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Cut Natya Rucitra Jacoeb
Proporsi virus papiloma humanus oral dan hubungannya dengan frekuensi seks oral pada pasien kondiloma akuminatum anogenital = Proportion of oral human papiloma virus and it s relation to oral sex frequency in patient with anogenital condyloma acuminata
"Latar belakang: Virus papilloma humanus (VPH) merupakan penyebab infeksi menular seksual yang sering ditemukan. VPH tipe mukosa terutama menyerang genitalia dan oral. Infeksi VPH oral saat ini dihubungkan dengan keganasan orofaring yang insidensnya makin meningkat. Prevalensi VPH oral pada populasi sehat berkisar 2-7%, sedangkan pada populasi pasien kondiloma akuminatum (KA) anogenaital sebesar 10,4%. Faktor risiko penularan ke rongga mulut terutama melalui hubungan seksual, frekuensi seks oral lebih bermakna dibandingkan dengan jumlah pasangan seks oral.
Tujuan: Mencari proporsi VPH oral pada pasien KA anogenital dan hubungannya dengan frekuensi seks oral.
Metode : Penelitian potong lintang, subyek penelitian (SP) adalah laki-laki atau perempuan dengan KA anogenital, berusia 18-60 tahun. Tempat penelitian di poliklinik RSUPN Dr. Cipto Mangunkusumo dan Klinik PKBI Jakarta. Bahan pemeriksaan VPH oral berasal dari bilas mulut, lalu diolah menggunakan express matrix VPH di Laboratorium Kalgen.
Hasil: Hasil VPH oral positif ditemukan pada 7 dari 75 SP. Uji statistik untuk melihat perbedaan VPH oral positif di antara kelompok frekuensi seks oral menggunakan Uji Kolmogorov-Smirnov dengan hasil P>0.05.
Kesimpulan: Proporsi VPH oral pada pasien KA anogenital sebesar 9,3%, dan tidak terdapat perbedaan proporsi VPH oral di antara kelompok SP berdasarkan frekuensi seks oral.
Mucosal types of HPV mainly infect anogenital and oral mucosa. Nowdays, oral cancer is strongly related to HPV infection and the incidence is increasing. Oral HPV prevalence in healthy population is 2-7%, meanwhile the prevalence in anogenital condyloma acuminata (CA) patients is 10,4%. The risk factors of oral HPV infection are mostly related to sexual behaviour, oral sex frequency is more related than total sex partner.
Objective : To know the oral HPV proportion in anogenital CA patients and it?s relation to oral sex frequency.
Methods: This is a cross sectional study. The subjects are anogenital CA patients, age 18-60 y.o, from outpatients clinic RSUPN Dr. Cipto Mangunkusumo and PKBI clinic, Jakarta. The sample was taken from mouth rinse, the HPV detection was done by using HPV express matrix at Kalgen laboratory.
Results : Oral HPV positif was found in 7 out of 75 subjects. We use Kolmogorof-Smirnov as statistical calculation to know the difference of oral HPV positive between oral sex frequency groups, the result is p>0,05.
Conclusions : Oral HPV proportion in anogenital CA patients is 9,3%, and there is no statistically difference beetwen oral sex frequency groups."
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2014
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UI - Tugas Akhir  Universitas Indonesia Library
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Ridha Rosandi
Korelasi kadar D-dimer dengan derajat keparahan dan lama sakit pasien urtikaria kronis = Correlation of D-dimer levels with severity and disease duration of chronic urticaria patients
"[Latar belakang : Terdapat beberapa studi yang menunjukkan keterlibatan jalur pembekuan darah dalam patogenesis urtikaria kronis. D-dimer yang merupakan produk akhir jalur pembekuan darah secara tidak langsung dapat digunakan untuk menilai trombin di darah. Trombin dapat menimbulkan edema karena dapat meningkatkan permeabilitas kapiler, dapat menstimulasi degranulasi sel mast, dan mengaktifkan komplemen C5a. Tujuan : Mengetahui rerata kadar D-dimer pada pasien urtikaria kronis serta korelasi antara kadar D-dimer dengan derajat keparahan penyakit dan lama sakit pasien urtikaria kronis. Metode : penelitian ini merupakan penelitian potong lintang, dengan subyek penelitian sebanyak 30 pasien. Dilakukan penilaian Urticaria Activity Score dan lama sakit serta pemeriksaan kadar D-dimer. Hasil: Nilai tengah kadar D-dimer pada 30 SP adalah 100 μg/L. Pada penelitian ini terdapat 5 SP (16,67%) yang terdapat peningkatan kadar D-dimer. Terdapat korelasi positif kuat antara kadar D-dimer dengan derajat keparahan urtikaria kronis (r = 0,8; p = 0,0000). Terdapat korelasi positif lemah antara kadar D-dimer dengan lama sakit pasien urtikaria kronis (r = 0,05; p = 0,979). Kesimpulan: Terdapat korelasi positif kuat antara kadar D-dimer dengan derajat keparahan urtikaria kronis dan korelasi positif lemah antara kadar D-dimer dengan lama sakit pasien urtikaria kronis., Background : There are some studies that show blood clotting pathways involved in the pathogenesis of chronic urticaria. D - dimer is a blood clotting pathway end products can indirectly be used to assess thrombin in the blood. Thrombin can induce edema because it can increase capillary permeability , can stimulate mast cell degranulation , and activating the complement C5a. Objective : Knowing the average levels of D - dimer in chronic urticaria patients and the correlation between D - dimer levels with severity and disease duration. Methods : This study is a cross sectional study , the study subjects were 30 chronic urticaria patients. Assessment urticaria activity score ,disease duration and D – dimer level on all patients. Results : Median of the D - dimer levels in 30 patients is 100 ug / L. In this study there were 5 patients ( 16.67 % ) with elevated levels of D - dimer. There is a strong positive correlation between D- dimer levels with severity of chronic urticaria ( r = 0.8 ; p = 0.0000 ). There is a weak positive correlation between D - dimer levels with disease duration ( r = 0.05 ; p = 0.979) . Conclusions : There is a strong positive correlation between D - dimer levels with disease severity and weak positive correlation between D - dimer levels with disease duration of chronic urticaria.]"
Fakultas Kedokteran Universitas Indonesia, 2014
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UI - Tugas Akhir  Universitas Indonesia Library
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Dwi Indria Anggraini
Perbandingan efek krim pelembap yang mengandung urea 10% dengan lanolin 10% dalam petrolatum terhadap hidrasi kulit pada pasien lanjut usia dengan kulit kering = Comparison between moisturizing cream containing 10% urea and 10% lanolin in petrolatum in skin hydration improvement among elderly
"ABSTRAK
Latar belakang dan tujuan: Prevalensi xerosis pada lanjut usia (lansia) berkisar antara
30-85%. Tatalaksana xerosis yang tidak adekuat dapat menimbulkan komplikasi. Urea
sebagai humektan dan lanolin 10% dalam petrolatum yang bersifat oklusif dan emolien
mampu memperbaiki hidrasi kulit. Penelitian ini bertujuan membandingkan efektivitas
dan efek samping krim yang mengandung urea 10% dengan lanolin 10%/petrolatum
pada pengobatan xerosis lansia.
Metode: Penelitian uji klinis acak tersamar ganda dilakukan pada 35 orang penghuni
suatu panti lansia di Jakarta. Evaluasi skin capacitance (SC), specified symptoms sum
score (SSRC), dan derajat gatal dilakukan pada awal terapi, minggu kedua dan keempat.
Setelah prakondisi selama dua minggu, setiap subjek penelitian mendapatkan pelembap
yang berbeda secara acak pada kedua tungkai bawah.
Hasil: Persentase peningkatan nilai SC setelah empat minggu lebih besar pada tungkai
yang mendapat krim urea 10% dibandingkan lanolin 10%/petrolatum (64,54% vs.
58,98%; p=0,036). Persentase penurunan SSRC setelah empat minggu tidak berbeda
antara kedua kelompok perlakuan (100%; p=0,089). Derajat gatal pada minggu kedua
menurun pada kedua kelompok, hingga menjadi tidak gatal pada seluruh SP (100%)
setelah minggu keempat. Efek samping rasa lengket lebih banyak ditemukan pada
kelompok krim urea 10% daripada lanolin10%/petrolatum, tetapi tidak bermakna secara
statistik.
Kesimpulan: Pelembap yang mengandung urea 10% meningkatkan SC lebih besar
secara bermakna daripada lanolin 10%/petrolatum setelah empat minggu pengolesan
pada tungkai lansia yang xerotik. Efek samping tersering adalah rasa lengket yang lebih
sering ditemukan pada lanolin 10%/petrolatum, tetapi tidak berbeda antar kelompok perlakuan.ABSTRACT Background and objectives: The prevalence of xerosis among elderly is 30-85%.
Inadequate treatment may result in complications. Urea as a humectant and 10% lanolin
in petrolatum as an occlusive agent and emollient can restore skin hydration. This study
aimed at comparing the efficacy and side effects of cream containing 10% urea and 10%
lanolin/petrolatum in the treatment of xerosis in elderly
Methods: A randomized, double blind clinical trial was conducted in 35 elderly from a
nursing home in Jakarta. Evaluation of skin capacitance (SC), specified symptoms sum
score (SSRC), and pruritic degree were measured at baseline, week-2 and -4 after the
start of therapy. Following a 2-week precondition period, each subject received a
random moisturizer for each limb, to be applied twice daily.
Results: The percentage of SC increase at week-4 was significantly higher in limb
receiving cream containing 10% urea than 10% lanolin/petrolatum (64.54% vs. 58.98%;
p=0.036). The percentage of SSRC decrease at week-4 did not differ between groups
(100%; p=0.089). Pruritus was equally improved in both groups at week-2, and
completely diminished at week-4. Sticky feel was more frequent in
lanolin10%/petrolatum than 10% urea cream, although not statistically significant.
Conclusion: After four-week application, moisturizer containing 10% urea gave higher
percentage of SC increase than 10% lanolin/petrolatum in the xerotic limbs of the
elderly. Sticky feeling was more frequently found in 10% lanolin/petrolatum group, but statistically not significant."
Fakultas Kedokteran Universitas Indonesia, 2016
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UI - Tugas Akhir  Universitas Indonesia Library
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Jonathan Raharjo Subekti
Proporsi kepositivan dan genotipe human papillomavirus pada suami pasien kanker serviks serta kesamaan genotipe di antara pasangan di RSUPN Dr. Cipto Mangunkusumo = The positivity proportion and genotype of human papillomavirus in cervical cancer patient's spouse and the genotype concordance between the couples at Dr. Cipto Mangunkusumo Hospital
"ABSTRAK
Latar belakang. Infeksi human papillomavirus (HPV) pada genital laki-laki selain dapat
menyebabkan kutil kelamin dan kanker penis juga meningkatkan risiko infeksi HPV pada
pasangan. Walaupun saat ini telah terdapat banyak penelitian mengenai peran HPV risiko
tinggi terhadap karsinogenesis serviks dan semakin jelas peran laki-laki sebagai vektor virus
HPV, namun pemeriksaan HPV pada laki-laki belum rutin dilakukan. Penelitian ini bertujuan
mengetahui proporsi kepositivan, variasi genotipe HPV pada suami pasien kanker serviks
serta kesamaan genotipe HPV antara suami pasien kanker serviks yang HPV positif dengan
pasien kanker serviks di RSUPN Dr Cipto Mangunkusumo. Metode. Penelitian potong
lintang. Pemilihan SP dilakukan secara berurutan (consecutive sampling). Sampel diambil
dengan menggunakan kertas amplas dan dacron swab. Pada spesimen dilakukan pemeriksaan
menggunakan HPV express matrix Kalgen®. Hasil. Sebanyak 47 SP dilibatkan dalam
penelitian ini, dengan rerata usia 50,7+10,6 tahun. Dari analisis spesimen diidentifikasi HPV
genital pada 9 (19%) SP, terdiri atas genotipe risiko rendah (3 SP) dan risiko tinggi (6 SP).
Genotipe HPV yang ditemukan adalah 6, 18, 31, 39, 43, 53, dan 56, dengan tipe tersering
adalah 18 dan 43. Tidak didapatkan kesamaan tipe HPV di antara pasangan HPV yang
positif. Kesimpulan. Proporsi kepositivan HPV pada suami pasien kanker serviks sebesar
19% dengan tipe 18 dan 43 paling banyak didapatkan, namun tidak didapatkan kesamaan tipe
HPV antara SP dengan pasien kanker serviks pasangannya.ABSTRACT
Background. Human papillomavirus (HPV) infection on male genital could cause genital
warts, penile cancer, but also increase the risk of HPV infection in their spouse. Despite
many current researches on role of high-risk HPV in cervix carcinogenesis and male partner?s
role as HPV vector is well known, HPV examination on male is not yet routinely performed.
The aim of this study is to find the positivity proportion and genotype variant of HPV on
cervical cancer patient?s spouse, and also the genotype concordance between the spouse with
HPV positive and the cervical cancer patient at dr Cipto Mangunkusumo hospital. Method.
Cross-sectional design. Subject was chosen consecutively (consecutive sampling). Sample
was collected with emery paper and dacron swab. The specimen was then analyzed with HPV
express matrix Kalgen®. Result. Fourty seven subject enrolled in this studi with mean age
50,7+10,6 y.o. Specimen analysis identified genital HPV on 9 (19%) subject, with low risk (3
subject) and high risk (6 subject) genotype. HPV genotypes found in this study are 6, 18, 31,
39, 43, 53, dan 56, with 18 and 43 as the most frequent. No genotype concordance found
between the cervical cancer patient?s spouse with HPV positive and their partners. HPV
genotypes variation found on cervical cancer?s spouses are type 6, 18, 31, 39, 43, 53, dan 56.
Conclusion. The positivity proportion of HPV on cervical cancer patient?s spouse was 19%,
with genotype 18 and 43 as the most frequent with no HPV genotype concordance found between subjects and the spouse.;Background. Human papillomavirus (HPV) infection on male genital could cause genital
warts, penile cancer, but also increase the risk of HPV infection in their spouse. Despite
many current researches on role of high-risk HPV in cervix carcinogenesis and male partner?s
role as HPV vector is well known, HPV examination on male is not yet routinely performed.
The aim of this study is to find the positivity proportion and genotype variant of HPV on
cervical cancer patient?s spouse, and also the genotype concordance between the spouse with
HPV positive and the cervical cancer patient at dr Cipto Mangunkusumo hospital. Method.
Cross-sectional design. Subject was chosen consecutively (consecutive sampling). Sample
was collected with emery paper and dacron swab. The specimen was then analyzed with HPV
express matrix Kalgen®. Result. Fourty seven subject enrolled in this studi with mean age
50,7+10,6 y.o. Specimen analysis identified genital HPV on 9 (19%) subject, with low risk (3
subject) and high risk (6 subject) genotype. HPV genotypes found in this study are 6, 18, 31,
39, 43, 53, dan 56, with 18 and 43 as the most frequent. No genotype concordance found
between the cervical cancer patient?s spouse with HPV positive and their partners. HPV
genotypes variation found on cervical cancer?s spouses are type 6, 18, 31, 39, 43, 53, dan 56.
Conclusion. The positivity proportion of HPV on cervical cancer patient?s spouse was 19%,
with genotype 18 and 43 as the most frequent with no HPV genotype concordance found between subjects and the spouse.;Background. Human papillomavirus (HPV) infection on male genital could cause genital
warts, penile cancer, but also increase the risk of HPV infection in their spouse. Despite
many current researches on role of high-risk HPV in cervix carcinogenesis and male partner?s
role as HPV vector is well known, HPV examination on male is not yet routinely performed.
The aim of this study is to find the positivity proportion and genotype variant of HPV on
cervical cancer patient?s spouse, and also the genotype concordance between the spouse with
HPV positive and the cervical cancer patient at dr Cipto Mangunkusumo hospital. Method.
Cross-sectional design. Subject was chosen consecutively (consecutive sampling). Sample
was collected with emery paper and dacron swab. The specimen was then analyzed with HPV
express matrix Kalgen®. Result. Fourty seven subject enrolled in this studi with mean age
50,7+10,6 y.o. Specimen analysis identified genital HPV on 9 (19%) subject, with low risk (3
subject) and high risk (6 subject) genotype. HPV genotypes found in this study are 6, 18, 31,
39, 43, 53, dan 56, with 18 and 43 as the most frequent. No genotype concordance found
between the cervical cancer patient?s spouse with HPV positive and their partners. HPV
genotypes variation found on cervical cancer?s spouses are type 6, 18, 31, 39, 43, 53, dan 56.
Conclusion. The positivity proportion of HPV on cervical cancer patient?s spouse was 19%,
with genotype 18 and 43 as the most frequent with no HPV genotype concordance found between subjects and the spouse."
Fakultas Kedokteran Universitas Indonesia, 2016
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UI - Tugas Akhir  Universitas Indonesia Library
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Hafiza Fathan
Pola resistensi bakteri terhadap antibiotik pada akne vulgaris sedang dan berat di Departemen Ilmu Kesehatan Kulit dan Kelamin RS Dr. Cipto Mangunkusumo = Antibiotic resistance of bacteria isolated from moderate and severe acne vulgaris patients visiting dermatology and venereology outpatient clinics Dr. Cipto Mangunkusumo Hospital, Jakarta
"ABSTRAK
Latar belakang dan tujuan. Penggunaan antibiotik pada akne vulgaris (AV) saat ini
dihadapi permasalahan resistensi Propionibacterium acnes (PA) dan bakteri lain
yang berperan pada AV. Data pola resistensi AVS dan AVB di RS Cipto
Mangunkusumo (RSCM) tahun 2006 menunjukkan adanya resistensi PA terhadap
eritromisin (63,2%), klindamisin (57,9%), dan tetrasiklin (47,4%). Tidak ditemukan
PA yang resisten terhadap doksisiklin maupun minosiklin. Penggunaan antibiotik
pada AV dapat menyebabkan perubahan pola resistensi sehingga penelitian ini
bertujuan memberikan data terbaru mengenai pola bakteri dan resistensinya terhadap
antibiotik lini pertama pada AVS dan AVB di Departemen Ilmu Kesehatan Kulit dan
Kelamin RSCM, yaitu tetrasiklin, doksisiklin, minosiklin, klindamisin dan
eritromisin.
Metode. Penelitian ini merupakan penelitian deskriptif dengan desain potong lintang.
Spesimen untuk kultur dan uji resistensi didapatkan dari ekstraksi komedo tertutup
yang selanjutnya dibiakkan secara aerob dan anaerob. Pemeriksaan uji resistensi
dilakukan secara kuantitatif dengan menggunakan MIC strip test.
Hasil. Dari 91 subjek, bakteri yang ditemukan terdiri atas PA 11,0%, Staphylococcus
epidermidis (SE) 50,5%, Staphylococcus aureus (SA) 7,7% dan bakteri lain sebesar
40,7% (aerob) dan 19,8% (anaerob). Sebagian kecil PA (10%) resisten terhadap
tetrasiklin, klindamisin, dan eritromisin. Tidak ditemukan PA yang resisten terhadap
doksisiklin dan minosiklin. Bakteri SE resisten terhadap eritromisin (65,2%),
klindamisin (52,2%), tetrasiklin (32,6%), dan doksisiklin (4,3%). Tidak ditemukan
SE yang resisten terhadap minosiklin. Sebagian kecil SA resisten terhadap
eritromisin (28,6%), doksisiklin (14,3%) dan klindamisin (14,3%). Tidak ditemukan
SA yang resisten terhadap tetrasiklin dan minosiklin.
Kesimpulan. Bakteri yang ditemukan pada pasien AVS dan AVB antara lain,
Staphylococcus epidermidis 50.5%, Propionibacterium acnes 11.0%, dan
Staphylococcus aureus 7.7%. Bakteri paling banyak ditemukan resisten terhadap
eritromisin dan ketiga bakteri tersebut seluruhnya masih sensitif terhadap minosiklin. ABSTRACT
Background and objective: The resistance of Propionibacterium acnes (PA) and
other bacteria that implicated in acne vulgaris (AV), has been a problem in AV
therapy. The latest data in the Department of Dermatology and Venereology, Cipto
Mangunkusumo Hospital, Jakarta (2006) showed resistance to erythromycin
(63.2%), clindamycin (57.9%) and tetracycline (47.4%), and no resistance to
doxycycline and minocycline. The use of antibiotics may cause changes in
susceptibility. This study aimed to provide the latest bacterial profile and resistance
pattern to first-line antibiotics used in moderate and severe AV: tetracycline,
doxycycline, minocycline, clindamycin and erythromycin.
Methods: This is a descriptive, cross-sectional study. Specimens were extracted
from closed comedones and cultured in media for aerobic and anaerobic bacteria.
Antibiotic resistance was measured quantitatively using MIC strip test.
Results: Bacteria were isolated from 91 subjects and consisted of Staphylococcus
epidermidis (SE)(50.5%), PA (11.0%), Staphylococcus aureus (SA)(7.7%) and other
bacteria [aerobic (40.7%) and anaerobic (19.8%)]. A small number of PA (10%) was
resistant to tetracycline, clindamycin, and erythromycin but not to doxycycline and
minocycline. SE was resistant to erythromycin (65.2%), clindamycin (52.2%),
tetracycline (32.6%), and doxycycline (4.3%) but not to minocycline. A small
number of SA was resistant to erythromycin (28.6%), doxycycline (14.3%) and
clindamycin (14.3%) but not to tetracycline and minocycline.
Conclusion: Bacterial profile in moderate and severe acne vulgaris consisted of
Staphylococcus epidermidis 50.5%, Propionibacterium acnes 11.0%, and
Staphylococcus aureus 7.7%. Bacteria were commonly resistant to erythromycin, but
still completely sensitive to minocycline.
;Background and objective: The resistance of Propionibacterium acnes (PA) and
other bacteria that implicated in acne vulgaris (AV), has been a problem in AV
therapy. The latest data in the Department of Dermatology and Venereology, Cipto
Mangunkusumo Hospital, Jakarta (2006) showed resistance to erythromycin
(63.2%), clindamycin (57.9%) and tetracycline (47.4%), and no resistance to
doxycycline and minocycline. The use of antibiotics may cause changes in
susceptibility. This study aimed to provide the latest bacterial profile and resistance
pattern to first-line antibiotics used in moderate and severe AV: tetracycline,
doxycycline, minocycline, clindamycin and erythromycin.
Methods: This is a descriptive, cross-sectional study. Specimens were extracted
from closed comedones and cultured in media for aerobic and anaerobic bacteria.
Antibiotic resistance was measured quantitatively using MIC strip test.
Results: Bacteria were isolated from 91 subjects and consisted of Staphylococcus
epidermidis (SE)(50.5%), PA (11.0%), Staphylococcus aureus (SA)(7.7%) and other
bacteria [aerobic (40.7%) and anaerobic (19.8%)]. A small number of PA (10%) was
resistant to tetracycline, clindamycin, and erythromycin but not to doxycycline and
minocycline. SE was resistant to erythromycin (65.2%), clindamycin (52.2%),
tetracycline (32.6%), and doxycycline (4.3%) but not to minocycline. A small
number of SA was resistant to erythromycin (28.6%), doxycycline (14.3%) and
clindamycin (14.3%) but not to tetracycline and minocycline.
Conclusion: Bacterial profile in moderate and severe acne vulgaris consisted of
Staphylococcus epidermidis 50.5%, Propionibacterium acnes 11.0%, and
Staphylococcus aureus 7.7%. Bacteria were commonly resistant to erythromycin, but
still completely sensitive to minocycline.
;Background and objective: The resistance of Propionibacterium acnes (PA) and
other bacteria that implicated in acne vulgaris (AV), has been a problem in AV
therapy. The latest data in the Department of Dermatology and Venereology, Cipto
Mangunkusumo Hospital, Jakarta (2006) showed resistance to erythromycin
(63.2%), clindamycin (57.9%) and tetracycline (47.4%), and no resistance to
doxycycline and minocycline. The use of antibiotics may cause changes in
susceptibility. This study aimed to provide the latest bacterial profile and resistance
pattern to first-line antibiotics used in moderate and severe AV: tetracycline,
doxycycline, minocycline, clindamycin and erythromycin.
Methods: This is a descriptive, cross-sectional study. Specimens were extracted
from closed comedones and cultured in media for aerobic and anaerobic bacteria.
Antibiotic resistance was measured quantitatively using MIC strip test.
Results: Bacteria were isolated from 91 subjects and consisted of Staphylococcus
epidermidis (SE)(50.5%), PA (11.0%), Staphylococcus aureus (SA)(7.7%) and other
bacteria [aerobic (40.7%) and anaerobic (19.8%)]. A small number of PA (10%) was
resistant to tetracycline, clindamycin, and erythromycin but not to doxycycline and
minocycline. SE was resistant to erythromycin (65.2%), clindamycin (52.2%),
tetracycline (32.6%), and doxycycline (4.3%) but not to minocycline. A small
number of SA was resistant to erythromycin (28.6%), doxycycline (14.3%) and
clindamycin (14.3%) but not to tetracycline and minocycline.
Conclusion: Bacterial profile in moderate and severe acne vulgaris consisted of
Staphylococcus epidermidis 50.5%, Propionibacterium acnes 11.0%, and
Staphylococcus aureus 7.7%. Bacteria were commonly resistant to erythromycin, but
still completely sensitive to minocycline.
;Background and objective: The resistance of Propionibacterium acnes (PA) and
other bacteria that implicated in acne vulgaris (AV), has been a problem in AV
therapy. The latest data in the Department of Dermatology and Venereology, Cipto
Mangunkusumo Hospital, Jakarta (2006) showed resistance to erythromycin
(63.2%), clindamycin (57.9%) and tetracycline (47.4%), and no resistance to
doxycycline and minocycline. The use of antibiotics may cause changes in
susceptibility. This study aimed to provide the latest bacterial profile and resistance
pattern to first-line antibiotics used in moderate and severe AV: tetracycline,
doxycycline, minocycline, clindamycin and erythromycin.
Methods: This is a descriptive, cross-sectional study. Specimens were extracted
from closed comedones and cultured in media for aerobic and anaerobic bacteria.
Antibiotic resistance was measured quantitatively using MIC strip test.
Results: Bacteria were isolated from 91 subjects and consisted of Staphylococcus
epidermidis (SE)(50.5%), PA (11.0%), Staphylococcus aureus (SA)(7.7%) and other
bacteria [aerobic (40.7%) and anaerobic (19.8%)]. A small number of PA (10%) was
resistant to tetracycline, clindamycin, and erythromycin but not to doxycycline and
minocycline. SE was resistant to erythromycin (65.2%), clindamycin (52.2%),
tetracycline (32.6%), and doxycycline (4.3%) but not to minocycline. A small
number of SA was resistant to erythromycin (28.6%), doxycycline (14.3%) and
clindamycin (14.3%) but not to tetracycline and minocycline.
Conclusion: Bacterial profile in moderate and severe acne vulgaris consisted of
Staphylococcus epidermidis 50.5%, Propionibacterium acnes 11.0%, and
Staphylococcus aureus 7.7%. Bacteria were commonly resistant to erythromycin, but
still completely sensitive to minocycline.
"
Fakultas Kedokteran Universitas Indonesia, 2016
SP-PDF
UI - Tugas Akhir  Universitas Indonesia Library