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Abstrak :
From the very beginning, the series focused on topical volumes covering hot concepts and technologies, and the reader will not miss any important topic in the field. The range of topics is as diverse as are the challenges facing modern drug developers, spanning the fields of organic chemistry, pharmacology, toxicology, life science, and analytics, the latter also including bioinformatics, chemoinformatics and proteomics.

Abstrak :
Sistem penghantaran obat ke kolon banyak digunakan untuk memfasilitasi zat aktif terlepas dan memberikan efek terapi pada kolon. Salah satu penyakit yang dapat disembuhkan dengan sistem penghantaran ini adalah fibrosis usus. Tetrandrine digunakan sebagai obat antifibrosis usus. Penelitian ini bertujuan untuk membuat beads dengan metode gelasi ionik menggunakan polimer natrium alginat yang tersambung silang dengan kation Ca2+. Beads kalsium-alginat tetrandrine dibuat dalam tiga formula dengan variasi konsentrasi kalsium klorida yang digunakan (2%, 3%, 4%). Ketiga formula tersebut dikarakterisasi meliputi bentuk dan morfologi, ukuran partikel, kadar air, efisiensi proses, efisiensi penjerapan, uji termal, analisis difraksi sinar x, dan uji daya mengembang. Beads yang dihasilkan berbentuk hampir bulat, distribusi ukuran partikel 742.753µm – 780,683µm. Efisiensi penjerapan dari ketiga formula berturut-turut yaitu 78,920%, 82,701%, dan 68,504%. Formula yang paling optimum (beads formula 2) disalut dengan HPMCP HP-55 atau CAP kemudian dilakukan uji pelepasan obat secara in vitro. Uji pelepasan dilakukan pada medium asam klorida pH 1,2, dapar fosfat pH 7,4 dan dapar fosfat pH 6,8. Hasil pengujian menunjukkan bahwa beads yang disalut dengan CAP 10% melepaskan obat dengan total kumulatif yang paling besar. Beads CAP 10% dilakukan uji pentargetan obat secara in vivo dan hasilnya beads ditemukan dalam usus tikus. ...... Colon drug delivery system has been used to facilitate drug to release and give therapeutic effects in colon. Intestinal fibrosis is one of the diseases that can be cured by colon drug delivery system. Tetrandrine was used as intestinal antifibrotic drug. The aim of this research was to prepare beads by ionic gelation method, where sodium alginate were crosslinked with Ca2+ cation. Calcium-alginate beads tetrandrine were prepared in three formulas which various concentration of CaCl2 (2%, 3%, 4%). These beads were characterized include shape and morphology, particle size, moisture content, process efficiency, entrapment efficiency, thermal analysis, x-ray diffraction analysis, and swelling analysis. The result showed that beads which produced have almost spherical form, most of particle size was between 742.753µm – 780,683µm. The entrapment efficiency of three formulas were 78.920%, 82.701%, dan 68.504%. The best formula (beads formula 2) coated with HPMCP HP-55 or CAP and tested by in vitro drug released. The release test performed in pH 1.2 hydrochloric acid, pH 7.4 and pH 6.8 phosphate buffer. The highest drug released of tetrandrine showed in beads which coated by CAP 10%, then tested by in vivo drug targeting and the result showed that beads were found in intestinal rat.

Abstrak :
Contents: 1 Bond type and bond strength; 2 Hydrocarbons: alkanes, alkenes, aromatics and alkylhalides; 3 Amines; 4 Neutral and acidic nitrogen compounds; 5 Oxygen- and sulphur-containing functional groups; 6 Protein structure and its relevance to drug action; 7 DNA structure and its importance to drug action; 8 Drug absorption, distribution, metabolism and excretion; 9 Structure, activity and drug design; 10 Drugs affecting the adrenergic system; 11 Drugs exerting non-adrenergic effects on cardiac output and vascular tone; 12 Drugs interacting with mammalian enzymes; 13 Central nervous system depressants; 14 Analgesics; 15 Local anaesthetics; 16 Anti-cholinergic agents; 17 Anti-histamine drugs;18 CNS stimulants and CNS-active drugs affecting the serotonergic system; 19 Drugs affecting haemostasis and thrombosis; 20 Drugs affecting the endocrine system; 21 Anticancer drugs; 22 Antimicrobial chemotherapy: A. Antibiotics. B. Antituberculosis drugs; 23 Antiviral drugs; 24 Antifungal chemotherapy; 25 Antiparasitic drugs; 26 Vitamins and minerals; 27 Biotechnologically produced products; 28 Drug and gene delivery systems; 29 Alcohol

Abstrak :
Drug-drug interactions in pharmaceutical development comprehensively reviews the relevant science, industrial practice, and regulatory agency positions on drug-drug interactions. It focuses on the evaluation of potential drug-drug interactions, allowing researchers to address risk factors before a drug is put to market. The book covers both clinical and nonclinical aspects for understanding drug-drug interactions as well as in vitro and in vivo studies for use in studying interactions at the drug discovery stage.