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"Praktik Kerja Profesi Apoteker (PKPA) di instansi Distributor dilaksanakan padaKimia Farma Trading & Distribution Jakarta 3 pada bulan November tahun 2022.Adapun kegiatan PKPA di instansi distributor bertujuan untuk pembelajaran danmemahami peran serta tanggung jawab seorang apoteker melingkupi pada ruanglingkup distributor. Pada pelaksanaan PKPA di distributor, dilakukan penyusunanlaporan tugas khusus terkait pengkajian penanganan produk rantai dingin sertaproduk retur pada Kimia Farma Trading & Distribution Jakarta 3. Kegiatan tersebutbertujuan untuk mengkaji penanganan produk rantai dingin meliputi kegiatanpenerimaan, penyimpanan, penyaluran, bangunan dan fasilitas. Pengkajianmengacu kepada pedoman Cara Distribusi Obat yang Baik (CDOB). Berdasarkanpengkajian yang telah dilakukan, terkait aspek penerimaan, penyimpanan,penyaluran, bangunan dan fasilitas serta kalibrasi alat yang digunakan padaPT.Kimia Farma Trading & Distribution Jakarta 3 telah sesuai dengan pedomanCara Distribusi Obat yang Baik (CDOB).

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Pharmacist Professional Work Practice (PKPA) at the Distributor institution was

held at Kimia Farma Trading & Distribution Jakarta 3 in November 2022. The

PKPA activities at the pharmacy agency aim to learn and understand the roles and

responsibilities of a pharmacist in the scope of the distributor. In the

implementation of PKPA at the distributor, a report was prepared related to the

assessment of cold chain product handling and returned products at Kimia Farma

Trading & Distribution Jakarta 3. The activity aims to assess the handling of cold

chain products including receiving, storage, distribution, buildings and facilities.

The assessment refers to the guidelines for Good Distribution Practice (GDP).

Based on the assessment that has been carried out, related aspects of receiving,

storage, distribution, buildings and facilities and calibration of equipment used at

PT Kimia Farma Trading & Distribution Jakarta 3 are in accordance with the

guidelines for Good Distribution Practice (GDP)."

"Praktik Kerja Profesi Apoteker (PKPA) di instansi Rumah Sakit dilaksanakan pada RumahSakit Universitas Indonesia pada bulan Januari dan Februari tahun 2023. Adapun kegiatanPKPA di instansi industri bertujuan untuk pembelajaran dan memahami peran serta tanggungjawab seorang apoteker melingkupi pada ruang lingkup rumah sakit. Pada pelaksanaan PKPAdi rumah sakit, dilakukan penyusunan laporan tugas khusus terkait pembuatan booklet sebagaisarana informasi pelayanan farmasi pada penyakit HIV. Kegiatan tersebut bertujuan sebagaisarana informasi mengenai pelayanan kefarmasian penyakit HIV yang mudah dipahami olehtenaga kesehatan di Rumah Sakit Universitas Indonesia. Pembuatan booklet berdasarkanberbagai sumber literatur yang telah dikumpulkan

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Pharmacist Professional Work Practice (PKPA) at the Hospital institution was held at the Rumah Sakit Universitas Indonesia in January and February 2023. The PKPA activities in industrial institutions aim to learn and understand the roles and responsibilities of a pharmacist

within the scope of the hospital. In the implementation of PKPA at the hospital, a report was prepared related to the preparation of a booklet as a means of information on pharmaceutical

services in HIV disease. This activity aims to provide information about pharmaceutical

clinical services for HIV disease that is easily understood by health workers at the Rumah Sakit Universitas Indonesia. The preparation of booklets based on various literature sources that have been collected."

"Praktik Kerja Profesi Apoteker (PKPA) di instansi Puskesmas dilaksanakan padaPuskesmas Kecamatan Pasar Rebo pada bulan Mei tahun 2023. Adapun kegiatanPKPA di instansi puskesmas bertujuan untuk pembelajaran dan memahami peranserta tanggung jawab seorang apoteker melingkupi pada ruang lingkup puskesmas.Pada pelaksanaan PKPA di puskesmas, dilakukan penyusunan laporan tugas khususterkait pengkajian pengelolaan obat pada gudang obat puskesmas kecamatan pasarrebo. Kegiatan tersebut bertujuan untuk mengevaluasi pengelolaan obat di GudangObat Puskesmas Kecamatan Pasar Rebo dan mengalanisis ketidaksesuaian stokfisik dengan kartu stok obat di Gudang Obat Puskesmas Kecamatan Pasar Reboserta dampak yang dapat ditimbulkan. Evaluasi menggunakan dasar pedomanPetunjuk Teknis Standar Pelayanan Kefarmasian di Puskesmas dan Cara DistribusiObat yang Baik (CDOB). Berdasarkan pengkajian yang telah dilakukan,pengelolaan obat di Gudang Obat Puskesmas Kecamatan Pasar Rebo telahdilakukan secara cukup baik namun terkait kegiatan penerimaan, penyimpanan,pengendalian, administrasi terdapat beberapa hal yang dapat ditingkatkan

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Pharmacist Professional Work Practice (PKPA) at the Puskesmas institution was

held at the Puskesmas Kecamatan Pasar Rebo in May 2023. The PKPA activities at

the puskesmas institution aim to learn and understand the roles and responsibilities

of a pharmacist in the scope of the puskesmas. In the implementation of PKPA at the puskesmas, a report was prepared related to the assessment of drug management

in the drug management of the Puskesmas Kecamatan Pasar Rebo. The activity

aims to evaluate drug management in the Puskesmas Kecamatan Pasar Rebo and analyze the discrepancy between physical stock and drug stock cards in the Puskesmas Kecamatan Pasar Rebo and the impact that can be caused. The

evaluation was based on the Technical Guidelines for Pharmaceutical Service

Standards at Puskesmas and the Good Drug Distribution Method (GDP). Based on

the assessment that has been carried out, drug management at the Puskesmas Kecamatan Pasar Rebo has been carried out quite well, but related to several activities included receiving, storing, controlling, and administering activities, there

are several things that can be improved."

"Praktik Kerja Profesi Apoteker (PKPA) di instansi Industri dilaksanakan pada PT CKD OTTOPharmaceuticals pada bulan April tahun 2023. Adapun kegiatan PKPA di instansi industribertujuan untuk pembelajaran dan memahami peran serta tanggung jawab seorang apotekermelingkupi pada ruang lingkup industri serta mempelajari impelemntasi Cara Pembuatan Obatyang Baik. Pada pelaksanaan PKPA di industri, dilakukan penyusunan laporan tugas khususterkait Penilaian Risiko Penyimpanan Material pada Ruang Penyimpanan Bahan Baku di PTCKD OTTO Pharmaceuticals. Kegiatan tersebut bertujuan untuk mengevaluasi risikopenyimpanan beberapa material di ruang penyimpanan bahan baku pada PT CKD OTTOPharmaceuticals. Penyimpanan termasuk ke dalam hal krusial yang mampu memengaruhikualitas bahan. Data pendukung utama untuk evaluasi ini ialah suhu ruang penyimpanan yangdiperoleh dari Environment Monitoring System (EMS). Berdasarkan evaluasi yang telahdilakukan, kualitas material yang terdampak telah dipastikan kualitasnya masih berada padakondisi yang baik

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Pharmacist Professional Work Practice (PKPA) in Industrial institutions was held at PT CKD OTTO Pharmaceuticals in April 2023. The PKPA activities in industrial institutions aim to learn and understand the roles and responsibilities of a pharmacist within the scope of the industry and

learning the implementation of Good Manufacturing Practices. In the implementation of PKPA in industry, a report was prepared related to the Risk Assessment of Material Storage in the Raw Material Storage Room at PT CKD OTTO Pharmaceuticals. The activity aims to evaluate the storage risk of several materials in the raw material storage room at PT CKD OTTO

Pharmaceuticals. Storage is a crucial issue that can affect the quality of materials. The main supporting data for this evaluation is the storage room temperature obtained from the Environment Monitoring System (EMS). Based on the evaluation that has been carried out, the quality of the affected materials has been confirmed to be in good condition"

"Praktik Kerja Profesi Apoteker (PKPA) di instansi Apotek dilaksanakan pada Apotek Kimia Farma 0078 Pasar Anyar pada bulan Desember tahun 2022. Adapunkegiatan PKPA di instansi apotek bertujuan untuk pembelajaran dan memahami peran serta tanggung jawab seorang apoteker melingkupi pengelolaan sediaan farmasi dan pelayanan farmasi klinik yang terjadi pada ruang lingkup apotek. Padapelaksanaan PKPA, dilakukan penyusunan laporan tugas khusus terkait edukasi dan sosialisasi sediaan obat suppositoria, tetes mata, dan salep mata di apotek kimia farma 0078 pasar anyar. Kegiatan tersebut bertujuan untuk memberikanpengetahuan dan informasi penggunaan sediaan farmasi tersebut secara benar dan tepat kepada pasien dan petugas yang berada di apotek. Media yang digunakan pada sosialisasi adalah poster. Penyusunan poster berdasarkan literatur disertai dengan ilustrasi guna memudahkan pemahaman pasien.

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Pharmacist Professional Work Practice (PKPA) at the Pharmacy institution was held at Apotek Kimia Farma 0078 Pasar Anyar in December 2022. The PKPA activities at the pharmacy institution aim to learn and understand the roles and responsibilities of a pharmacist include the management of Drug and clinical pharmaceutical services that occur within the scope of the pharmacy. In the implementation of PKPA, a special assignment report was prepared related to the education and socialization of suppositories, eye drops, and eye ointments at the

Kimia Farma 0078 Pasar Anyar pharmacy. This activity aims to provide knowledge and information on the correct and appropriate use of these pharmaceutical preparations to the patient and officers in the pharmacy. The media used in

socialization activity is a poster. Preparation of posters based on literature accompanied by illustrations to facilitate patient understanding"

"Tanaman sambiloto (Andrographis paniculate) adalah salah satu tanaman yang umum digunakan pada obat tradisional di Indonesia. Pada tanaman sambiloto, terdapat senyawa aktif yakni andorgrafolid. Senyawa andrografolid memiliki banyak aktivitas farmakologi termasuk aktivitas antivirus terhadap virus SARS-CoV-2. Namun, andrografolid memiliki kelemahan yakni rasanya yang pahit, sukar larut dalam air serta bioavailabilitas yang rendah. Sehingga, andrografolid perlu diformulasikan secara optimum guna dapat mengatasi kelemahan andrografolid. Penelitian ini bertujuan untuk memperoleh formulasi Nanostructured Lipid Carrier dengan kandungan andrografolid dengan karakteristik sesuai sediaan parenteral. Formulasi Nanostructured Lipid Carrier dibuat menggunakan zat aktif andrografolid, minyak kelapa sawit, minyak zaitun, gliserin, aquabidest serta variasi gliseril monostearat yakni 2%, 3%, 4%. NLC dibuat menggunakan alat homogenizer selanjutnya dilakukan pengurangan ukuran globul dengan ultrasonikasi amplitude 60% selama 12 menit. NLC diuji karakteristiknya meliputi ukuran globul, potensial zeta, indeks polidispersitas, viskositas, tegangan permukaan, morfologi globul, efisiensi penjerapan serta penetapan kadar. Pada penelitian ini memperlihatkan bahwa formula optimum yakni NLC dengan gliseril monostearate 2%. NLC yang diperoleh memenuhi kriteria sediaan rute parenteral yakni ukuran globul, indeks polidispersitas, zeta potensial, serta efisiensi penjerapan berturut-turut yakni 438,33 ± 90,71; 0,237 ± 0,01; -37,1 ± 0,34; 82,8890 ± 0,10% dan memiliki ukuran globul yakni sferis namun NLC masih belum memenuhi syarat sterilitas. Berdasarkan uji stabilitas yang dilakukan, NLC memiliki kestabilan fisik termasuk uji cucling, uji sentrifugasi, serta uji pada tiga kondisi suhu berbeda. Hasil penelitian yakni formula optimum NLC dengan GMS 2% memiliki kestabilan fisik baik hingga minggu ke-12.

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Sambiloto (Andrographis paniculata) is one of the plants used as traditional medicine in Indonesia. The active substance in Sambiloto, namely andrographolide, has many pharmacological activities. One of them is pharmacological activity against the SARS-CoV-2 virus. However, andrographolide has its limitation such as low solubility in water, low bioavailability, and bitter taste. Therefore, andrographolide needs to formulated optimally to overcome these limitation. This study aims to obtain formulation of nanostructured lipid carrier andrographolide with suitable characteristics for parenteral administration. The NLC formulation consisted of andrographolide, palm oil, olive oil, glycerin, and double-distilled water with variances of glyceryl monostearate 2%, 3%, 4%. The manufactured of NLC using a homogenizer was continued with 60% amplitude ultrasonication for 12 minutes. The test of NLC characteristics included globule size, polydispersity index, assay, viscosity, surface tension, globule morphology, encapsulation efficiency, and sterility test. The study showed that, the optimum formula NLC with 2% glyceryl monostearate. NLC met the criteria for the parenteral route of administration which is globul size, polydispersity index, zeta potensial and encapsulation efficiency, respectively, 438.33±90.71; 0.237±0.01; -37.1 ± 0.34; 82.889±0.10%, and spherical shaped globule but did not meet the requirements for sterility. In addition, the physical stability of NLC was also carried out including centrifugation test, cycling test, test at three different temperatures. This study showed that formula optimum NLC with GMS 2% also the results of the physical test showed that NLC had good physical stability until 12th week."