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Nadia Christina
Profil epidemiologi penyakit kanker di Rumah Sakit Umum Pusat Nasional Cipto Mangunkusumo berdasarkan hospital based cancer registry tahun 2011-2012 = Cancer epidemiological profile at Cipto Mangunkusumo National Hospital based on hospital based cancer registry year 2011-2012
Abstrak :
Satu dari tujuh kematian di dunia disebabkan karena kanker. Beban akibat kanker di masa depan diprediksikan akan terus meningkat terutama di negara berkembang termasuk Indonesia. Penelitian ini melaporkan profil epidemiologi penyakit kanker di RSUPN Cipto Mangunkusumo tahun 2011-2012 berdasarkan data Registrasi Kanker Berbasis Rumah Sakit, dengan total 7399 penderita kanker, terdiri dari 2794 laki-laki dan 4605 perempuan. 54.52 penderita berasal dari luar Jakarta. Rentang usia tersering adalah 45-54, 35-44 dan 55-64 tahun. Mayoritas pasien bekerja sebagai ibu rumah tangga, pekerja kantor, dan pedagang. Pada laki-laki, penyakit kanker tersering adalah nasofaring, sistem hematopoetik dan retikuloendotelial, kelenjar getah bening, hepar dan duktus bilier, dan rektum, sedangkan perempuan, serviks uteri, payudara, ovarium, sistem hematopoetik dan retikuloendotelial, dan tiroid dengan mayoritas rentang usia diantara 45-54 tahun, kecuali keganasan sistem hematopoetik dan retikuloendotelial tersering pada usia 5-14 tahun. Kanker nasofaring dan kelenjar getah bening lebih banyak diderita oleh laki-laki, sedangkan keganasan sistem hematopoetik dan retikuloendotelial cukup seimbang jumlahnya antara laki-laki dan perempuan. Sebagian besar penyakit kanker ditemukan pada stadium 3 dan 4. Berdasarkan morfologi tersering, kanker serviks uteri dan nasofaring adalah neoplasma ganas, karsinoma payudara duktal invasif, leukemia prekursor sel limfoblastik dan limfoma non Hodgkin. ......One in seven deaths in the world is due to cancer. The future burden of cancer is predicted to keep rising, especially in developing countries including Indonesia. This study reports on cancer epidemiological profile in Cipto Mangunkusumo National Hospital year 2011 2012 based on Hospital Based Cancer Registry data, with a total of 7399 cancer patients consists of 2794 male and 4605 female. 54.52 patients are from outside Jakarta. Most common age range are 45 54, 35 44 and 55 64 years old. Majority of the patients are housewives, officers, and merchants. In male, the leading sites of cancer are nasopharyngeal, the hematopoietic and reticuloendothelial system, lymph nodes, liver and biliary duct, and rectum, whereas in women there are uterine cervix, breast, ovary, the hematopoietic and reticuloendothelial system, and thyroid with the majority of age between 45 54 years old, except malignancy of the hematopoietic and reticuloendothelial systems are more common in the age range of 5 14. Nasopharyngeal and lymph nodes malignancies are more common in men, whereas the hematopoietic system and reticuloendothelial malignancy is quite balanced between male and female cases. Mostly there are at stage 3 and 4. Based on the most common morphologies, uterine cervix and nasopharyngeal are malignant neoplasms, invasive ductal carcinoma of breast, precursor cell lymphoblastic leukemia and non Hodgkin 39 s lymphoma.
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2017
T55693
UI - Tesis Membership  Universitas Indonesia Library
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Ngakan Putu Daksa Ganapati
Profil epidemiologi penyakit kanker di Rumah Sakit Umum Pusat Nasional Cipto Mangunkusumo tahun 2008-2010 = Cancer epidemiology profile at Cipto Mangunkusumo National Hospital year 2008 2010
Abstrak :
ABSTRAK
Ketersediaan data mengenai kanker di Indonesia masih sangat rendah. Pengumpulan data kanker sangat erat kaitannya dengan registrasi kanker. Registrasi kanker didefinisikan sebagai proses yang berkelanjutan dalam pengumpulan data secara sistematis pada kejadian dan karakteristik neoplasma. Penelitian ini dilakukan untuk mengetahui profil epidemiologi penyakit kanker pada tahun 2008-2010 di RSUPN Cipto Mangunkusumo RSCM . Penelitian ini merupakan penelitian deskriptif cross sectional terhadap seluruh penyakit kanker periode Januari 2008 - Desember 2010 yang teregistrasi di HBCR RSCM 2008-2012. Didapatkan 10.865 kasus kanker, dengan rasio laki-laki dibandingkan wanita 1:1,7. Mayoritas pasien berusia 45-54 tahun, sebagian besar penderita berdomisili di luar jakarta. Data pekerjaan tidak tercatat dengan baik, namun untuk yang diketahui jenis pekerjaannya, ibu rumah tangga adalah yang terbanyak. Berdasarkan lokasi tumor, kanker serviks menempati urutan pertama, diikuti oleh kanker payudara, kanker nasofaring, keganasan sistem hematopoetik dan kanker pada kelenjar getah bening. Untuk jenis kelamin perempuan, penyakit kanker tersering adalah kanker serviks, diikuti kanker payudara, kanker ovarium, keganasan sistem hematopoetik, serta kanker tiroid. Sedangkan pada jenis kelamin laki-laki ditemukan jenis kanker tersering adalah kanker nasofaring diikuti dengan keganasan sistem hematopoetik, kanker kelenjar getah bening, kanker hati dan kanker kulit. Data mengenai stadium pada penelitian ini sangat rendah, dikarenakan pencatatan yang tidak memadai. Morfologi tersering untuk 5 jenis penyakit kanker tersering adalah karsinoma sel skuamosa tidak berkeratin kanker serviks , karsinoma duktal invasif kanker payudara , karsinoma sel skuamosa tidak berkeratin kanker nasoaring , leukemia limfoblastik akut keganasan sistem hematopoetik dan limfoma maligna non hodgkin kanker kelenjar getah bening . Secara umum, karakteristik pasien pada penelitian ini selaras dengan data HBCR terdahulu di RSCM ABSTRACT The availability of cancer data in Indonesia is still very low. Cancer data collection is closely associated with cancer registration. Cancer registration defined as a continous process in a systematic data collection of incidence and characteristics of the neoplasm. This study provides an overview of cancer epidemiology at Cipto Mangunkusumo 2008 2010. This study is a descriptive cross sectional study of all registered cancer patients from January 2008 December 2010 in Cipto Mangunkusumo Hospital Based Cancer Registry 2008 2012 The result are as follows frequency of cancer in RSCM during 2008 2010 were 10,865 cancer cases. The number of male patients compared with female was 1 1.7. The peak age is 45 54 years old. During 2008 2010, RSCM serve more cancer patients from outside of Jakarta than from Jakarta, most frequent jobs were housewives. Based on location, cervical cancer, breast cancer, nasopharynx cancer, malignancies of hematopoietic and reticuloendothelial systems, and lymphnodes malignancies are the most common cancer type. For female, the most common cancer cases are cervical, breast, ovarian, hematopoietic and reticuloendothelial systems and tiroid. For male, the most common cancer cases are nasopharynx, hematopoietic and reticuloendothelial systems, lymph nodes, liver and skin. Data on the stage of disease in this study was very little due to inadequate medical report recording.Most common Histopathological types were non keratinized squamous cell carcinoma cervical , invasive ductal carcinoma breast , non keratinized squamous cell carcinoma nasopharynx , acute lymphoblastic leukemia hematopoietic and reticuloendothelial systems , and malignant lymphoma non hodgkin lymph nodes . This study showed that characteristics of cancer patients in Cipto Mangunkusumo were similar with patients profile in prior RSCM HBCR Studies.
Fakultas Kedokteran Universitas Indonesia, 2017
T55694
UI - Tugas Akhir  Universitas Indonesia Library
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Kartika Erida Brohet
Profil epidemiologi kanker berdasarkan data registrasi kanker berbasis rumah sakit di RSUPN dr. Cipto Mangunkusumo tahun 2013. = Cancer epidemiology profile based on hospital based cancer registry at Cipto Mangunkusumo national hospital year 2013
Abstrak :
Kanker merupakan penyebab kematian utama pada negara maju maupun berkembang. Untuk menentukan arah kebijakan rumah sakit dan sebagai basis penelitian di bidang kanker, diperlukan data komprehensif mengenai epidemiologi kanker di Rumah Sakit Cipto Mangunkusumo. Penelitian ini memberikan gambaran profil epidemiologi kanker di Rumah Sakit Cipto Mangunkusumo berdasarkan Registrasi Kanker Berbasis Rumah Sakit RSCM tahun 2013 sebagai berikut. Frekuensi kanker di RSCM pada tahun 2013 adalah 5.554 kasus kanker. Data demografi pasien kanker di RSCM tahun 2013 adalah: mayoritas pasien berusia 45-54 tahun secara keseluruhan, 45-54 tahun untuk wanita dan 55-64 tahun untuk laki-laki. Jumlah pasien perempuan dibandingkan laki-laki adalah 1,5:1. Selama tahun 2013, RSCM lebih banyak melayani pasien kanker dari luar Jakarta dibandingkan dari Jakarta dan pekerjaan yang paling banyak adalah ibu rumah tangga. Secara keseluruhan, kanker payudara, serviks dan leukemia merupakan jenis kanker tersering. Untuk jenis kelamin perempuan yang tersering adalah payudara, serviks dan ovarium. Untuk jenis kelamin laki-laki yang tersering adalah leukemia, nasofaring dan kegasanan kelenjar getah bening limfoma. Sebagian besar pasien kanker payudara dan serviks datang dalam stadium lokal lanjut dan lanjut. Jenis histopatologi yang paling sering dari 3 kasus kanker terbanyak di RSCM tahun 2013 adalah : Karsinoma duktal invasif payudara, karsinoma sel skuamosa tak berkeratin serviks, leukemia limfoblastik akut leukemia. ......Cancer is the leading cause of death in developed and developing countries. To determine the direction of hospital policy and to provide basic data in aiding cancer research, comprehensive cancer epidemiology profile in Cipto Mangunkusumo Hospital is needed. This study provides an overview of cancer epidemiology profile at Cipto Mangunkusumo based on Hospital based Cancer Registry in 2013. The result is as follows frequency of cancer in RSCM in 2013 were 5,554 cancer cases. The demography data of cancer patients in RSCM in 2013 were the majority of patients aged 45 54 overall, 45 54 for women and 55 64 for men. The number of female patients compared with males was 1.5 1. During the year 2013, RSCM serve more cancer patients from outside of Jakarta than from Jakarta, most frequent jobs were housewives. Overall, breast cancer, cervical cancer and leukemia is the most common cancer type. For female, the most common cancer cases are breast, cervical and ovarian. For male, the most common cancer cases are leukemia, nasopharynx and lymph nodes lymphoma. The majority of breast and cervical cancer patients seeks help in locally advanced and advanced stages. Most common Histopathological typewere invasive ductal carcinoma breast, non keratinized squamous cell carcinoma cervical, acute lymphoblastic leukemia leukemia .
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2016
SP-pdf
UI - Tugas Akhir  Universitas Indonesia Library
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Salinah
Ekspresi protein p16ink4a pada model tikus kanker endometrioid = Expression of p16ink4a in endometrioid cancer rat model
Abstrak :
ABSTRAK
Latar Belakang: Kanker endometrioid merupakan keganasan ginekologi yang sering terjadi pada wanita. Hewan coba kanker endometrioid dengan karakteristik yang sesuai manusia diperlukan untuk memahami karsinogenesis secara molekular dan pengembangan terapi baru. p16INK4amerupakan gen supresor tumor yang ekspresinya menurun pada kanker endometrioid dan memiliki nilai prognostik. Ekspresi protein ini pada hewan coba diteliti untuk menilai kesesuaian dengan kanker endometrioid pada manusiaMetode: 15 blok parafin yang terdiri dari 5 jaringan uterus tikus normal, 5 jaringan uterus hiperlasia atipia dan 5 jaringan kanker endometrioid dilakukan pulasan imunohistokimia dan dinilai intesitas ekspresi p16INK4a dengan IHC profiler Image-J.Hasil dan Diskusi:Skor ekspresi p16INK4a meningkat bermakna pada kelompok hiperplasia dibandingkan dengan ekspresi pada kelompok normal p = 0,003 dan menurun bermakna pada kelompok kanker endometrioid dibandingkan kelompok normal p = 0,01 . Ekspresi berlebihan dari gen supresor tumor pada kelompok hiperplasia dapat merupakan salah satu mekanisme sel untuk mengurangi peningkatan proliferasi.Kesimpulan: Ekspresi tertinggi p16INK4a ditemukan pada hiperplasia endometrium dan menunjukkan ekspresi menurun hingga negatif pada kanker endometrioid yang sesuai dengan gambaran ekspresi pada manusia.
ABSTRACT
BackgroundEndometrioid cancer is one of the most common cancer in female. Animal model that representative to human endometrioid cancer is needed to develop new therapy and understanding molecular carcinogenesis. Decrease expression of p16INK4a, a tumor suppressor gene, is found in endometrioid cancer and has prognostic value. Expression of this protein in animal model was studied to evaluate its similarity with human endometrioid cancer.Method15 paraffin blocks of rat consist of 5 normal uterine tissues, 5 atypical hyperplasia of uterine tissues, and 5 endometrioid cancer tissues were stained for immunohistochemistry analysis of p16INK4a expression by using IHC profiler Image J software.Result and DiscussionExpression score of p16INK4a was significantly increase in hyperplasia group compared to normal group p 0,003 and decrease significantly in endometrioid cancer group compared to normal group p 0,01 . Excessive expression of p16INK4a in hyperplasia group is one of cells mechanism to reduce proliferation activity.ConclusionHighest expression of p16INK4a was found in hyperplasia group and decrease to negative expression in endometrioid cancer group. These patterns was similar to human endometrioid cancer.
2017
SP-Pdf
UI - Tugas Akhir  Universitas Indonesia Library
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Fransisca Noela R.M.H.
Profil data epidemiologi kanker ovarium di RSCM tahun 2010-2014 = Epidemiology data of ovarian cancer in RSCM from 2010-2014 / Fransisca Noela R.M.H.
Abstrak :
[ABSTRAK
Penelitian ini bertujuan untuk mengetahui gambaran umum kanker ovarium di Rumah Sakit Ciptomangunkusumo (RSCM) 5 tahun terakhir beserta faktor-faktor yang berhubungan dengan kanker ovarium. Penelitan ini mengambil data pasien kanker ovarium selain tipe borderline yang terdapat di Cancer Registry divisi Ginekologi Onkologi dan masih memiliki rekam medis di RSCM pada periode Januari 2010 – Desember 2014, dilakukan follow up untuk mengetahui kesintasan hidup selama 4 tahun. Kami mendapatkan 98 subyek penelitian. Pada penelitian ini didapatkan insidensi kanker ovarium terbanyak pada usia 45-54 tahun (33,6%), insidensi kanker ovarium menurun dengan bertambahnya jumlah anak, sebagian besar kanker ovarium merupakan tipe epitelial (76,5%) dan sebagian besar pasien didiagnosa pada stadium lanjut (55.1%). Kesintasan hidup 4 pasien kanker ovarium tipe epitelial 77%; tipe germinal 83.3%; tipe stroma 100%. Kesintasan hidup 4 tahun dengan terapi pembedahan 84.1%; pembedahan disertai kemoterapi adjuvan 83.3%; kemoterapi neoadjuvan sebelum pembedahan 68.4%. Terdapat 63% respon komplit pada kelompok kemoterapi adjuvan; dan 41.2% pada kelompok kemoterapi neoadjuvan.
ABSTRACT
The aim of this research is to describe the incidence of ovarian cancer and its characteristic in Ciptomangunkusumo Hospital in the last 5 year. The data was collected from Gynecology Oncology Division’s Cancer Registry and RSCM’s medical record from Januari 2010 – December 2014, follow up was performed to know the survival. There was 98 subject in this research. The result was : majority incidence of ovarian cancer was in the age 45-54 years old (33,6%); ovarian cancer incidence decrease in parity’s group; the majority histotype was epithelial (76.5%); and most of them were diagnosed on advanced stage (55.1%). The 4 year survival rate for epithelial was 77%; germinal was 83,3%; and stromal was 100%. Based on therapy the 4 year survival rate was 84.1%; 83.3% in adjuvant chemotherapy group; and 68.4% in neoadjuvan chemotherapy. In the group of adjuvant chemotherapy there was 63% complete respon and 41.2% in neoadjuvan chemotherapy.;The aim of this research is to describe the incidence of ovarian cancer and its characteristic in Ciptomangunkusumo Hospital in the last 5 year. The data was collected from Gynecology Oncology Division’s Cancer Registry and RSCM’s medical record from Januari 2010 – December 2014, follow up was performed to know the survival. There was 98 subject in this research. The result was : majority incidence of ovarian cancer was in the age 45-54 years old (33,6%); ovarian cancer incidence decrease in parity’s group; the majority histotype was epithelial (76.5%); and most of them were diagnosed on advanced stage (55.1%). The 4 year survival rate for epithelial was 77%; germinal was 83,3%; and stromal was 100%. Based on therapy the 4 year survival rate was 84.1%; 83.3% in adjuvant chemotherapy group; and 68.4% in neoadjuvan chemotherapy. In the group of adjuvant chemotherapy there was 63% complete respon and 41.2% in neoadjuvan chemotherapy.;The aim of this research is to describe the incidence of ovarian cancer and its characteristic in Ciptomangunkusumo Hospital in the last 5 year. The data was collected from Gynecology Oncology Division’s Cancer Registry and RSCM’s medical record from Januari 2010 – December 2014, follow up was performed to know the survival. There was 98 subject in this research. The result was : majority incidence of ovarian cancer was in the age 45-54 years old (33,6%); ovarian cancer incidence decrease in parity’s group; the majority histotype was epithelial (76.5%); and most of them were diagnosed on advanced stage (55.1%). The 4 year survival rate for epithelial was 77%; germinal was 83,3%; and stromal was 100%. Based on therapy the 4 year survival rate was 84.1%; 83.3% in adjuvant chemotherapy group; and 68.4% in neoadjuvan chemotherapy. In the group of adjuvant chemotherapy there was 63% complete respon and 41.2% in neoadjuvan chemotherapy., The aim of this research is to describe the incidence of ovarian cancer and its characteristic in Ciptomangunkusumo Hospital in the last 5 year. The data was collected from Gynecology Oncology Division’s Cancer Registry and RSCM’s medical record from Januari 2010 – December 2014, follow up was performed to know the survival. There was 98 subject in this research. The result was : majority incidence of ovarian cancer was in the age 45-54 years old (33,6%); ovarian cancer incidence decrease in parity’s group; the majority histotype was epithelial (76.5%); and most of them were diagnosed on advanced stage (55.1%). The 4 year survival rate for epithelial was 77%; germinal was 83,3%; and stromal was 100%. Based on therapy the 4 year survival rate was 84.1%; 83.3% in adjuvant chemotherapy group; and 68.4% in neoadjuvan chemotherapy. In the group of adjuvant chemotherapy there was 63% complete respon and 41.2% in neoadjuvan chemotherapy.]
Fakultas Kedokteran Universitas Indonesia, 2015
T-Pdf
UI - Tesis Membership  Universitas Indonesia Library