Hasil Pencarian  ::  Simpan CSV :: Kembali

"Latar belakang : Sekuel Tuberkulosis (TB) adalah deformitas permanen sebagai gejala sisa pada pasien yang telah menjalani pengobatan TB lengkap atau sudah dinayatakan sembuh. Pembedahan merupakan tata laksana efektif sekuel TB, meski tidak terbebas dari komplikasi. Penelitian ini ditujukan melakukan evaluasi peran pemberian OAT terhadap komplikasi pascabedah, dan menilai pengaruh riwayat Diabetes mellitus (DM), merokok dan status gizi kurang terhadap kejadian komplikasi pascabedah kasus sekuel TB.Metode : Dilakukan suatu studi kohort retrospektif pada pasien pasien yang menjalani operasi sekuel TB di Rumah Sakit Umum Pusat Persahabatan dalam periode 1 Januari 2016 hingga 31 Desember 2019. Faktor pemberian OAT, riwayat DM, kebiasaan merokok dan status gizi kurang serta pengaruhnya pada komplikasi pascabedah merupakan variabel penelitian. Dilakukan uji statistik dengan kemaknaan p<0,05.Hasil : Sebanyak 58 subjek dilibatkan sebagai sampel penelitian. Komplikasi pascabedah terjadi pada 36 (62,1%) subjek. OAT diberikan pada 26 (44,8%) subjek. Pemberian OAT menurunkan odds kejadian komplikasi yang bermakna secara statistik rasio odds 0,06 (0,01- 0,24); p < 0,001Simpulan : Pemberian OAT pascabedah menurunkan kejadian komplikasi pascabedah secara bermakna. Komplikasi pascabedah lebih banyak terjadi pada pasien yang tidak menerima OAT pascabedah.

---

Introduction: Tuberculosis (TB) sequelae are permanent deformities identified as residual signs after completion of TB treatment or cured TB cases. Surgery has been demonstrated to be an effective treatment of TB sequelae albeit with possible post-surgical complications. This study aimed to assess the role of antituberculosis chemotherapy in postoperative complications and to evaluate the impact of diabetes mellitus (DM), smoking and nutritional status on the incidence of postoperative complications.

Method: A retrospective cohort trial was conducted on patients who underwent surgery of TB sequelae at the Rumah Sakit Umum Pusat Persahabatan from January 1, 2016 to December 31, 2019. Administration of antituberculosis chemotherapy, diabetes mellitus (DM), smoking habits, nutritional status and their effects on postoperative complications were evaluated. Statistical analysis concluded to be significant if p<0.05.

Results: A total of 58 subjects were included in the study. Postoperative complications were observed in 36 (62.1%) subjects. Antituberculosis chemotherapy was administered to 26 (44.8%) subjects. Post-surgical administration of antituberculosis drug reduced the likelihood of complications [OR 0.06, 95% CI 0.01-0.24, p <0.001).

Conclusion: Antituberculosis chemotherapy significantly reduced the occurence of postoperative complications. Patient who encountered postoperative complication tend not to receive antituberculous chemotherapy."

"ABSTRAKRifampisin merupakan salah satu obat pilihan untuk terapi laten tuberkulosis dan sedang dikembangkan untuk penghantaran tertarget ke paru-paru. Penelitian ini bertujuan untuk mendapatkan formula serbuk inhalasi rifampisin dengan pembawa kitosan-xanthan KX yang optimal menggunakan metode respon permukaan Response Surface Methodology. Suatu desain eksperimen yang terpola secara statistik dibuat dengan metode Box Behnken dengan variasi konsentrasi larutan KX, rasio rifampisin/KX, dan variasi suhu inlet pada alat spray dryer. Serbuk inhalasi dikarakterisasi terhadap respon efisiensi penjerapan EE , ukuran partikel, serta pelepasan rifampisin di kondisi paru pH 7,4 dan makrofag paru pH 4,5. Hasil penelitian diperoleh 14 formula serbuk inhalasi dengan nilai efisiensi penjerapan 112,00 -149,08 , ukuran partikel rata-rata 0,599-5,506 m, pelepasan rifampisin di dalam medium pH 7,4 6,54 -22,95 dan medium pH 4,5 12,02-48,60 . Berdasarkan program Design Expert 9.0.6.2, didapatkan kondisi yang optimal untuk pembuatan serbuk inhalasi rifampisin adalah nilai konsentrasi larutan KX 0,5, rasio rifampisin:KX 1:1, dan suhu inlet spray dryer 143 C. Pada kondisi dan parameter tersebut, diprediksikan akan didapatkan serbuk inhalasi rifampisin dengan nilai EE 107,1 , ukuran partikel 1,001 m, pelepasan rifampisin di dalam medium pH 7,4 17,8 dan medium pH 4,5 32,6 dengan nilai desirability yaitu 0,86.

---

ABSTRACTRifampicin is drug of choice for anti tuberculosis therapy and currently be developed to be targeting drug delivery to pulmonary. The study was aimed to get an optimal formula of Rifampicin dry powder inhalation with chitosan xanthan CX carrier by spray dry method using response surface methodology RSM. An experiment design was formed statistically by Box Behnken method and was designed by variation of CX solution, Rifampicin CX ratio, and variation of inlet temperature at the spray dryer. The dry powder inhalation was characterized with response of entrapment efficiency EE, particle size, and rifampicin release inside pulmonary pH 7.4 and pulmonary macrophage pH 4.5. The characterization from 14 formulas were resulted the response of EE as 112.00 149.08, average particle size 0.599 ndash 5.506 m, rifampicin release in medium pH 7.4 s 6.54 22.95 and in medium pH 4.5 as 12.02 ndash 48.60 . The optimal formula of Rifampicin dry powder inhalation with CX was obtained from Design expert software in CX concentration 0.5, Rifampicin CX ration 1 1, and inlet temperature of the spray dryer is 143 C. If the manufacturing process of dry powder inhalation was prepared in those condition and parameters, was predicted that the result of Rifampicin dry powder inhalation with EE 107,1 , particle size 1.001 m, the release of rifampicin in medium pH 7.4 as 17.8 and medium pH 4.5 as 32.6 with desirability value 0.86."