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"ABSTRAK Saat ini non-alcoholic fatty liver disease (NAFLD) merupakan penyebab terbanyak dari penyakit kronik hati pada anak dan dewasa. Penelitian terbaru memperlihatkan chemerin yang merupakan salah satu zat yang diproduksi oleh jaringan lemak memiliki andil penting pada NAFLD. Tujuan penelitian ini adalah membandingkan kadar chemerin dalam darah dibandingkan enzim transaminase dalam mendeteksi secara dini kerusakan sel hati karena non alcoholic fatty liver disease (NAFLD) pada anak dengan obesitas. Penelitian deskriptif potong lintang (n=57) dilakukan pada 2 buah sekolah di Jakarta pada anak usia 9-12 tahun dengan obesitas. Anak yang masuk kriteria penelitian dilakukan pemeriksaan ultrasonografi hati untuk mendeteksi perlemakan hati. Kedua kelompok tersebut sama sama dilakukan pemeriksan kadar enzim transaminase dan chemerin darah. Hasil dari penelitian ini di dapatkan nilai rerata chemerin pada anak yang menderita NAFLD sebesar 96,71 ng/ml sedangkan yang tidak menderita NAFLD sebesar 92,8 ng/ml dengan P= 0,463. Hal ini menunjukkan nilai rerata anak dengan NAFLD dibandingkan dengan anak tanpa NAFLD tidak terdapat perbedaan bermakna. Pada penelitian ini didapatkan pula bahwa pemeriksaan chemerin darah memiliki nilai AUC 0,52 dimana nilainya lebih rendah dibandingkan nilai AUC pemeriksaan SGOT dan SGPT yakni 0,81 dan 0,90. Hasil ini menunjukkan bahwa kadar chemerin darah tidak dapat menjadi prediktor yang lebih baik untuk mendeteksi perlemakan hati dibandingkan pemeriksaan kadar SGOT dan SGPT pada penelitian ini. Manfaat chemerin sebagai prediktor kelainan hati pada anak dengan obesitas perlu diteliti lebih lanjut. ABSTRACT Non-alcoholic fatty liver disease (NAFLD) is currently the most common cause of chronic liver disease in both adults and children. Current studies have shown that chemerin, one of the biologically active substance produced by fat tissue, may have an important role in the progression of NAFLD. The aim of this research was to study whether chemerin is able to predict liver abnormalities due to NAFLD in obese children better than serum transaminases. A cross-sectional descriptive study was conducted in 57 obese subjects 9-12 years of age at 2 elementary schools in Jakarta, Indonesia. Liver ultrasound was performed in eligible subjects to detect fatty liver, along with serum chemerin and serum transaminase tests. Mean chemerin level in NAFLD and non-NAFLD children were 96.71 ng/mL and 92.8 ng/mL (p=0.463), showing no significant difference between serum chemerin level in the NAFLD and non-NAFLD group. The area under the curve (AUC) for serum chemerin was 0.52, lower than the AUC for AST (0.81) and AST (0.90). This shows that serum chemerin is not superior in predicting fatty liver compared to serum transaminase levels in this study. The role of chemerin as a marker to predict liver abnormalities in obese children still needs to be further investigated.;Non-alcoholic fatty liver disease (NAFLD) is currently the most common cause of chronic liver disease in both adults and children. Current studies have shown that chemerin, one of the biologically active substance produced by fat tissue, may have an important role in the progression of NAFLD. The aim of this research was to study whether chemerin is able to predict liver abnormalities due to NAFLD in obese children better than serum transaminases. A cross-sectional descriptive study was conducted in 57 obese subjects 9-12 years of age at 2 elementary schools in Jakarta, Indonesia. Liver ultrasound was performed in eligible subjects to detect fatty liver, along with serum chemerin and serum transaminase tests. Mean chemerin level in NAFLD and non-NAFLD children were 96.71 ng/mL and 92.8 ng/mL (p=0.463), showing no significant difference between serum chemerin level in the NAFLD and non-NAFLD group. The area under the curve (AUC) for serum chemerin was 0.52, lower than the AUC for AST (0.81) and AST (0.90). This shows that serum chemerin is not superior in predicting fatty liver compared to serum transaminase levels in this study. The role of chemerin as a marker to predict liver abnormalities in obese children still needs to be further investigated.;Non-alcoholic fatty liver disease (NAFLD) is currently the most common cause of chronic liver disease in both adults and children. Current studies have shown that chemerin, one of the biologically active substance produced by fat tissue, may have an important role in the progression of NAFLD. The aim of this research was to study whether chemerin is able to predict liver abnormalities due to NAFLD in obese children better than serum transaminases. A cross-sectional descriptive study was conducted in 57 obese subjects 9-12 years of age at 2 elementary schools in Jakarta, Indonesia. Liver ultrasound was performed in eligible subjects to detect fatty liver, along with serum chemerin and serum transaminase tests. Mean chemerin level in NAFLD and non-NAFLD children were 96.71 ng/mL and 92.8 ng/mL (p=0.463), showing no significant difference between serum chemerin level in the NAFLD and non-NAFLD group. The area under the curve (AUC) for serum chemerin was 0.52, lower than the AUC for AST (0.81) and AST (0.90). This shows that serum chemerin is not superior in predicting fatty liver compared to serum transaminase levels in this study. The role of chemerin as a marker to predict liver abnormalities in obese children still needs to be further investigated."

"[ABSTRAKLatar Belakang Lemak merupakan sumber energi penting, komponen utama struktur membran sel dan media penyerapan vitamin larut lemak A, D, E, dan K. Lemak adalah nutrisi utama perkembangan otak anak, penting untuk memeriksa malabsorpsi lemak secara akurat dan tepat. RSCM merupakan rujukan pemeriksaan analisis feses, dengan sekitar 840 pemeriksaan mikroskopik lemak per tahun. Pemeriksaan mikroskopik lemak merupakan satu-satunya yang tersedia di laboratorium RSCM untuk pemeriksaan lemak feses.Tujuan Mengetahui kehandalan pemeriksaan mikroskopik lemak pada analisis feses dalam menggambarkan malabsorpsi lemak pada anak.Metode Uji diagnostik kehandalan pemeriksaan mikroskopik lemak menggunakan Sudan III dibandingkan dengan steatokrit dalam mendiagnosis malabsorpsi lemak pada anak usia 6-60 bulan.Hasil Didapatkan 68 sampel yang terdiri dari 41 laki-laki dan 27 perempuan, median usia 14,3 bulan. Konsistensi feses terbanyak adalah lembek (50,0%). Dengan metode mikroskopik didapatkan lemak terbanyak adalah positif satu pada 29 sampel (42,6%). Sensitivitas pemeriksaan mikroskopik lemak didapatkan sebesar 49,15%, spesifisitas sebesar 66,67%, dengan nilai prediksi positif 90,63% dan nilai prediksi negatif 16,67%.Kesimpulan Pemeriksaan mikroskopik lemak memiliki sensitivitas yang tidak terlalu tinggi dalam mendiagnosis malabsorpsi lemak dan perlu dilengkapi dengan metode lain seperti steatokrit.

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ABSTRACTBackground Lipid is a very important source of energy, major component of cell membrane structure and media for absorption of lipid-soluble vitamins A, D, E, and K. Lipid is the major nutrition for brain development, and thus it is important to test lipid malabsorption accurately. RSCM is the referral hospital for fecal analysis, with 840 lipid microscopic examination done each year. This microscopic test is the only method currently available for fecal lipid malabsorption at RSCM laboratory.Objective To know whether the lipid microscopid test as a part of fecal analysis that have been done so far is effective in representing lipid malabsorption in children.Methods Diagnostic test for effectivity of lipid microscopic test using Sudan III compared to steatocrit test in diagnosing lipid malabsorption in children 6-60 months old suspected to have lipid malabsorption.Results Sixty-eight children consisting of 41 boys and 27 girls were included in the study, with median age 14,3 months. The most common stool consistency was mushy (50,0%). Using microscopic method the most frequent group was positive one in 29 subjects (42,6%). Sensitivity of lipid microscopic test was found to be 49,15% with specificity 66,67%, PPV 90,63% and NPV 16,67%.Conclusion The lipid microscopic test has a moderate sensitivity in diagnosing fat malabsorption, and needs to be complemented with other method such as steatocrit., Background Lipid is a very important source of energy, major component of cell membranestructure and media for absorption of lipid-soluble vitamins A, D, E, and K. Lipid is themajor nutrition for brain development, and thus it is important to test lipid malabsorptionaccurately. Cipto Mangunkusumo Hospital (CMH) is a referral hospital for fecal analysis,with 840 lipid microscopic examination done each year. This microscopic test is the onlymethod currently available for fecal lipid malabsorption at CMH laboratory.Objective To know whether the lipid microscopic test as a part of fecal analysis that isperformed routinely so far is effective in representing lipid malabsorption in children.Methods Diagnostic test for effectivity of lipid microscopic test using Sudan III compared tosteatocrit test in diagnosing lipid malabsorption in children 6-60 months old suspected tohave lipid malabsorption.Results Sixty-nine children consisting of 41 boys and 27 girls were included in the study,with median age 14,3 months. The most common stool consistency was mushy (50,0%).Using microscopic method the most frequent group was positive one in 29 subjects (42,6%).Sensitivity of lipid microscopic test was found to be 49,15% with specificity 66,67%, PPV90,63% and NPV 16,67%.Conclusion Lipid microscopic test has a moderate sensitivity in diagnosing fat malabsorption, and needs to be complemented with other method such as steatocrit.]"

"ABSTRAK Penelitian mengenai asupan serat pangan dan air dan kejadian konstipasi pada remaja masih belum banyak Tujuan penelitian ini untuk mendapatkan profil jumlah asupan serat pangan dan air pada remaja serta hubungan antara asupan serat pangan dan air terhadap pola buang air besar konsistensi tinja dan konstipasi Studi potong lintang dilakukan pada 120 siswa SMU berusia 15 17 tahun dilakukan selama Oktober Desember 2015 Data jumlah asupan energi karbohidrat protein lemak air dan serat bahan makanan dan minuman dikumpulkan dengan menggunakan food record form selama 2x24 jam dan food frequency questionnaire FFQ Subjek terdiri dari 82 anak perempuan 68 3 dan 38 anak lelaki 31 7 sebagian besar dengan gizi baik dan perawakan normal Hanya dua subjek yang mengalami konstipasi Median asupan energi protein lemak dan karbohidrat air dan serat berturut turut sebanyak 1419 3 kalori 54 6 gram 48 4 gram dan 183 2 gram 2079 mL dan 5 1 gram Jumlah asupan energi karbohidrat dan air subjek lelaki secara bermakna lebih tinggi dibandingkan perempuan Tidak didapatkan hubungan bermakna antara asupan serat pangan dan air dengan kejadian konstipasi Data yang didapat menunjukkan jumlah asupan serat pangan remaja usia 15 17 tahun di bawah AKG yang dianjurkan Sebaliknya jumlah asupan air sesuai dengan AKG yang dianjurkan Data yang didapat diharapkan dapat dipergunakan sebagai dasar untuk penelitian selanjutnya ABSTRACT Indonesian children and adolescent are alleged not to consume sufficient fiber and water while studies show fiber and water affect defecation profile This cross sectional study records the amount of fiber and water intake of Indonesian adolescents aged 15 17 years and their defecation pattern Subjects are 120 SMU 68 students aged 15 17 years 82 girls and 38 boys The study was conducted between October and December 2015 We attempt to find any correlation between fiber and water intake and defecation profile Most of the subjects were well nourished and normal stature Median water and fiber intake were 2079 mL and 5 1 grams The median of energy protein fats and carbohydrates intake were 1419 3 calories 54 6 grams 48 4 grams and 183 2 grams consecutively Only two subjects who experienced constipation About 49 subjects had abdominal pain according to Rome III Criteria We found there is no significant association between dietary fiber intake and water consumption and constipation However we feel that future study should be carried out to encrich our data in this field ;Indonesian children and adolescent are alleged not to consume sufficient fiber and water while studies show fiber and water affect defecation profile This cross sectional study records the amount of fiber and water intake of Indonesian adolescents aged 15 17 years and their defecation pattern Subjects are 120 SMU 68 students aged 15 17 years 82 girls and 38 boys The study was conducted between October and December 2015 We attempt to find any correlation between fiber and water intake and defecation profile Most of the subjects were well nourished and normal stature Median water and fiber intake were 2079 mL and 5 1 grams The median of energy protein fats and carbohydrates intake were 1419 3 calories 54 6 grams 48 4 grams and 183 2 grams consecutively Only two subjects who experienced constipation About 49 subjects had abdominal pain according to Rome III Criteria We found there is no significant association between dietary fiber intake and water consumption and constipation However we feel that future study should be carried out to encrich our data in this field ;Indonesian children and adolescent are alleged not to consume sufficient fiber and water while studies show fiber and water affect defecation profile This cross sectional study records the amount of fiber and water intake of Indonesian adolescents aged 15 17 years and their defecation pattern Subjects are 120 SMU 68 students aged 15 17 years 82 girls and 38 boys The study was conducted between October and December 2015 We attempt to find any correlation between fiber and water intake and defecation profile Most of the subjects were well nourished and normal stature Median water and fiber intake were 2079 mL and 5 1 grams The median of energy protein fats and carbohydrates intake were 1419 3 calories 54 6 grams 48 4 grams and 183 2 grams consecutively Only two subjects who experienced constipation About 49 subjects had abdominal pain according to Rome III Criteria We found there is no significant association between dietary fiber intake and water consumption and constipation However we feel that future study should be carried out to encrich our data in this field "