Yosita Anggraeni
Abstrak :
[ABSTRAK
Suplemen besi yang mengandung ferrous sulfat umum digunakan untuk anti
anemia. Sediaan ini memiliki rasa tidak enak, menyebabkan mual dan jika
digunakan dengan dosis besar dan jangka waktu lama dapat menyebabkan efek
samping. Perlu dicari alternative sumber lain, termasuk dari tanaman. Daun
Moringa pterigospera Gaertn dipilih karena mengandung besi dan suplemen lain.
Penelitian ini bertujuan untuk membuat formulasi serbuk instan untuk anti anemia
sebagai alternatif suplementasi zat besi selain dari ferous sulfat, dengan
menggunakan ekstrak dari daun kelor (Moringa pterigosperma Gaertn). Ekstrak
diperoleh dengan metode Microwave Assisted Extraction. Optimasi kondisi
dibuat dengan memvariasikan pelarut etanol (0-70%), daya listrik microwave
(450-900 watt) dan waktu ekstraksi 3-10 menit. Analisa kadar besi dilakukan
menggunakan Spektrofotometer Serapan Atom pada panjang gelombang 248 nm.
Formula serbuk instan dibuat dengan 3 konsentrasi natrium CMC sebagai bahan
pensuspensi. Penelitian menunjukkan bahwa kondisi optimal ekstraksi yang
menghasilkan kandungan besi paling besar (2,4 mg/g ekstrak) dicapai dengan
daya listrik 900 watt, waktu ekstraksi 10 menit dan pelarut air suling. Berdasarkan
uji hedonis dengan 30 panelis, formula dengan 5% natrium CMC paling disukai.
Bentuk serbuk memiliki kadar air 2,31%, laju alir 7,74 g/detik dan bentuk
rekonstitusinya memiliki pH 5,78, dan viskositas 15,98 cps.
ABSTRACT
Iron supplement contains ferrous sulfate is commonly used for anemia. Ferrous
sulfate has bad taste, can cause nausea, and made adverse effects if taken in large
doses for long periods. It is necessary to find an alternative source of raw
materials, including those from plants. Moringa pterigospera Gaertn leaves was
selected because it contains iron and other nutritions. The purpose of this work
was to make instant powder formula for anti anemia using Moringa leave?s extract
as an alternative for ferous suphate iron suplementation. The extraction was
performed by Microwave Assisted Extraction method. Optimation of extraction
condition was performed by creating some variations in solvent composition (0-
70% ethanol), microwave power (450 to 900 watts) and extraction time (3 to 10
min). Iron content was determined by Atomic Absorption Spectrophotometer at
wavelength of 248 nm. Instant powder formula was made in 3 concentrations of
sodium CMC as suspending agent. Results of the study showed that the most
optimal extraction condition which resulted the highest iron content (2.4 mg
iron/g extracts) achieved with 900 watts microwave power, 10 min extraction time
and aquademineralisata. According to 30 panelists of hedonic test, formula which
used 5% w/w of sodium CMC got the highest scores. Its powder form had 2.31%
of loss on drying and 7.74 g/sec of flow rate for powder form and pH of 5.78,
viscosity of 15.98 cps for reconstituted form.;Iron supplement contains ferrous sulfate is commonly used for anemia. Ferrous
sulfate has bad taste, can cause nausea, and made adverse effects if taken in large
doses for long periods. It is necessary to find an alternative source of raw
materials, including those from plants. Moringa pterigospera Gaertn leaves was
selected because it contains iron and other nutritions. The purpose of this work
was to make instant powder formula for anti anemia using Moringa leave’s extract
as an alternative for ferous suphate iron suplementation. The extraction was
performed by Microwave Assisted Extraction method. Optimation of extraction
condition was performed by creating some variations in solvent composition (0-
70% ethanol), microwave power (450 to 900 watts) and extraction time (3 to 10
min). Iron content was determined by Atomic Absorption Spectrophotometer at
wavelength of 248 nm. Instant powder formula was made in 3 concentrations of
sodium CMC as suspending agent. Results of the study showed that the most
optimal extraction condition which resulted the highest iron content (2.4 mg
iron/g extracts) achieved with 900 watts microwave power, 10 min extraction time
and aquademineralisata. According to 30 panelists of hedonic test, formula which
used 5% w/w of sodium CMC got the highest scores. Its powder form had 2.31%
of loss on drying and 7.74 g/sec of flow rate for powder form and pH of 5.78,
viscosity of 15.98 cps for reconstituted form., Iron supplement contains ferrous sulfate is commonly used for anemia. Ferrous
sulfate has bad taste, can cause nausea, and made adverse effects if taken in large
doses for long periods. It is necessary to find an alternative source of raw
materials, including those from plants. Moringa pterigospera Gaertn leaves was
selected because it contains iron and other nutritions. The purpose of this work
was to make instant powder formula for anti anemia using Moringa leave’s extract
as an alternative for ferous suphate iron suplementation. The extraction was
performed by Microwave Assisted Extraction method. Optimation of extraction
condition was performed by creating some variations in solvent composition (0-
70% ethanol), microwave power (450 to 900 watts) and extraction time (3 to 10
min). Iron content was determined by Atomic Absorption Spectrophotometer at
wavelength of 248 nm. Instant powder formula was made in 3 concentrations of
sodium CMC as suspending agent. Results of the study showed that the most
optimal extraction condition which resulted the highest iron content (2.4 mg
iron/g extracts) achieved with 900 watts microwave power, 10 min extraction time
and aquademineralisata. According to 30 panelists of hedonic test, formula which
used 5% w/w of sodium CMC got the highest scores. Its powder form had 2.31%
of loss on drying and 7.74 g/sec of flow rate for powder form and pH of 5.78,
viscosity of 15.98 cps for reconstituted form.]
Depok: Fakultas Farmasi Universitas Indonesia, 2014
T43438
UI - Tesis Membership Universitas Indonesia Library
