Hasil Pencarian  ::  Simpan CSV :: Kembali

Abstrak :
Zinc merupakan mikronutrien yang mempengaruhi status gizi anak usia 10-12 tahun. Status gizi yang tidak ideal merupakan salah satu masalah kesehatan anak usia sekolah 10-12 tahun di SD Negeri X Kampung Serang yang lokasinya berdekatan dengan Tempat Pembuangan Akhir Sampah Bantar Gebang. Tujuan penelitian ini adalah untuk mengetahui status gizi anak usia sekolah dan hubungannya dengan asupan zinc dari makanan. Desain penelitian adalah cross-sectional. Pengambilan data dilakukan pada bulan Januari 2011 dari hasil pengukuran antopometri dan wawancara survei konsumsi makanan (Food Frequency Questionnaire) pada 68 subjek dengan yang dipilih berdasarkan consecutive sampling. Data yang terkumpul kemudian diolah melalui nutrisurvey untuk mengetahui asupan zinc dalam makanan sedangkan data status gizi didapat dari klasifikasi berdasarkan IMT/U, BB/U dan TB/U. Mayoritas responden memiliki status gizi kurang, yakni 51.2% berdasarkan BB/U dan 51.5% berdasarkan TB/U. Dilihat dari asupannya, 67 responden (99%) memiliki asupan zinc kurang. Dari uji statistik (Fisher), diketahui terdapat hubungan tidak bermakna antara asupan zinc dengan status gizi anak, baik berdasarkan IMT/U, BB/U maupun TB/U dengan nilai probabilitas masing-masing adalah p=0.879, p=0.576 dan p=0.515 (p>0.05). Disimpulkan bahwa status gizi dan asupan zinc pada anak sekolah usia 10-12 tahun di SDN X tidak memiliki hubungan yang bermakna. ......Zinc is a micronutrient that affects nutritional status of children aged 10-12 years. Nutritional status which is not ideal is one of the health problems of children aged 10- 12 years in the SDN X, Serang Village, which is located close to the Final Disposal Waste Bantar Gebang. The purpose of this study is to determine the nutritional status of school-age children and its relation to zinc intake from food. The research is designed using cross sectional method. The data was collected in January 2011 from an antopometri measurement and an interview of food consumption in 68 subjects based on consecutive sampling. The data then processed through nutrisurvey to know he intake of zinc in the diet while the nutritional status data was classified based on weight-age percentil, height-age percentil and body mass index-age percentil. Most respondents have less nutritional status, which is 51.2% based on weight-age percentil and 51.5% based on height-age percentil. 67 respondents (99%) have less zinc intake. Based on statistical tests (Fisher), there is no significant relationship between zinc intake and nutritional status of children based on the weight-age percentil, height-age percentil and body mass index-age percentil with probability value p = 0879, p = 0576 and p = 0515 (p> 0.05). In conclusion, nutritional status of school children aged 10-12 years in SDN X has no significant relationship with zinc intake.

Abstrak :
Latar belakang: Infeksi SARS-CoV-2 menyebabkan disregulasi sistem imun sehingga memperberat klinis pasien. Penilaian CT dan parameter inflamasi pejamu (neutrofil, limfosit, CRP dan feritin) saat admisi diharapkan membantu klinisi memberi tatalaksana efektif bagi pasien berisiko perburukan. Tujuan: Mengetahui pengaruh nilai CT dan parameter inflamasi pejamu saat admisi terhadap derajat penyakit COVID-19 dalam 14 hari sejak onset gejala. Metode: Studi kohort retrospektif dengan menelusuri rekam medis pasien COVID-19 berusia >18 tahun yang dirawat di RSCM dan RS Medistra pada Juni 2020-Februari 2021. Dilakukan analisis bivariat antara nilai CT, neutrofil, limfosit, CRP, feritin saat admisi dengan keparahan COVID-19, dilanjutkan analisis ROC untuk mendapatkan titik potong optimal. Setelahnya, dilakukan analisis multivariat dan membuat model klinis terbaik menilai kemungkinan keparahan COVID-19. Hasil: Dari 336 subjek didapatkan COVID-19 berat-kritis sejumlah 75,3%. Tidak terdapat hubungan antara nilai CT rendah-sedang dan CT rendah-tinggi terhadap keparahan COVID-19 dengan nilai p masing-masing 0129 dan 0,913, sementara itu terdapat hubungan signifikan antara neutrofil, limfosit, CRP dan feritin terhadap keparahan COVID-19 dengan masing-masing nilai p<0,001. Dari analisis ROC, didapat titik potong optimal neutrofil (>71,5%), limfosit (<18,5%), CRP (>17,2 mg/dL), feritin (270 ng/mL) terhadap terjadinya COVID-19 berat-kritis dalam 14 hari sejak onset gejala. Hasil analisis multivariat menujukkan faktor yang mempengaruhi COVID-19 berat-kritis antara lain neutrofil (aRR 1,850 [IK 95% 1,482-2,311]), limfosit (aRR 1,877 [IK 95% 1,501 – 2,348]), CRP (aRR 2,068 [IK 95% 1,593 – 2,685]), dan feritin (aRR 1,841 [IK 95% 1,438 – 2,357]). Model klinis kombinasi neutrofil, limfosit, CPR dan feritin terhadap COVID-19 berat-kritis memiliki nilai AUC 0,933 (IK 95% 0,902 – 0,963). Kesimpulan: nilai CT tidak mempengaruhi COVID-19 tidak berat dan berat-kritis. Neutrofil, limfosit, CRP, dan feritin saat admisi mempengaruhi terjadinya COVID-19 tidak berat dan berat-kritis Kombinasi neutrofil, limfosit, CRP dan feritin merupakan model klinis terbaik menilai kemungkinan keparahan COVID-19 dalam 14 hari sejak onset gejala. ......Background: SARS-CoV-2 infection leads to immune dysregulation and hyperinflammation, thus potentially exacerbating clinical outcomes. Assessing CT value and host inflammatory parameters such as neutrophils, lymphocytes, CRP, and feritin upon admission may assist clinicians in providing effective management, especially for patient at risk of severe-critical condition. Objective: To analyze the effect of CT values and host inflammatory parameters upon admission on the severity of COVID-19 within 14 days of symptom onset. Methods: A retrospective cohort study tracing COVID-19 patient’s medical records aged >18 years admitted to RSUPN Ciptomangunkusumo and RS Medistra from June 2020 to February 2021. Bivariate analysis was conducted between CT values, neutrophils, lymphocytes, CRP, feritin on admission with COVID-19 severity, then ROC analysis to determine the optimal cut off points. Multivariate analysis was performed to control confounding factors. The best clinical model was analyzed for severe-critical outcome within 14 days of symptom onset. Results: Out of 336 subjects, 75,3% had severe-critical COVID-19. There was no association between low-moderate CT value and low-high CT value with COVID-19 severity, with p value 0,129 and 0,913 respectively. However, there was significant association between neutrophils, lymphocytes, CRP, and feritins with COVID-19 severity, each with p<0.001. ROC analysis determined optimal cut off for neutrophils (>71.5%), lymphocytes (<18.5%), CRP (>17.2 mg/dL), and feritin (270 ng/mL) for the occurrence of severe-critical COVDI-19 within 14 days symptom onset. Multivariate analysis revealed factors influencing severe-critical COVID-19 including neutrophils (aRR 1.850 [95% CI 1.482-2.311]), lymphocytes (aRR 1.877 [95% CI 1.501 – 2.348]), CRP (aRR 2.068 [95% CI 1.593 – 2.685]), and feritin (aRR 1.841 [95% CI 1.438 – 2.357]). Combination of neutrophil, lymphocytes, CRP, and feritin was the best clinical model for severe-critical COVID-19 with AUC value 0.933 (95% CI 0.902 – 0.963). Conclusion: Neutrophils, lymphocytes, CRP, and feritin value upon admission effect COVID-19 severity within 14 days of symptom onset