akseptor berkisar antara 0,06 - 9,69 nM. Pada 31 akseptor didapatkan kadar F 1.2 lebih tinggi dari 1,7 nM, yaitu kadar tertinggi yang didapatkan pada orang Indonesia sehat. Pada 24 akseptor dari 31 akseptor tersebut, kadar F 1.2 ternyata lebih tinggi dari 2,78 nM , yaitu kadar tertinggi yang didapatkan pada kelompok Caucasia sehat. Tujuh belas akseptor dari 24 akseptor tersebut diatas, memiliki kadar F 1.2 yang lebih tinggi dari 4,2 nM yang merupakan kadar rata-rata pada kasus tromboemboli.
Hasil Spearman test, tidak didapatkan hubungan antara kadar F 1.2 terhadap umur, lama pemakaian implan levonorgestrel dan besarnya paritas. Kesimpulan pemeriksaan pada 100 akseptor implan levonorgestrei, didapatkan 24 % akseptor dengan kadar F 1.2 yang tinggi yang dapat menunjukkan adanya aktivasi sistem koagulasi. Karena hanya merupakan cross sectional studi tanpa kontrol, maka belum dapat menerangkan apakah kadar F 1.2 yang tinggi ini disebabkan karena penggunaan implan. Untuk itu masih diperlukan penelitian prospektif acak terkontrol penentuan kadar F 1.2 serta aktivitas AT III, Tidak didapatkan hubungan antara kadar F 1.2 dengan umur, lama pemakaian implan dan paritas.

The Levels of Prothrombin Fragmenti.2. (F 1.2 ) Among Levonorgestrel Implant UsersScope and Method of Study : The use of hormonal contraceptives has some potential side effects, one of them is thromboembolism. The levels of F 1.2 can be used to determine the risk of thromboembolism because the high level of this peptide can indicates that there is an activation of coagulation system.
The main objective of this study was to find out the level of F 1.2 among the levonorgestrel implant users by mean of an ELISA method. The other objectives were to know the correlation between the levels of F 1.2 with age, duration of use the implant, and the parity of the acceptors. The study was done in 100 acceptors who had been using these implants for four years or more. The subjects were recruited from the Family Planning Clinic Pulogadung - Jakarta. No special preparation or fasting of the acceptors is needed.
Results and Conclusions : The range of F 1.2 levels of all acceptors was between 0.06 - 9.69 nM, while in 31 acceptors the levels were higher than the upper limit level previously found in healthy Indonesian subjects (1.7 nM). In 24 out of 31 acceptors, the levels of F 1.2 were higher than the upper limit level of normal value in a Caucasian population (2.78 nM).
In 17 out of 24 acceptors the levels of F 1.2 were higher than 4.2 nM, which was the mean level detected in thromboembolic cases reported previously.
Using the Spearmans test, it was evident that there was no correlation between F 1.2 levels and age, the duration of implant use, and the parity of the acceptors.
Conclusions, among 100 levonorgestrel implant acceptors, 24 % of them showed high F 1.2 levels that could indicate the activation of coagulation system. Based on these limited data which was done only through a cross sectional study without control, the high F 1.2 levels could not be interpreted as the cause by of the implant. A further prospective randomized controlled study, is need to find out the correlation between F 1.2 level and AT III is needed. No correlations were observed between F 1.2 levels and age, duration of implant use, and parity.
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Depok: Fakultas Kedokteran Universitas Indonesia, 1998
T-pdf
UI - Tesis Membership  Universitas Indonesia Library
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Biran Affandi
"ABSTRACT
Pure water, a sanitary environment, and nutritious food have long been recognized as prerequisites of good health. In the last two decades, medical studies have revealed another essential component of health strategies: family planning. Uncontrolled fertility directly threatens the health of mother and other family members. Today no health program can be considered complete unless it can also offer all potential parents ready access to appropriate family planning measures for all potential parents.

It is an unfortunate evolutionary fact that women become fertile several years before what is, for mother and child, the safest time for birth; moreover, they usually remain fertile for ten to fifteen years beyond the period of lowest risk. While the onset of fertility ranges from age 10 to the mid-tens, pregnancy becomes safest from a biological point of view around the age of 20. The period of maximum safety lasts for about a decade; then, when a woman reaches the age of about 30, risks to mother and child begin to rise and they continue to escalate with each passing year.

The number of children a woman bears in her life affects her health significantly. Her first birth carries a slightly higher risk of complications or death for her and her child than second and third births do, primarily because the first birth reveals any physical weaknesses of genetic abnormalities in the mother or the father. A woman's second and third births are generally the safest but with the fourth birth, the incidences of maternal death, stillbirth, and infant and even childhood mortality begin to rise, jumping sharply with the birth of the fifth and every succeeding child. Beyond a certain point, then, practice does not make perfect in childbearing; quite the contrary, it entails escalating dangers. The actual level of risk involved in bearing large numbers of children depends, of course, on the mother's social milieu. But one pattern prevails in every country and in every social class: risks increase as the number of children passes 3. Contrary to the belief held by many people, including some doctors, that women with many children are apt to give birth easily and painlessly, such women are in fact particularly susceptible to the complications and diseases associated with pregnancy.

Some studies found that about 60 percent of all severely undernourished children were of the fourth or later birth order. It is calculated that even without any other improvements in income, food availability, or medical care, the "limitation of family size to 3 children would bring down the incidence of severe forms of protein calorie malnutrition by at least 60 percent". The ill effects of numerous births on both mothers and their children are more likely to occur when the intervals between these births are short. Studies have shown that infants born less than two years after the previous child are 50 percent more likely to die by age 1 than are infants born two to four years after the previous child. Considering the health of mother and children, the risks related to the reproductive process could be reduced to the lowest level possible if:

1. The birth of the first-born can be deferred until the mother is 20 years old
2. The space between children's births must be at least 2 years
3. No more than 2-3 children are to be born
4. No more births after the mother's age reaches 30 years or over should be expected.
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1987
D7
UI - Disertasi Membership  Universitas Indonesia Library
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Yuli Amran
"Dalam siklus reproduksi, bertambah usia, jumlah anak dan kondisi kesehatan menimbulkan kebutuhan jenis alat kontrasepsi baru yang lebih rasional. Peralihan ke metode yang tidak rasional dapat berdampak pada kehamilan tidak direncanakan. Pengetahuan yang tinggi serta persepsi efektifitas dan efisiensi penggunaan alat kontrasepsi berhubungan dengan pola penggantian metode rasional. Oleh karena itu, studi ini bertujuan untuk mengevaluasi pola penggantian metode kontrasepsi, serta membuktikan perbedaan hubungan pengetahuan serta persepsi penggunaan alat kontrasepsi dengan pola penggantian metode kontrasepsi rasional antara perempuan akseptor KB di Jawa Timur dan NTB.Studi ini menggunakan pendekatan kuantitatif dengan desain studi Cross-Sectional. Subyek penelitian adalah wanita usia subur dengan jumlah 4616 perempuan di Jawa Timur dan 4819 perempuan di NTB. Perubahan jenis kontrasepsi ditinjau dari perbedaan jenis kontrasepsi saat ini dengan sebelumnya selama rentang waktu mengikuti program KB. Penilaian rasionalitas ditinjau dari kecocokan metode kontrasepsi terakhir dengan usia, jumlah anak dan motivasi KB. Pengetahuan yang diukur terkait MKJP. Sementara persepsi yang diukur terkait efektifitas efek samping dan cara pemakaian dan efisiensi biaya dan kemudahan memperoleh alat kontrasepsi. Data dianalisis dengan meggunakan multilevel analisis regresi logistik berganda untuk membuktikan hipotesis penelitian. Pola pengantian metode kontrasepsi didominasi oleh perpindahan dari non MKJP ke non MKJP lainnya. Hanya sebagian kecil perempuan berisiko tinggi yang beralih menggunakan kontrasepsi rasional baik di NTB maupun Jawa Timur. Persepsi terhadap efek samping terbukti berhubungan dengan pola penggantian rasional pada perempuan di Jawa Timur, dan persepsi terhadap cara pemakaian alat kontrasepsi terbukti berhubungan dengan pola penggantian metode kontrasepsi rasional pada perempuan di NTB. Persepsi terhadap biaya alat kontrasepsi terbukti berhubungan dengan pola penggantian metode kontrasepsi rasional pada perempuan di Jawa Timur dan NTB.Dapat disimpulkan ada perbedaan hubungan persepsi penggunaan alat kontrasepsi dengan pola penggantian metode kontrasepsi antara Jawa Timur dan NTB. Oleh karena itu, disarankan strategi KIE pada perempuan di Jawa Timur fokus pada penyelesaian masalah persepsi terkait efek samping dan pada perempuan NTB fokus pada penyelesaian masalah persepsi cara pemakaian alat kontrasepsi. Untuk menyelesaikan permasalah terkait persepsi biaya alat kontrasepsi pada perempuan di Jawa Timur dan NTB, perlu didukung keberlanjutan program penggratisan alat kontrasepsi pada masyarakat miskin dan juga masyarakat katagori lainnya melalui program BPJS.

In the reproductive cycle, the increasing age, number of children and health conditions lead to the need for more rational types of new contraceptives. Switching contraception to irrational methods may cause unintended pregnancies. High knowledge and perceptions of the effectiveness and efficiency of contraceptive use are related to the rational switching method pattern. Therefore, this study aims to evaluate the pattern of switching contraceptive methods, and to prove the difference association of knowledge and perception of contraceptive use with the pattern of rational switching contraceptive methods among women of Family Planning FP acceptors in East Java and West Nusa Tenggara.This study used a quantitative approach with Cross Sectional study design. Research subjects were women of reproductive age with 4616 women in East Java and 4819 women in West Nusa Tenggara. Changes in types of contraceptives were reviewed from the different types of contraceptives with the previous one during the timeframe of the FP program. Assessment of rationality was reviewed from the compatibility of the last method of contraception with age, number of children and family planning motivation. Knowledge was measured related to Long Term Contraceptive Method LTCM . While, perception rsquo s measurement was related to the effectiveness side effects and mode of use and efficiency cost and ease of obtaining of contraceptives. Data were analyzed using Multilevel Multiple Logistic Regression analysis to prove the research hypothesis.The switching pattern of contraceptive methods was dominated by changing from non LTCM to other non LTCM. Only a small proportion of high risk women switched to use rational contraception both in West Nusa Tenggara and East Java. Perceptions of side effect was associated with rational patterns of switching method in women in East Java, and perceptions of the use of contraceptives had relationship with patterns of rational contraceptive methods for women in West Nusa Tenggara. Perceptions of the cost of contraceptives was foundto be related withrational switching pattern of contraceptive methods among women in East Java and West Nusa Tenggara.In conclusion, there was a difference relationship of perceptionon contraception use and switching contraceptive method between East Java and West Nusa Tenggara. Therefore, it is recommended that Communication, Information and Education CIE strategies for women in East Java should focus on solving perceptual problems related to side effect while in West Nusa Tenggara women more focus on solving perception problems about how to use contraceptives. To solve the problems related to perception of contraceptive cost among women in East Java and West Nusa Tenggara, it is necessary to support the continuity of contraceptive application program for the poor and other categories through the Social Insurance Administration Organization Badan Penyelenggara Jaminan Sosial BPJS program."
Depok: Fakultas Kesehatan Masyarakat Universitas Indonesia, 2018
D2401
UI - Disertasi Membership  Universitas Indonesia Library