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Abstrak :
Salah satu pelayanan unggulan di RSMH adalah pelayanan kemoterapi terpadu.Sebagai salah satu sumber daya dalam mendukung pelayanan tersebut adalah persediaan farmasi yang termasuk di dalamnya adalah obat Kemoterapi yang relative mahal. Dalam melakukan pengendalian persediaan RSUP Dr. Mohammad Hoesin belum mengklasifikasikan obat berdasarkan nilai pemakaian, nilai investasi dan kekritisan obat melalui metode tertentu. Maka dalam penelitian ini bertujuan untuk melakukan pengendalian obat kemoterapi melalui pendekatan Analisis ABC Indeks Kritis di ruang pencampuran Kemoterapi Instalasi Farmasi RSUP Dr. Mohammad Hoesin Palembang. Penelitian ini menggunakan desain riset operasional dengan analisis deskriptif kuantitatif dan kualitatif . Hasil penelitian menunjukkan bahwa dari 83 item obat, untuk kelompok A(60%-30%- 10%) item obat kemoterapi adalah Paxus 100 mg injeksi. dengan nilai investasi sebesar Rp. 3.220.525.650,- dari total investasi Rp 33.509.826.356,-. Analisis Indeks Kritis kelompok A (70%-20%-10%) dengan nilai investasi sebesar Rp 11.045.150.780,- dari keseluruhan nilai investasi Rp 33.509.826.356,- terdiri dari 6 jenis item yaitu : Holoxan 1 gram injeksi, Leocovorin injeksi, Doxorubicin 50 mg injeksi, Brexel 20 mg injeksi, Brexel 80 mg injeksi dan Paxus 100 mg injeksi. Sedangkan kelompok A ( 80%-10%-10%) atau senilai Rp. 12.472.877.428,- dari total nilai investasi Rp. 33.509.826.356,- terdiri dari 8 item yaitu: Carboplatin 150 mg injeksi Holoxan 1 gram injeksi, Leocovorin injeksi, Doxorubicin 50 mg injeksi, Brexel 20 mg injeksi, Brexel 80 mg injeksi dan Paxus 100 mg injeksi, dan Taxotere 20 mg injeksi. Metode Analisis ABC Indeks Kritis ini dapat membantu rumah sakit dalam merencanakan kebutuhan obat dengan mempertimbangkan pemakaian, nilai investasi, kekritisan obat untuk melakukan efisiensi biaya rumah sakit. ......One of the featured services at RSMH is integrated chemotherapy services. One of the resources in support of these services is a pharmaceutical supplies including the Chemotherapy drugs are relatively expensive. In conducting the inventory control Dr. Mohammad Hoesin Hospital not classify drugs based on user value, investment value and criticality of drugs through certain methods. So in this study aims to conduct chemotherapy drug control approach ABC Analysis Critical Index in the Cytostatica Handling Room of Pharmacy Instalation Dr. Mohammad Hoesin Hospital Palembang. This study design using operational research with quantitative and qualitative descriptive analysis. The results showed that out of 83 drug items, for group A (60% -30% -10%) is a Paxus 100 mg injection. with an investment of IDR. 3,220,525,650, - of the total investment of IDR. 33,509,826,356, -.Critical Index Analysis group A (70% -20% -10%) with an investment of IDR. 11,045,150,780, - of the total investment value of IDR 33,509,826,356, - consists of six types of items, namely: Holoxan 1 gram injection, Leocovorin injection, doxorubicin 50 mg injection, Brexel 20 mg injection, Brexel 80 mg injection and Paxus 100 mg injection. While the group A (80% -10% -10%) or IDR. 12,472,877,428, - of the total investment value of IDR. 33,509,826,356, - consists of eight items, namely: Carboplatin 150 mg injection, Holoxan 1 gram injection, Leocovorin injection, doxorubicin 50 mg injection, Brexel 20 mg injection, 80 mg injection Brexel and Paxus 100 mg injection, and Taxotere 20 mg injection. Critical Index ABC Analysis method can assist the hospital in a drug needs planning to consider: consumption, investment value, the criticality of drugs for hospital cost efficiency.

Abstrak :
HIV/AIDS merupakan masalah kesehatan masyarakat yang serius, karena terus terjadi peningkatan kasus setiap tahunnya. Berdasarkan Infodatin AIDS 2016, bahwa DKI Jakarta merupakan provinsi dengan jumlah kasus HIV tertinggi. Dari tahun 2014 sampai tahun 2016, terjadi peningkatan insiden HIV di Puskesmas Kecamatan Tanah Abang. Tujuan penelitian ini adalah mengetahui determinan yang berhubungan dengan status HIV/AIDS pasien di Poli VCT (Voluntary Counselling and Testing) Puskesmas Kecamatan Tanah Abang Tahun 2017. Penelitian ini menggunakan data sekunder yang berasal dari data pasien di Poli VCT yang sudah terinput ke SIHA (Sistem Informasi HIV dan AIDS) pada bulan Januari sampai Desember tahun 2017. Penelitian ini menggunakan desain cross sectional dengan sampel seluruh pasien di Poli VCT yang memenuhi kriteria inklusi. Metode pengambilan sampel yang digunakan adalah total sampling dengan jumlah sampel adalah 1229 sampel. Penelitian dilakukan pada bulan April sampai Mei tahun 2018 di Puskesmas Kecamatan Tanah Abang. Analisis dalam penelitian ini adalah univariat, bivariat dan stratifikasi. Hasil analisis menunjukan variabel yang berhubungan bermakna dengan status HIV/AIDS adalah jenis kelamin (P= 0,000), tingkat pendidikan (P= 0,007), pekerjaan (P= 0,025), status perkawinan (P= 0,009 dan P=0,022), status penyakit sifilis (P= 0,000), hubungan anal seks berisiko (P= 0,032), dan bergantian peralatan suntik (P= 0,000). Variabel jenis kelamin merupakan variabel confounding pada hubungan vagina seks berisiko dengan status HIV/AIDS (P-Interaksi= 0,371 , Perubahan PR= 11,36%). Kesimpulan pada penelitian ini adalah terdapat hubungan antara jenis kelamin, tingkat pendidikan, pekerjaan, status perkawinan, status penyakit sifilis, hubungan anal seks berisiko, bergantian peralatan suntik dengan status HIV/AIDS, dan jenis kelamin merupakan variabel confounding pada hubungan vagina seks berisiko dengan status HIV/AIDS ......HIV/AIDS is a serious public health problem because its incidence continues to raise each year. Based on AIDS Infodatin 2016, it is found that DKI Jakarta is the province with the highest number of HIV cases. Since 2014 to 2016, there is an increased of incidence of HIV in Primary Health Center Tanah Abang. The purpose of this study is to know the determinants related to HIV / AIDS patients status at VCT (Voluntary Counseling and Testing) Primary Health Center Tanah Abang in 2017. This study used a secondary data derived from patient data in Polyclinic VCT which had been computed to SIHA (System Information on HIV and AIDS) from January to December 2017. This study used a cross-sectional design with a sample of all patients in VCT Polyclinic who met the inclusion criteria. The sampling method used is total sampling with total sample is 1229 samples. The study was conducted from April to May 2018 at Primary Health Center Tanah Abang. The analysis in this study is univariate, bivariate and stratification. The results of the analysis showed significant variables with HIV/AIDS status were sex (P = 0,000), education level (P = 0.007), occupation (P = 0.009), marital status (P = 0.009 and P = 0.022), syphilis status (P = 0.000), risky anal sex relationship (P = 0.032), and sharing injection equipment (P = 0,000). Sex variables are confounding variables in risky vaginal sex relationship with HIV/AIDS status (P-Interaction = 0.371, PR change = 11.36%). This study concluded that there is a relationship between sex, education level, occupation, marital status, syphilis status, risky anal sex relationship, sharing injection equipment with HIV/AIDS status, and sex is a confounding variable on risky vaginal sex relationship with status HIV/AIDS

Abstrak :
PURPOSE: A triplet regimen of docetaxel, cisplatin, and S-1(DCS) is highly effective against metastatic gastric cancer. We performed this study to clarify the safety and efficacy of surgical resection in patients with initially unresectable gastric cancer, after down-staging or disease control was achieved by DCS chemotherapy.

METHODS: The subjects of this retrospective study were 31 consecutive patients with initially unresectable gastric cancer, who underwent surgical resection between October, 2006 and December, 2012, after downstaging or disease control was achieved by DCS chemotherapy. We evaluated the clinicopathological factors and clinical outcomes and assessed radiographic response based on the RECIST criteria, not by central review.

RESULT: Before DCS chemotherapy, 18 patients had extraregional lymph node metastasis, 5 had liver metastasis, 8 had macroscopic peritoneal metastasis, and 8 had pancreatic head invasion. Twenty-three (74.2%) of the 31 patients underwent R0 resection. Postoperative morbidity and mortality rates were 16.1 and 0%. During chemotherapy, grade 3/4 toxicities included neutropenia (54.8%), leukopenia (32.3%), and anemia (16.1%). Median progression-free survival and median overall survival (OS) were 42.1 and 56.1 months, respectively. These results were similar for all patients, except those with locally advanced disease alone. In the multivariate analysis for OS, ypN remained an independent negative prognostic factor (p = 0.018).

CONCLUSION: Surgical resection after DCS chemotherapy for initially unresectable gastric cancer was safe and provided a reasonable R0 resection rate and good midterm survival.