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"Pada tahap pengerasannya, material bioaktif akan mengalami mekanisme hidrasi dengan melepaskan beberapa ion yang dikandungnya. Reaksi pada permukaan material ini dapat melepaskan dan merubah konsentrasi dari ion-ion terlarut yang akan memicu terjadinya respon intraseluler dan ekstraseluler dan akan mengkonduksi terjadinya pembentukan jaringan keras. Ion kalsium (Ca2+) yang dilepas material bioaktif berperan dalam fungsinya sebagai peningkat pH, bakterisid, menekan aktivitas osteoklas, serta merangsang pembentukan fibroblas.Tujuan dari penelitian ini adalah untuk menganalisis pelepasan ion Ca2+ dari material bioaktif MTA-Angelus® dan Biodentine®. Sebanyak 46 sampel dipersiapkan dengan ukuran Ø 2 mm dan tinggi 2 mm, terdiri dari 23 sampel kelompok MTA Angelus®, dan 23 sampel kelompok Biodentine® direndam dalam air deionisasi selama 1 jam dan 48 jam. Larutan perendam kemudian diukur kadar pelepasan ion Ca2+-nya menggunakan alat atom absorption sphectropometer, kemudian hasilnya diuji statistik menggunakan uji Kruskal Wallis. Hasil uji statistik post hoc Mann Whitney menunjukkan adanya perbedaan yang bermakna diantara semua kelompok dengan nilai signifikansi p≤0,05. Biodentine® terbukti melepaskan ion Ca2+ lebih banyak dibandingkan dengan MTA Angelus® pada waktu pengukuran 1 jam dan 48 jam.MTA Angelus® melepaskan ion Ca2+ lebih cepat jika dibandingkan dengan Biodentine®.

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On the setting stage, the bioactive materials will experience hydration mechanism by releasing a number of their ions. The reaction on the surface of these materials can release and alter dissolved ions concentration which will trigger an intracellular and extracellular responses. This process will also conduct remineralization. The released Ca2+ ions will increase alkalinizing activity, antibacterial, suppressing osteoclast activity as well as stimulating fibroblast formation. The aim of this study is to analyze Ca2+ ion release from MTA Angelus® dan Biodentine® as a bioactive material. As many as 46 samples are prepare with the size of 2 mm in diameters and 2 mm in height. The samples consist of 23 of MTA Angelus® samples, and 23 of Biodentine® samples. Both materials were soaked in deionized water for an hour which will then be measured. Both materials will then be transferred into fresh solution and will be soaked for 48 hours before they would be measured for the second time. The measurements will be conducted by using atom absorption sphectropometer. The result will later be statistically tested using a Kruskal Wallis test. Mann Whitney post hoc’s statistic test result showed a significant discrepancy among all groups, whit the significant value of p≤0,05. . Biodentine® was proven to release more Ca2+ ions compared to MTA Angelus® during the 1 and 48-hour measurments. MTA Angelus® released Ca2+ ion faster than Biodentine® does."

"ABSTRAK Latar Belakang: MTA bersifat biokompatibel dan dapat digunakan untuk perawatan kaping pulpa. Saat ini dikembangkan semen berbasis kalsium silikat sama seperti MTA dengan penambahan steroid, yaitu Odontocem. Tujuan:Membandingkan efek toksisitas odontocem dan MTA-Angelus terhadap viabilitas sel fibroblas. Metode:Sel fibroblast embrio ayam direndam dalam larutan odontocemdan dan MTA-Angeluspada 24 dan 72 jam. Viabilitas sel dihitung menggunakanMTT Assay. Hasil:Pada kelompok odontcemdan MTA-Angelus, terdapat perbedaan bermakna (p≤0,05 ) dibandingkan dengan kontrol. Pada paparan 24 jam, tidak terdapat perbedaan bermakna antara odontocem dengan MTA-Angelus. Kesimpulan:Odontocem dan dan MTA-Angelus menurunkan viabilitas sel pada 24 jam dan meningkatkan pada 72 jam.ABSTRACT Background:MTA is proved tobe biocompatible and can be used for pulp capping treatment.Currently, calcium silicate based cement similar to MTA with steroid,called Odontocem has been developed.Objective:To compare effects of odontocem and MTA-Angelus toxicity towards fibroblast cells viability.Method:Fibroblast cells of chicken embryonic were immersed separately in odontocem and MTA-Angelus solution for 24 and 72 hours.Cells viability was analyzed with MTT Assay.Result:There was a significant difference (p>0.05) in Odontocem and MTA-Angelus group compared to control.At the24-hour immersion, there was nosignificant difference between odontocem and MTA-Angelus.Conclusion:Odontocem and MTA-Angelus decreased the viability of fibroblast at 24 hours and increased them at 72 hours.;Background:MTA is proved tobe biocompatible and can be used for pulp capping treatment.Currently, calcium silicate based cement similar to MTA with steroid,called Odontocem has been developed.Objective:To compare effects of odontocem and MTA-Angelus toxicity towards fibroblast cells viability.Method:Fibroblast cells of chicken embryonic were immersed separately in odontocem and MTA-Angelus solution for 24 and 72 hours.Cells viability was analyzed with MTT Assay.Result:There was a significant difference (p>0.05) in Odontocem and MTA-Angelus group compared to control.At the24-hour immersion, there was nosignificant difference between odontocem and MTA-Angelus.Conclusion:Odontocem and MTA-Angelus decreased the viability of fibroblast at 24 hours and increased them at 72 hours.;Background:MTA is proved tobe biocompatible and can be used for pulp capping treatment.Currently, calcium silicate based cement similar to MTA with steroid,called Odontocem has been developed.Objective:To compare effects of odontocem and MTA-Angelus toxicity towards fibroblast cells viability.Method:Fibroblast cells of chicken embryonic were immersed separately in odontocem and MTA-Angelus solution for 24 and 72 hours.Cells viability was analyzed with MTT Assay.Result:There was a significant difference (p>0.05) in Odontocem and MTA-Angelus group compared to control.At the24-hour immersion, there was nosignificant difference between odontocem and MTA-Angelus.Conclusion:Odontocem and MTA-Angelus decreased the viability of fibroblast at 24 hours and increased them at 72 hours.;Background:MTA is proved tobe biocompatible and can be used for pulp capping treatment.Currently, calcium silicate based cement similar to MTA with steroid,called Odontocem has been developed.Objective:To compare effects of odontocem and MTA-Angelus toxicity towards fibroblast cells viability.Method:Fibroblast cells of chicken embryonic were immersed separately in odontocem and MTA-Angelus solution for 24 and 72 hours.Cells viability was analyzed with MTT Assay.Result:There was a significant difference (p>0.05) in Odontocem and MTA-Angelus group compared to control.At the24-hour immersion, there was nosignificant difference between odontocem and MTA-Angelus.Conclusion:Odontocem and MTA-Angelus decreased the viability of fibroblast at 24 hours and increased them at 72 hours."