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Abstrak :
The human cardiovascular and respiratory control systems represent an important focal point for developing physiological control theory because of the complexity of the control mechanisms involved, the interaction between cardiovascular and respiratory function, and the importance of this interaction in many clinical situations. This volume brings together the range of control processes involved in the effective regulation of these systems and develops modeling themes, strategies, and key clinical applications using contemporary mathematical and control methodologies. The reader will gain an appreciation of how analytical techniques and ideas from optimal control theory, systems theory, and numerical analysis can be utilized to better understand the regulation processes in human cardiovascular and respiratory systems. Cardiovascular and Respiratory Systems: Modeling, Analysis, and Control uses a principle-based modeling approach and analysis of feedback control regulation to elucidate the physiological relationships. Models are arranged around specific questions or conditions, such as exercise or sleep transition, and are generally based on physiological mechanisms rather than on formal descriptions of input-output behavior. The authors ask open questions relevant to medical and clinical applications and clarify underlying themes of physiological control organization. Current problems, key issues, developing trends, and unresolved questions are highlighted.

Abstrak :
This book offers a mathematical update of the state of the art of the research in the field of mathematical and numerical models of the circulatory system. It is structured into different chapters, written by outstanding experts in the field. Many fundamental issues are considered, such as : the mathematical representation of vascular geometries extracted from medical images, modelling blood rheology and the complex multilayer structure of the vascular tissue, and its possible pathologies, the mechanical and chemical interaction between blood and vascular walls, and the different scales coupling local and systemic dynamics. All of these topics introduce challenging mathematical and numerical problems, demanding for advanced analysis and efficient simulation techniques, and pay constant attention to applications of relevant clinical interest.