Hasil Pencarian  ::  Simpan CSV :: Kembali

Hasil Pencarian

Ditemukan 7 dokumen yang sesuai dengan query
cover
Krouse, John H.
Philadelphia: Churchill Livingstone, Elsevier, 2008
616.97 MAN
Buku Teks SO  Universitas Indonesia Library
cover
"Rhinos® SR adalah kapsul kombinasi tetap loratadin 5 mg dengan pseudoefedrin 60 mg lepas cepat dan pseudoefedrin 60 mg lepas lambat. Studi ini bertujuan untuk menilai efikasi Rhinos® SR pada nasal airway resistance (NAR) secara obyektif dengan rhinomanometer dan gejala-gejala nasal serta nonnasal pada pasien dengan rinitis alergik sepanjang tahun (RAST) di negara tropis. Ini adalah studi paralel berpembanding plasebo, acak, tersamar ganda, dilakukan pada 59 pasien RAST berobat jalan di klinik THT RS Umum Dr. Soetomo, Surabaya. Pasien laki-laki dan perempuan, menderita RAST sedang sampai berat minimal 2 tahun, berumur 12 tahun ke atas, dengan total skor gejala nasal (TSGN) > 6 dan skor kongesti nasal (SKN) > 2, mendapat Rhinos® SR atau plasebo 2 kali sehari selama 7 hari. Parameter efikasi yang utama adalah berkurangnya nilai-nilai NAR (yang diukur dengan rhinomanometer pada hari pertama) dari Rhinos® SR dibandingkan dengan plasebo. Nilai-nilai NAR dihitung sebagai luas area di bawah kurva (area under the curve = AUC) dari NAR terhadap waktu. Parameter efikasi sekunder adalah berkurangnya gejala-gejala klinik (nasal dan nonnasal) yang dinilai oleh pasien maupun oleh dokter peneliti setelah 1 minggu penggunaan Rhinos® SR atau plasebo. Dari 59 pasien yang memenuhi syarat, semuanya menyelesaikan studi 1 minggu ini. Untuk nilai-nilai NAR, setelah baseline disamakan menjadi 100%, AUC0-10 jam tidak berbeda bermakna antara Rhinos® SR dan plasebo. Akan tetapi waktu pseudoefedrin mencapai kadar puncak, yakni 2 jam untuk yang lepas cepat dan 6 jam untuk yang lepas lambat, maka AUC0-2 jam dan AUC0-6 jam Rhinos® SR lebih rendah secara bermakna dibandingkan dengan plasebo. TSGN berdasarkan penilaian penderita (jumlah skor 3 pagi terakhir) untuk Rhinos® SR menurun 33.0% dari skor awal (p < 0.001), untuk plasebo juga menurun 21.9% dari skor awal (p = 0.002), tetapi penurunan oleh Rhinos tidak berbeda bermakna dengan penurunan oleh plasebo. Penurunan TSGN berdasarkan penilaian dokter peneliti, serta penurunan skor kongesti nasal (SKN) dan total skor gejala (nasal dan nonnasal), dan bahkan skor masing-masing gejala, berdasarkan penilaian pasien maupun dokter peneliti, menunjukkan pola yang sama, yakni Rhinos® SR dan plasebo menurunkan gejala secara bermakna dari nilai awal, dan penurunan oleh Rhinos® SR lebih besar dibandingkan penurunan oleh plasebo tetapi tidak berbeda bermakna. Dalam studi ini tidak ditemukan efek samping. Dari penelitian ini disimpulkan bahwa pada pasien RAST sedang sampai berat di negara tropis, Rhinos® SR efektif dalam mengurangi kongesti nasal dengan pengukuran obyektf NAR. Rhinos® SR 2 x sehari selama 7 hari juga efektif dalam mengurangi gejala-gejala klinik RAST meskipun tidak mencapai kemaknaan statistik dibandingkan dengan plasebo, serta dapat ditoleransi dengan baik.

Abstract
Rhinos® SR is a fixed combination of 5 mg loratadine and 60 mg pseudoephedrine immediate release and 60 mg pseudoephedrine sustained release. The present study was aimed to assess the efficacy of Rhinos® SR on nasal airway resistance (NAR) objectively using rhinomanometer and on nasal symptoms in patients with perennial allergic rhinitis (PAR) in a tropical country. This was a randomized, double-blind, parallel group study in 59 PAR patients who visited the ENT clinic at Dr. Soetomo General Hospital, Surabaya. Outpatients of both gender, having moderate to severe PAR for a minimal of 2 years, aged 12 years or older, with a total nasal symptom score (TNSS) > 6 and a nasal congestion score > 2, received Rhinos® SR or placebo twice daily for 7 days. The primary efficacy parameter was the decrease in the NAR values (measured by rhinomanometer on Day 1) of Rhinos® SR from those of placebo. The NAR values were calculated as the area under the curve (AUC) of NAR versus time. The secondary efficacy parameters were the percentage reduction of the clinical symptoms (nasal and nonnasal) evaluated by both the patient and the physician after 1 week use of Rhinos® SR or placebo. From 59 eligible patients, all completed this 1-week trial. For NAR values, after the baseline were considered as 100%, the AUC0-10 h were not significantly different between Rhinos® SR and placebo. However, as the pseudoephedrine reached its peak concentration, i.e. 2 hrs for the immediate release and 6 hrs for the sustained release, then AUC0-2 h and AUC0-6 h of Rhinos® SR were significantly lower compared to those of placebo. Total nasal symptom score (TNSS) evaluated by the patient (sum of the last 3 mornings) for Rhinos® SR decreased 33.0% from baseline (p < 0.001), for placebo decreased 21.9% from baseline (p = 0.002), but the decrease by Rhinos® SR was not significantly different from the decrease by placebo. TNSS evaluated by the physician, nasal congestion score (NCS) and total symptom score (TSS, total nasal and nonnasal), and even the individual symptom scores, evaluated by the patient and the physician, showed similar pattern, i.e. both Rhinos® SR and placebo decreased the symptoms significantly from baseline, and the decreases by Rhinos® SR were larger than the decreases by placebo, but the decreases by Rhinos® SR and placebo were not statistically different. No adverse event was found in this study. From the present study it was concluded that in patients with moderate to severe PAR in a tropical country, Rhinos® SR was effective in relieving nasal congestion by objective measurements of NAR. Rhinos® SR twice a day for 7 days was also effective in reducing the clinical symptoms of PAR although the reductions did not reach statistical significance compared to those by placebo, and was well tolerated. "
[Fakultas Kedokteran Universitas Indonesia, Fakultas Kedokteran Universitas Indonesia], 2008
pdf
Artikel Jurnal  Universitas Indonesia Library
cover
Agus J. Susanto
"Background: house dust mites (HDM) are an important inhalant allergen in allergic asthma. However, molecular diagnostic study of specific IgE to HDM allergens has not been done in Indonesia. In addition, the association of quantitative specific IgE measurement with asthma severity has not been investigatedd. This study aimed to investigate the difference of serum quantitative specific IgE levels induced by Dermatophagoides (D.) pteronyssinus, D. farinae and Blomia tropicalis sensitization in intermittent and persistent allergic asthma. Methods:this was a cross-sectional study on adult allergic asthma patients who were invited for serum specific IgE testing. This study was a part of a larger study within the Division of Allergy and Immunology, Cipto Mangunkusumo Hospital. Asthma severity was defined based on Global Initiative on Asthma (GINA) 2015 criteria and were grouped as intermittent or persistent. Quantitative specific IgE testing was done on blood serum using a multiple allergosorbent test (Polycheck Allergy, Biocheck GmbH, Munster, Germany). The HDM allergens tested were D. pteronyssinus, D. farinae, and Blomia tropicalis. Difference between two groups were analyze using Mann-Whitney test. Results: a total of 87 subjects were enrolled in this study; 69 (79.3%) were women. Mean patients’ age was 40, 2 years. Sixty-three (72.4%) subjects had asthma and allergic rhinitis. Fifty-eight (66.7%) subjects were classified as persistent asthma. The prevalence of sensitization was 62.1% for D. farinae, 51.7% for D. pteronyssinus, and 48.3% for Blomia tropicalis. The median of specific IgE levels were significantly higher in persistent asthma compares to intermittent asthma induced by D. farinae (median 1.30 vs. 0.0 kU/L; p=0.024) and B. tropicalis (median 0.57 vs. 0.0 kU/L; p=0.015) sensitization. Level of Specific IgE D. pteronyssinus was also to be higher in persistent asthma than the level measured in intermittent asthma (0.67 vs. 0.00 kU/L; p=0.066). Conclusion: Sensitization of HDM allergens was shown to be highest for D. farinae 62.1%, followed by D. pteronyssinus 51.7% and Blomia tropicalis 48.3%. Specific IgE level induced by D. farinae and Blomia tropicalis sensitization were significantly higher in patients with persistent asthma compared to intermittent asthma, whereas specific IgE level induced by D. pteronyssinus sensitization was higher in persistent asthma although not statistically significant.

Latar belakang: tungau debu rumah (TDR) merupakan alergen hirup yang penting pada asma alergik. Namun, penelitian diagnostik molekuler menggunakan Imunoglobulin E (IgE) spesifik akibat sensitisasi alergen TDR dihubungkan dengan derajat keparahan asma alergik belum pernah dilakukan di Indonesia. Penelitian ini bertujuan mengetahui perbedaan kadar IgE spesifik serum kuantitatif akibat sensitisasi alergen Dermatophagoides (D.) pteronyssinus, D. farinae dan Blomia (B.) tropicalis pada asma alergik intermiten dan persisten. Metode: desain penelitian potong lintang pada pasien asma alergik dewasa yang diundang untuk pemeriksaan IgE spesifik serum dan merupakan bagian dari penelitian payung di Divisi Alergi dan Imunologi Klinik, RS Cipto Mangunkusumo. Derajat keparahan asma ditentukan berdasarkan kriteria Global Initiative on Asthma (GINA) 2015 dan dikelompokkan menjadi intermiten dan persisten. Pemeriksaan IgE spesifik serum kuantitatif menggunakan metode multiple allergosorbent test (Polycheck Allergy, Biocheck GmbH, Munster, Germany). Alergen TDR yang diperiksa adalah D. pteronyssinus, D. farinae, dan B. tropicalis. Perbedaan antara dua kelompok dianalisis dengan uji Mann-Whitney. Hasil: sebanyak 87 subyek dilibatkan dalam penelitian ini; 69 (79,3%) subyek adalah perempuan. Rerata usia pasien adalah 40,2 tahun. Enam puluh tiga (72,4%) pasien menderita asma dan rinitis alergik. Sebanyak 58 (66,7%) pasien asma persisten. Gambaran sensitisasi alergen TDR adalah 62,1% D. farinae; 51,7% D. pteronyssinus dan 48,3% B.tropicalis. Median kadar IgE spesifik secara bermakna lebih tinggi pada asma persisten dibandingkan asma intermiten untuk alergen D. farinae (1,30 vs. 0,0 kU/L; p=0,024) dan B. tropicalis (0,57 vs. 0,0 kU/L; p=0,015). Kadar IgE spesifik D. pteronyssinus lebih tinggi pada asma persisten dibandingkan intermiten (0,67 vs. 0,00 kU/L; p=0,066). Kesimpulan: gambaran sensitisasi alergen secara berurutan didapatkan D. farinae 62,1%, D. pteronyssinus 51,7% dan B. tropicalis 48,3%. Kadar IgE spesifik akibat sensitisasi D. farinae dan B. tropicalis lebih tinggi secara bermakna pada pasien asma persisten dibandingkan asma intermiten. Kadar IgE spesifik akibat sensitisasi D. pteronyssinus lebih tinggi pada pasien asma persisten dibandingkan asma intermiten, tetapi secara statistik tidak bermakna."
Jakarta: Interna Publishing, 2017
610 UI-IJIM 49:4 (2017)
Artikel Jurnal  Universitas Indonesia Library
cover
Suriani Alimuddin
"Background: nowadays, specific IgE measurement has been conducted in Indonesia, however there is still lack of data regarding diagnostic test to detect inhalant allergen in patients with respiratory allergies. This study aimed to determine the accuracy of specific IgE test in diagnosing specific sensitization of inhalant allergen in patients with respiratory allergies.
Methods: this was a cross sectional study in patients with respiratory allergies and part of epidemiology study regarding to specific IgE sensitization in Allergy-Immunollogy Division, Cipto Mangunkusumo Hospital, Jakarta within November-December 2016. Measurement of specific IgE sensitization using Immunoblot method (Euroline, Euroimmun AG, Germany). The tested allergen is house dust mites Dermatophagoides pteronyssinus (Der p), Dermatophagoides farinae (Der f), Blomia tropicalis (Blo t) and cockroach Blatella germanica (Bla g). The result is compared with gold standard, skin prick test. The diagnostic result includes sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), positive likelihood ratio (LR+), and negative likelihood ratio (LR-).
Results: a total of 101 patients were enrolled; 77 (76.2%) were women. Patients mean age was 38.8 years old. Based on SPT, sensitization was highest for Blo t (76.2%), followed by Der p (70.3%), Der f (69.3%), and Bla g (41.6%). Specific IgE-sensitization was highest for Der f (52.9%), followed by Der p (38.2%), Blo t (33.3%) and Bla g (10.8%). Der p allergen had 50.7% sentivity, 90% specificity, 92.3% PPV, 43.5% NPV, 5.1 LR+ and 0.1LR-. Der f showed 71.4% sensitivity, 87.1% specificity, 82.6% PPV, 57.4% NPV, 5.5 LR+ and 0.3 LR-. Blo t allergen had 41.6% sensitivity, 91.7% specificity, 94.1% PPV, 32.8% NPV, 5.0 LR+, and 0.6 LR-. Bla g allergen had 23.8% sensitivity, 98.3% specificity, 90.9% PPV, 64.4% NPV, 14.5 LR+ and 0.8 LR-.
Conclusion: serum specific IgE testing to common inhalant allergen in patients with respiratory allergy showed only low-to-moderate sensitivity, but high specificity and PPV. This new assay can be used to diagnose allergen sensitization in the population with high prevalence of TDR and cockroach.

Latar belakang: pemeriksaan IgE spesifik serum baru diperkenalkan di Indonesia, tetapi belum ada data uji diagnostik mengenai kinerjanya dalam mendeteksi alergen hirupan yang sering pada pasien alergi pernapasan. Tujuan penelitian ini adalah untuk mendapatkan akurasi diagnostik pemeriksaan IgE spesifik serum dalam mendiagnosis sensitisasi alergen hirupan tertentu pada pasien alergi pernapasan.
Metode: penelitian ini adalah studi potong lintang pada pasien alergi pernapasan dan merupakan bagian dari studi epidemiologi mengenai sensitisasi IgE spesifik di Divisi Alergi-Immunologi, RS Cipto Mangunkusumo, Jakarta, pada bulan November sampai Desember 2016. Pengukuran sensitisasi IgE spesifik dilakukan dengan metode imunoblot (Euroline®, Euroimmun AG, Germany). Alergen yang diuji adalah tungau debu rumah [Dermatophagoides pteronyssinus (Der p), Dermatophagoides farinae (Der f), Blomia tropicalis (Blo t)], dan kecoa [Blatella germanica (Bla g)]. Hasilnya dibandingkan dengan baku emas uji tusuk kulit. Uji diagnostik yang dilakukan meliputi sensitivitas, spesifisitas, positive predicitive value (PPV), negative predictive value (NPV), likelihood ratio positif dan negatif (LR+ and LR-).
Hasil: sebanyak 101 pasien dilibatkan dalam studi, 77 (76,2%) di antaranya adalah perempuan. Rerata usia pasien adalah 38,8 tahun. Berdasarkan uji tusuk kulit, sensitisasi tertinggi yang didapatkan adalah terhadap Blo t (76,2%), disusul oleh Der p (70,3%), Der f (69,3%), dan Bla g (41,6%). Sensitisasi IgE-spesifik tertinggi ditunjukkan oleh Der f (52,9%), diikuti oleh Der p (38,2%), Blo t (33,3%) dan Bla g (10,8%). Alergen Der p memiliki 50,7% sentivitas, 90% spesifisitas, 92,3% PPV, 43,5% NPV, 5,1 LR+ dan 0,1 LR-. Der f memperlihatkan 71,4% sensitivitas, 87,1% spesifisitas, 82,6% PPV, 57,4% NPV, 5,5 LR+ dan 0,3 LR-. Alergen Blo t menunjukkan 41,6% sensitivitas, 91,7% spesifisitas, 94,1% PPV, 32,8% NPV, 5,0 LR+, dan 0,6 LR-. Alergen Bla g menghasilkan 23,8% sensitivitas, 98,3% spesifisitas, 90,9% PPV, 64,4% NPV, 14,5 LR+ dan 0,8 LR-.
Kesimpulan: pemeriksaan IgE spesifik serum terhadap alergen inhalan pada pasien alergi pernapasan memperlihatkan sensitivitas rendah sampai sedang, tetapi spesifisitas dan PPV yang tinggi. Pemeriksaan dapat digunakan mendiagnosis sensitisasi alergen pada populasi dengan prevalensi TDR dan kecoa yang tinggi.
"
Jakarta: Faculty of Medicine University of Indonesia, 2018
610 UI-IJIM 50: 2 (2018)
Artikel Jurnal  Universitas Indonesia Library
cover
Adi Surya Komala
"ABSTRAK
Latar Belakang: Asma alergi merupakan salah satu jenis fenotipe asma yang terbanyak, ditandai dengan adanya sensitisasi terhadap alergen lingkungan. Pada asma alergi terjadi respons inflamasi tipe 2 yang akan menghasilkan periostin yang dapat dideteksi dalam darah. Salah satu faktor yang mempengaruhi keterkontrolan asma adalah paparan alergen yang dapat bervariasi bergantung pada pola musim. Wilayah Indonesia sebagai benua maritim memiliki dua musim (hujan dan kemarau) berbeda dengan wilayah lain yang memiliki empat musim. Tujuan: Penelitian ini bertujuan untuk melihat perbedaan kadar periostin serum pada asma alergi terkontrol dan tidak terkontrol. Metode: Penelitian ini merupakan penelitian potong lintang dengan subjek penelitian adalah pasien asma alergi yang berobat ke poliklinik divisi Alergi Imunologi Klinik Rumah Sakit Dr Cipto Mangunkusumo bulan Januari-April 2017. Keterkontrolan asma dinilai dengan skor Tes Kontrol Asma sementara periostin serum digunakan sebagai penanda proses inflamasi Th2. Hasil: Dari 80 pasien asma alergi didapatkan rerata usia 39,7 tahun dengan proporsi perempuan lebih banyak (76%). Sebagian besar pasien memiliki riwayat rinitis alergi (73,8%) dan riwayat asma dalam keluarga (71%). Tungau debu rumah merupakan jenis alergen yang banyak memberikan sensitisasi. Kadar periostin serum pada subjek yang tidak terkontrol tidak berbeda dengan subjek yang terkontrol (209,78 ng/mL vs 627,66 ng/mL, p = 0,424) Simpulan: Tidak terdapat perbedaan kadar periostin pada kelompok asma alergi terkontrol dan tidak terkontrol.

ABSTRACT
Background: Allergic asthma is the most common asthma phenotype, defined by the presence of sensitization to environmental allergens. In allergic asthma, following allergen exposure there will be an activation of T2-type inflammation producing periostin that can be detected from blood. Many factors can influence asthma control, including allergen exposure, which may vary greatly with climatic and seasonal changes. The Indonesia region as the Maritime Continent is characterized by a wet and a dry season which is different from other regions with four seasons. Objective: To see the difference of serum periostin level in uncontrolled and controlled allergic asthma. Methods: This is a cross sectional study using samples from allergic asthma patients who went to Allergy and Clinical Immunology Clinic, Dr. Cipto Mangunkusumo Hospital in January to April 2017. Asthma control was assessed clinically by using Asthma Control Test, while serum periostin was used as biological markers reflecting Th2 inflammation. Results: From 80 allergic asthma patients, the average of age was 39.7 years old with a greater proportion of women (76%). Most of the subjects had history of allergic rhinitis (73.8%) and positive family history of asthma (71%). House dust mites were the most common cause of sensitization. Serum periostin level in uncontrolled allergic asthma was not different from those in controlled allergic asthma (209,78 ng/mL vs 627,66 ng/mL, p = 0,424). Conclusions: There was no difference in the level of serum periostin in controlled and uncontrolled allergic asthma."
2019
SP-pdf
UI - Tugas Akhir  Universitas Indonesia Library
cover
"Purpose: Rhinitis and conjunctivitis are common diseases worldwide that are frequently associated. Nevertheless, the risk factors for rhinoconjurc tiitis are not well-described and the impact of conjunctivitis on rtinitis and asthma in children remains unknown. This study explored the different risk factors and evaluated the burden of rhinoconjunctivitis among adolescents. Methods: This was a cross-sectional study conducted on a random sample of schoolchildren, aged 10-17 years, using skin prick tests and a self-administered questionnaire on respiratory health investigating pact of thinitis and rhinoconjunctivitis on daily activities. Results: A complete evaluation was obtained for 2.150 children. The prevalence of rhinitis alone was 18.2% and tinitis associated with conjunctivitis was 20.5%. Rhinoconjunctivitis was more frequently associated with females, a parental history of atopt domestic exposure to mold/dampness, passive smoke exposure, and reported truck traffic in residential streets. Moreover, rhino-conjunctivitis was associated with a higher level of allergic sensitization. The prevalence of current asthma was 1.7% in subjects without rhinitis or rhinoconjunctivitis, 5.1% in rhinitis and 10.7% in rhinoconjunctivitis. In a logistic model, rhinoconjunctivitis yielded a 2-fold risk for current asthma with respect to thinitis Subjects with rhinoconjunctivitis had poorer quality of life (QoL); there was an impact on daily activities in 4.6% of rhinitis and 107% of rhinoconjunctivitis. Conclusions: Ocular symptoms increase the role of rhinitis as a risk factor for asthma and its impact on daily activities in children. "
AAIR 7:1 (2015)
Artikel Jurnal  Universitas Indonesia Library
cover
Jonathan Darell Widjaja
"Background: Vitamin D role in immune system have been investigated due to the presence of VDR on immune cells. Based on this information deficient level of vitamin D could affect the progression of allergic rhinitis. Unfortunately the data regarding vitamin D status in the normal population and allergic rhinitis patient were very limited in Indonesia. This research was done to provide illustration regarding the status of vitamin D in healthy and allergic rhinitis patients in Jakarta and also to investigate the factor that might affect the level of vitamin D in allergie rhinitis. Methods: This research was an observational cross sectional research. There were 22 subjects used during this research all diagnosed with moderate-severe allergic rhinitis. The study used the Electrochemiluminescence Immunoassay (ECLIA) technique. The data then were analyzed with IBM® SPSS statistic version 22 Results: The difference between the mean vitamin D of patients suffering from allergic rhinitis with healthy controls (12.7±10.3 ng/mL to 15.1±8.1 ng/mL). There was no significant diference in mean vitamin D between the gender groups (Independent Sample T-test p= 0.62). There were no statistical difference between the vitamin D level in patient with different eosinophil count and IL-5 level (IL-5 group: one-way ANOVA: p= 0.897; eosinophil group: One Way ANOVA: p = 0.752). Conclusion: The mean level of vitamin D in allergic rhinitis patients compared to healthy controls showed no significant difference. Comparison studies about level of vitamin D between groups with different gender, IL-5 and eosinophil count showed no significant difference"
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2015
S70303
UI - Skripsi Membership  Universitas Indonesia Library