Hasil Pencarian  ::  Simpan CSV :: Kembali

"Pengaruh Ekstrak Daun Jintan (Plectranthus amboinicus) terhadap Kadar BUN dan Kreatinin serta Respon Seluler Faktor Proinflamasi TNF-α dan IL-1β Pasien Gout Artritis. Pengobatan gout artritis (GA) saat ini dikembangkan berbasis anti sitokin yaitu blokade kemokin, penghambatan pelepasan IL-1β dan TNF-α. Tujuan penelitian ini adalah mengembangkan pengobatan berbasis anti sitokin dengan menggunakan ekstrak daun jintan yang diaplikasikan pada penderita GA. Penelitian ini adalah penelitian eksperimental semu dengan desain penelitian randomized pretest-posttest control group design. Pengambilan sampel pasien GA di Instalasi Rawat Jalan Poli Penyakit Dalam RSU Haji Surabaya yang memenuhi kriteria inklusi dan eksklusi. Jumlah sampel sebanyak 30 responden terbagi menjadi kelompok perlakuan dan kelompok kontrol masing-masing 15 responden. Pada kelompok perlakuan diminta untuk minum obat dari Rumah Sakit ditambah dengan kapsul ekstrak daun jintan selama 7 hari, dengan dilakukan pengamatan keradangan sendi. Pada kelompok kontrol minum obat dari Rumah Sakit dan dilakukan pengamatan keradangan sendi. Sampel darah diambil sebelum dan sesudah perlakuan untuk mengukur kadar BUN, kreatinin, konsentrasi TNF-α dan IL-1β. Terdapat penurunan kadar BUN dan kreatinin pada kelompok kontrol namun tidak signifikan yaitu menurun sebesar 3% dan 8%. Sementara pada kelompok perlakuan terdapat peningkatan kadar BUN dan Kreatinin namun juga tidak signifikan sebesar 3% dan 7%. Terdapat penurunan konsentrasi TNF-α pada kelompok kontrol sebesar 9% dan kelompok perlakuan sebesar 22%, keduanya tidak signifikan. Sementara konsentrasi IL-1β terjadi peningkatan pada kelompok kontrol sebesar 18%, sementara pada kelompok perlakuan terjadi penurunan sebesar 3%, keduanya tidak signifikan.

---

The purpose of this research was to develop anti-cytokine-based treatment using extract of Plectranthus amboinicus applied to gout arthritis (GA) patients. The research was quasi experimental, with a pretest-posttest randomized control group design. The samples were GA patients in the Outpatient Installation of Internal Medicine in General Hospital Haji, Surabaya. The sample was comprised of 30 respondents. The respondents were divided into a treatment group and a control group. The treatment group was asked to take medicine from the hospital, coupled with P. amboinicus extract capsules, for 7 days, during which time patients? joint inflammation was observed. The control group was provided with only medication from the hospital, and their joint inflammation was likewise observed. Blood samples were taken before and after treatment, to measure the levels of blood urea nitrogen (BUN) and creatinine, as well as the concentrations of TNF-α and IL-1β. There was a decrease in BUN and creatinine levels in the control group, but it was not significant, decreasing by 3% and 8%, respectively. The treatment group also showed elevated levels of BUN and creatinine, which also was not significant at 3% and 7%, respectively. There was a decrease in the concentration of TNF-α in the control group by 9% and 22%. The concentration of IL-1β in the control group increased by 18%, whereas,in the treatment group, it decreased by 3%; however, the decreases in both groups were not significant."

"Background: The aim of this study was to analyse differences in bone density and vitamin D and calcium concentrationsbetween pregnant and non-pregnant women. Methods: This was an analytical, cross-sectional study of women aged 30years or over, residing in the Puskesmas Bangkalan district. The sample population was chosen at random and included10 pregnant women in their third trimester and 10 non-pregnant women. This observational study consisted of aninterview, a blood test, and a 24-hour recall. The concentration of serum vitamin D (25(OH)D) was measured by GasChromatography and a Photometric Test measured the concentration of serum calcium. Participant’s bone density wasmeasured by bone ultra sonometer. The data was analysed using the Mann-Whitney test and assessed ultraviolet-Bexposure, bone density values, and consumption of vitamin D, calcium, energy, and protein. The Student t-test wasused to analyse serum vitamin D and calcium concentrations. Results: There were no differences between the groups’serum vitamin D concentrations (p = 0.946). However, there were significant differences between the groups’ serumcalcium concentrations (p = 0.047) and bone density values (p = 0.019). Conclusions: A high prevalence of vitamin Ddeficiency (25(OH)D < 50 nmol/L) and insufficiency (25(OH)D < 80 nmol/L) was observed in both groups. The meanserum calcium concentrations and bone density values were lower in pregnant subjects than non-pregnant subjects."

"The purpose of this research was to develop anti-cytokine-based treatment using extract of Plectranthus amboinicusapplied to gout arthritis (GA) patients. The research was quasi experimental, with a pretest-posttest randomized controlgroup design. The samples were GA patients in the Outpatient Installation of Internal Medicine in General HospitalHaji, Surabaya. The sample was comprised of 30 respondents. The respondents were divided into a treatment group anda control group. The treatment group was asked to take medicine from the hospital, coupled with P. amboinicus extractcapsules, for 7 days, during which time patients’ joint inflammation was observed. The control group was provided withonly medication from the hospital, and their joint inflammation was likewise observed. Blood samples were takenbefore and after treatment, to measure the levels of blood urea nitrogen (BUN) and creatinine, as well as theconcentrations of TNF-α and IL-1β. There was a decrease in BUN and creatinine levels in the control group, but it wasnot significant, decreasing by 3% and 8%, respectively. The treatment group also showed elevated levels of BUN andcreatinine, which also was not significant at 3% and 7%, respectively. There was a decrease in the concentration ofTNF-α in the control group by 9% and 22%. The concentration of IL-1β in the control group increased by 18%,whereas,in the treatment group, it decreased by 3%; however, the decreases in both groups were not significant.Pengaruh Ekstrak Daun Jintan (Plectranthus amboinicus) terhadap Kadar BUN dan Kreatinin serta ResponSeluler Faktor Proinflamasi TNF-α dan IL-1β Pasien Gout Artritis. Pengobatan gout artritis (GA) saat inidikembangkan berbasis anti sitokin yaitu blokade kemokin, penghambatan pelepasan IL-1β dan TNF-α. Tujuanpenelitian ini adalah mengembangkan pengobatan berbasis anti sitokin dengan menggunakan ekstrak daun jintan yangdiaplikasikan pada penderita GA. Penelitian ini adalah penelitian eksperimental semu dengan desain penelitianrandomized pretest-posttest control group design. Pengambilan sampel pasien GA di Instalasi Rawat Jalan PoliPenyakit Dalam RSU Haji Surabaya yang memenuhi kriteria inklusi dan eksklusi. Jumlah sampel sebanyak 30responden terbagi menjadi kelompok perlakuan dan kelompok kontrol masing-masing 15 responden. Pada kelompokperlakuan diminta untuk minum obat dari Rumah Sakit ditambah dengan kapsul ekstrak daun jintan selama 7 hari,dengan dilakukan pengamatan keradangan sendi. Pada kelompok kontrol minum obat dari Rumah Sakit dan dilakukanpengamatan keradangan sendi. Sampel darah diambil sebelum dan sesudah perlakuan untuk mengukur kadar BUN,kreatinin, konsentrasi TNF-α dan IL-1β. Terdapat penurunan kadar BUN dan kreatinin pada kelompok kontrol namuntidak signifikan yaitu menurun sebesar 3% dan 8%. Sementara pada kelompok perlakuan terdapat peningkatan kadarBUN dan Kreatinin namun juga tidak signifikan sebesar 3% dan 7%. Terdapat penurunan konsentrasi TNF-α padakelompok kontrol sebesar 9% dan kelompok perlakuan sebesar 22%, keduanya tidak signifikan. Sementara konsentrasiIL-1β terjadi peningkatan pada kelompok kontrol sebesar 18%, sementara pada kelompok perlakuan terjadi penurunansebesar 3%, keduanya tidak signifikan."