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Abstrak :
[Cuka apel telah lama digunakan untuk menekan nafsu makan dengan tujuan untuk menurunkan berat badan. Namun, belum banyak bukti penelitian ilmiah yang membuktikan pengaruh penekanan nafsu makan tersebut. Dengan demikian peneliti melakukan sebuah studi eksperimental dengan hipotesis yang akan diuji adalah efektivitas cuka apel dalam menurunkan nafsu makan tikus tidak sebaik yang dimiliki mazindol. Jenis tikus yang digunakan sebagai sampel penelitian adalah tikus Sprague Dawley dengan berat 190- 250 gram. Sampel berjumlah 24 ekor dan dibagi dalam 3 kelompok, yaitu kelompok kontrol (sebagai kontrol negatif), kelompok mazindol (sebagai kontrol positif), dan kelompok cuka apel. Semua sampel mendapat perlakuan yang sama. Nafsu makan, yang ditunjukkan oleh berat sisa makanan yang diamati selama 2 minggu. Data berat sisa makanan dianalisis menggunakan uji hipotesis One Way Anova dan uji Post Hoc. Peneliti mendapati ada perbedaan bermakna secara statistik berat sisa makanan antara kelompok kontrol dan kelompok cuka apel (p = 0,000) dengan uji One Way Anova dan (p = 0,000) dengan uji Post Hoc. Sementara itu, tidak adanya perbedaan bermakna terlihat pada kelompok kontrol dan mazindol (p = 0,623) dengan uji Post Hoc. Dengan demikian disimpulkan efektivitas cuka apel dalam menurunkan nafsu makan lebih baik daripada mazindol.;Apple cider vinegar has beend used for ages in suppressing appetite in order to lose weight. Meanwhile, there are only few valid studies regarding this matter. Thereby, researcher conducted an experimental study and define the effectiveness of apple cider vinegar is not as good as mazindol for suppressing appetite as the hypothesis. Researcher used Sprague Dawley strain rats which weight are 190-250 grams as research sample. Twenty four rats devided into 3 groups, that is control group (as negative control), mazindol group (as positive control), and apple cider vinegar group. All samples given same treatment. Appetite assessed by the weight of leftovers which has been monitored for 2 weeks. The data of leftovers analyzed by One Way Anova and Post Hoc hyphoteses tests. Researcher found that there is significance difference of leftovers between control and apple cider vinegar group (p = 0,000) using One Way Anova test and (p = 0,000) using Post Hoc test. Meanwhile there is no significance difference between control and mazindol group (p = 0,623) using Post Hoc hypothesis test. In conclusion, the effectiveness of apple cider vinegar in suppressing appetite is better than mazindol.;Apple cider vinegar has beend used for ages in suppressing appetite in order to lose weight. Meanwhile, there are only few valid studies regarding this matter. Thereby, researcher conducted an experimental study and define the effectiveness of apple cider vinegar is not as good as mazindol for suppressing appetite as the hypothesis. Researcher used Sprague Dawley strain rats which weight are 190-250 grams as research sample. Twenty four rats devided into 3 groups, that is control group (as negative control), mazindol group (as positive control), and apple cider vinegar group. All samples given same treatment. Appetite assessed by the weight of leftovers which has been monitored for 2 weeks. The data of leftovers analyzed by One Way Anova and Post Hoc hyphoteses tests. Researcher found that there is significance difference of leftovers between control and apple cider vinegar group (p = 0,000) using One Way Anova test and (p = 0,000) using Post Hoc test. Meanwhile there is no significance difference between control and mazindol group (p = 0,623) using Post Hoc hypothesis test. In conclusion, the effectiveness of apple cider vinegar in suppressing appetite is better than mazindol.;Apple cider vinegar has beend used for ages in suppressing appetite in order to lose weight. Meanwhile, there are only few valid studies regarding this matter. Thereby, researcher conducted an experimental study and define the effectiveness of apple cider vinegar is not as good as mazindol for suppressing appetite as the hypothesis. Researcher used Sprague Dawley strain rats which weight are 190-250 grams as research sample. Twenty four rats devided into 3 groups, that is control group (as negative control), mazindol group (as positive control), and apple cider vinegar group. All samples given same treatment. Appetite assessed by the weight of leftovers which has been monitored for 2 weeks. The data of leftovers analyzed by One Way Anova and Post Hoc hyphoteses tests. Researcher found that there is significance difference of leftovers between control and apple cider vinegar group (p = 0,000) using One Way Anova test and (p = 0,000) using Post Hoc test. Meanwhile there is no significance difference between control and mazindol group (p = 0,623) using Post Hoc hypothesis test. In conclusion, the effectiveness of apple cider vinegar in suppressing appetite is better than mazindol.;Apple cider vinegar has beend used for ages in suppressing appetite in order to lose weight. Meanwhile, there are only few valid studies regarding this matter. Thereby, researcher conducted an experimental study and define the effectiveness of apple cider vinegar is not as good as mazindol for suppressing appetite as the hypothesis. Researcher used Sprague Dawley strain rats which weight are 190-250 grams as research sample. Twenty four rats devided into 3 groups, that is control group (as negative control), mazindol group (as positive control), and apple cider vinegar group. All samples given same treatment. Appetite assessed by the weight of leftovers which has been monitored for 2 weeks. The data of leftovers analyzed by One Way Anova and Post Hoc hyphoteses tests. Researcher found that there is significance difference of leftovers between control and apple cider vinegar group (p = 0,000) using One Way Anova test and (p = 0,000) using Post Hoc test. Meanwhile there is no significance difference between control and mazindol group (p = 0,623) using Post Hoc hypothesis test. In conclusion, the effectiveness of apple cider vinegar in suppressing appetite is better than mazindol., Apple cider vinegar has beend used for ages in suppressing appetite in order to lose weight. Meanwhile, there are only few valid studies regarding this matter. Thereby, researcher conducted an experimental study and define the effectiveness of apple cider vinegar is not as good as mazindol for suppressing appetite as the hypothesis. Researcher used Sprague Dawley strain rats which weight are 190-250 grams as research sample. Twenty four rats devided into 3 groups, that is control group (as negative control), mazindol group (as positive control), and apple cider vinegar group. All samples given same treatment. Appetite assessed by the weight of leftovers which has been monitored for 2 weeks. The data of leftovers analyzed by One Way Anova and Post Hoc hyphoteses tests. Researcher found that there is significance difference of leftovers between control and apple cider vinegar group (p = 0,000) using One Way Anova test and (p = 0,000) using Post Hoc test. Meanwhile there is no significance difference between control and mazindol group (p = 0,623) using Post Hoc hypothesis test. In conclusion, the effectiveness of apple cider vinegar in suppressing appetite is better than mazindol.]

Abstrak :
Latar Belakang: American Association of Endodontist (AAE) (2021) menganjurkan penggunaan irigasi NaOCl 1,5% - 3% dan EDTA 17% pada prosedur regeneratif endodontik. Namun, kedua larutan irigasi tersebut memiliki efek terhadap sel punca dan jaringan dentin. Oleh karena itu bahan pengganti bersumber dari bahan alami mulai diteliti, salah satunya adalah cuka apel. Tujuan: Menganalis efek larutan cuka apel berbagai konsentrasi dan larutan irigasi sintetik terhadap topografi dan kekasaran permukaan dentin saluran akar. Metode: 28 spesimen dentin setebal 1 mm dibagi random pada 7 kelompok, lalu tiap kelompok terdiri dari 4 spesimen. Spesimen dentin direndam dengan aquades, NaOCl 1,5%, NaOCl 2,5%, EDTA 17%, larutan cuka apel 2,5%, 5% dan 10% dengan volume 1,8 ml selama 1 menit. Pengamatan topografi dan analisis kekasaran permukaan dentin saluran akar dilakukan dengan mikroskop digital. Hasil: Terdapat efek larutan cuka apel berbagai konsentrasi dan larutan irigasi sintetik terhadap topografi dan kekasaran permukaan dentin saluran akar yang dievaluasi dengan mikroskop digital. Namun tidak terdapat perbedaan efek larutan cuka apel konsentrasi 2,5%, 5% dan 10% dibandingkan dengan NaOCl 1,5%, 2,5% dan EDTA 17% terhadap kekasaran permukaan dentin saluran akar. Kesimpulan: Larutan cuka apel memiliki efek terhadap kekasaran permukaan dentin saluran akar. Nilai rerata kekasaran permukaan terendah adalah cuka apel 2,5% walaupun nilainya tidak berbeda bermakna dengan larutan uji lainnya. ......Background: The American Association of Endodontist (AAE) (2021) recommends the use of 1.5% - 3% NaOCl irrigation and 17% EDTA in regenerative endodontic procedures. However, these two irrigant solutions had an effect on stem cells and dentine tissue. Therefore, substitutes derived from natural ingredients have begun to be researched, one of which is apple vinegar. Objective: To analyze the effect of various concentrations of apple vinegar and synthetic irrigation solutions on topography and surface roughness of root canal dentin Method: 28 specimens of 1 mm thick dentin were randomly devided into 7 groups, then each group consisted of 4 specimens. Dentin specimens were immersed in distilled water, 1.5% NaOCl, 2.5% NaOCl, 17% EDTA, 2.5%, 5% and 10% apple vinegar solution with 1.8 ml volume of solution for 1 minute. The topography and surface roughness observation was carried out using digital microscope. Results: There was effect of apple vinegar solutions with various concentrations and synthetic irrigant solutions on topography and surface roughness of root canal dentin evaluated by digital microscopy. However, there was no difference in the effect of apple vinegar solution concentrations of 2.5%, 5% and 10% compared to 1.5%, 2.5% NaOCl and 17% EDTA on surface roughness of root canal dentin. Conclusion: Apple vinegar solution has an effect on surface roughness of root canal dentin. The lowest average surface roughness value was 2.5% apple vinegar, although the value was not significantly different from the other test solutions.