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"Latar belakang : Pasien penyakit jantung bawaan memiliki risiko untuk mengalamikehilangan berbagai macam mikronutrien sesudah operasi koreksi dengan mesin pintasjantung paru, salah satunya adalah vitamin D. Defisiensi vitamin D dapat memperberatkomplikasi yang terjadi sesudah operasi koreksi dengan mesin pintas jantung paru.Penelitian ini bertujuan untuk menilai efek dari mesin pintas jantung paru terhadapkadar vitamin D sesudah operasi koreksi penyakit jantung bawaan.Metode : Penelitian dilakukan secara kohort prospektif dari bulan Maret-Juli 2020.Pada penelitian ini didapatkan total 30 pasien yang menjalani operasi koreksi denganmesin pintas jantung paru. Pemeriksaan kadar vitamin D dilakukan sebelum operasi dan24 jam sesudah mesin pintas jantung paru dimatikan.Hasil : Rerata kadar vitamin D preoperasi adalah 27,24 ng/mL dengan yang mengalamiinsufisiensi dan defisiensi sebanyak 70%. Rerata kadar vitamin D sesudah operasiadalah 20,73 ng/mL dengan jumlah subjek yang mengalami insufisensi dan defisiensimeningkat sebanyak 90%. Setelah operasi, terdapat penurunan vitamin D sebanyak 6,52ng/mL (24% dari kadar sebelum operasi). Uji korelasi antara penurunan kadar vitaminD dengan penggunaan mesin PJP menunjukkan hasil yang signifikan dengan nilai P <0,001. Sedangkan tidak ditemukan hubungan yang signifikan antara durasi penggunaanmesin pintas jantung paru dan durasi aortic cross clamp dengan penurunan kadarvitamin D.Kesimpulan : Terdapat hubungan yang bermakna antara penggunaan mesin pintasjantung paru dengan penurunan kadar vitamin D, namun penurunan ini tidakdipengaruhi oleh durasi penggunaan mesin pintas jantung paru dan durasi aortic crossclamp.

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Background: Patients with congenital heart disease are at risk of losing various

micronutrients after corrective surgery with a cardio-pulmonary bypass machine, one

of which is vitamin D. Vitamin D deficiency can exacerbate complications that occur

after corrective surgery with a cardio-pulmonary bypass machine. This study aimed to

assess the effect of the cardio-pulmonary bypass machine on vitamin D levels after

corrective surgery for congenital heart disease.

Methods: This study was conducted in a prospective cohort from March to July 2020.

In this study, a total of 30 patients underwent corrective surgery with cardio-pulmonary

bypass machine. Vitamin D level checks were carried out before surgery and 24 hours

after the machine was turned off.

Results: The mean preoperative vitamin D level was 27.24 ng / mL with insufficiency

and deficiency as much as 70%. The mean postoperative vitamin D level was 20.73

ng/mL with the number of subjects experiencing insufficiency and deficiency increasing

by 90%. After surgery, there was a decrease in vitamin D by 6.52 mg / mL (24% of the

preoperative level). The correlation test between decreased levels of vitamin D and the

use of cardio-pulmonary bypass machines showed significant results with a P-value

<0.001. Meanwhile, there was no significant relationship between the duration of using

the cardio-pulmonary bypass machine and the duration of aortic cross clamp with a

decrease in vitamin D

Conclusion: There is a significant relationship between the use of cardio-pulmonary

bypass machines and a decrease in vitamin D levels, but this decrease was not

influenced by the duration of using the cardio-pulmonary bypass machine and the

duration of the aortic cross clamp."