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"In this thesis, Claudia Backes guides the reader through her multidisciplinary research into the non-covalent functionalization of carbon nanotubes in water. Although one of the most remarkable materials of the 21st century, carbon nanotubes often have limited application because of their intrinsically low solubility and polydispersity. The author shows that rational surfactant design is a powerful tool for chemists because it can unmask the key to solubilization and allow us to tailor nanotube surface and optical properties in a fully reversible fashion. Aspects of organic, physical and analytical chemistry, as well as colloidal sciences are covered in this outstanding work which brings us one step closer to exploiting this super-material to its full potential."

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Efavirenz perlu mencapai konsentrasi serum memadai (1-4 µg/mL) karena ketidaksesuaian kadar obat dapat menyebabkan kegagalan terapi atau toksisitas sistem saraf pusat. Terdapat variabilitas yang signifikan dalam respon pasien terhadap pengobatan efavirenz sehingga perlu dilakukan pemantauan terapi obat (PTO) pada pasien yang menerima efavirenz. Oleh karena itu, diperlukan pengembangan metode bioanalisis efavirenz. Sebelumnya telah dikembangkan metode analisis efavirenz dalam dried blood spot (DBS) menggunakan Kromatografi Cair Kinerja Tinggi-Photodiode Array (KCKT-PDA) tanpa menggunakan baku dalam dengan hasil analisis yang kurang baik pada parameter sensitivitas, akurasi dan presisi, serta tidak sesuai dengan panduan bioanalisis terkini. Penelitian ini bertujuan untuk mengembangkan metode analisis efavirenz dalam DBS yang optimal dan tervalidasi menggunakan baku dalam. Preparasi sampel DBS dilakukan menggunakan metode presipitasi protein dengan volume penotolan darah 30 µL, pengeringan selama 2 jam, ekstraksi menggunakan 300 µL metanol, pengocokan dengan vorteks selama 10 detik, sonikasi selama 1 menit, dan sentrifugasi dengan kecepatan 5.000 rpm selama 5 menit. 200 µL supernatan dipipet dan diuapkan dengan aliran gas nitrogen, kemudian direkonstitusi dengan 100 μL fase gerak. Hasil preparasi sampel dianalisis dengan elusi isokratik menggunakan kolom C18 (Sunfire^TM 5 µm; 250 x 4.6 mm) pada suhu 40^oC; fase gerak asetonitril (ACN):dapar fosfat 10 mMol pH 3 (70:30); laju alir 0,8 mL/min; deteksi UV pada 245 nm; dan baku dalam warfarin natrium. Metode ini memperoleh LLOQ 0,1 μg/mL dan menunjukkan linearitas dalam rentang konsentrasi 0,1-30 μg/mL. Metode ini telah terbukti valid sesuai dengan persyaratan yang ditetapkan oleh US Food and Drug Administration (2018) dan European Medicines Agency (2022). Metode ini lebih sensitif serta lebih akurat dan presisi dengan penambahan baku dalam. Metode juga lebih sederhana sehingga membuat aplikasinya pada PTO menjadi lebih mudah dengan memberikan hasil yang tepat untuk mengurangi risiko efek samping dan meningkatkan efektivitas pengobatan.

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Efavirenz needs to reach adequate serum concentrations (1-4 µg/mL) as inconsistencies in drug levels may result in treatment failure or central nervous system toxicity. Significant variability in patient response to efavirenz treatment requires monitoring of drug levels in blood. Therefore, the development of bioanalytical methods for efavirenz is necessary. The previously published method for determining efavirenz in dried blood spot (DBS) using High-Performance Liquid Chromatography-Photodiode Array (HPLC-PDA) did not use any internal standard and showed poor results in terms of sensitivity, accuracy, and precision. It also did not comply with the current bioanalytical guidelines. This study aims to develop an optimum and validated analysis of efavirenz in DBS, utilizing an internal standard. DBS sample preparation used the protein precipitation method with 30 µL blood spotting volume, dried for 2 hours, extracted using 300 µL of methanol, vortexed for 10 seconds, sonicated for 1 minute, and centrifuged at 5000 rpm for 5 minutes. The 200 µL supernatant was pipetted and evaporated using nitrogen gas flow, then reconstituted with 100 µL of mobile phase.  Samples were analyzed with isocratic elution using C18 column (Sunfire TM 5 µm; 250 x 4.6 mm) at 40^oC; mobile phase acetonitrile (ACN):phosphate buffer 10 mM pH 3 (70:30); flow rate of 0.8 mL/min; UV detection at 245 nm; and warfarin as internal standard. This method obtained LLOQ of 0.1 μg/mL and shows linearity within the concentration range of 0.1-30 μg/mL. The method has been validated according to the requirements set by the US Food and Drug Administration (2018) and the European Medicines Agency (2022). This method is more sensitive, accurate, and precise with the addition of an internal standard. This simpler method makes its application for therapeutic drug monitoring (TDM) easier and ensures appropriate results, thereby reducing the risk of side effects and increasing the effectiveness of the treatment.

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"Chapters authored by known leading figures in the fluorescence field, new volume publishes annually, comprehensive coverage of the year's hottest and emerging topics, each Reviews in fluorescence volume is citable (ISI) and indexed. Reviews in Fluorescence 2010 topics include, novel metal-based luminophores for biological imaging. Hydration dynamics of probes and peptides in captivity, how does tobacco etch viral mRNA get translated? A fluorescence study of competition, stability and kinetics, synchronous fluorescence spectroscopy and Its applications in clinical analysis and food safety evaluation, quantitative molecular imaging in living cells via FLIM, a multiparametric imaging of cellular coenzymes for monitoring metabolic and mitochondrial activities, optimal conditions for live cell microscopy and Raster Image Correlation Spectroscopy (RICS)."

"David I.A. Millar's thesis explores the effects of extreme conditions on energetic materials. His study identifies and structurally characterises new polymorphs obtained at high pressures and/or temperatures. The performance of energetic materials (pyrotechnics, propellants and explosives) can depend on a number of factors including sensitivity to detonation, detonation velocity, and chemical and thermal stability. Polymorphism and solid-state phase transitions may therefore have significant consequences for the performance and safety of energetic materials. In order to model the behaviour of these important materials effectively under operational conditions it is essential to obtain detailed structural information at a range of temperatures and pressures."

"This compendium focuses on what the research community labels as solid state gas sensors, where a gas directly changes the electrical properties of a solid, serving as the primary signal for the transducer. It starts with a visionary approach to how life in future buildings can benefit from the power of gas sensors. The requirements for various applications. Further contributions highlight current trends in new sensing principles, such as the use of nanomaterials and how to use new sensing principles for innovative applications in e.g. meteorology. "

"This book offers an overview of state-of-the-art in non amplified DNA detection methods and provides chemists, biochemists, biotechnologists and material scientists with an introduction to these methods. In fact all these fields have dedicated resources to the problem of nucleic acid detection, each contributing with their own specific methods and concepts. This book will explain the basic principles of the different non amplified DNA detection methods available, highlighting their respective advantages and limitations. Non-amplified DNA detection can be achieved by adopting different techniques. Such techniques have allowed the commercialization of innovative platforms for DNA detection that are expected to break into the DNA diagnostics market. The enhanced sensitivity required for the detection of non amplified genomic DNA has prompted new strategies that can achieve ultrasensitivity by combining specific materials with specific detection tools. Advanced materials play multiple roles in ultrasensitive detection. Optical and electrochemical detection tools are among the most widely investigated to analyze non amplified nucleic acids. Biosensors based on piezoelectric crystal have been also used to detect unamplified genomic DNA. The main scientific topics related to DNA diagnostics are discussed by an outstanding set of authors with proven experience in this field."