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Abstrak :
[ABSTRAK
Usaha Kecil Menengah (UKM) mempunyai peran yang strategis dalam pembangunan ekonomi nasional, karena selain berperan dalam pertumbuhan ekonomi dan penyerapan tenaga kerja juga berperan dalam pendistribusian hasil-hasil pembangunan. Terdapat beberapa aspek yang dapat mempengaruhi keberlangsungan UKM, yaitu sumber daya manusia, finansial, kepuasan konsumen, proses produksi dan infrastruktur UKM. Namun lebih dari 70% usaha kecil dan menengah “mati” dalam waktu lima tahun sejak usaha tersebut didirikan akibatnya kurangnya penerapan sistem manajemen mutu pada UKM. Sistem manajemen mutu yang populer digunakan adalah ISO 9001. Saat ini akan segera hadir edisi terbaru ISO 9001:2015 yang menekankan pentingnya penerapan manajemen risiko pada bisnis. Sehingga penerapan sistem manajemen mutu untuk UKM berdasarkan ISO 9001:2015 dengan fokus pada manajemen risiko terhadap aspek-aspek yang mempengaruhi keberlangsungan UKM perlu dilakukan untuk mempermudah para pemilik UKM menjaga keberlangsungan bisnisnya. Langkah pertama yang dilakukan adalah penentuan 20 faktor dari kelima aspek yang ada, setelah itu dilakukan validasi faktor sehingga diperoleh 14 faktor yang dianggap memiliki risiko penting terhadap keberlangsungan UKM untuk selanjutnya dibobotkan menggunakan metode multi criteria decision making (AHP) dengan bantuan software Expert Choice. Tahap selanjutnya adalah identifikasi dan analisa risiko dari keempat belas faktor yang dianggap memiliki risiko penting terhadap keberlangsungan UKM, dari hasil analisa diperoleh 6 faktor (keahlian dan keterampilan pegawai, kinerja pegawai, tanggung jawab pegawai, harga yang kompetitif, mutu pelayanan, mutu produk) yang berada pada kategori level risiko tinggi dan tidak dapat diterima.

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ABSTRACT
Small and medium enterprises (SME) has a role in a strategicway to national economic development, its role in economic growth, creating job and also participate in distribution of development. There are several aspects that might affect the sustainability of small and medium business like human resources, financial, customer satisfaction, production process and infrastructure of SME. However, more that 70% of SME are “death” within five years since its established as a result a lack of the implementation quality management system (QMS) for SME. A popular QMS used to implementing in business is ISO 9001. Soon, there will be ISO 9001:2015 as the newest edition of ISO 9001 that emphasizes the importance of risk management iplementation for business. Therefore the implementation of QMS for SME based on ISO 9001:2015 with the focus on risk management againts the aspect that affect sustainability of SME is necessary to be done to ease the owners of SME in maintaining the sustaianability of their business. The first step is determinating of 20 factors from the fifthh aspects, and then validating the factors so obtained 14 factors considered to have an important risk for the sustainability of SME to be weighting using a multi criteria decision making method (AHP) by Expert Choice Software. The next step is identificating and analyzing the risk of 14 factors that affecting sustainability of SME, the results is there are 6 factors (skill of employee, performance of employee, responsibility of employee, competitive price, quality of product and quality of service) that affecting sustainability of SME most and unacceptable because it located on a high level of risk .;Small and medium enterprises (SME) has a role in a strategicway to national economic development, its role in economic growth, creating job and also participate in distribution of development. There are several aspects that might affect the sustainability of small and medium business like human resources, financial, customer satisfaction, production process and infrastructure of SME. However, more that 70% of SME are “death” within five years since its established as a result a lack of the implementation quality management system (QMS) for SME. A popular QMS used to implementing in business is ISO 9001. Soon, there will be ISO 9001:2015 as the newest edition of ISO 9001 that emphasizes the importance of risk management iplementation for business. Therefore the implementation of QMS for SME based on ISO 9001:2015 with the focus on risk management againts the aspect that affect sustainability of SME is necessary to be done to ease the owners of SME in maintaining the sustaianability of their business. The first step is determinating of 20 factors from the fifthh aspects, and then validating the factors so obtained 14 factors considered to have an important risk for the sustainability of SME to be weighting using a multi criteria decision making method (AHP) by Expert Choice Software. The next step is identificating and analyzing the risk of 14 factors that affecting sustainability of SME, the results is there are 6 factors (skill of employee, performance of employee, responsibility of employee, competitive price, quality of product and quality of service) that affecting sustainability of SME most and unacceptable because it located on a high level of risk ., Small and medium enterprises (SME) has a role in a strategicway to national economic development, its role in economic growth, creating job and also participate in distribution of development. There are several aspects that might affect the sustainability of small and medium business like human resources, financial, customer satisfaction, production process and infrastructure of SME. However, more that 70% of SME are “death” within five years since its established as a result a lack of the implementation quality management system (QMS) for SME. A popular QMS used to implementing in business is ISO 9001. Soon, there will be ISO 9001:2015 as the newest edition of ISO 9001 that emphasizes the importance of risk management iplementation for business. Therefore the implementation of QMS for SME based on ISO 9001:2015 with the focus on risk management againts the aspect that affect sustainability of SME is necessary to be done to ease the owners of SME in maintaining the sustaianability of their business. The first step is determinating of 20 factors from the fifthh aspects, and then validating the factors so obtained 14 factors considered to have an important risk for the sustainability of SME to be weighting using a multi criteria decision making method (AHP) by Expert Choice Software. The next step is identificating and analyzing the risk of 14 factors that affecting sustainability of SME, the results is there are 6 factors (skill of employee, performance of employee, responsibility of employee, competitive price, quality of product and quality of service) that affecting sustainability of SME most and unacceptable because it located on a high level of risk .]

Abstrak :
Senyawa bioaktif Annonaceous acetogenin yang berasal dari tanaman sirsak (Annona muricata) ditemukan memiliki sifat sitotoksik dan antitumor secara spesifik terhadap beberapa jenis kanker, di antaranya adalah kanker usus, payudara, paru-paru, pankreas, dan ginjal. Acetogenin yang diperoleh dari proses ekstraksi daun sirsak, kemudian dianalisis secara kualitatif (TLC, BST, FTIR) dan kuantitatif (Spektrofotometri UV-Vis). Hasil ekstraksi terbagi menjadi lima fraksi yang diberi nama F001, F002, F003, F0004, F005, dan diduga bahwa F005 mengandung acetogenin. F005 kemudian diisolasi dan terpisah ke dalam 13 bagian dengan bagian 6-9 mengandung acetogenin. Analisis kuantitatif dilakukan dengan menghitung kandungan gugus lakton acetogenin, menggunakan senyawa standar andrographolida. Penggunaan andrographolida sebagai senyawa standar dikarenakan senyawa murni acetogenin sulit didapat, dan andrographolida memiliki gugus lakton yang hampir sama dengan acetogenin, selain itu pada daun sirsak hanya acetogenin yang memiliki gugus lakton sehingga penentuan berdasarkan gugus lakton dapat dilakukan. Berdasarkan analisis kualitatif, hasil ekstraksi dan isolasi positif mengandung senyawa aktif acetogenin dan dari hasil analisis kualitatif diketahui F005 mengandung acetogenin paling banyak dibandingkan dengan hasil isolasi. Besarnya kandungan acetogenin pada F005 adalah 14.2% sedangkan untuk hasil isolasi berkisar antara 7% - 12%. ......Bioactive substance annonaceous acetogenin which is originated/derived from soursop plant (Annona muricata) has been found to posses specific cytotoxic and anti-tumor properties to several cancers including colon, pancreatic, lung, and breast cancers. The acatogenin extracted from sousop leaves was analyzed qualitatively using TLC, BST, FTIR and quantititavely using UV-Vis spectrophotometry. The extracts were divided into 5 (five) fractions and F005 fraction was found to contain acetogenin. The F005 was isolated, producing 13 bottles in which bottles 6 to 9 contained acetogenin. Quantitaive analysis was performed by measuring acetogenin lactone group using standard andrographolida compound. The use of this standard compound was due to the difficulty in finding pure acetogenin compound, and by the fact that andrographolida compound have similar lactone group with that of acetogenin, In addition, in soursop leaves there was only acetogenin which had lactone group so that the determination based on lacton group could be carried out. On the basis of qualitative analysis, the result of extraction and isolation were positively confirmed to contain the active acetogenin ingredient, while the quantitative analysis showed that F005 produced more acetogenin than the isolation.