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"Latar Belakang: Celah bibir dan palatum merupakan salah satu kelainan kongenital yang paling sering terjadi. Kelainan ini dapat menyebabkan kendala dalam berbicara, abnormalitas telinga tengah, masalah psikologis, serta kelainan dental seperti anodontia parsial dan supernumerary teeth. Perawatan autologous alveolar bone grafting yang diambil dari tulang ilium pasien merupakan standar perawatan bagi pasien celah bibir dan palatum. Namun, pengambilan tulang tersebut bersifat invasif dan memiliki tingkat morbiditas dan mortalitas yang tinggi. Teknik rekayasa jaringan yang terdiri dari scaffold, faktor pertumbuhan, dan sel punca dapat menjadi solusi untuk masalahtersebut. Sumber donor sel punca yang tidak invasif bisa didapatkan dari sel punca pulpa gigi sulung (SHED) dan sel punca pulpa gigi permanen (DPSCs). Salah satu syarat dapat digunakannya suatu sel punca adalah memiliki kapasitas proliferasi yang baik. Perbandingan antara kapasitas proliferasi SHED dan DPSCs pada pasien normaltelah diketahui, namun pada pasien celah palatum belum pernah diteliti. Tujuan: Penelitian ini bertujuan untuk mengetahui perbandingan kapasitas proliferasi sel punca pulpa gigi sulung dan sel punca pulpa gigi permanen pasien celah bibir dan palatum. Metode: SHED dan DPSCs pasien celah bibir dan palatum dikultur hinga tingkatconfluency 70-80%, setelah itu sel dipanen dan dilakukan Uji PDT pada sel yang telah dikultur selama 7 hari. Hasil: SHED pasien celah bibir dan palatum menunjukkan nilai PDT yang lebih tinggi dibandingkan dengan DPSCs, namun secara statistik perbedaan tersebut tidak berbeda bermakna. Kesimpulan: SHED dan DPSCs penderita celah bibir dan palatum memiliki kapasitas proliferasi yang sama baiknya.

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Background: Cleft lip and palate is one of the most common congenital abnormalities. This disorder can cause speech impediments, middle ear abnormalities, psychological problems, and dental abnormalities such as partial anodontia and supernumerary teeth. Treatment of autologous alveolar bone grafting taken from the patient's ilium bone is the standard of care for cleft lip and palate patients. However, bone removal is invasive and carries a high rate of morbidity and mortality. Tissue engineering techniques consisting of scaffolds, growth factors, and stem cells can be a solution to the problem that. Sources of non-invasive stem cell donors can be obtained from primary dental pulp stem cells (SHED) and permanent dental pulp stem cells (DPSCs). One of the conditions for the use of a stem cell is to have a good proliferative capacity. Comparison between the proliferative capacity of SHED and DPSCs in normal patients known, but in cleft palate patients it has not been studied. Objective: This study was aimed to compare the proliferative capacity of pulp stem cells of primary teeth and pulp stem cells of permanent teeth in cleft lip and palate patients. Methods: SHED and DPSCs of cleft lip and palate patients were cultured to level

70-80% confluency, after that the cells were harvested and PDT test was performed on cells that had been cultured for 7 days. Results: SHED of cleft lip and palate patients showed a higher PDT value than DPSCs, but statistically the difference was not significantly different. Conclusion: SHED and DPSCs patients with cleft lip and palate have the same good proliferative capacity."

"Latar Belakang : Sejak diperkenalkan oleh Pena dan deVries, posterior sagittal anorectoplasty (PSARP) telah menjadi operasi standar pada tatalaksanan malformasi anorektal. Masalah kontinensia merupakan salah satu faktor yang memengaruhi kualitas hidup pasien-pasien malformasi anorektal. Saat ini tidak ditemukan kepustakaan Indonesia yang melakukan studi evaluasi fungsi kontinensia pasca tindakan PSARP dan kaitannya dengan usia saat operasi. Metode: Dilakukan penelitian cross sectional pada 40 pasien pasca PSARP di RSCM pada periode 1 Januari 2006 - 31 Desember 2012. Evaluasi fungsi kontinensia pasca PSARP menggunakan skoring Rintala dan uji statistik menggunakan SPSS 20. Hasil: Dari 40 pasien, 28 (70%) pasien perempuan dengan 26 pasien dengan fistel (17 rektovestibuler, 6 perineal, 2 rektovagina dan 1 kloaka. Pada pasien laki-laki 9 dengan fistel (7 rektouretra dan 2 perineal). Pada evaluasi kontinensia dengan skor Rintala didapatkan 47,5% pasien dengan kontinensia normal, dimana 73,7% diantaranya adalah pasien atresia ani letak rendah. Rata-rata Functional Outcome Score (FOS) adalah 16,17. Kesimpulan: Pasien PSARP di RSCM memiliki kemungkinan untuk mendapat fungsi kontinensia yang lebih baik. Tidak ada hubungan yang bermakna antara usia saat operasi dengan hasil kontinensia pasien.

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Background: Since introduced by Pena and deVries, posterior sagittal anorectoplasty (PSARP) has became standard operation for management of anorektal malformation. Continens problem is the one of factors that impact the quality of life who had anorektal malformations. Until now, there is no discovered about references in Indonesia which is doing evaluation study about continence function after PSRAP operation and the correlation between age at procedure and continence result.

Method: The study used cross sectional study in 40 patients who had post PSRAP operation in RSCM from 1 January 2006 – 31 Desember 2012. Performing evaluation of continence function of after PSRAP Operation was using the Rintala score and the statistic test was using SPSS 20.

Result: from 40 patients, there were 28 (70%) female patients with 26 patients had fistula (17 rectovestibular, 6 perineal, 2 rectovagina and 1 cloaca). In 9 male patients had fistula (7 rectouretra, 2 perineal). Based on evaluation of continens with using the Rintala score, there is 45,% patients with normal continens, which is 73,7% is the patient who had atresia ani low location. The average of Functional Outcome Score (FOS) is 16.17.

Conclusion: Patients who had PSRAP Operation in RSCM has probability to get better continence function. There is no significant correlation between age at operation and continence."

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