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"ABSTRAK Prevalensi obesitas meningkat di seluruh dunia termasuk Indonesia. Obesitas merupakan faktor risiko dari berbagai penyakit yang dapatmenyebabkan turunnya performa dan produktifitas pekerja. Salah satu faktor yangdihubungkan sebagai faktor risiko obesitas adalah kerja gilir. Kerja gilir lazimdigunakan oleh pekerja dibidang pelayanan kesehatan seperti perawat. Penelitianini bertujuan untuk menilai pengaruh kerja gilir terhadap risiko berat badan berlebihdan obesitas serta faktor-faktor lain yang mempengaruhinya pada perawat di rumahsakit.Metode: Penelitian ini menggunakan desain comparative cross sectionalmembandingkan IMT 43 perawat kerja gilir dengan 43 perawat bukan kerja gilir.Dilakukan penilaian terhadap faktor-faktor risiko yang dinilai dapat meningkatkanrisiko berat badan berlebih dan obesitas antara lain jenis kelamin, usia, statusperkawinan, riwayat obesitas dalam keluarga, kebiasaan olahraga, riwayat merokok,jumlah jam tidur dan asupan kalori.Hasil: Prevalensi berat badan berlebih dan obesitas pada perawat kerja gilir dirumah sakit adalah 69.8% dan prevelensi berat badan berlebih dan obesitas padaperawat bukan kerja gilir di rumah sakit adalah 48.4%, ditemukan hubunganbermakna antara kerja gilir dengan berat badan berlebih-obesitas dengan OR =2.418 (1.000 ? 5.851). Faktor risiko yang meningkatkan risiko berat badan berlebihdan obesitas adalah kerja gilir, jumlah jam tidur kurang dari 7 jam dan asupan kalorberlebih. Kesimpulan: Dari semua faktor, asupan kalori berlebih merupakan faktor risiko dominan dengan OR = 4.473 (1.781-11.235).ABSTRACT The prevalence of obesity is increasing worldwide, including inIndonesia. Obesity is a risk factor for many diseases that can cause a decline in theperformance and productivity of workers. One factor that is associated with obesityis shift work. Shift work is commonly needed for health care workers, includingnurses. This study aimed to assess the association of shift work with overweightand obese as well as other related factors among hospital nurses.Method: This study used a comparative cross-sectional design comparing the BodyMass Index (BMI) of 43 nurses working shifts with 43 nurses who only workregular hours. An assessment was conducted of the risk factors that are consideredincreasing the risk of being overweight and obese among others gender, age, maritalstatus, family history of obesity, exercise habits, smoking history, number of hoursof sleep and calorie intake.Results: The prevalence of being overweight and obese in hospital nurses on shiftwork was 69.8% and in nurses not on shift work at the hospital was 48.4%. Asignificant relationship between shift work with overweight-obesity with OR =2.418 (1.000-5.851) was found. Risk factors that increase the risk of overweightand obesity were shift work, number of hours of sleep less than 7 hours and intakeof excessive calories.Conclusion: Of all the factors, excessive caloric intake is the dominant risk factor with OR = 4.473 (1.781-11.235).;Background: The prevalence of obesity is increasing worldwide, including inIndonesia. Obesity is a risk factor for many diseases that can cause a decline in theperformance and productivity of workers. One factor that is associated with obesityis shift work. Shift work is commonly needed for health care workers, includingnurses. This study aimed to assess the association of shift work with overweightand obese as well as other related factors among hospital nurses.Method: This study used a comparative cross-sectional design comparing the BodyMass Index (BMI) of 43 nurses working shifts with 43 nurses who only workregular hours. An assessment was conducted of the risk factors that are consideredincreasing the risk of being overweight and obese among others gender, age, maritalstatus, family history of obesity, exercise habits, smoking history, number of hoursof sleep and calorie intake.Results: The prevalence of being overweight and obese in hospital nurses on shiftwork was 69.8% and in nurses not on shift work at the hospital was 48.4%. Asignificant relationship between shift work with overweight-obesity with OR =2.418 (1.000-5.851) was found. Risk factors that increase the risk of overweightand obesity were shift work, number of hours of sleep less than 7 hours and intakeof excessive calories.Conclusion: Of all the factors, excessive caloric intake is the dominant risk factor with OR = 4.473 (1.781-11.235).;Background: The prevalence of obesity is increasing worldwide, including inIndonesia. Obesity is a risk factor for many diseases that can cause a decline in theperformance and productivity of workers. One factor that is associated with obesityis shift work. Shift work is commonly needed for health care workers, includingnurses. This study aimed to assess the association of shift work with overweightand obese as well as other related factors among hospital nurses.Method: This study used a comparative cross-sectional design comparing the BodyMass Index (BMI) of 43 nurses working shifts with 43 nurses who only workregular hours. An assessment was conducted of the risk factors that are consideredincreasing the risk of being overweight and obese among others gender, age, maritalstatus, family history of obesity, exercise habits, smoking history, number of hoursof sleep and calorie intake.Results: The prevalence of being overweight and obese in hospital nurses on shiftwork was 69.8% and in nurses not on shift work at the hospital was 48.4%. Asignificant relationship between shift work with overweight-obesity with OR =2.418 (1.000-5.851) was found. Risk factors that increase the risk of overweightand obesity were shift work, number of hours of sleep less than 7 hours and intakeof excessive calories.Conclusion: Of all the factors, excessive caloric intake is the dominant risk factor with OR = 4.473 (1.781-11.235)."

"ABSTRAK Prevalensi Rinitis Akibat Kerja (RAK) berkisar antara 5-48%. Penyebab RAKantara lain adalah partikulat debu yang beterbangan di lingkungan kerja. Hal iniakan meningkatkan beban pembiayaan baik terhadap pekerja itu sendiri maupunperusahaan tempat ia bekerja. Penelitian ini bertujuan untuk mengetahuiprevalensi RAK serta hubungan antara kadar partikulat debu dengan kejadianRAK dengan populasi pekerja parkir basement di sebuah Hotel dan RSUD diJakarta dengan waktu pengumpulan sampel dilakukan selama bulan Desember 2014 hingga Maret 2015. Sampel penelitian adalah yang memenuhi kriteria inklusi yakni area kerja di parkir basement, usia 20-40 tahun, masa kerja lebihdari 1 tahun dan bersedia mengikuti prosedur penelitian. Subyek penelitian diwawancara dan diperiksa kadar eosinofil kerokan mukosa hidung sebelum dansesudah bekerja. RAK positif apabila terdapat gejala rinitis, memberat ketikabekerja dan ada peningkatan eosinofil kerokan mukosa hidung. Analisa penelitiandilakukan berdasarkan karakteristik usia, jenis kelamin, masa kerja, kebiasaanmerokok dan bagian kerja (terpapar langsung atau tidak dengan partikulat debu).Dari 57 subyek penelitian, 6 orang (10.5%) mengalami peningkatan eosinofildengan karakterisktik sebagai berikut: 4 orang memiliki masa kerja > 4 tahun; 4orang memiliki kebiasaan merokok; dan 3 orang bekerja di bagian kerja yangterpapar langsung dengan partikulat debu. Dari 6 orang tersebut terdapat 3 orang(5.2%) yang memenuhi kriteria RAK dengan karakteristik sebagai berikut: 2orang berusia 30-40 tahun, 2 orang adalah laki-laki, 2 orang mempunyai masakerja ≤ 4 tahun, dan 2 orang berasal dari bagian kerja yang terpapar tidaklangsung dengan partikulat debu. Terdapat hubungan bermakna antara riwayatatopi dengan peningkatan eosinofil (OR 23.33 dan 95%CI 2.40-224.62). Namuntidak ditemukan hubungan antara kadar partikulat debu dan masa kerja dengan RAK yang bermakna. ABSTRACT The prevalence of occupational rhinitis ranges between 5-48%. It is caused byparticulate dust in the workplace. It will increase financial burden both for theworkers themselves and the company. This study aims to determine theprevalence of OR and the relation between the levels of particulate dust with ORincident among workers who work in a hotel or hospital basement parking lot inJakarta, during December 2014 to March 2015. The sample inclusion criteriawere: age 20-40 years, working period of more than one year and are willing toparticipate in the study. The subjects were interviewed and nasal mucosal scrapings eosinophil levels were measured before and after work. OR was defined as has symptoms of rhinitis, increase during work and there is anincrease in eosinophils nasal mucosal scrapings. Analysis of the research carriedout based on the characteristics of age, sex, years of smoking and workingdirectly or indirectly exposed to dust particulates. Of the 57 subjects of the study,6 (10.5%) experienced an increase in eosinophils with the followingcharacteristics: 4 people has a work period > 4 years; 4 people smoke; and 3people work directly exposed to particulate dust. Three subjects (5.2%) meet allthe OR criteria with the following characteristics: 2 were aged 30-40 years, 2were male, 2 have a working period of ≤ 4 years and 2 were indirectly exposed toparticulate dust. There is a very significant association between history of atopywith increased eosinophils (, OR 23.3 and 95% CI 2.40-224.62). However, no association was found between levels of particulate dust and working period.;The prevalence of occupational rhinitis ranges between 5-48%. It is caused byparticulate dust in the workplace. It will increase financial burden both for theworkers themselves and the company. This study aims to determine theprevalence of OR and the relation between the levels of particulate dust with ORincident among workers who work in a hotel or hospital basement parking lot inJakarta, during December 2014 to March 2015. The sample inclusion criteriawere: age 20-40 years, working period of more than one year and are willing toparticipate in the study. The subjects were interviewed and nasal mucosal scrapings eosinophil levels were measured before and after work. OR was defined as has symptoms of rhinitis, increase during work and there is anincrease in eosinophils nasal mucosal scrapings. Analysis of the research carriedout based on the characteristics of age, sex, years of smoking and workingdirectly or indirectly exposed to dust particulates. Of the 57 subjects of the study,6 (10.5%) experienced an increase in eosinophils with the followingcharacteristics: 4 people has a work period > 4 years; 4 people smoke; and 3people work directly exposed to particulate dust. Three subjects (5.2%) meet allthe OR criteria with the following characteristics: 2 were aged 30-40 years, 2were male, 2 have a working period of ≤ 4 years and 2 were indirectly exposed toparticulate dust. There is a very significant association between history of atopywith increased eosinophils (, OR 23.3 and 95% CI 2.40-224.62). However, no association was found between levels of particulate dust and working period.;The prevalence of occupational rhinitis ranges between 5-48%. It is caused byparticulate dust in the workplace. It will increase financial burden both for theworkers themselves and the company. This study aims to determine theprevalence of OR and the relation between the levels of particulate dust with ORincident among workers who work in a hotel or hospital basement parking lot inJakarta, during December 2014 to March 2015. The sample inclusion criteriawere: age 20-40 years, working period of more than one year and are willing toparticipate in the study. The subjects were interviewed and nasal mucosal scrapings eosinophil levels were measured before and after work. OR was defined as has symptoms of rhinitis, increase during work and there is anincrease in eosinophils nasal mucosal scrapings. Analysis of the research carriedout based on the characteristics of age, sex, years of smoking and workingdirectly or indirectly exposed to dust particulates. Of the 57 subjects of the study,6 (10.5%) experienced an increase in eosinophils with the followingcharacteristics: 4 people has a work period > 4 years; 4 people smoke; and 3people work directly exposed to particulate dust. Three subjects (5.2%) meet allthe OR criteria with the following characteristics: 2 were aged 30-40 years, 2were male, 2 have a working period of ≤ 4 years and 2 were indirectly exposed toparticulate dust. There is a very significant association between history of atopywith increased eosinophils (, OR 23.3 and 95% CI 2.40-224.62). However, no association was found between levels of particulate dust and working period.;The prevalence of occupational rhinitis ranges between 5-48%. It is caused byparticulate dust in the workplace. It will increase financial burden both for theworkers themselves and the company. This study aims to determine theprevalence of OR and the relation between the levels of particulate dust with ORincident among workers who work in a hotel or hospital basement parking lot inJakarta, during December 2014 to March 2015. The sample inclusion criteriawere: age 20-40 years, working period of more than one year and are willing toparticipate in the study. The subjects were interviewed and nasal mucosal scrapings eosinophil levels were measured before and after work. OR was defined as has symptoms of rhinitis, increase during work and there is anincrease in eosinophils nasal mucosal scrapings. Analysis of the research carriedout based on the characteristics of age, sex, years of smoking and workingdirectly or indirectly exposed to dust particulates. Of the 57 subjects of the study,6 (10.5%) experienced an increase in eosinophils with the followingcharacteristics: 4 people has a work period > 4 years; 4 people smoke; and 3people work directly exposed to particulate dust. Three subjects (5.2%) meet allthe OR criteria with the following characteristics: 2 were aged 30-40 years, 2were male, 2 have a working period of ≤ 4 years and 2 were indirectly exposed toparticulate dust. There is a very significant association between history of atopywith increased eosinophils (, OR 23.3 and 95% CI 2.40-224.62). However, no association was found between levels of particulate dust and working period."

"ABSTRAK Perilaku keselamatan kerja pada pekerja Usaha Mikro Kecil dan Menengah (UMKM)khususnya pengolahan kayu di Indonesia masih kurang baik, ditandai dengan masih tingginyaangka disabilitas akibat kecelakaan kerja. Tujuan penelitian ini adalah diketahui dandiperolehnya faktor-faktor yang mempengaruhi perilaku keselamatan kerja pada pekerjaUMKM pengolahan kayu. Studi kualitatif menggunakan wawancara mendalam dan kelompok diskusi terfokus denganpedoman wawancara semi-struktur pendekatan teori Green di 2 perusahaan informalpengolahan kayu. Wawancara mendalam dilakukan pada 2 orang bagian manajemen, 2 orangmandor, 4 orang pekerja. Kelompok diskusi terfokus dilakukan pada 2 kelompok dengan 5orang pekerja di setiap kelompok. Pekerja pengolahan kayu memiliki persepsi yang cukup baik mengenai perilaku keselamatankerja hal ini dikarenakan memiliki pengalaman bekerja cukup lama meskipun berlatarbelakang pendidikan rendah. Sikap dan perilaku yang belum mencerminkan perilakukeselamatan kerja dipengaruhi motivasi, minat, role model, kesiapan, kebijakan danpengawasan yang masih kurang. Mandor masih kurang ketat bertindak sebagai role modeldan melakukan pengawasan terhadap pekerja di lapangan. Manajemen perusahaan sudahmelakukan penyediaan sarana dan prasarana sesuai standar tetapi tidak diikuti oleh adanyakebijakan, peraturan, pelatihan serta reward dan punishment. Persepsi baik berperilaku keselamatan kerja pada pekerja pengolahan kayu dalam mencegahkecelakaan kerja dipengaruhi oleh pengetahuan, pengalaman dan sarana prasarana standaryang cukup baik. Tetapi kurangnya motivasi, minat, contoh teladan, kesiapan danpengawasan mempengaruhi sikap dan perilaku keselamatan kerja yang kurang baik.Manajemen dan mandor yang kurang menerapkan kebijakan, peraturan, pelatihan, rewarddan punishment juga mempengaruhi perilaku keselamatan kerja bagi para pekerja pengolahankayu.ABSTRACT Workers in MSME lack good safety behavior specially carpenters in Indonesia, marked by ahigh incidence of disability caused by occupational accidents. The aim of this study is to identify influencing factors to workers?s safety behavior of carpenter in the micro, small andmedium enterprises (MSME). A Qualitative study was conducted using in-depth interviews and focus group discussion withsemi-structured guidelines from Green theory, conducted in 2 MSME carpenter industry. Indepthinterviews involving 2 management staffs, 2 supervisors and 4 carpenters. Focusgroup discussion was conducted with 2 groups, each consisting of 5 carpenters in . Adequacy of good safety behavior perceptions was found, due to carpenter?s long experience,although they have low educational level. Carpenter?s attitude and behavior did not complywith safe behavior, influenced by lack of motivation, interest, role model, readiness, policyand supervision. Supervisors were not regarded as role models and are weak in supervision.Management already provides standar infrastructure and facilities, but lack of policy,regulation, training also reward and punishment system. The micro, small and medium enterprises (MSME) carpenter?s good perceptions tooccupational accident prevention influenced by knowledge, experience and standardinfrastructure and facilities, but Carpenters?s lack of motivation, interest, role model,readiness and supervision influenced low attitude and lack of safety behavior.Managementand supervisor?s also fail to support carpenter?s safety behavior by not implementing policy,regulation, training, reward and punishment system.;Workers in MSME lack good safety behavior specially carpenters in Indonesia, marked by ahigh incidence of disability caused by occupational accidents. The aim of this study is to identify influencing factors to workers?s safety behavior of carpenter in the micro, small andmedium enterprises (MSME). A Qualitative study was conducted using in-depth interviews and focus group discussion withsemi-structured guidelines from Green theory, conducted in 2 MSME carpenter industry. Indepthinterviews involving 2 management staffs, 2 supervisors and 4 carpenters. Focusgroup discussion was conducted with 2 groups, each consisting of 5 carpenters in . Adequacy of good safety behavior perceptions was found, due to carpenter?s long experience,although they have low educational level. Carpenter?s attitude and behavior did not complywith safe behavior, influenced by lack of motivation, interest, role model, readiness, policyand supervision. Supervisors were not regarded as role models and are weak in supervision.Management already provides standar infrastructure and facilities, but lack of policy,regulation, training also reward and punishment system. The micro, small and medium enterprises (MSME) carpenter?s good perceptions tooccupational accident prevention influenced by knowledge, experience and standardinfrastructure and facilities, but Carpenters?s lack of motivation, interest, role model,readiness and supervision influenced low attitude and lack of safety behavior.Managementand supervisor?s also fail to support carpenter?s safety behavior by not implementing policy,regulation, training, reward and punishment system.;Workers in MSME lack good safety behavior specially carpenters in Indonesia, marked by ahigh incidence of disability caused by occupational accidents. The aim of this study is to identify influencing factors to workers?s safety behavior of carpenter in the micro, small andmedium enterprises (MSME). A Qualitative study was conducted using in-depth interviews and focus group discussion withsemi-structured guidelines from Green theory, conducted in 2 MSME carpenter industry. Indepthinterviews involving 2 management staffs, 2 supervisors and 4 carpenters. Focusgroup discussion was conducted with 2 groups, each consisting of 5 carpenters in . Adequacy of good safety behavior perceptions was found, due to carpenter?s long experience,although they have low educational level. Carpenter?s attitude and behavior did not complywith safe behavior, influenced by lack of motivation, interest, role model, readiness, policyand supervision. Supervisors were not regarded as role models and are weak in supervision.Management already provides standar infrastructure and facilities, but lack of policy,regulation, training also reward and punishment system. The micro, small and medium enterprises (MSME) carpenter?s good perceptions tooccupational accident prevention influenced by knowledge, experience and standardinfrastructure and facilities, but Carpenters?s lack of motivation, interest, role model,readiness and supervision influenced low attitude and lack of safety behavior.Managementand supervisor?s also fail to support carpenter?s safety behavior by not implementing policy,regulation, training, reward and punishment system."

"ABSTRAK Latar Belakang Penelitian dilakukan untuk mengetahui hubungan antara kesertaan latihan fisik usia dan jabatan dengan pengendalian berat badan karyawan perusahaan T yaitu perusahaan minyak dan gas di Kalimantan Timur Metode Penelitian dilakukan dengan metode potong lintang kepada karyawan perusahaan T yang konsisten mengikuti Medical Check Up MCU dari tahun 2009 ndash 2011 Data sekunder didapatkan dari hasil MCU tahun 2009 ndash 2011 dan daftar hadir latihan fisik di tempat kerja tahun 2009 ndash 2011 Hasil Penelitian Jumlah karyawan yang konsisten mengikuti MCU adalah 110 orang merupakan jumlah sampel yang diteliti Proporsi karyawan dengan berat badan terkendali lebih banyak yang tidak latihan fisik usia 21 ndash 35 tahun dan teknisi Secara statistik menunjukkan proporsi karyawan dengan berat badan terkendali pada kelompok mengikuti latihan fisik tidak berbeda bermakna dengan yang tidak mengikuti latihan fisik OR 0 64 90 CI 0 28 ndash 1 41 proporsi karyawan dengan berat badan terkendali pada kelompok usia 21 ndash 35 tahun tidak berbeda bermakna dengan 35 tahun OR 1 63 90 CI 0 85 ndash 3 40 akan tetapi tingkat pengendalian berat badan karyawan teknisi berbeda bermakna dengan superintendent dan supervisor OR 5 61 90 CI 2 75 ndash 16 46 Analisis multivariat menunjukkan jabatan memiliki hubungan signifikan dengan pengendalian berat badan OR 5 41 90 CI 2 26 ndash 12 92 Dari 29 karyawan yang mengikuti latihan fisik proporsi karyawan dengan berat badan terkendali lebih banyak pada usia 21 ndash 35 tahun dan teknisi Secara statistik menunjukkan bahwa proporsi karyawan dengan berat badan terkendali pada kelompok usia 21 ndash 35 tahun tidak berbeda bermakna dengan 35 tahun OR 3 75 90 CI 1 01 ndash 13 80 akan tetapi tingkat pengendalian berat badan karyawan teknisi berbeda bermakna dengan superintendent dan supervisor OR 7 333 90 CI 1 80 ndash 29 73 Analisis multivariat menunjukkan jabatan memiliki hubungan signifikan dengan pengendalian berat badan OR 5 63 90 CI 1 26 ndash 25 07 Kesimpulan Karyawan teknisi perusahaan T mempunyai peluang memiliki berat badan terkendali 5 415 kali dibanding jabatan lain setelah dikontrol variabel kesertaan latihan fisik dan usia Kata Kunci aktivitas fisik berat badan lebih latihan fisik pengendalian berat badan program pengendalian di tempat kerja.ABSTRACT Background This study was conducted to determine the association between participation in physical exercise age and position with employees body weight control company T which is an oil and gas company in East Kalimantan Method The study was conducted by cross sectional method to employees who consistently perform Medical Check Up MCU in 2009 ndash 2011 Secondary data used were MCU result and attendance list participating in physical exercise in 2009 ndash 2011 at the company T Result The number of employees who consistently perform MCU in 2009 2011 was 110 who became the sample of this study The proportion of employees with controlled body weight was higher among employees who do not participate in physical exercise were at the age 21 ndash 35 years and were technicians There were no significant association between participation in physical exercise and age with controlled body weight but a very significant difference in controlled body weight was found between technicians and superintendent supervisor OR 5 61 90 CI 2 75 to 16 46 Multivariate analysis showed that job position has a very significant association with body weight control ORadj 5 41 90 CI 2 27 to 12 93 Among 29 people who attend physical exercise the proportion of employees with controlled body weight were higher in employees aged 21 ndash 35 years and technicians There were no significant associations between age with controlled body weight but a significant difference in controlled body weight was found between technicians and superintendent supervisor OR 7 33 90 CI 1 81 to 29 73 Multivariate analysis showed that job position has a significant association with body weight control ORadj 5 63 90 CI 1 27 to 25 1 Conclusion Technicians in company T have opportunity to have controlled body weight 5 41 times compared to other positions after controlled by participation rate in physical exercise and age variable Key words body weight control control programs in the work place obesity overweight physical activity physical exercise."

"Latar belakang : Toluena merupakan zat pelarut sering digunakan di berbagai industri seperti dalam pembuatan cat, lem dan lainnya. Toluena mempunyai sifat lipofilik dan memberikan efek toksik ke beberapa organ seperti sistem saraf pusat. Pada tahap biomolekuler, toluena merubah struktur lipid pada membran sel, sehingga terjadi peningkatan kadar MDA plasma dan jaringan. Pada Sistem Saraf Pusat, toluena bisa melewati sawar otak dan menyebabkan gangguan pada serebelum otak sehingga dapat meningkatkan kadar MDA serta terjadi perubahan struktur pada dinding sel astrosit. Metode : Untuk mengetahui efek pajanan toluena selama 14 hari dengan dosis dibawah nilai ambang pada organ serebelum otak, dan dilakukan pemeriksaan kadar MDA serebelum otak, serta kerusakan dari sel Astrosit, menggunakan lima kelompok tikus jenis Wistar jantan dengan pajanan sebesar 1,6 ml; 3,2 ml; 6,4 ml; 12,8 ml; dan kelompok kontrol tanpa pajanan. Hasil: Analisis uji nilai kadar MDA serebelum otak menggunakan One Way Anova dengan hasil tidak ada perbedaan rerata (p=0.133) antar kelompok pajanan dengan kelompok kontrol, dan analisis jumlah sel Astrosit dengan menggunakan One Way Anova didapatkan (p=0,310) dengan hasil tidak ada perbedaan antar kelompok pajanan. Kesimpulan : Tidak ada perbedaan rerata pada kelompok pajanan pada nilai MDA serebelum Otak maupun jumlah Sel Astrosit yang terpajan toluena dengan dosis dibawah nilai ambang.

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Backgrounds : Toluene is a solvent commonly used in various industries such as in the manufacture of paint, glue and others. Toluene has lipophilic properties and toxic effects to some organs such as the central nervous system. At this stage of biomolecular, toluene alters the structure of the lipids in cell membranes, resulting in an increased of plasma and tissue levels of MDA. In the Central Nervous System, toluene can cross the blood brain barrier and cause a disruption in the cerebellum of the brain, thereby increasing the levels of MDA and structural changes in the structure of astrocytes’ cells.

Methods : To determine the effect of toluene exposure for 14 days at doses below the threshold value on the organ brain cerebellum and cerebellar MDA examination of the brain, as well as causing damage to Astrocytes cells, using five groups of male Wistar rats with four types of exposure of 1.6 ml; 3.2 ml; 6.4 ml; 12.8 ml; and a control group without exposure.

Results : MDA value analysis test brain cerebellum using One Way Anova showed no significance mean difference (p = 0.133) between the exposed group and the control group. From the analysis of the number of cells Astrocytes using One Way Anova that obtained (p = 0.310) with no difference in outcomes among exposed groups.

Conclusion : There was no significance difference in the group mean exposure to MDA values and the number of cells of the cerebellum Brain Astrocytes exposed to toluene at a dose below the threshold value."