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"Measurement of solid tumor response to treatment relies mainly on imaging. WHO tumor response criteria and, more recently, RECIST (response evaluation criteria in solid tumors) have provided means to objectively measure tumor response in clinical trials with imaging. These guidelines have been rapidly adopted in clinical practice to monitor patient treatment and for therapy planning. However, relying only on anatomical information is not always sufficient when evaluating new drugs that will reduce a tumor's functionality while preserving its size. Finding more reliable and reproducible measures of tumor response is one of the most important and difficult challenges facing modern radiology as it requires an entirely new approach to imaging. The aim of this book is to address the assessment of response to treatment by adopting a multidisciplinary perspective, just as occurs in real life in a comprehensive cancer center. Oncologists and imaging experts consider two cancer models, locally advanced disease and metastatic disease, jointly exploring both conventional and advanced means of measuring response to standard treatment protocols and new targeted therapies."

"Kanker paru-paru, khususnya Non-Small Cell Lung Cancer (NSCLC), dapat diberikan perawatan radioterapi baik untuk tujuan kuratif maupun paliatif. Selama radioterapi, perubahan anatomi pasien dapat terjadi, sehingga radioterapi adaptif menjadi sangat penting. Penelitian ini bertujuan untuk mengevaluasi akurasi registrasi citra deformable pada pasien NSCLC dengan menggunakan dua metode yang berbeda: Intermediate Deformable Image Registration (IDIR) sebagai metode registrasi klasik dan VoxelMorph sebagai metode berbasis pembelajaran mesin. Data yang digunakan adalah citra CT dan CBCT dari 17 pasien NSCLC di Siloam Hospital TB Simatupang, Jakarta Selatan. Citra diberi empat label menggunakan model YOLOv9 dan dievaluasi menggunakan metrik Dice Similarity Coefficient (DSC) serta Mean Distance to Agreement (MDA). Metode IDIR dengan rata-rata runtime 198,128 detik, menghasilkan nilai rata-rata DSC macro 0,786 dan micro 0,923. Rata-rata MDA segmentasi 0,166mm dan MDA dengan ambang batas sebesar 7,218mm. Sementara itu, metode VoxelMorph dengan rata-rata runtime 0,735 detik, menghasilkan nilai rata-rata DSC macro 0,635 dan micro 0,987. Rata-rata MDA segmentasi 0,588mm dan MDA dengan ambang batas sebesar 9,634mm. Hasilnya, evaluasi citra hasil registrasi deformable menunjukkan keberhasilan proses registrasi yang dilakukan. IDIR menunjukkan akurasi tinggi dengan runtime cenderung lebih lama, sedangkan VoxelMorph unggul dalam efisiensi runtime dengan penurunan hasil evaluasi.

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Lung cancer, especially Non-Small Cell Lung Cancer (NSCLC), can be treated with radiotherapy for both curative and palliative purposes. During radiotherapy, anatomical changes in patients may occur, making adaptive radiotherapy crucial. This study aims to evaluate the accuracy of deformable image registration in NSCLC patients using two different methods: Intermediate Deformable Image Registration (IDIR) as a classical registration method and VoxelMorph as a machine learning-based method. The data used consists of CT and CBCT images from 17 NSCLC patients at Siloam Hospital TB Simatupang, South Jakarta. The images were annotated with four labels using the YOLOv9 model and evaluated using Dice Similarity Coefficient (DSC) and Mean Distance to Agreement (MDA) metrics. IDIR method, with an average runtime of 198.128 seconds, yielded average DSC macro values of 0.786 and micro values of 0.923. The average segmentation MDA was 0.166mm, and the boundary MDA was 7.218mm. On the other hand, VoxelMorph method, with an average runtime of 0.735 seconds, produced average DSC macro values of 0.635 and micro values of 0.987. The average segmentation MDA was 0.588mm, and the boundary MDA was 9.634mm. Overall, the evaluation of deformable image registration results indicated successful registration processes. IDIR demonstrated high accuracy with longer runtimes, whereas VoxelMorph excelled in runtime efficiency with slightly lower evaluation results."

"Latar belakang: Berbagai faktor yang mempengaruhi respon tumor pasca TACE pada karsinoma sel hati berukuran besar serta tingginya permintaan TACE membuat perlunya dibuat model prediksi tercapainya responder pasca tindakan konvensional TACE yang pertama kali. Metode: Dari Januari 2014 hingga Januari 2020 terdapat 36 pasien KSH diterapi konvensional TACE dan memiliki imaging sebelum serta sesudah tindakan. Delapan faktor prediktor pada pasien dievaluasi dengan keluaran akhir adalah responder (complete response atau partial response) dan non-responder (stable disease atau progressive disease) sesuai mRECIST. Faktor yang mempengaruhi respons tumor dianalisis menggunakan analisis multivariat regresi logistik. Hasil: Setelah terapi konvensional TACE, hanya 42% pasien masuk kategori responder. Tidak ada pasien Child Pugh B yang menjadi responder. Pada analisis multivariat pada kelompok pasien Child Pugh A, diameter terbesar lesi 5-10 cm (OR 8,78; 95% CI 1,73–44,55; P 0,009) dan kapsul tumor (OR 3,93; 95% CI 0,78–19,72; P 0,09) merupakan faktor prediktor independen untuk responder pasca TACE pertama. Kesimpulan: Faktor prediktor respons tumor pasca konvensional TACE pertama pada pasien Child-Pugh A adalah diameter terbesar tumor 5-10 cm dan kapsul tumor. Kemungkinan responder adalah sebesar 58,18% jika hanya memiliki faktor diameter 5-10 cm; 38,46% jika hanya memiliki kapsul dan 84,55% jika tumor berdiameter 5-10 cm dan berkapsul.

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Background: Various factors affect post-TACE tumor response in large hepatocellular carcinoma as well as the high demand for TACE procedure, make the need to make a predictive model of achieving responders after the first conventional TACE. Methods: From January 2014 to January 2020, there were 36 HCC patients treated with conventional TACE who had imaging before and after the procedure. Eight predictor factors were evaluated with the final status as responders (complete response or partial response) and non-responder (stable disease or progressive disease) according to mRECIST criteria. Factors that affect tumor response were analyzed using multivariate analysis of logistical regression. Results: After conventional TACE, only 42% of patients fall into the category of responders. None of the Child Pugh B patients were responders. In multivariate analysis of the Child Pugh A patient group, the largest diameter of lesions (5-10 cm) (OR 8,78; 95% CI 1,73–44,55; P 0,009) and tumor capsules (OR 3,93; 95% CI 0,78–19,72; P 0,09) is an independent predictor factor after the first TACE. Conclusions: The predictor factors after the first conventional TACE in Child-Pugh A patients are the diameter of tumors 5-10 cm and the tumor capsules. The probability of responders is 58.18% if it only has a diameter factor of 5-10 cm; 38.46% if only have capsules and 84.55% if the tumor is 5-10 cm in diameter and tumor capsules."

"Imaging is crucial in the multidisciplinary approach to head and neck cancer management. The rapid technological development of recent years makes it necessary for all members of the multidisciplinary team to understand the potential applications, limitations, and advantages of existing and evolving imaging technologies. It is equally important that the radiologist has sufficient clinical background knowledge to understand the clinical significance of imaging findings. This book provides an overview of the findings obtained using different imaging techniques during the evaluation of head and neck neoplasms, both before and after therapy. All anatomic areas in the head and neck are covered, and the impact of imaging on patient management is discussed in detail. The authors are recognized experts in the field, and numerous high-quality images are included. This second edition provides information on the latest imaging developments in this area, including the application of PET-CT and diffusion-weighted magnetic resonance imaging."

"Breast MRI is a comprehensive, practical resource entirely devoted to this state-of-the-art technique, which has emerged as a valuable adjunct to the conventional imaging modalities in the detection of primary and recurrent breast cancer. This brand-new medical reference book utilizes an atlas-type format that showcases numerous examples of each aspect of breast MRI, equipping you with the latest knowledge on effective breast image interpretation. Compare your breast imaging findings to a wealth of breast MRI examples that capture the characteristic clinical presentation of both normal and diseased patients. Apply the most up-to-date information available on all aspects of breast MRI, including MRI-guided biopsy, breast cancer screening with MRI, MRI features of benign and malignant lesions, and MRI in the evaluation of newly diagnosed breast cancer.Take advantage of an image-rich, atlas-type format that offers the visual clarity you need for accurate interpretation.Access the full text and images online at Expert Consult."

"Bone tumors: a practical guide to imaging is a concise guide to common tumors encountered by physicians in daily practice. The authors make use of high-yield facts, differential diagnoses, and extensive radiological images to introduce a wide range of bone tumors. The book includes explanations of methods for properly evaluating bone lesions, common imaging modalities used for diagnosis, and individual chapters covering different classes of benign and malignant tumors, including cartilage, osseous, fibrous, miscellaneous, and bone metastases. Bone tumors is an ideal resource for practicing physicians and residents in radiology, orthopedic surgery, pathology, and primary care."

"The horizons of sophisticated imaging have expanded with the use of combined positron emission tomography (PET) and computed tomography (CT). PET-CT has revolutionized medical imaging by adding anatomic localization to functional imaging, thus providing physicians with information that is vital for the accurate diagnosis and treatment of pathologies. Since the integration of PET and CT several years ago, PET/CT procedures are now routine at leading medical centers throughout the world. This has increased the importance of nuclear medicine physicians acquiring a broad knowledge in sectional anatomy for image interpretation. The Atlas of Sectional Radiological Anatomy for PET/CT is a user-friendly guide presenting high-resolution, full-color images of anatomical detail and focuses solely on normal FDG distribution throughout the head & neck, thorax, abdomen, and pelvis, the primary sites for cancer detection and treatment through PET/CT."