Hasil Pencarian  ::  Simpan CSV :: Kembali

Abstrak :
Transfersom merupakan suatu nano vesikel yang bersifat sangat elastis, sehingga ia dapat menembus membran tidak hanya karena sifatnya yang ampifilik namun juga karena ia dapat berubah bentuk. Namun, transfersom memiliki kekurangan, yaitu mudah mengalami degradasi oksidatif. Oleh karena itu, transfersom yang sudah jadi dilindungi di dalam suatu sistem mikrosfer. Tujuan dari penelitian ini adalah untuk menghasilkan mikrosfer transfersom dengan karakteristik yang baik dan stabil secara fisikokimia. Pada penelitian ini, transfersom dibuat menggunakan metode hidrasi lapis tipis dengan variasi perbandingan antara fosfolipid dan Span 80, yaitu 95:5, 90:10, dan 85:15. Dari ketiga formulasi, formula pertama terpilih untuk dijadikan mikrosfer menggunakan metode semprot kering, dengan bentuk yang sferis, berukuran 78,75 nm, indeks polidispersitas sebesar 0,187, zeta potensial sebesar -37,5 mV dan efisiensi penjerapan sebesar 47,96 5,81. Kemudian, mikrosfer yang dihasilkan berbentuk tidak sferis dan berkerut, memiliki ukuran partikel 2058,44 nm dengan indeks polidispersitas 0,545, efisiensi penjerapan sebesar 59,27 0,59 , kadar air 5,21 dan indeks mengembang sebesar 289,36 setelah 4 jam. Setelah dilakukan uji disolusi, jumlah EGCG kumulatif yang diperoleh adalah 69,15 7,66 . Dari hasil tersebut diketahui bahwa, stabilitas mikrosfer transfersom dan serbuk transfersom tidak memiliki perbedaan yang siginifikan. ......Transfersome is an elastic nano vesicle. It can go through a membrane because it is an amphiphilic and ultradeformable particle. However, transfersome has a weakness, it can go through oxidative degradation. Therefore, transfersome needs to be protected in a microsphere system. The aim of this study was to prepare transfersome loaded microsphere which has good characteristic and physicochemical stability. In this research, transfersome was made using thin layer hydration method. Green tea leaves extract transfersomes were formulated in the ratio of 95 5, 90 10, and 85 15 based on the amount of phospholipid and Span 80. The best formula was formula 1 F1 that had spherical shape, its size was 78.75 nm, polydispersity index 0.187, zeta potential 37.5 mV and entrapment efficiency 47.96 5.81. After that, transfersome was loaded into microsphere using spray dry method. It had non spherical and wrinkled shape, its size was 2058,44 nm, polydispersity index 0.545, entrapment efficiency 59.27 0.59, moisture content 5.21, and swelling index 289.36 after 4 hours. Total cumulative amount of EGCG after dissolution test was 69.15 7.66. The conclusion is that transfersome loaded microsphere has no significant difference with transfersome powder in physicochemical stability.

Abstrak :
ABSTRAK Laporan ini menjelaskan tentang praktik kerja profesi yang dilakukan oleh mahasiswa apoteker di Apotek Kimia Farma Nomor 352 Depok. Tujuan dilakukannya praktik kerja profesi adalah agar mahasiswa apoteker mampu memahami tugas dan tanggung jawab apoteker dalam pengelolaan apotek, serta melakukan praktik pelayanan kefarmasian sesuai dengan ketentuan perundang-undangan dan etika yang berlaku, memiliki wawasan, pengetahuan, keterampilan, dan pengalaman praktis untuk melakukan praktik kefarmasian di apotek serta memiliki gambaran nyata tentang permasalahan praktik kefarmasian dan mempelajari strategi dan kegiatan-kegiatan yang dapat dilakukan dalam rangka pengembangan praktik kefarmasian. Praktik kerja profesi ini dilaksanakan selama satu bulan. Tugas khusus yang diberikan selama praktik kerja profesi adalah ldquo;Pengkajian Resep Penyakit Kardiovaskular di Apotek Kimia Farma Nomor 352 Depok Periode Bulan Januari 2018 rdquo;. Penulisan laporan ini dilakukan berdasarkan pengamatan langsung dan dilihat kesesuaiannya dengan peraturan perundang-undangan. Hasil dari praktik kerja ini diantaranya mengenai tanggung jawab apoteker di bidang manajerial dan farmasi klinik dan apotek sudah beroperasi sesuai dengan ketentuan.

---

This report describes the internship experience which was done by an apothecary student at Kimia Farma 352 Depok Pharmacy. The purpose of this internship were to understand the duties and responsibilities of pharmacists in pharmacy management, as well as to practice pharmaceutical services in accordance with applicable legislation and ethics, have insight, knowledge, skills and practical experience to perform pharmaceutical practices at the pharmacy as well as having a clear picture of the pharmaceutical practice issues and studying the strategies and activities that can be undertaken in order to develop pharmaceutical practices. This internship was conducted for a month. The special assignment given during the internship was called Assessment of Cardiovascular Disease Prescription at Kimia Farma 52 Depok Pharmacy Period January 2018 . The writing of this report was based on direct observation to verify the conformity towards the valid regulation. The conclusion were that the pharmacy has always been complied with the provisions and pharmacists are responsible in both managerial and pharmacy clinic.

Abstrak :
ABSTRAK Laporan ini menjelaskan tentang praktik kerja profesi yang dilakukan oleh mahasiswa apoteker di PT Aventis Pharma. Tujuan dilakukannya praktik kerja profesi adalah agar mahasiswa apoteker mampu memahami peranan, tugas, dan tanggung jawab apoteker di industri farmasi, memiliki pengetahuan, keterampilan, dan pengalaman praktik untuk melakukan pekerjaan kefarmasian di industri farmasi, memahami penerapan CPOB di industri farmasi, serta memiliki gambaran nyata tentang permasalahan kefarmasian di industri farmasi. Praktik kerja profesi ini dilaksanakan selama dua bulan. Tugas khusus yang diberikan selama praktik kerja profesi adalah ldquo;Penyiapan Dokumen Registrasi Variasi Major pada Produk Vaksin ldquo;X rdquo; rdquo;. Penulisan laporan ini dilakukan berdasarkan pengamatan langsung dan dilihat kesesuaiannya dengan CPOB. Hasil dari praktik kerja ini diantaranya mahasiswa telah memahami mengenai tanggung jawab apoteker di industri farmasi dan industri farmasi sudah beroperasi sesuai dengan CPOB.

---

This report describes the internship experience which was done by an apothecary student at PT Aventis Pharma. The purpose of this internship were to understand the role, duties and responsibilities of pharmacists in the pharmaceutical industry, have the knowledge, skills and practical experience to undertake pharmaceutical work in the pharmaceutical industry, understand the application of GMP in the pharmaceutical industry, and have a clear picture about pharmaceutical issues in the pharmaceutical industry. This internship was conducted for two months. The special assignment given during the internship was called Preparing the Major Variation Registration Document on Vaccine Product X . The writing of this report was based on direct observation to verify the conformity towards GMP. The conclusion were that the student has understood the responsibility of pharmacists in the pharmaceutical industry and PT Aventis Pharma has always been complied with GMP.

Abstrak :
ABSTRAK Laporan ini menjelaskan tentang praktik kerja profesi yang dilakukan oleh mahasiswa apoteker di Suku Dinas Kesehatan Kota Administrasi Jakarta Timur. Tujuan dilakukannya praktik kerja profesi adalah agar calon apoteker mampu memahami peranan, tugas, dan tanggung jawab apoteker di instansi pemerintahan seperti Suku Dinas Kesehatan, memiliki pengetahuan tentang tupoksi instansi-instansi pemerintahan di bidang farmasi, memiliki wawasan, pengetahuan, keterampilan, dan pengalaman praktis melakukan pekerjaan di pemerintahan serta emiliki gambaran nyata tentang permasalahan kefarmasian di pemerintahan.. Tugas khusus yang diberikan selama praktik kerja profesi adalah ldquo;Pemutakhiran Data Pangan Industri Rumah Tangga di Suku Dinas Kesehatan Jakarta Timur Tahun 2014 s.d. 2016 rdquo;. Penulisan laporan ini dilakukan berdasarkan pengamatan langsung dan dilihat kesesuaiannya dengan peraturan yang berlaku. Hasil dari praktik kerja ini diantaranya mahasiswa telah memahami mengenai tanggung jawab apoteker di pemerintahan dan Suku Dinas Kesehatan Kota Administrasi Jakarta Timur sudah beroperasi sesuai dengan peraturan yang berlaku

---

This report describes the internship experience which was done by an apothecary student at East Jakarta Sub Department of Health. The purpose of this internship were to understand the role, duties and responsibilities of the pharmacist in government institutions such as the sub department of health, having knowledge of the duties of government agencies in pharmacy, having knowledge, skills, knowledge and practical experience work in the government and have a clear picture of pharmaceutical problems in the government.. This internship was conducted for two weeks. The special assignment given during the internship was called Upgrading the Processed Food from Household Industry Data at East Jakarta Sub Department of Health from 2014 to 2016 . The writing of this report was based on direct observation to verify the conformity towards the valid regulations. The conclusion were that the student has understood the responsibility of pharmacists in the sub department of health and East Jakarta Sub Department of Health has always been complied with the regulations.