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"Pendahuluan: Kejang pascaoperasi merupakan salah satu komplikasi pascakraniotomi tumor. Prevalensinya antara 4 - 20%, dan paling banyak muncul satu minggu pascaoperasi. Penambahan obat fenitoin pada pemberian obat levetiracetam untuk mengendalikan kejang pascaoperasi belum pernah ditelilti. Tujuan: Untuk mengetahui apakah terdapat perbedaan antara kelompok yang mendapatkan levetiracetam dengan dan tanpa penambahan fenitoin dalam hal kejadian kejang pascaoperasi, efek samping, peningkatan dosis steroid, serta gambaran faktor risiko kejang pascaoperasi. Metode: Penelitian ini merupakan penelitian pendahuluan menggunakan metode uji klinis. Pasien dirandomisasi dan dikelompokkan menjadi kelompok yang mendapatkan levetiracetam saja dan levetiracetam dengan fenitoin. Diobervasi selama 7 hari pascaoperasi, apakah terdapat kejang, efek samping, dan peningkatan dosis steroid. Pada kelompok yang mendapatkan fenitoin, kadar fenitoin dalam darah diukur pada hari ke-7. Hasil: Manfaat penambahan fenitoin pada pemberian levetiracetam masih belum bisa dinilai karena jumlah sampel masih sedikit. Efek samping lebih banyak ditemukan pada kelompok yang mendapatkan penambahan fenitoin.

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Introduction: Postoperative seizure is one of complications of brain tumor surgery. Prevalence is 4-20% and mostly occurred in the first postoperative week. The beneficial of giving add on phenytoin to levetiracetam has never been studied before.

Aims: To determine the difference of postoperative seizure incidence, side effect, elevation of steroid dose, and risk factors profile in both groups, the levetiracetam group and levetiracetam with add on phenytoin group.

Methods: This is a pilot study with clinical trial design. Patients were randomized and allocated into two groups, levetiracetam group and levetiracetam with add on phenytoin group. Observation was done in 7 postoperative days. Any incidence of postoperative seizures, drug side effects, and elevation of steroid dose was noted. In group receiving phenyotin, the blood level of phenytoin was measured on the 7th day.

Result: The benefit of add on phenytoin to levetiracetam therapy for postoperative seizure in brain tumor patients could not be evaluated due to small sample size. More drug related side effects were found on group receiving phenytoin."

"Pasien dengan kasus tumor otak memerlukan perawatan yang komprehensif dan membutuhkan waktu yang lama untuk pasien dapat beradaptasi dengan perubahan-perubahan yang terjadi pada dirinya. Selama pasien menjalani masa perawatan di rumah sakit, asuhan keperawatan yang tepat diberikan kepada pasien adalah dengan model konsep teori adaptasi Roy. Asuhan dengan pendekatan model adaptasi ini menjadi pilihan yang sesuai untuk kasus-kasus perawatan jangka panjang sehingga pasien dapat menjalani kehidupan lanjutan pasca perawatan dengan baik, mengembalikan kemandirian, kepercayaan diri terutama konsep gambaran diri dan status peran di masyarakat. Perawat dengan pendidikan spesialis harus mampu menjalankan berbagai peran terutama sebagai Clinical Care Manager, dengan demikian peningkatan layanan keperawatan di rumah sakit dapat dicapai dengan lebih optimal dan memberikan kepuasan pelanggan. Laporan analisis praktek ini membahas mengenai asuhan keperawatan perioperative pada pasien dengan tumor otak, laporan praktik keperawatan berbasis fakta yaitu early mobilization dan resume pasien dengan gangguan neurologis di RS PON Jakarta,serta e handbook peran perawat perioperative dalam pembedahan spinal. Analisis praktik residensi ini dapat digunakan sebagai dasar perawat dalam latihan critical thinking, mengelola kasus sulit dan menerapkan asuhan keperawatan berbasis bukti.

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Patients with cases of brain tumor require comprehensive care and require a long time for the patient to adapt of the changes that occur. As long as the patient is undergoing treatment in the hospital, the appropriate nursing care is using Roy's adaptation teori concept model. Adaptation model approach is an appropriate choice for cases of long-term care so that patients can live a good post- treatment follow-up life, restore independence, self-confidence, especially the concept of self-image and role status in society. Nurses with specialist education must be able to carry out various roles, especially as Clinical Care Managers, thus improving nursing services in hospitals can be achieved more optimally and provide customer satisfaction. This practice analysis report discusses perioperative nursing care for patients with brain tumor, a fact-based nursing practice report, namely and resumes of patients early mobilization with neurological disorders at National brain centre Hospital Jakarta. E handbook about perioperative nursing at spinal surgery. This residency practice analysis can be used as a basis for nurses in critical thinking exercises, managing difficult cases and implementing evidence-based nursing care. Keywords: Brain tumor, Roy's adaptation model, early mobilization, E handbook about perioperative nursing at spinal surgery."

"This third volume of the Springer series discussing pediatric cancer focuses on diagnosing, treating, and assessing the future course of malignant brain neoplasms in children. In addition to a general introduction to the principals involved, the material includes vital research in molecular genetics, a major contribution to the molecular characterization of solid tumors, which will define new biomarkers of the disease and identify molecular pathways. The volume includes presentations of present and future therapies. The volume also explains AT/RT’s dissemination to the cerebral fluid, the molecular mechanisms underlying the progression of medulloblastoma, and the importance of gamma knife radiosurgery during multimodality management of medulloblastoma/PNET tumors. Other topics discussed include using magnetic resonance imaging for diagnosing retinoblastoma, and mapping the effects of radiotherapy in low-grade glioma in children. Information on alterations in cell-cycle regulators that are influenced by tumor suppressor genes and oncogenes is detailed. Contributors provide recommendations concerning non-narcotic analgesic routines for children recovering from cranial and spinal surgery. "