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Taolin Agustinus
Abstrak :
ABSTRAK
Latar belakang: Konstipasi fungsional kronik adalah masalah yang sering ditemukan di masyarakat dengan prevalensi sekitar 15-25%. Konstipasi menimbulkan berbagai gejala, meningkatkan angka kesakitan dan biaya kesehatan. Saat ini, penggunaan probiotik untuk pengobatan konstipasi kronik pada dewasa telah diteliti, namun, dari berbagai penelitian yang telah dilakukan hasil yang diperoleh masih terbatas dan menimbulkan kontroversi. Tujuan: Untuk menilai manfaat Lactobacillus reuteri dalam memperbaiki skor konstipasi Agachan, jumlah L. reuteri feses dan pH feses pada pasien konstipasi fungsional kronik. Metode: Uji acak tersamar ganda dilakukan pada 40 pasien dewasa (12 laki-laki/ 28 perempuan), rerata usia 45,95+/-16 tahun, yang menderita konstipasi fungsional kronik sesuai kriteria Rome III, selanjutnya dilakukan randomisasi dan diberikan L.reuteri atau Plasebo selama 4 minggu. Hasil: Pada minggu ke-4, setelah pemberian L.reuteri terjadi perbaikan gejala konstipasi, yang dinilai dari penurunan skor konstipasi Agachan dari 17 menjadi 8 dengan p <0.001. Terjadi peningkatan jumlah L.reuteri feses dari 6,80x10 menjadi 2,12x10 8 dengan p <0,001 dan penurunan pH feses dari 5,44 (SB 0,70) menjadi 4,78 (SB 0,56) dengan p <0,001 pada kelompok L.reuteri, sedangkan pada kelompok Plasebo tidak didapatkan hasil yang bermakna pada perbaikan skor konstipasi Agachan, jumlah L.reuteri feses dan pH feses. Kesimpulan: L.reuteri lebih efektif dibandingkan Plasebo dalam memperbaiki konstipasi, meningkatkan jumlah L.reuteri feses dan menurunkan pH feses pada pasien konstipasi fungsional kronik dewasa.
ABSTRACT
Background: Chronic functional constipation is a common problem that affects between 15-25% of the population and cause symptoms and disorders, that creates discomfort, morbidity and high costs for health care. Recently, the consumption of probiotics in treating chronic constipation in adults have been investigated. However, there are still limited and controversial evidences available from controlled trials. Aim: To evaluate the effects of L. reuteri in improving the Agachan constipation score, the number of L. reuteri in the feces and the fecal pH in the patients with chronic functional constipation. Methods: A double-blind, placebo RCT was conducted in 40 adult (12 male/ 28 female with mean age 45,95+/-16 years) affected by chronic functional constipation according to Rome III criteria. Patients were randomly assigned to receive a supplementation of L.reuteri or Placebo for 4 weeks. Results: At week 4, the decrease in Agachan constipation score was from 17.00 to 8.00 with p <0.001, the increase number of L.reuteri was from 6,80x10 with p <0,001 and the decrease of pH feces was from 5,44 (SB 0,70) to 4,78 (SB 0,56) with p <0,001 in the L. reuteri group, otherwise in the Placebo group there were no significant results in Agachan constipation score, the number of L.reuteri and fecal pH assessed. Conclusion: L.reuteri is more effective than the Placebo group in improving the Agachan constipation score, increasing the number of L. reuteri in the feces and decreasing the fecal pH in adult with chronic functional constipation.;Background: Chronic functional constipation is a common problem that affects between 15-25% of the population and cause symptoms and disorders, that creates discomfort, morbidity and high costs for health care. Recently, the consumption of probiotics in treating chronic constipation in adults have been investigated. However, there are still limited and controversial evidences available from controlled trials. Aim: To evaluate the effects of L. reuteri in improving the Agachan constipation score, the number of L. reuteri in the feces and the fecal pH in the patients with chronic functional constipation. Methods: A double-blind, placebo RCT was conducted in 40 adult (12 male/ 28 female with mean age 45,95+/-16 years) affected by chronic functional constipation according to Rome III criteria. Patients were randomly assigned to receive a supplementation of L.reuteri or Placebo for 4 weeks. Results: At week 4, the decrease in Agachan constipation score was from 17.00 to 8.00 with p <0.001, the increase number of L.reuteri was from 6,80x10 with p <0,001 and the decrease of pH feces was from 5,44 (SB 0,70) to 4,78 (SB 0,56) with p <0,001 in the L. reuteri group, otherwise in the Placebo group there were no significant results in Agachan constipation score, the number of L.reuteri and fecal pH assessed. Conclusion: L.reuteri is more effective than the Placebo group in improving the Agachan constipation score, increasing the number of L. reuteri in the feces and decreasing the fecal pH in adult with chronic functional constipation.;Background: Chronic functional constipation is a common problem that affects between 15-25% of the population and cause symptoms and disorders, that creates discomfort, morbidity and high costs for health care. Recently, the consumption of probiotics in treating chronic constipation in adults have been investigated. However, there are still limited and controversial evidences available from controlled trials. Aim: To evaluate the effects of L. reuteri in improving the Agachan constipation score, the number of L. reuteri in the feces and the fecal pH in the patients with chronic functional constipation. Methods: A double-blind, placebo RCT was conducted in 40 adult (12 male/ 28 female with mean age 45,95+/-16 years) affected by chronic functional constipation according to Rome III criteria. Patients were randomly assigned to receive a supplementation of L.reuteri or Placebo for 4 weeks. Results: At week 4, the decrease in Agachan constipation score was from 17.00 to 8.00 with p <0.001, the increase number of L.reuteri was from 6,80x10 with p <0,001 and the decrease of pH feces was from 5,44 (SB 0,70) to 4,78 (SB 0,56) with p <0,001 in the L. reuteri group, otherwise in the Placebo group there were no significant results in Agachan constipation score, the number of L.reuteri and fecal pH assessed. Conclusion: L.reuteri is more effective than the Placebo group in improving the Agachan constipation score, increasing the number of L. reuteri in the feces and decreasing the fecal pH in adult with chronic functional constipation.
2015
SP-Pdf
UI - Tugas Akhir  Universitas Indonesia Library
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Wildawati Nurdin
Abstrak :
ABSTRAK
Latar belakang : Gastritis merupakan suatu peradangan pada mukosa lambung sebagai respon terhadap infeksi atau iritasi lambung. Penyebab gastritis kronik yang paling sering adalah infeksi Helicobacter pylori. Adanya Helicobacter pylori berkaitan dengan terjadinya inflamasi, atropi, serta metaplasia intestinal. Bakteri Helicobacter pylori secara morfologi dikenal dengan 2 bentuk yaitu berupa batang dan coccoid. Bakteri yang berbentuk coccoid sulit terdeteksi dengan pewarnaan Giemsa. Untuk itu diperlukan pewarnaan imunohistokimia Helicobacter pylori dan mengukur sensitivitas Helicobacter pylori berbentuk coccoid. Bahan dan metode: Studi potong lintang terhadap 90 jaringan biopsi pasien gastritis kronik pada tahun 2015 dan 2014 yang meliputi 30 kasus Giemsa dengan Helicobacter pylori positif, 30 kasus gastritis kronik aktif dengan Helicobacter pylori negatif tapi ditemukan bentuk coccoid, dan 30 kasus gastritis kronik non aktif, kemudian dilakukan pewarnaan imunohistokimia Helicobacter pylori. Hasil: Ekspresi Helicobacter pylori bentuk coccoid pada kronik aktif memiliki perbedaan yang bermakna (p<0,05) pada pulasan imunohistokimia. Terdapat perbedaan yang bermakna antara gastritis kronik aktif H.pylori positif dan H.pylori negatif pada pulasan IHK dengan derajat inflamasi. Uji sensitivitas dan spesifisitas antara pemeriksaan Giemsa dan pulasan imunohistokimia, hasil sensitivitas 65% dan spesifisitasnya 100% . Kesimpulan: Pewarnaan imunohistokimia pada gastritis kronik aktif lebih sensitif dibandingkan dengan pewarnaan Giemsa untuk mendeteksi Helicobacter pylori terutama jenis coccoid . Kata kunci: gastritis kronik aktif, Giemsa, imunohistokimia Helicobacter pylori
ABSTRACT
Background: Gastritis is a mucosal inflammation response against infection or gastric irritation. Chronic gastritis most frequently was caused by Helicobacter pylori infection. The presence of Helicobacter pylori was associated with inflammation, atrophy, as well as intestinal metaplasia. Helicobacter pylori bacteria has two morphological form consist of rods and coccoid. Bacteria coccoid shaped was hard to detect with Giemsa staining. It is necessary to perform immunohistochemical staining to increase the diagnosis sensitivity of Helicobacter pylori and Helicobacter pylori in coccoid. Materials and Methods: This was a cross sectional study against 90 biopsy of chronic gastritis years 2015 and 2014 which covers 30 cases of Giemsa staining with Helicobacter pylori positive, 30 cases chronic gastritis active with Helicobacter pylori negative but with coccoid form of Helicobacter pylori, and 30 cases discovered form coccoid, and 30 cases chronic gastritis non active , then performed immunohistochemical staining for Helicobacter pylori. Results: Expression of Helicobacter pylori in active chronic coccoid form has a significant difference ( p < 0.05 ) on immunohistochemical staining . There is a significant difference between active chronic gastritis H. pylori- positive and H. pylori- negative staining Immunohistochemistry with the degree of inflammation . The sensitivity and specificity test result between Giemsa examination and immunohistochemical staining was sensitivity of 65% and specificity of 100 % . Conclusions : Immunohistochemical Staining in active chronic gastritis is more sensitive than Giemsa staining to detect Helicobacter pylori especially in coccoid form. Keywords: Active chronic gastritis, Giemsa, immunohistochemistry Helicobacter pylori
2016
SP-Pdf
UI - Tugas Akhir  Universitas Indonesia Library
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Nia Rosliany
Abstrak :
Karya ilmiah akhir KIA merupakan laporan praktik residensi keperawatan medikal bedah yang menganalisis peran perawat spesialis sebagai pemberi asuhan, peneliti, dan pembaharu. Peran-peran tersebut diterapkan dalam mengelola kasus pasien kanker dengan pendekatan chronic illness trajectory model, penerapan evidence based nursing program perawatan spiritual pada pasien leukemia untuk menurunkan depresi, dan melakukan proyek inovasi kelompok tentang manajemen edukasi bagi pasien yang menjalani perawatan isolasi radioaktif Iodine 131 di Ruang Isolasi Radio Aktif RIRA RSK Dharmais. Konsep trajectory merupakan salah satu teori keperawatan yang akan membantu memberdayakan pasien dan caregiver karena memberikan perawatan yang sesuai dengan tahapan atau fase penyakit pasien serta berfokus pada perawatan paliatif. Perawatan paliatif merupakan salah satu area fokus perawat spesialis pada bidang perawatan kanker yang akan membantu meningkatkan kemandirian dan kualitas hidup pasien. Penerapan perawatan program spiritual bersifat non-invasif, murah, aman, dan secara tehnis praktis dalam mengelola status depresi pasien. Edukasi dapat memperbaiki pemahaman pasien tentang radioterapi dan efek sampingnya sehingga dapat meningkatkan kualitas mutu pelayanan keperawatan.
The final scientific paper is a report on the medical surgical nursing residency program that analyzes the role of nurse specialist as careprovider, researcher, and innovator. The roles are applied on nursing care of cancer patients that used the chronic illness trajectory model approach, application of evidence based nursing practise in spiritual care program on leukemia patients to reduce depression, and perform innovation group project on educational management for patients undergoing radioactive Iodine 131 in Radioactive Isolation Ward Dharmais Cancer Hospital. The trajectory concept is one of the nursing theories that assist patients and caregivers rsquo empowerment to provide appropriate care in the stage and phase of patient 39 s illness and focuses on palliative care. Palliative care is one of the focus areas of nurse specialist in the field of cancer care that will improve the patient 39 s independence and quality of life. The application of spiritual care program is non invasive, cheap, safe, and practically in managing the patient 39 s depression status. Education could improve patients 39 understanding of radiotherapy and its side effects to improve the quality of nursing care.
Depok: Universitas Indonesia, 2017
SP-Pdf
UI - Tugas Akhir  Universitas Indonesia Library
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Cinthya Charlotte Rosalin
Abstrak :
ABSTRAK
Studi ini meneliti dampak modal sosial seseorang terhadap beragam kesehatan dengan menggunakan ldquo;the Indonesian Family Life Survey rdquo; IFLS4 dan IFLS5 . Beberapa studi terdahulu telah meneliti hubungan antara modal sosial tipe ldquo;bridging rdquo; dan hasil kesehatan. Studi ini menganalisa apakah kepercayaan secara umum, modal sosial jenis rdquo;bridging rdquo; percaya terhadap banyak etnis suku dan percaya pada banyak agama , dan isolasi sosial mempunyai dampak terhadap berbagai macam kesehatan. Hasil estimasi untuk model efek tetap tidak menunjukkan hasil yang signifikan terhadap variabel kesehatan, kecuali isolasi sosial, yang mempunyak efek positif terhadap kesehatan yang dirasakan sendiri. Lebih lanjut lagi, hasil estimasi terhadap model efek tidak tetap probit menunjukkan bahwa percaya pada semua orang memiliki pengaruh positif namun sedikit terhadap kesehatan yang dinilai sendiri, sedangkan percaya terhadap semua etnis suku memiliki hubungan yang negatif. Sementara itu, percaya terhadap banyak agama tidak berdampak apapun terhadap hasil kesehatan. Terakhir, isolasi sosial memiliki efek negatif terhadap berbagai macam kesehatan yang dinilai sendiri dan kesehatan mental.
ABSTRACT
This paper examines the effects of individual social capital on various health outcomes using the Indonesian Family Life Survey IFLS4 and IFLS5 . Few studies have covered the relationship between bridging social capital and health outcomes. This paper analyzes whether generalized trust, bridging social capital trust in many ethnic groups, trust in many religious beliefs , and social isolation have effects on various health outcomes. The estimated results for fixed effects models do not show any significance in all health outcome variables, except social isolation, which has positive effect on self perceived health. Moreover, the estimated results for random effect probit models show that generalized trust has a weak positive impact on self rated health, while trust in many ethnic groups has negative association. Meanwhile, trust in many religions does not have an effect on different health outcomes. In addition, social isolation has negative effects on almost various self rated health and mental health outcomes.
2017
T49762
UI - Tesis Membership  Universitas Indonesia Library