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Penelitian ini dilakukan untuk mencari cara sterilisasi guta-perca yang efektif dan efisien sebelum digunakan untuk mengisi saluran akar. Guta-perca yang dicemari Staphylococcus aureus dan Bacillus subtilis direndam dalam natrium hipoklorit dengan konsentrasi 5,25 % ; 2,65 % ; 1,31 % dan ke dalam povidon yodium dengan konsentrasi 10 % ; 1 % ; 0,5 % selama 0,5; 1; 3; 6 menit. Kemudian dibilas dengan merendam dalam larutan fisiologis NaCl steril, lalu dibiak dalam perbenihan thioglikolat,dan dieramkan pada suhu 370C selama 72 jam, untuk dilihat apakah perbenihan tetap jernih, atau menjadi keruh. Ternyata efek kedua desinfektans ini tidak berbeda bermakna. Dapat disimpulkan bahwa kedua bahan ini bisa digunakan untuk sterilisasi guta-perca sebelum pengisian saluran akar. Pada konsentrasi yang kecil dan dalam waktu yang singkat kedua desinfektans ini sudah cukup efektif mematikan kuman Staphylococcus aureus dan Bacillus subtilis.

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Latar Belakang : Penambahan fluor ke dalam proses PILP memiliki potensi meningkatkan remineralisasi intrafibril dan ekstrafibril kolagen dentin. Tujuan : Penelitian ini bertujuan untuk mengetahui pengaruh penambahan fluor dalam proses PILP terhadap remineralisasi intrafibril dan ekstrafibril kolagen dentin. Metode : 8 sampel blok dentin dibagi ke dalam 4 kelompok: Kelompok 1 demineralized dentin sebagai kontrol, kelompok 2 demineralized dentin disimpan dalam larutan remineralisasi PILP yang ditambahkan fluor 5 ppm, kelompok 3 demineralized dentin disimpan dalam larutan remineralisasi PILP yang ditambahkan fluor 25 ppm, kelompok 4 demineralized dentin disimpan dalam larutan remineralisasi PILP tanpa fluor (0 ppm) Kemudian seluruh sampel disimpan dalam shaking incubator pada suhu 37°C selama 14 hari. Selanjutnya dilakukan pemeriksaan dengan TEM/SAED untuk melihat remineralisasi intrafibril dan ekstrafibril kolagen dentin dan kristalinitas kristal yang dihasilkan. Hasil : Terjadi remineralisasi intrafibril dan ekstrafibril kolagen dentin pada kelompok perlakuan 2, 3, dan 4. Remineralisasi intrafibril dan ekstrafibril terlihat paling padat pada kelompok 2. Terdapat perbedaan kristalinitas kristal di antara kelompok 1, 2, 3, dan 4. Kesimpulan: Penambahan fluor 5 ppm ke dalam proses PILP menghasilkan remineralisasi intrafibril dan ekstrafibril kolagen dentin. Remineralisasi yang dihasilkan berupa kristal apatit dengan tingkat kristalinitas yang padat. ......Background: Fluoride addition into PILP process has the potential to increase intrafibrillar and extrafibrillar dentin collagen remineralization. Objective: This research aim to evaluate the influence of fluoride addition into PILP process towards intrafibrillar and extrafibrillar dentin collagen remineralization. Methods: 8 dentin blocks were divided into 4 sample groups. Group 1 (demineralized dentin) as control group, group 2 is demineralized dentin that were soaked in PILP process with 5 ppm fluoride addition, group 3 is demineralized dentin that were soaked in PILP process with 25 ppm fluoride addition, and group 4 is demineralized dentin that were soaked in PILP process with no fluor (0 ppm) addition. All of the samples were incubated in shaking incubator at 37o C for 14 days. Result: Intrafibrillar and extrafibrillar dentin collagen remineralization occurred in group 2, 3, and 4. The most dense intrafibrillar and extrafibrillar dentin collagen remineralization was seen in group 2. There are differences of crystal's crystallinity between group 1, 2, 3, and 4. Conclusion: 5 ppm fluoride addition into PILP process produced intrafibrillar and extrafibrillar dentin collagen remineralization. The remineralization were consisted by high-density apatite crystals.

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Odontocem® dan Biodentine®, berbahan dasar kalsium silikat. Tetapi terdapat kandungan lain yang mungkin memiliki efek pada viabiltas sel. Contohnya penambahan steroid dalam Odontocem®. Belum diketahui apakah penambahan steroid tersebut memiliki efek atau tidak terhadap viabilitas sel. Sel fibroblas yang diambil dari Telur Embrio Tertunas (TET), dipajan dengan Odontocem® dan Biodentine® dengan jumlah masing-masing kelompok sebesar 15 well. Kemudian viabilitas sel diukur selama 24 jam dan 72 jam. Hasil penelitian diuji dengan uji statistik Kruskal Wallis dengan uji post hoc Mann-Whitney. Berdasarkan hasil penelitian, didapatkan bahwa Odontocem® dan Biodentine® memiliki efek menurunkan viabiltas sel fibroblas pada pengukuran 24 jam dan 72 jam. Juga viabilitas sel fibroblas pada kelompok perlakuan Odontocem ® lebih tinggi daripada Biodentine® baik pada pengukuran 24 jam maupun 72 jam. ABSTRACT
Odontocem® and Biodentine®, both consist of calcium silicate. But there are other substances which may have an effect on cell viability. For example, addition of steroids in Odontocem®. It is not yet known whether these steroids have an effect or not on the cell viability. Fibroblasts taken from Chicken Embryo, added with Odontocem® and Biodentine® by each group of 15 wells. Then the cell viability was measured for 24 hours and 72 hours. The result were tested by Kruskal Wallis statistical test with post hoc test of Mann-Whitney. Based on this research, it was found that Odontocem® and Biodentine® have a lowering effect on the fibroblast cell viability for 24 hours and 72 hours. Thus, fibroblast cell viability the treatment group Odontocem ® is higher than both the measurement Biodentine® 24 hours or 72 hours.;Odontocem® and Biodentine®, both consist of calcium silicate. But there are other substances which may have an effect on cell viability. For example, addition of steroids in Odontocem®. It is not yet known whether these steroids have an effect or not on the cell viability. Fibroblasts taken from Chicken Embryo, added with Odontocem® and Biodentine® by each group of 15 wells. Then the cell viability was measured for 24 hours and 72 hours. The result were tested by Kruskal Wallis statistical test with post hoc test of Mann-Whitney. Based on this research, it was found that Odontocem® and Biodentine® have a lowering effect on the fibroblast cell viability for 24 hours and 72 hours. Thus, fibroblast cell viability the treatment group Odontocem ® is higher than both the measurement Biodentine® 24 hours or 72 hours.

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Latar belakang: Ketahanan ikatan antara resin komposit dengan dentin merupakan penentu keberhasilan restorasi resin komposit. Tujuan: Menganalisis EBA terhadap kekuatan ikat resin-dentin. Metode: 48 sampel dentin dibagi menjadi 6 kelompok. Kemudian seluruh kelompok di ukur kekuatan ikat gesernya menggunakan UTM. Data dianalisa statistik dengan uji hipotesis Kruskal Wallis yang dilanjutkan dengan uji Mann Whitney. Hasil: Median tertinggi kelompok 3, sedangkan median terendah kelompok 5. Kesimpulan: Ekstrak biji anggur yang diaplikasikan sebelum etsa dapat meningkatkan kekuatan ikat gesek namun tidak dapat menghambat biodegradasinya.ABSTRACT
Background: Resilience of resin-dentin bonding known as one of success composite resin restoration determinants. Aim: To analyze the effect of grape seed extract on resin-dentin shear bond strength. Methods: 48 dentin sample were divided into 6 groups. Shear bond strengths measured using UTM. Statistical analysis was done by Kruskal Wallis test and Mann Whitney test. Results: The highest median value was highest on group 3, and the lowest was group 5. Conclusion: Grape seed extract can improve the shear bond strength but not have effect on reducing the biodegradation. ;Background: Resilience of resin-dentin bonding known as one of success composite resin restoration determinants. Aim: To analyze the effect of grape seed extract on resin-dentin shear bond strength. Methods: 48 dentin sample were divided into 6 groups. Shear bond strengths measured using UTM. Statistical analysis was done by Kruskal Wallis test and Mann Whitney test. Results: The highest median value was highest on group 3, and the lowest was group 5. Conclusion: Grape seed extract can improve the shear bond strength but not have effect on reducing the biodegradation.

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Latar Belakang: siler polidimetilsiloksan merupakan siler baru yang berpotensi menutup saluran akar lebih baik. Tujuan: membandingkan tingkat kerapatan pengisian di sepertiga apeks antara teknik kon tunggal (KT) dan downpackbackfill (DB) menggunakan siler polidimetilsiloksan. Metode: empat puluh gigi premolar bawah dibagi menjadi dua kelompok KT dan DB. Setelah pengisian saluran akar, sampel diinkubasi, dilapisi cat kuku, direndam dalam tinta India, lalu dibuat transparan dengan metode Robertson. Kebocoran di sepertiga apeks dievaluasi dengan mikroskop stereo. Hasil: skor kebocoran terendah (0-0,5 mm) dimiliki oleh kelompok KT dan skor kebocoran tertinggi (>1 mm) dimiliki oleh kelompok DB. Kesimpulan: teknik kon tunggal memberikan tingkat kerapatan yang lebih baik dibandingkan downpack-backfill, walaupun secara statistik perbedaan antar keduanya tidak signifikan. ABSTRACT
Background: polydimethylsiloxane sealer is a brand new sealer that potentially has a better sealing ability to the root canal. Aim: to compare the apical sealing ability in one third apex between single cone (SC) and downpack-backfill (DB) technique using polydimethylsiloxane sealer. Methods: fourty extracted human manibular premolars devided into two group, SC and DB. After obturated with polydimethylsiloxane sealer, samples were stored in incubator, coated with nail varnish, immersed in India ink, and then specimens were cleared using Robertson?s technique. The apical dye penetration was evaluated using a stereomicroscope. Result: the lowest leakage score (0-0,5 mm) was found in SC group and the highest score(>1 mm) in DB group. Summary: single cone technique exibited better sealing ability rather than downpack-backfill technique, although no statistical significant difference between this two techniques. ;Background: polydimethylsiloxane sealer is a brand new sealer that potentially has a better sealing ability to the root canal. Aim: to compare the apical sealing ability in one third apex between single cone (SC) and downpack-backfill (DB) technique using polydimethylsiloxane sealer. Methods: fourty extracted human manibular premolars devided into two group, SC and DB. After obturated with polydimethylsiloxane sealer, samples were stored in incubator, coated with nail varnish, immersed in India ink, and then specimens were cleared using Robertson?s technique. The apical dye penetration was evaluated using a stereomicroscope. Result: the lowest leakage score (0-0,5 mm) was found in SC group and the highest score(>1 mm) in DB group. Summary: single cone technique exibited better sealing ability rather than downpack-backfill technique, although no statistical significant difference between this two techniques. ;Background: polydimethylsiloxane sealer is a brand new sealer that potentially has a better sealing ability to the root canal. Aim: to compare the apical sealing ability in one third apex between single cone (SC) and downpack-backfill (DB) technique using polydimethylsiloxane sealer. Methods: fourty extracted human manibular premolars devided into two group, SC and DB. After obturated with polydimethylsiloxane sealer, samples were stored in incubator, coated with nail varnish, immersed in India ink, and then specimens were cleared using Robertson?s technique. The apical dye penetration was evaluated using a stereomicroscope. Result: the lowest leakage score (0-0,5 mm) was found in SC group and the highest score(>1 mm) in DB group. Summary: single cone technique exibited better sealing ability rather than downpack-backfill technique, although no statistical significant difference between this two techniques.

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Latar Belakang. P.gingivalis merupakan bakteri periodonsium yang dapat berpindah ke saluran akar pada lesi endoperio kombinasi murni. Jumlah dan proporsinya berperan terhadap keparahan penyakit karena sifat virulensinya. Tujuan: Menganalisis jumlah dan proporsi P.gingivalis saluran akar dan poket lesi endoperio kombinasi murni, lesi endo primer, dan lesi perio primer. Metode: 16 sampel diambil dari 3 kelompok, kuantifikasi dengan PCR real-time. Hasil: Jumlah P.gingivalis terbesar pada poket lesi perio primer, proporsi P.gingivalis terbesar pada saluran akar lesi endo primer. Jumlah dan proporsi P.gingivalis tidak berbeda bermakna antara saluran akar dan poket lesi endoperio kombinasi murni. Kesimpulan. Jumlah dan proporsi P.gingivalis sebanding antara saluran akar dan poket lesi endoperio kombinasi murni. ABSTRACT
Background : P.gingivalis is a periodontium pathogen that can be transferred to the root canal of the true combined endoperio lesions. Quantity and proportion takes part in the severity of the disease because of its virulence. Objective: to analyze the quantity and proportion of P.gingivalis in the root canals and pocket of true combined endoperio lesions, primary endodontic lesions, and primary periodontal lesions. Methods 16 samples were taken from 3 groups, quantification with real-time PCR. Results : P.gingivalis largest quantity was found in pockets of primary periodontal lesions, P.gingivalis largest proportion was found in root canals of primary endodontic lesions. There were no significant differences in quantity and proportion of P.gingivalis in root canals and pockets of true combined endoperio lesions. Conclusion. Quantity and proportion of P.gingivalis were comparable between the root canals and pockets of true combined endoperio lesions. ;Background : P.gingivalis is a periodontium pathogen that can be transferred to the root canal of the true combined endoperio lesions. Quantity and proportion takes part in the severity of the disease because of its virulence. Objective: to analyze the quantity and proportion of P.gingivalis in the root canals and pocket of true combined endoperio lesions, primary endodontic lesions, and primary periodontal lesions. Methods 16 samples were taken from 3 groups, quantification with real-time PCR. Results : P.gingivalis largest quantity was found in pockets of primary periodontal lesions, P.gingivalis largest proportion was found in root canals of primary endodontic lesions. There were no significant differences in quantity and proportion of P.gingivalis in root canals and pockets of true combined endoperio lesions. Conclusion. Quantity and proportion of P.gingivalis were comparable between the root canals and pockets of true combined endoperio lesions. ;Background : P.gingivalis is a periodontium pathogen that can be transferred to the root canal of the true combined endoperio lesions. Quantity and proportion takes part in the severity of the disease because of its virulence. Objective: to analyze the quantity and proportion of P.gingivalis in the root canals and pocket of true combined endoperio lesions, primary endodontic lesions, and primary periodontal lesions. Methods 16 samples were taken from 3 groups, quantification with real-time PCR. Results : P.gingivalis largest quantity was found in pockets of primary periodontal lesions, P.gingivalis largest proportion was found in root canals of primary endodontic lesions. There were no significant differences in quantity and proportion of P.gingivalis in root canals and pockets of true combined endoperio lesions. Conclusion. Quantity and proportion of P.gingivalis were comparable between the root canals and pockets of true combined endoperio lesions. ;Background : P.gingivalis is a periodontium pathogen that can be transferred to the root canal of the true combined endoperio lesions. Quantity and proportion takes part in the severity of the disease because of its virulence. Objective: to analyze the quantity and proportion of P.gingivalis in the root canals and pocket of true combined endoperio lesions, primary endodontic lesions, and primary periodontal lesions. Methods 16 samples were taken from 3 groups, quantification with real-time PCR. Results : P.gingivalis largest quantity was found in pockets of primary periodontal lesions, P.gingivalis largest proportion was found in root canals of primary endodontic lesions. There were no significant differences in quantity and proportion of P.gingivalis in root canals and pockets of true combined endoperio lesions. Conclusion. Quantity and proportion of P.gingivalis were comparable between the root canals and pockets of true combined endoperio lesions. ;Background : P.gingivalis is a periodontium pathogen that can be transferred to the root canal of the true combined endoperio lesions. Quantity and proportion takes part in the severity of the disease because of its virulence. Objective: to analyze the quantity and proportion of P.gingivalis in the root canals and pocket of true combined endoperio lesions, primary endodontic lesions, and primary periodontal lesions. Methods 16 samples were taken from 3 groups, quantification with real-time PCR. Results : P.gingivalis largest quantity was found in pockets of primary periodontal lesions, P.gingivalis largest proportion was found in root canals of primary endodontic lesions. There were no significant differences in quantity and proportion of P.gingivalis in root canals and pockets of true combined endoperio lesions. Conclusion. Quantity and proportion of P.gingivalis were comparable between the root canals and pockets of true combined endoperio lesions.

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Latar Belakang: E.faecalis merupakan bakteri saluran akar yang dapat bermigrasi ke jaringan periodonsium pada lesi endo-perio kombinasi murni. Jumlahnya berperan terhadap keparahan penyakit karena sifat virulensinya. Tujuan: Menganalisis tipe strain dan jumlah E.faecalis di saluran akar dan poket lesi endo-perio kombinasi murni, lesi endo primer, dan lesi perio primer. Metode: 16 sampel dari 3 kelompok, analisis strain dengan sequencing dan kuantifikasi dengan Real Time PCR. Hasil: Terdapat persamaan strain E.faecali,s jumlah terbesar terdapat pada poket lesi endo-perio kombinasi murni. Tidak berbeda bermakna antara saluran akar dan poket pada lesi endo-perio kombinasi murni. Kesimpulan; terdapat strain yang sama dan jumlah E.faecalis sebanding antara saluran akar dan poket lesi endo-perio kombinasi murni.ABSTRACT
Background: E.faecalis is a root canal pathogen that can migrate to periodontal tissue in true combined endo-perio lesion. The quantity of E.faecalis takes part in the severity of the disease because of its virulence. Objective: To analyze the strain type and quantity of E.faecalis taken from root canal and pocket of true combined endo-perio lesion, primary endodontic lesion and primary periodontal lesion. Methods: 16 samples were taken from 3 groups, strain type was analyzed by sequencing and quantification by Real Time PCR. Results: There were similarities of E. faecalis strain. The largest number were found in the pockets of true combined endo-perio lesion. There were no significant differences between root canal and pocket of true combined endo-perio lesions. Conclusion: There were similarities strain and quantity of E. faecalis were equal between root canal and pocket true combined endo-perio lesions. ;Background: E.faecalis is a root canal pathogen that can migrate to periodontal tissue in true combined endo-perio lesion. The quantity of E.faecalis takes part in the severity of the disease because of its virulence. Objective: To analyze the strain type and quantity of E.faecalis taken from root canal and pocket of true combined endo-perio lesion, primary endodontic lesion and primary periodontal lesion. Methods: 16 samples were taken from 3 groups, strain type was analyzed by sequencing and quantification by Real Time PCR. Results: There were similarities of E. faecalis strain. The largest number were found in the pockets of true combined endo-perio lesion. There were no significant differences between root canal and pocket of true combined endo-perio lesions. Conclusion: There were similarities strain and quantity of E. faecalis were equal between root canal and pocket true combined endo-perio lesions. ;Background: E.faecalis is a root canal pathogen that can migrate to periodontal tissue in true combined endo-perio lesion. The quantity of E.faecalis takes part in the severity of the disease because of its virulence. Objective: To analyze the strain type and quantity of E.faecalis taken from root canal and pocket of true combined endo-perio lesion, primary endodontic lesion and primary periodontal lesion. Methods: 16 samples were taken from 3 groups, strain type was analyzed by sequencing and quantification by Real Time PCR. Results: There were similarities of E. faecalis strain. The largest number were found in the pockets of true combined endo-perio lesion. There were no significant differences between root canal and pocket of true combined endo-perio lesions. Conclusion: There were similarities strain and quantity of E. faecalis were equal between root canal and pocket true combined endo-perio lesions. ;Background: E.faecalis is a root canal pathogen that can migrate to periodontal tissue in true combined endo-perio lesion. The quantity of E.faecalis takes part in the severity of the disease because of its virulence. Objective: To analyze the strain type and quantity of E.faecalis taken from root canal and pocket of true combined endo-perio lesion, primary endodontic lesion and primary periodontal lesion. Methods: 16 samples were taken from 3 groups, strain type was analyzed by sequencing and quantification by Real Time PCR. Results: There were similarities of E. faecalis strain. The largest number were found in the pockets of true combined endo-perio lesion. There were no significant differences between root canal and pocket of true combined endo-perio lesions. Conclusion: There were similarities strain and quantity of E. faecalis were equal between root canal and pocket true combined endo-perio lesions.

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Latar Belakang : Enterococcus faecalis merupakan bakteri yang mampu membentuk biofilm dan banyak ditemukan pada kasus kelainan periapeks. Tujuan : Melihat daya antibakteri campuran triantibiotik dibandingkan dengan klorheksidin 2% terhadap E. faecalis dalam biofilm. Metode : Menilai kekeruhan larutan E. faecalis dalam biofilm pasca pemaparan bahan uji, dengan ELISA reader. Hasil : Terdapat daya antibakteri campuran triantibiotik terhadap biofilm bakteri E. faecalis tetapi tidak terdapat perbedaan bermakna dengan klorheksidin 2% (p>0.05). Kesimpulan : Daya antibakteri campuran triantibiotik terhadap biofilm E. faecalis sebanding dengan klorheksidin 2%. ABSTRACT
Background : Enterococcus faecalis has the ability to form biofilm and is often found in cases of periapical lesions. Aim: To analyze the effectivity of triantibiotic mixture compared to 2% chlorhexidine against biofilm of E. faecalis. Method : Score the turbidity of E. faecalis in biofilm after immersion in antibacterial agent, with ELISA reader. Result : Triantibiotic mixture has antibacterial effectivity against E. faecalis biofilm but has no significant difference compared to 2% chlorhexidine (p>0.05). Conclusion : Antibacterial effectivity of triantibiotic mixture against E. faecalis biofilm is equal to2% chlorhexidine. ;Background : Enterococcus faecalis has the ability to form biofilm and is often found in cases of periapical lesions. Aim: To analyze the effectivity of triantibiotic mixture compared to 2% chlorhexidine against biofilm of E. faecalis. Method : Score the turbidity of E. faecalis in biofilm after immersion in antibacterial agent, with ELISA reader. Result : Triantibiotic mixture has antibacterial effectivity against E. faecalis biofilm but has no significant difference compared to 2% chlorhexidine (p>0.05). Conclusion : Antibacterial effectivity of triantibiotic mixture against E. faecalis biofilm is equal to2% chlorhexidine. ;Background : Enterococcus faecalis has the ability to form biofilm and is often found in cases of periapical lesions. Aim: To analyze the effectivity of triantibiotic mixture compared to 2% chlorhexidine against biofilm of E. faecalis. Method : Score the turbidity of E. faecalis in biofilm after immersion in antibacterial agent, with ELISA reader. Result : Triantibiotic mixture has antibacterial effectivity against E. faecalis biofilm but has no significant difference compared to 2% chlorhexidine (p>0.05). Conclusion : Antibacterial effectivity of triantibiotic mixture against E. faecalis biofilm is equal to2% chlorhexidine. ;Background : Enterococcus faecalis has the ability to form biofilm and is often found in cases of periapical lesions. Aim: To analyze the effectivity of triantibiotic mixture compared to 2% chlorhexidine against biofilm of E. faecalis. Method : Score the turbidity of E. faecalis in biofilm after immersion in antibacterial agent, with ELISA reader. Result : Triantibiotic mixture has antibacterial effectivity against E. faecalis biofilm but has no significant difference compared to 2% chlorhexidine (p>0.05). Conclusion : Antibacterial effectivity of triantibiotic mixture against E. faecalis biofilm is equal to2% chlorhexidine.

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Latar Belakang: Remineralisasi dentin dapat dicapai melalui beberapa metode, di antaranya secara Guided Tissue Remineralization (GTR) dalam sistem Polymer-Induced Liquid Precursor (PILP). Remineralisasi secara GTR terbukti dapat meremineralisasi affected dentin dengan membentuk mineral intrafibrillar dan ekstrafibrillar. Melalui sistem PILP, kristal terbentuk dengan ukuran kecil sehingga remineralisasi lebih banyak terjadi secara intrafibrillar. Penambahan fluor dalam sistem PILP diharapkan dapat membentuk kristal fluoroapatit yang berukuran lebih besar dan mampu menyempurnakan remineralisasi hingga ke ekstrafibrillar. Penelitian yang ada selama ini hanya berfokus pada permukaan dentin, sedengkan belum terdapat penelitian untuk membuktikan remineralisasi dengan penambahan fluor yang terjadi pada dinding tubulus dentin. Tujuan: Mengetahui pengaruh penambahan fluor 5ppm dan 25ppm dalam sistem PILP terhadap perubahan topografi dinding tubulus dentin dan persentase fluoroapatit. Metode: Sampel blok dentin terdemineralisasi direndam pada larutan remineralisasi dengan penambahan 5ppm dan 25ppm fluor. Sampel blok dentin kemudian akan dipotong lintang menggunakan metode fraktur lalu diamati dan dianalisis menggunakan uji FE-SEM dan XRD. Hasil: Terjadi perubahan topografi pada dinding tubulus dentin setelah dilakukan remineralisasi melalui proses PILP dengan penambahan 5ppm dan 25ppm fluor selama 14 hari yang dievaluasi secara deskriptif menggunakan FE-SEM. Hasil analisis XRD menunjukkan tidak ada perbedaan bermakna secara statistik penambahan fluor pada larutan remineralisasi PILP terhadap persentase fasa mineral fluoroapatit, namun secara substansi terjadi peningkatan persentase fluorapatit. Kesimpulan: Penambahan fluor dalam sistem PILP berpengaruh terhadap perubahan topografi dinding tubulus dentin dan persentase fluoroapatit. ...... Background: Dentine remineralization can be achieved through several methods, including Guided Tissue Remineralization (GTR) in the Polymer-Induced Liquid Precursor (PILP) system. GTR remineralization has been shown to remineralize affected dentin by forming intrafibrillar and extrafibrillar minerals. Through the PILP system, crystals are formed with small sizes so that more remineralization occurs intrafibrillarly. The addition of fluorine in the PILP system is expected to form larger fluoroapatite crystals and be able to complete the remineralization to extrafibrillar. Existing research so far has only focused on the dentin surface, although there has been no research to prove remineralization with the addition of fluorine that occurs in the dentine tubule walls. Objective: To determine the effect of adding 5ppm and 25ppm fluorine in the PILP system on changes in the topography of the dentinal tubule walls and the percentage of fluoroapatite. Methods: Demineralized dentine block samples were immersed in remineralization solution with the addition of 5 ppm and 25 ppm fluorine. The dentine block samples will then be cross-sectioned using the fracture method and then observed and analyzed using the FE-SEM and XRD tests. Results: Topographical changes occurred in the dentinal tubule walls after remineralization through the PILP process with the addition of 5ppm and 25ppm fluorine for 14 days which were evaluated descriptively using FE-SEM. The results of the XRD analysis showed that there was no statistically significant difference in the addition of fluorine to the percentage of fluoroapatite mineral phase in the addition of fluorine to the percentage of fluoroapatite, but in substance there was an increase in the percentage of fluorapatite. Conclusion: The addition of fluorine in the PILP system affected the topography of the dentinal tubule walls and the percentage of fluoroapatite.