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Abstrak :
Mata ajaran kimia berada di bawah Departemen/Bagian Dasar Keperawatan dan Keperawatan Dasar, diberikan kepada mahasiswa program A FIK-UI pada tahun akademik pertama tepatnya pada semester gasal. Mata ajaran kimia dikelompokkan ke dalam Mata Kuliah Dasar Keahlian (MKDK) karena merapakan prasyarat dalam mempelajari mata ajaran Biokimia, dan sebagai landasan dalam mempelajari ilmu-ilmu lanjutan lainnya yang berkaitan. Mata ajaran ini terdiri dad 2 sks, dengan rincian 1,5 sks teori dan 0,5 sks praktikum. 1.1 Deskripsi Mata Ajaran
Fokus pada teori-teori dasar kimia prinsip-prinsip kimiawi larutan dan senyawa organik, dengan penekanan pada sifat-sifat larutan, keseimbangan asam basa dan sistem buffer tubuh, kelarutan gas, sifat-sifat fisik dan kimia serta manfaat dari senyawa organik, karbohidrat, lipid dan protein.
1.2 Sasaran-Sasaran Pembelajaran
1.2.1 Tujuan Intruksional Umum Mata Ajaran.
Setelah menyelesaikan mata ajaran ini, mahasiswa mampu memahami teori dan prinsip-prinsip kimia sebagai landasan dalam. mempelajari ilmu-ilmu lanjutan lainnya yang berkaitan, untuk diterapkan dalam melaksannkan asuhan keperawatan.
1.2.2 Sasaran Pembelajaran Terminal Mata Ajaran
Setelah menyelesaikan mata ajaran ini mahasiswa mampu menggunakan teori -teori dasar kimia dari gas, campuran zat cair, asam-basa, prinsip-prinsip kimia dari cairan tubuh manusia dan sifat-sifat fisik dan kimia dari senyawa organik sebagai landasan dalam mempelajari ilmu-ilmu lanjutan yang mendasari tindakan asuhan keperawatan.

Abstrak :
Alpha-glucosidase (EC 3.2.1.20) is a carbohydrase that catalyzes the liberation of a-glucose from the nonreducing end of the diet carbohydrate. In diabetic patients, inhibition of these enzymes causes the restraint of glucose absorption and decreases the postprandial hyperglycemia. The purpose of this research is to study the antihyperglycemic activity of mahkota dewa [Phaleria macrocarpa (Scheff.) Boerl.] leaf extracts by inhibition test to alpha glucosidase enzyme. This research was conducted in three steps: fractionation and extraction samples with methanol, ethyl acetate, n-butanol, and water, followed by phytochemistry screening and alpha-glucosidase inhibition test. The alpha-glucosidase inhibition test was performed by using alpha-glucosidase enzyme and p-nitrophenyl α-D-glucopyranoside as a substrate. The result of phytochemistry screening showed that Mahkota dewa leaves contain class of phenolics, thanins, flavonoids, alkaloids, and carbohydrates. The result of alpha-glucosidase inhibition test showed that ethyl acetate fraction extract had the highest inhibition activity with inhibition percentage at 50 ppm for old leaves which is 55.04% and for young leaves which is 56.92%. At 50 ppm, inhibition activity from the methanol extract and boiled water extract of old leaves is higher than that of young leaves with inhibition percentage of old leaves methanol extract which is 14.25% and 10.97% for young leaves and for old leaves; boiled water extract is 10.32% and 6.85% for young leaves. For n-butanol fraction extract, inhibition activity of young leaf extract (14.26%) is higher than old leaf extract (9.49%).