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Abstrak :
ABSTRAK
Mual muntah dan gangguan pengecapan merupakan efek samping kemoterapi yang dialami oleh pasien kanker yang berdampak terhadap gangguan nutrisi. Edukasi dengan metode dan media yang efektif dapat membantu meningkatkan pengetahuan dan self care pasien untuk mengurangi mual muntah dan gangguan pengecapan. Tujuan: untuk mengetahui cost effectiveness edukasi berulang dan booklet dengan edukasi tunggal dalam mengurangi mual muntah dan gangguan pengecapan pasca kemoterapi. Metode: Desain penelitian quasi eksperimen dengan pre-post test design dan pengukuran dilakukan pada hari kedua setelah kemoterapi. Pengambilan sampel menggunakan consecutive sampling dengan jumlah sampel sebanyak 38 pasien kanker ginekologi di RS. Kanker Dharmais Jakarta. Analisa data menggunakan wilcoxon test dan paired t test. Hasil: Penelitian menunjukkan adanya perbedaan bermakna (p value < 0,05) setelah diberikan edukasi baik pada kelompok edukasi berulang dan booklet maupun kelompok edukasi tunggal dalam membantu meningkatkan kemampuan pasien untuk mengurangi keluhan mual muntah dan gangguan pengecapan. Rekomendasi : pemberian edukasi dengan frekuensi satu kali dengan menggunakan media penyuluhan lembar balik lebih efektif dibandingkan dengan pemberian edukasi berulang dan booklet. Perawat sebaiknya dapat memberikan edukasi dengan metode dan media yang tepat serta cost effectivenes dalam meningkatkan kemampuan perawatan diri pasien.

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ABSTRACT
Nausea, vomiting and disturbance of taste is a chemotherapy side effect which is experienced by cancer patients that lead to nutritional deficiencies. Education with effective methods and media can help to improve patient’s knowledge and selfcare to relieve nausea, vomiting and taste disturbance. Purpose: to determine the cost effectiveness recurrent education and booklet with single education in relieving nausea, vomiting and taste disturbance after chemotherapy. Methods: The study design quasi-experimental with pre-post test design and the measurement is performed on the second day after chemotherapy. Sampling test taken by using Consecutive sampling with 38 cancer gynaecology patients at Dharmais Cancer Hospital Jakarta. Data analysis uses Wilcoxon Test and Paired T Test. Results: The results showed significant differences (p value <0.05) after being given education both in recurrent education group and booklet also single education group in helping to improve the patient's ability to relieve complaints of nausea, vomiting and tasting disturbance. Recommendation: Education Provision with one frequency by using flipchart media counceling is more effective than recurrent education and booklets. Nurses should be able to provide education with appropriate methods and cost effectivenes in improving patient’s self care ability.

Abstrak :
Mual muntah merupakan efek yang paling sering muncul pada pasien yang mendapatkan kemoterapi. Minuman jahe hangat merupakan salah satu terapi komplementer pada pasien yang mengalami mual muntah. Tujuan penelitian untuk mengidentifikasi pengaruh minuman jahe hangat terhadap mual muntah pada pasien yang menderita kanker. Desain penelitian adalah kuasi eksperimen dengan pre - post test control design. Tehnik pengambilan sampel dengan consecutive sampling yang terdiri dari 34 responden yang terbagi di kelompok intervensi dan kelompok kontrol. Pemberian minuman jahe hangat diberikan selama dua hari dengan frekuensi 3 x perhari. Hasil penelitian menunjukkan perbedaan bermakna pada penurunan gejala mual muntah setelah mendapat minuman jahe hangat (p value= 0,00) dibandingkan dengan kelompok kontrol. Disarankan agar pemberian minuman jahe hangat dapat diterapkan sebagai intervensi keperawatan dalam menangani pasien yang mengalami mual muntah akibat kemoterapi.

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ABSTRACT
Nausea and vomiting is one of the most common side effects of patient who underwent chemotherapy. Warm ginger drink is one of the complementary therapy for nausea and vomiting. The purpose of this study is to determine the influence of warm ginger drink on nausea and vomiting on cancer patients who undergo chemotherapy. This is quasi experiment study pretest and posttest control design. Consecutive sampling was used to recruit 34 respondents from intervention and control groups. Respondents both in intervention and control group received pharmacology therapy standard for nausea and vomiting, but warm ginger drink 3 times a day were received only in intervention group. The result shows significant different on nausea and vomiting between respondent from intervention and control groups (p value= 0,000). It is suggested that warm ginger drink can be given as nursing intervention to ease nausea and vomiting on cancer patient who undergo chemotherapy.

Abstrak :
Pendahuluan MicroRNA (miR)-544a telah diidentifikasi sebagai pengatur potensial dalam jalur WNT/β-Catenin, namun perannya yang spesifik pada kanker paru-paru non-sel kecil (KPKBSK) dan hubungannya dengan resistensi kemoterapi berbasis platinum masih belum jelas. Oleh karena itu, kami bertujuan untuk menentukan hubungan antara ekspresi miR-544a dan GSK-3β, β-catenin, dan CD44 dengan resistensi kemoterapi berbasis platinum pada pasien KPKBSK stadium lanjut. Metode Penelitian ini dirancang sebagai studi kasus kontrol di mana individu yang didiagnosis dengan KPKBSK stadium lanjut (III-IV) dari Januari 2018 hingga Juli 2023 dari 6 rumah sakit berbeda di Indonesia. Analisis tingkat miR-544a dilakukan menggunakan Kit PCR QuantiTect SYBR Green secara real-time. Ekspresi GSK, β-catenin, dan CD44 menggunakan pewarnaan imunohistokimia (IHK) dilakukan dari formalin-fixed paraffin embedded (FFPE). Evaluasi intensitas IHK dibagi menjadi empat kategori ekspresi: negatif atau tidak berwarna, positif lemah, positif sedang, dan positif kuat. Dari 500 sel, kami menggunakan rumus semi-kuantitatif H-score. Hasil Studi ini melibatkan 62 pasien KPKBSK stadium lanjut yang menjalani kemoterapi berbasis platinum dan menemukan miR-544a lebih tinggi pada responden yang buruk, dengan nilai p yang signifikan sebesar 0,009. Model prediktif untuk miR-544a menunjukkan nilai Roctab sebesar 0,6957. Nilai batas miR-544a sebesar 2,08 menghasilkan sensitivitas 64% dan spesifisitas 67,57%. Tingkat miR-544a di atas 2,08 secara signifikan terkait dengan respons pengobatan yang lebih buruk (OR 2,159, 95% CI 1,132 - 4,117, p = 0,016). Kesimpulan Studi ini menunjukkan bahwa tingkat miR-544a merupakan biomarker yang signifikan untuk memprediksi respons kemoterapi pada pasien dengan KPKBSK stadium lanjut. ......Introduction MicroRNAs (miR)-544a has been identified as a potential regulator in the Wnt/β-Catenin pathway, but its specific role in non-small cell lung cancer (NSCLC) and its relationship with platinum-based chemotherapy resistance, remains unclear. Thus, we aim to determine the relationship between the expression of miR-544a and GSK-3β, β-catenin, and CD44 with platinum-based chemotherapy resistance in advanced stage NSCLC patients. Methods The research is designed as a case control study in which individuals diagnosed with advanced stage (III-IV) NSCLC from January 2018 and July 2023 from 6 different hospitals in Indonesia. The analysis of miR-544a levels was done using the real-time QuantiTect SYBR Green PCR Master Kit. The expression of GSK, β-catenin, and CD44 expression using immunohistochemistry (IHC) staining was performed from the formalin-fixed paraffin embedded (FFPE). The evaluation of IHC intensity was divided into four expression categories: negative or unstained, weakly positive, moderately positive, and strongly positive. From 500 cells, we used the semi-quantitative H-score formula. Results This study of 62 advance NSCLC patients undergoing platinum-based chemotherapy and found miR-544a were higher in poor responders, with a significant p-value of 0.009. The predictive model for MiR-544a demonstrated a Roctab value of 0.6957. A miR-544a cutoff value of 2.08 yielded sensitivity of 64% and specificity of 67.57%. MiR-544a levels above 2.08 were significantly associated with poorer treatment response (OR 2.159, 95% CI 1.132 - 4.117, p = 0.016). Conclusions The study demonstrates that miR-544a levels are a significant biomarker for predicting chemotherapy response in patients with advance NSCLC.

Abstrak :
Summary: A Guide to Oncology Symptom Management (second edition) is a comprehensive, evidence-based resource to lead oncology nursing practice, education, and research. Each chapter addresses a particular symptom, such as pain or fatigue, or an area of impact, such as spirituality or electrolyte imbalances. It takes a holistic approach, addressing a range of common concerns-physical, emotional, social, and spiritual. Some chapters also address specific populations that may have unique symptom experiences, including older adults and caregivers. All chapters provide Definitions of relevant constructs and inclusion of useful theoretical perspectives A review of pathophysiology and etiology related to cancer and specific treatments A framework for symptom assessment, including diagnostic criteria An evidence-based review of pharmacologic and nonpharmacologic management Delineation of the expected outcomes Recommendations for future research. In addition, the authors have provided case studies, patient teaching points, and links to useful information, such as clinical practice guidelines, ONS Putting Evidence Into Practice evidence reviews, and resources for patient teaching. All new to the second edition are chapters that address symptom management at the end of life, family caregiver burden, and distress, which you'll find most helpful given the new American College of Surgeons Commission on Cancer's distress screening and management standards. Also included are emerging data related to the genomics of certain symptom phenotypes such as anticipatory nausea and vomiting. The new edition is a must-have resource for oncology nurse clinicians, educators, and scientists. Add it to your medical library today.

Abstrak :
The book is the third in a series of timely and indispensable books on fertility preservation for cancer patients—the first one focused on advances in basic science research and the second one offered ethical, legal, and social perspectives on the theme. This book elucidates the latest practices and emerging treatments in oncofertility and provides necessary information on the successes, risks, and limitations of fertility preserving technologies. Authoritative and insightful, written by an impressive multi-disciplinary cadre of specialists, this book is a valuable up-to-date resource for all those practicing in this demanding field.