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Alida Widiawaty
Efektivitas pesan singkat elektronik terhadap kepatuhan pengobatan akne vulgaris ringan di Poliklinik Ilmu Kesehatan Kulit dan Kelamin Rumah Sakit dr. Cipto Mangunkusumo = The effectiveness of electronic text messaging to adherence of acne vulgaris therapy in Dermatology and Venereology Clinic dr. Cipto Mangunkusumo Hospital
"[ABSTRAK
Latar belakang dan tujuan: Akne vulgaris (AV) adalah penyakit peradangan menahun unit pilosebasea yang bersifat swasirna, ditandai dengan lesi pleomorfik berupa papul, komedo, pustul, dan nodul. Pengobatan AV memerlukan waktu yang cukup lama. Penyakit menahun dengan waktu pengobatan yang lama, berdampak terhadap kepatuhan pasien. Kepatuhan pengobatan topikal lebih rendah daripada sistemik. Hanya akne vulgaris ringan (AVR) yang diterapi menggunakan obat-obatan topikal saja. Layanan pesan singkat merupakan salah satu cara yang praktis dan efisien dalam upaya meningkatkan kepatuhan pengobatan AV, dengan pertimbangan prevalensi AV lebih banyak pada usia remaja dan dewasa muda yang merupakan pengguna terbanyak layanan tersebut. Dengan layanan ini, diharapkan pasien tidak lupa menggunakan obat topikal pada AVR. Penelitian ini dilakukan untuk mengetahui efektivitas penggunaan pesan singkat elektronik terhadap kepatuhan pengobatan AVR.
Metode: Studi eksperimen dengan desain randomized controlled trial (RCT) terhadap pasien AVR usia 15-25 tahun yang berobat ke Poliklinik Ilmu Kesehatan Kulit dan Kelamin (IKKK) Rumah Sakit dr. Cipto Mangunkusumo (RSCM). Penelitian ini melibatkan 2 kelompok, yaitu: kelompok intervensi yang mendapat pesan singkat elektronik dan kelompok kontrol. Kedua kelompok diberi pengobatan tretinoin krim 0,05% dan/atau klindamisin gel 1,2% selama 6 minggu.
Hasil: Tidak terdapat perbedaan bermakna antara kepatuhan pengobatan AVR kelompok kontrol dengan kelompok intervensi pada minggu kedua (p=0,376) dan keempat (p=0,432). Namun pada minggu keenam, kelompok intervensi secara bermakna lebih patuh daripada kelompok kontrol (p=0,032).
Kesimpulan: Pesan singkat elektronik meningkatkan kepatuhan pengobatan AVR terutama pada minggu keenam di Poliklinik IKKK RSCM.
ABSTRACT
Background and objectives: Acne vulgaris (AV) is a self limited, chronic inflammatory disease of pilosebaceous unit, characterized by pleomorphic lesions consist of papules, comedones, pustules, and nodules. Acne vulgaris requires a long duration of treatment. Chronic disease with a long duration of therapy usually has an impact on adherence. Topical therapy adherence is lower than systemic. Only mild AV is treated with topical medications. Electronic text messaging is a practical and efficient method in order to improve adherence to AV therapy, with a consideration of the AV prevalence are more on teens and young adults who are the majority users of electronic text messaging service. With this method, patients are expected not to forget the use of medication. This study was conducted to determine the effectiveness of electronic text messaging to improve adherence of mild AV therapy.
Methods: Experimental study, randomized controlled trial (RCT) to mild AV patients, age 15-25 years old who came to Dermatology and Venereology Clinic dr. Cipto Mangunkusumo Hospital. This study involved two groups: intervention group who received electronic text messaging, and the contrary is the control group. Both groups were prescribed tretinoin 0,05% cream and/or clindamycin 1,2% gel for six weeks.
Results: There were no significant differences in adherence of mild AV therapy between both groups in the second (p = 0.376) and fourth week (p = 0.432). The intervention group was significantly higher in terms of adherence than the control group in the sixth week (p = 0.032).
Conclusions: Electronic text messaging improve adherence of mild AV therapy especially in the sixth week at Dermatology and Venereology Clinic dr. Cipto Mangunkusumo Hospital.;Background and objectives: Acne vulgaris (AV) is a self limited, chronic
inflammatory disease of pilosebaceous unit, characterized by pleomorphic lesions
consist of papules, comedones, pustules, and nodules. Acne vulgaris requires a
long duration of treatment. Chronic disease with a long duration of therapy
usually has an impact on adherence. Topical therapy adherence is lower than
systemic. Only mild AV is treated with topical medications. Electronic text
messaging is a practical and efficient method in order to improve adherence to
AV therapy, with a consideration of the AV prevalence are more on teens and
young adults who are the majority users of electronic text messaging service.
With this method, patients are expected not to forget the use of medication. This
study was conducted to determine the effectiveness of electronic text messaging
to improve adherence of mild AV therapy.
Methods: Experimental study, randomized controlled trial (RCT) to mild AV
patients, age 15-25 years old who came to Dermatology and Venereology Clinic
dr. Cipto Mangunkusumo Hospital. This study involved two groups: intervention
group who received electronic text messaging, and the contrary is the control
group. Both groups were prescribed tretinoin 0,05% cream and/or clindamycin
1,2% gel for six weeks.
Results: There were no significant differences in adherence of mild AV therapy
between both groups in the second (p = 0.376) and fourth week (p = 0.432). The
intervention group was significantly higher in terms of adherence than the control
group in the sixth week (p = 0.032).
Conclusions: Electronic text messaging improve adherence of mild AV therapy especially in the sixth week at Dermatology and Venereology Clinic dr. Cipto Mangunkusumo Hospital.;Background and objectives: Acne vulgaris (AV) is a self limited, chronic
inflammatory disease of pilosebaceous unit, characterized by pleomorphic lesions
consist of papules, comedones, pustules, and nodules. Acne vulgaris requires a
long duration of treatment. Chronic disease with a long duration of therapy
usually has an impact on adherence. Topical therapy adherence is lower than
systemic. Only mild AV is treated with topical medications. Electronic text
messaging is a practical and efficient method in order to improve adherence to
AV therapy, with a consideration of the AV prevalence are more on teens and
young adults who are the majority users of electronic text messaging service.
With this method, patients are expected not to forget the use of medication. This
study was conducted to determine the effectiveness of electronic text messaging
to improve adherence of mild AV therapy.
Methods: Experimental study, randomized controlled trial (RCT) to mild AV
patients, age 15-25 years old who came to Dermatology and Venereology Clinic
dr. Cipto Mangunkusumo Hospital. This study involved two groups: intervention
group who received electronic text messaging, and the contrary is the control
group. Both groups were prescribed tretinoin 0,05% cream and/or clindamycin
1,2% gel for six weeks.
Results: There were no significant differences in adherence of mild AV therapy
between both groups in the second (p = 0.376) and fourth week (p = 0.432). The
intervention group was significantly higher in terms of adherence than the control
group in the sixth week (p = 0.032).
Conclusions: Electronic text messaging improve adherence of mild AV therapy especially in the sixth week at Dermatology and Venereology Clinic dr. Cipto Mangunkusumo Hospital., Background and objectives: Acne vulgaris (AV) is a self limited, chronic
inflammatory disease of pilosebaceous unit, characterized by pleomorphic lesions
consist of papules, comedones, pustules, and nodules. Acne vulgaris requires a
long duration of treatment. Chronic disease with a long duration of therapy
usually has an impact on adherence. Topical therapy adherence is lower than
systemic. Only mild AV is treated with topical medications. Electronic text
messaging is a practical and efficient method in order to improve adherence to
AV therapy, with a consideration of the AV prevalence are more on teens and
young adults who are the majority users of electronic text messaging service.
With this method, patients are expected not to forget the use of medication. This
study was conducted to determine the effectiveness of electronic text messaging
to improve adherence of mild AV therapy.
Methods: Experimental study, randomized controlled trial (RCT) to mild AV
patients, age 15-25 years old who came to Dermatology and Venereology Clinic
dr. Cipto Mangunkusumo Hospital. This study involved two groups: intervention
group who received electronic text messaging, and the contrary is the control
group. Both groups were prescribed tretinoin 0,05% cream and/or clindamycin
1,2% gel for six weeks.
Results: There were no significant differences in adherence of mild AV therapy
between both groups in the second (p = 0.376) and fourth week (p = 0.432). The
intervention group was significantly higher in terms of adherence than the control
group in the sixth week (p = 0.032).
Conclusions: Electronic text messaging improve adherence of mild AV therapy especially in the sixth week at Dermatology and Venereology Clinic dr. Cipto Mangunkusumo Hospital.]"
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2015
T58825
UI - Tesis Membership  Universitas Indonesia Library
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Hafiza Fathan
Pola resistensi bakteri terhadap antibiotik pada akne vulgaris sedang dan berat di Departemen Ilmu Kesehatan Kulit dan Kelamin RS Dr. Cipto Mangunkusumo = Antibiotic resistance of bacteria isolated from moderate and severe acne vulgaris patients visiting dermatology and venereology outpatient clinics Dr. Cipto Mangunkusumo Hospital, Jakarta
"ABSTRAK
Latar belakang dan tujuan. Penggunaan antibiotik pada akne vulgaris (AV) saat ini
dihadapi permasalahan resistensi Propionibacterium acnes (PA) dan bakteri lain
yang berperan pada AV. Data pola resistensi AVS dan AVB di RS Cipto
Mangunkusumo (RSCM) tahun 2006 menunjukkan adanya resistensi PA terhadap
eritromisin (63,2%), klindamisin (57,9%), dan tetrasiklin (47,4%). Tidak ditemukan
PA yang resisten terhadap doksisiklin maupun minosiklin. Penggunaan antibiotik
pada AV dapat menyebabkan perubahan pola resistensi sehingga penelitian ini
bertujuan memberikan data terbaru mengenai pola bakteri dan resistensinya terhadap
antibiotik lini pertama pada AVS dan AVB di Departemen Ilmu Kesehatan Kulit dan
Kelamin RSCM, yaitu tetrasiklin, doksisiklin, minosiklin, klindamisin dan
eritromisin.
Metode. Penelitian ini merupakan penelitian deskriptif dengan desain potong lintang.
Spesimen untuk kultur dan uji resistensi didapatkan dari ekstraksi komedo tertutup
yang selanjutnya dibiakkan secara aerob dan anaerob. Pemeriksaan uji resistensi
dilakukan secara kuantitatif dengan menggunakan MIC strip test.
Hasil. Dari 91 subjek, bakteri yang ditemukan terdiri atas PA 11,0%, Staphylococcus
epidermidis (SE) 50,5%, Staphylococcus aureus (SA) 7,7% dan bakteri lain sebesar
40,7% (aerob) dan 19,8% (anaerob). Sebagian kecil PA (10%) resisten terhadap
tetrasiklin, klindamisin, dan eritromisin. Tidak ditemukan PA yang resisten terhadap
doksisiklin dan minosiklin. Bakteri SE resisten terhadap eritromisin (65,2%),
klindamisin (52,2%), tetrasiklin (32,6%), dan doksisiklin (4,3%). Tidak ditemukan
SE yang resisten terhadap minosiklin. Sebagian kecil SA resisten terhadap
eritromisin (28,6%), doksisiklin (14,3%) dan klindamisin (14,3%). Tidak ditemukan
SA yang resisten terhadap tetrasiklin dan minosiklin.
Kesimpulan. Bakteri yang ditemukan pada pasien AVS dan AVB antara lain,
Staphylococcus epidermidis 50.5%, Propionibacterium acnes 11.0%, dan
Staphylococcus aureus 7.7%. Bakteri paling banyak ditemukan resisten terhadap
eritromisin dan ketiga bakteri tersebut seluruhnya masih sensitif terhadap minosiklin. ABSTRACT
Background and objective: The resistance of Propionibacterium acnes (PA) and
other bacteria that implicated in acne vulgaris (AV), has been a problem in AV
therapy. The latest data in the Department of Dermatology and Venereology, Cipto
Mangunkusumo Hospital, Jakarta (2006) showed resistance to erythromycin
(63.2%), clindamycin (57.9%) and tetracycline (47.4%), and no resistance to
doxycycline and minocycline. The use of antibiotics may cause changes in
susceptibility. This study aimed to provide the latest bacterial profile and resistance
pattern to first-line antibiotics used in moderate and severe AV: tetracycline,
doxycycline, minocycline, clindamycin and erythromycin.
Methods: This is a descriptive, cross-sectional study. Specimens were extracted
from closed comedones and cultured in media for aerobic and anaerobic bacteria.
Antibiotic resistance was measured quantitatively using MIC strip test.
Results: Bacteria were isolated from 91 subjects and consisted of Staphylococcus
epidermidis (SE)(50.5%), PA (11.0%), Staphylococcus aureus (SA)(7.7%) and other
bacteria [aerobic (40.7%) and anaerobic (19.8%)]. A small number of PA (10%) was
resistant to tetracycline, clindamycin, and erythromycin but not to doxycycline and
minocycline. SE was resistant to erythromycin (65.2%), clindamycin (52.2%),
tetracycline (32.6%), and doxycycline (4.3%) but not to minocycline. A small
number of SA was resistant to erythromycin (28.6%), doxycycline (14.3%) and
clindamycin (14.3%) but not to tetracycline and minocycline.
Conclusion: Bacterial profile in moderate and severe acne vulgaris consisted of
Staphylococcus epidermidis 50.5%, Propionibacterium acnes 11.0%, and
Staphylococcus aureus 7.7%. Bacteria were commonly resistant to erythromycin, but
still completely sensitive to minocycline.
;Background and objective: The resistance of Propionibacterium acnes (PA) and
other bacteria that implicated in acne vulgaris (AV), has been a problem in AV
therapy. The latest data in the Department of Dermatology and Venereology, Cipto
Mangunkusumo Hospital, Jakarta (2006) showed resistance to erythromycin
(63.2%), clindamycin (57.9%) and tetracycline (47.4%), and no resistance to
doxycycline and minocycline. The use of antibiotics may cause changes in
susceptibility. This study aimed to provide the latest bacterial profile and resistance
pattern to first-line antibiotics used in moderate and severe AV: tetracycline,
doxycycline, minocycline, clindamycin and erythromycin.
Methods: This is a descriptive, cross-sectional study. Specimens were extracted
from closed comedones and cultured in media for aerobic and anaerobic bacteria.
Antibiotic resistance was measured quantitatively using MIC strip test.
Results: Bacteria were isolated from 91 subjects and consisted of Staphylococcus
epidermidis (SE)(50.5%), PA (11.0%), Staphylococcus aureus (SA)(7.7%) and other
bacteria [aerobic (40.7%) and anaerobic (19.8%)]. A small number of PA (10%) was
resistant to tetracycline, clindamycin, and erythromycin but not to doxycycline and
minocycline. SE was resistant to erythromycin (65.2%), clindamycin (52.2%),
tetracycline (32.6%), and doxycycline (4.3%) but not to minocycline. A small
number of SA was resistant to erythromycin (28.6%), doxycycline (14.3%) and
clindamycin (14.3%) but not to tetracycline and minocycline.
Conclusion: Bacterial profile in moderate and severe acne vulgaris consisted of
Staphylococcus epidermidis 50.5%, Propionibacterium acnes 11.0%, and
Staphylococcus aureus 7.7%. Bacteria were commonly resistant to erythromycin, but
still completely sensitive to minocycline.
;Background and objective: The resistance of Propionibacterium acnes (PA) and
other bacteria that implicated in acne vulgaris (AV), has been a problem in AV
therapy. The latest data in the Department of Dermatology and Venereology, Cipto
Mangunkusumo Hospital, Jakarta (2006) showed resistance to erythromycin
(63.2%), clindamycin (57.9%) and tetracycline (47.4%), and no resistance to
doxycycline and minocycline. The use of antibiotics may cause changes in
susceptibility. This study aimed to provide the latest bacterial profile and resistance
pattern to first-line antibiotics used in moderate and severe AV: tetracycline,
doxycycline, minocycline, clindamycin and erythromycin.
Methods: This is a descriptive, cross-sectional study. Specimens were extracted
from closed comedones and cultured in media for aerobic and anaerobic bacteria.
Antibiotic resistance was measured quantitatively using MIC strip test.
Results: Bacteria were isolated from 91 subjects and consisted of Staphylococcus
epidermidis (SE)(50.5%), PA (11.0%), Staphylococcus aureus (SA)(7.7%) and other
bacteria [aerobic (40.7%) and anaerobic (19.8%)]. A small number of PA (10%) was
resistant to tetracycline, clindamycin, and erythromycin but not to doxycycline and
minocycline. SE was resistant to erythromycin (65.2%), clindamycin (52.2%),
tetracycline (32.6%), and doxycycline (4.3%) but not to minocycline. A small
number of SA was resistant to erythromycin (28.6%), doxycycline (14.3%) and
clindamycin (14.3%) but not to tetracycline and minocycline.
Conclusion: Bacterial profile in moderate and severe acne vulgaris consisted of
Staphylococcus epidermidis 50.5%, Propionibacterium acnes 11.0%, and
Staphylococcus aureus 7.7%. Bacteria were commonly resistant to erythromycin, but
still completely sensitive to minocycline.
;Background and objective: The resistance of Propionibacterium acnes (PA) and
other bacteria that implicated in acne vulgaris (AV), has been a problem in AV
therapy. The latest data in the Department of Dermatology and Venereology, Cipto
Mangunkusumo Hospital, Jakarta (2006) showed resistance to erythromycin
(63.2%), clindamycin (57.9%) and tetracycline (47.4%), and no resistance to
doxycycline and minocycline. The use of antibiotics may cause changes in
susceptibility. This study aimed to provide the latest bacterial profile and resistance
pattern to first-line antibiotics used in moderate and severe AV: tetracycline,
doxycycline, minocycline, clindamycin and erythromycin.
Methods: This is a descriptive, cross-sectional study. Specimens were extracted
from closed comedones and cultured in media for aerobic and anaerobic bacteria.
Antibiotic resistance was measured quantitatively using MIC strip test.
Results: Bacteria were isolated from 91 subjects and consisted of Staphylococcus
epidermidis (SE)(50.5%), PA (11.0%), Staphylococcus aureus (SA)(7.7%) and other
bacteria [aerobic (40.7%) and anaerobic (19.8%)]. A small number of PA (10%) was
resistant to tetracycline, clindamycin, and erythromycin but not to doxycycline and
minocycline. SE was resistant to erythromycin (65.2%), clindamycin (52.2%),
tetracycline (32.6%), and doxycycline (4.3%) but not to minocycline. A small
number of SA was resistant to erythromycin (28.6%), doxycycline (14.3%) and
clindamycin (14.3%) but not to tetracycline and minocycline.
Conclusion: Bacterial profile in moderate and severe acne vulgaris consisted of
Staphylococcus epidermidis 50.5%, Propionibacterium acnes 11.0%, and
Staphylococcus aureus 7.7%. Bacteria were commonly resistant to erythromycin, but
still completely sensitive to minocycline.
"
Fakultas Kedokteran Universitas Indonesia, 2016
SP-PDF
UI - Tugas Akhir  Universitas Indonesia Library
cover
Artini Wijayanti Islami
Korelasi kadar profil lipid darah dan kadar sebum kulit dengan derajat keparahan akne vulgaris pada pasien non-obesitas = Correlation between blood lipids sebum excretion levels and severity of acne vulgaris in non obese patients
"Latar belakang: Akne vulgaris AV adalah penyakit kulit yang ditandai dengan terjadinya sumbatan dan peradangan kronik pada unit pilosebasea. Penelitian sebelumnya tentang kadar lipid darah pada pasien AV menunjukkan hasil yang bervariasi. Lipid darah diduga memengaruhi aktivitas kelenjar sebasea.
Tujuan: Mengetahui korelasi antara kadar lipid darah dan kadar sebum dengan derajat keparahan AV, serta mengetahui korelasi kadar lipid darah dengan kadar sebum kulit wajah.
Metode: Studi potong lintang ini dilakukan terhadap 30 pasien AV non-obesitas, yang terbagi berdasarkan tiga derajat keparahan AV. Dilakukan pemeriksaan kolesterol total, trigliserida, LDL, HDL darah dan kadar sebum kulit wajah pada SP.
Hasil: Terdapat korelasi yang bermakna antara kadar sebum dengan derajat keparahan AV r = 0,6689, p = 0,0001 . Tidak terdapat korelasi antara kadar kolesterol total, trigliserida, LDL, HDL darah dengan derajat keparahan AV. Tidak terdapat korelasi antara sebum kulit wajah dengan kadar kolesterol total, trigliserida, LDL, HDL darah.
Kesimpulan: Hasil penelitian ini menunjukkan bahwa kadar lipid darah tidak memengaruhi keparahan AV dan kadar sebum, sedangkan peningkatan kadar sebum kulit wajah dapat meningkatkan keparahan AV.
......
Background: Acne vulgaris is a common chronic skin disease involving blockage and inflammation of pilosebaceous units. Previous studies about blood lipids in acne patients revealed variable results. Blood lipids were considered affecting sebum production.
Objective: To identify the correlation between blood lipids, sebum excretion rate and acne severity. This study also determines the correlation between blood lipids and sebum excretion rate.
Methods: This study was conducted at Dr. Cipto Mangunkusumo Hospital in Jakarta. This was a cross sectional study with total of 30 non obese AV patients. The patients were divided into 3 groups based on the severity of AV. Total cholesterol, triglycerides, LDL, HDL serum and sebum excretion rate were measured.
Results: The results revealed significant correlation between sebum excretion rate and severity of acne vulgaris r 0,6689, p 0,0001 . There were no correlation between total cholesterol, LDL, triglycerides, HDL and acne severity. Blood lipids had no correlation with sebum excretion rate.
Conclusion: The results of this study has proven that blood lipids does not affect the severity of acne and sebum excretion rate. While increased sebum secretion would increase acne severity."
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2017
SP-Pdf
UI - Tugas Akhir  Universitas Indonesia Library
cover
Eva Riani
Korelasi kadar homosistein plasma dengan derajat keparahan akne vulgaris pada pasien perempuan di RSUPN Dr. Cipto Mangunkusumo = Correlation between plasma homocysteine levels and the degree of acne vulgaris severity in female patients at Dr. Cipto Mangunkusumo National General Hospital
"Latar belakang: Akne vulgaris (AV) merupakan kelainan kulit akibat peradangan kronik folikel pilosebasea yang sering dijumpai pada remaja dan dewasa muda. Pada pasien perempuan didapatkan prevalensi AV yang lebih tinggi dan dampak psikososial yang lebih berat. Beberapa studi meneliti terdapat hubungan antara peningkatan kadar homosistein dengan derajat keparahan AV, namun peran homosistein dalam patogenesis AV masih belum jelas. Kadar homosistein ditentukan oleh multifaktor sehingga temuan di Indonesia dapat berbeda dibandingkan penelitian terdahulu. Secara fisiologis, kadar homosistein pada perempuan lebih rendah dari laki-laki.
Tujuan: Mendapatkan data kadar homosistein plasma pada pasien perempuan dengan AV ringan (AVR), AV sedang (AVS), dan AV berat (AVB) serta mengetahui korelasi kadar homosistein plasma dengan berbagai derajat keparahan AV.
Metode: Studi potong lintang dilakukan terhadap 46 subjek penelitian (SP), direkrut secara consecutive sampling, yang terdiagnosis AV berdasarkan kriteria Lehmann pada bulan April-Juni 2019. Setiap SP akan diambil darahnya untuk dilakukan pemeriksaan kadar homosistein plasma dengan metode chemiluminescent microparticle immuno assay (CMIA).
Hasil: Pada pasien perempuan dengan AV didapatkan rerata kadar homosistein plasma kelompok AVR, AVS, dan AVB yaitu 7,39 (1,84) μmol/L, 7,14 (1,73) μmol/L, dan 6,95 (1,14) μmol/L. Terdapat korelasi negatif lemah yang tidak bermakna antara kadar homosistein plasma dengan derajat keparahan AV (r=-0,0964, p=0,524).
Kesimpulan: Kadar homosistein plasma ditemukan lebih rendah pada kelompok AVS dan AVB. Dari hasil penelitian didapatkan bahwa semakin rendah kadar homosistein plasma, maka semakin berat derajat keparahan AV.
......Background: Acne vulgaris (AV) is a skin disorder caused by chronic inflammation of pilosebaceus that is primarily found in adolescents and young adults. In female patient, there is a higher prevalence of AV and more severe psychosocial impact. Several studies have investigated association between the levels of serum homocysteine and severity of AV, but the role of homocysteine in AV is not clearly understood. Homocysteine levels are thought to be affected by varying factors, so it is assumed that homocysteine levels in Indonesian people will yield a different results. Physiologically, female has a lower homocysteine levels.
Objective: This study aims to know the levels of homocysteine plasma in female patients suffering from mild, moderate, and severe AV, also its correlation with the degree of AV severity.
Methods: This cross-sectional study included 46 subjects, recruited by consecutive sampling, who have been diagnosed with AV based on Lehmann criteria on April-June
2019. Blood sample will be taken from each subject to measure homocycsteine plasma levels by using chemiluminescent microparticle immuno assay method (CMIA).
Results: In female patients, the mean plasma homocycteine levels of mild, moderate, and severe groups were respectively 7,39 (1,84) μmol/L, 7,14 (1,73) μmol/L, and 6,95 (1,14) μmol/L. There was no significant corelation between plasma homocysteine levels and the degree of acne severity (r=-0,0964, p=0,524).
Conclusion: Levels of plasma homocysteine was found lower on moderate and severe AV groups. The lower the levels of plasma homocysteine, the more severe the the degree of acne severity.
"
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2019
SP-pdf
UI - Tugas Akhir  Universitas Indonesia Library
cover
Christa Desire Gracia
Perbandingan kualitas hidup pasien akne vulgaris derajat sedang berdasarkan Acne-QoL-INA menggunakan terapi standar dengan dan tanpa ekstraksi lesi akne: Uji klinis acak terkontrol tersamar tunggal = A comparison of the quality of life of patients with moderate acne vulgaris based on Acne-QoL-INA using standard therapy with and without acne lesion extraction: Single-blind randomized controlled clinical trial
"Latar belakang: Akne vulgaris (AV) adalah penyakit unit pilosebasea kronis tersering yang dapat menimbulkan dampak psikologis berat dan mengganggu kualitas hidup penderitanya. Penggunaan terapi ajuvan yaitu ekstraksi lesi akne yang dikombinasikan dengan terapi standar dapat memperbaiki kondisi klinis dan kualitas hidup penderita akne. Pengukuran kualitas hidup penting dilakukan untuk menilai keberhasilan terapi. Saat ini telah tersedia kuesioner kualitas hidup spesifik akne berbahasa Indonesia (Acne-QoL- INA) yang tervalidasi, namun belum pernah ada data mengenai perbandingan kualitas hidup antara terapi kombinasi dan terapi standar.
Metode: Studi uji klinis acak terkontrol tersamar tunggal ini dilakukan pada subjek akne vulgaris dewasa derajat sedang berdasarkan kriteria Lehmann yang dibagi ke dalam kelompok terapi kombinasi standar dan ekstraksi lesi akne (terapi kombinasi) serta terapi standar tanpa ekstraksi lesi akne (terapi standar). Skor kualitas hidup berdasarkan kuesioner Acne-QoL-INA dinilai pada baseline, minggu ke-4, dan minggu ke-8 setelah terapi. Selain itu, penilaian jumlah lesi dan derajat keparahan akne diukur pada setiap kunjungan oleh seorang evaluator secara tersamar melalui foto klinis.
Hasil: Sebanyak 40 subjek dengan median usia 24 tahun (18–48), 17,5% laki-laki dan 82,5% perempuan berpartisipasi dalam penelitian ini. Skor Acne-QoL-INA baseline untuk kelompok kombinasi dan kelompok terapi standar masing-masing adalah 41 (37,5– 57) dan 45,5 (37–63), meningkat menjadi 79 (67,5–94,5) dan 72,5 (59,25–98,5) pada minggu ke-8 namun tidak berbeda bermakna secara statistik antar kedua kelompok (p=0,602). Jumlah lesi baseline pada kedua kelompok masing-masing 35 dan 32, menurun menjadi 18 dan 13 pada minggu ke-8 (p<0,0001) dan perbaikan derajat keparahan menjadi akne ringan pada 100% subjek di minggu ke-8.
Kesimpulan: Tidak ada perbedaan dalam skor Acne-QoL-INA dan perbaikan klinis antara kelompok terapi kombinasi dan terapi standar pada pasien AV sedang. Namun, terapi kombinasi cenderung meningkatkan kualitas hidup dan pengurangan lesi lebih baik daripada terapi standar.
......Background: Acne Vulagis (AV) is the most commom chronic disease of the pilosebaceous unit that can have a significant psychological impact and reduce the quality of life. The use of adjuvant therapy such as acne lesion extraction, in combination with standard therapy could better improve clinical outcomes and quality of life. Assessing quality of life is crucial to evaluate the success of therapy. Currently, there has been a validated acne-specific quality of life questionnaire in Indonesian (Acne-QoL-INA), but there is no existing data on the comparison of quality of life between combination therapy and standard therapy.
Method: This single-blinded randomized controlled study was conducted on adult subjects with moderate acne vulgaris based on Lehmann criteria, who were divided into combinations of standard therapy with acne lesion extraction (combination therapy) group, and standard therapy without acne lesion extraction (standard therapy) group. Quality of life score based on the Acne-QoL-INA questionnaire was assessed at the baseline, 4th, and 8th week after therapy. Additionally, the assessment of lesion number and acne grading is also measured at each visit by a blinded evaluator through clinical photos.
Results: A total of 40 subjects with a median age of 24 years old (18–48), comprising 17.5% males and 82.5% females, participated in this study. The baseline Acne-QoL-INA scores for the combination therapy and the standard therapy group were 41 (37.5–57) and 45.5 (37–63), respectively. These scores increased to 79 (67.5–94.5) and 72.5 (59.25– 98.5) at week 8 but did not show statistically significant differences between the two groups (p=0.602). The baseline lesion count in both groups was 35 and 32, respectively, and decreased to 18 and 13 at week 8 (p<0.0001), with an improvement in the severity to mild acne in 100% of subjects by week 8.
Conclusion: There was no difference in Acne-QoL-INA scores and clinical improvement between the combination therapy and standard therapy groups in moderate AV patients. However, combination therapy tended to improve the quality of life and lesion reduction better than standard therapy."
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2024
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Maria Clarissa Wiraputranto
Efektivitas terapi standar akne vulgaris berdasarkan panduan praktik klinis (PPK) di Indonesia = Effectiveness of standard therapy for acne vulgaris based on clinical practice guidelines in Indonesia
"Latar Belakang: Akne vulgaris (AV) adalah peradangan kronik pilosebasea yang umum terjadi pada semua usia, terutama remaja dan dewasa muda serta dapat memengaruhi psikologis pasien. Tata laksana AV merupakan sebuah tantangan karena keberagaman dalam menentukan diagnosis dan pilihan terapi antar negara. Indonesia mempunyai beberapa pedoman tatalaksana AV yang mempunyai similaritas antara lain konsensus IAEM 2015, PPK Perdoski dan PPK RSCM di tahun 2017.
Tujuan: Penelitian ini bertujuan untuk menganalisis efektivitas terapi standar AV berdasarkan panduan praktik klinis di Indonesia.
Metode: Penelitian merupakan studi observasional analitik secara retrospektif di Rumah Sakit Umum Pusat Nasional dr. Cipto Mangunkusumo menggunakan rekam medis tahun 2017-2019. Sampel penelitian merupakan rekam medis pasien AV baru yang diikuti selama 3 bulan dan dengan metode total sampling. Data subjek yang diambil termasuk karakteristik sosiodemografi, karakteristik klinis, diagnosis, terapi berdasarkan PPK RSCM 2017, dan hasil terapi. Studi dan analisis dilakukan pada bulan April 2023 hingga Juli 2023.
Hasil: Terdapat 131 SP yang memenuhi kriteria, 63,4% AV sedang, 20,6% AV ringan, dan 16% AV berat. Sebagian besar SP (92,4%) mempunyai AV dengan awitan sebelum usia 25 tahun. Median lama sakit AV yaitu 48 bulan. Riwayat terapi AV sebelumnya ditemukan pada 58% SP dan riwayat konsumsi obat akne pada 16% SP. Faktor risiko terbanyak berupa riwayat AV pada orang tua. Terapi utama paling banyak digunakan yaitu kombinasi retinoic acid, benzoyl peroxide, antibiotik topikal dan antibiotik oral pada 22,2% SP. Terapi standar AV secara bermakna menurunkan median jumlah lesi noninflamasi (25 vs. 8; p<0,001), median jumlah lesi inflamasi (10 vs. 2; p<001), median jumlah lesi total (41 vs. 10; p<0,001) setelah 3 bulan terapi, dengan median penurunan ketiga jumlah lesi lebih dari 50%. Proporsi derajat keparahan AV berbeda secara bermakna pada 3 bulan (p<0,001), dimana AV ringan meningkat (20,6% vs 93,1%) dan AV sedang atau berat menurun (sedang = 63,6% vs. 6,1%; berat = 16% vs. 0,8%).
Kesimpulan: Terapi standar AV berdasarkan PPK di Indonesia efektif dalam mengurangi jumlah lesi noninflamasi, lesi inflamasi, dan lesi total, dan menurunkan derajat keparahan AV.
......Background: Acne vulgaris is a prevalent chronic inflammation of the pilosebaceous unit affecting all ages, especially teenagers and young adults, and often leads to psychological impairment. Management of acne vulgaris has been challenging due to various diagnostic parameters and treatment options across nations. Several treatment guidelines are available in Indonesia, of which have similarities among one another, such as consensus by Indonesian Acne Expert Meeting in 2015 and clinical practice guidelines by the Indonesian Society of Dermatology and Venereology and by Dr. Cipto Mangunkusumo National Central General Hospital in 2017.
Objective: This study aims to investigate the effectiveness of standard therapy for acne based on the clinical practice guidelines in Indonesia
Methods: This is an analytical retrospective observational study using medical records from Dr. Cipto Mangunkusumo National Central General Hospital between 2017 – 2019. Research samples were medical records of new acne patients followed for 3 months by a total sampling technique. Extracted data included sociodemographic and clinical characteristics, diagnosis, and therapy based on the clinical practice guideline by Dr.Cipto Mangunkusumo National Central General Hospital in 2017 and the results. This study was conducted from April 2023 to July 2023.
Results: There were 131 subjects included, of which 63,4% were with moderate acne, 20,6% with mild acne, and 16% with severe acne. Most participants (92,4%) experienced acne for the first time before 25 years old. The median duration from the first occurrence of acne to the visit was 48 months. History of topical and oral acne therapy was found in 58% and 16% of participants, respectively. History of acne in parents was the most reported risk factor. Most subjects (22,2%) received a combination of retinoic acid, benzoyl peroxide, topical antibiotic, and oral antibiotic. Standard therapies significantly reduced the median of non-inflammatory lesions (25 vs. 8; p<0,001), inflammatory lesions (10 vs. 2; p<001), and total lesions (41 vs. 10; p<0,001) after a 3 month-therapy, with the median of reduction for all type of lesions over 50%. The proportion of acne severity differed significantly after three months (p<0,001), with an increasing proportion of mild acne (20,6% vs 93,1%) and decreasing percentage of moderate and severe acne (moderate = 63,6% vs. 6,1%; severe = 16% vs. 0,8%).
Conclusion: Standard therapy for acne vulgaris in clinical practice guidelines in Indonesia is effective for noninflammatory lesions, inflammatory lesions, and total lesions, as well as acne severity after 12 weeks."
2023
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