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"Penelitian ini bertujuan untuk mengetahui korelasi antara asupan karbohidrat, protein dan lemak dengan kadar C-Reactive Protein pada pasien kanker paru stadium IIIB-IV. Progresivitas kanker paru dipengaruhi oleh sistem kekebalan tubuh, faktor genetik dan respon inflamasi. CRP sebagai salah satu marker inflamasi dapat diandalkan sebagai salah satu parameter untuk memprediksi perkembangan kanker. Subjek didapatkan melalui consecutive sampling yang melibatkan 49 subjek kanker paru stadium IIIB ndash; IV yang tidak sedang menjalani terapi di RS Kanker 'Dharmais'. Hasil penelitian didapatkan rerata usia 55,82 12,26 tahun, sebanyak 63,3 berjenis kelamin laki-laki. Nilai median CRP yaitu 23,82 0,30 - 207,29 mg/L. Pada penelitian ini tidak ditemukan adanya korelasi yang bermakna antara asupan karbohidrat dengan kadar CRP serum p = 0,919 , asupan protein dengan kadar CRP serum p = 0,257 dan asupan lemak dengan kadar CRP serum p = 0,986 . Kesimpulan: pada penelitian ini tidak didapatkan korelasi antara asupan karbohidrat, protein dan lemak dengan kadar CRP serum sebagai penanda perkembangan kanker.

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The aim of the study was to determine the correlation between carbohydrate, fat and protein intake with the serum C Reactive Protein level in lung cancer patients stage IIIB ndash IV. The progression of lung cancer is influenced by immune system, genetic factors and inflammatory response, therefore CRP can be relied as one of the parameters for predicting cancer cell growth. Subjects were recruited by consecutive sampling, 49 subjects with lung cancer stage IIIB IV who currently not receving any treatment in Dharmais Cancer Hospital participating in this study. The mean age of subject was 55,82 12,26 years old and 63,3 were male. The median value of CRP was 23,82 0,30 207,29 mg L. This study did not showed significant correlation between carbohydate, protein and fat intake with serum CRP value p 0,919 p 0,257 p 0,986, respectively. In conclusion, there is no correlation between carbohydrate, protein and fat intake with serum CRP level in lung cancer stage IIIB ndash IV."

"Proses inflamasi pada kanker kepala dan leher menyebabkan peningkatan sitokin proinflamasi dan sintesis protein fase akut c-reactive protein, CRP yang kemudian menyebabkan perubahan metabolisme dan anoreksia pada penderitanya. Seng merupakan zat gizi yang memiliki peran penting dalam menekan inflamasi, namun dilaporkan sekitar 65 pasien kanker kepala dan leher mengalami kekurangan seng. Penelitian potong lintang ini bertujuan mengetahui korelasi antara asupan seng dan kadar seng serum dengan kadar c-reactive protein CRP sebagai upaya menekan inflamasi sehingga dapat mengurangi morbiditas dan mortalitas pasien kanker kepala leher. Dari 49 subyek yang dikumpulkan secara konsekutif di Poliklinik Onkologi RS Kanker Dharmais, 67,3 adalah laki-laki, rentang usia subyek 46 ndash;65 tahun. Frekuensi terbanyak 65,3 adalah kanker nasofaring dan 69,4 berada pada stadium IV. Seratus persen subyek memiliki asupan seng dibawah nilai angka kecukupan gizi. Rerata kadar seng serum subyek adalah 9,83 2,62 mol/L. Sebanyak 51 subyek memiliki kadar CRP yang meningkat. Terdapat korelasi negatif yang lemah antara kadar seng dengan kadar CRP subyek r =-0,292, p =0,042, namun tidak terdapat korelasi antara asupan seng dengan kadar CRP subyek p =0,86.

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The inflammatory process of head and neck cancer leads to increase the proinflammatory cytokines and the synthesis of c reactive protein CRP , which then causes metabolic alteration and anorexia in the patients. Zinc is one of nutrient that has an important role in suppressing inflammation. It is reported that about 65 of head and neck cancer patients have zinc deficiency. The aim of this cross sectional study is to determine the correlation between zinc intake and serum zinc levels with CRP level as an effort to reduce inflammation to reduce the morbidity and mortality of head and neck cancer patients. Subjects were collected by consecutive sampling in the Oncology Polyclinic Dharmais Cancer Hospital, from 49 subjects 67,3 were men, most subjects were in the age range between 46 ndash 65 years. The highest frequency 65,3 is nasopharyngeal cancer and 69,4 are already in stage IV. All subjects in this study have a zinc intake below the recommended dietary allowance RDA in Indonesia. The mean serum zinc level of the subjects was 9.83 2.62 mol L. Most subjects have elevated CRP levels. There was a weak significant negative correlation between zinc concentration and CRP levels of subjects r 0.292, p 0.042, but there was no correlation between zinc intake and CRP levels of subjects p 0.86. "