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Hasil Pencarian

Ditemukan 3 dokumen yang sesuai dengan query
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Pustika Amalia Wahidiyat
Faktor-faktor genetik pengubah manifestasi klinis thalassemia interaksi antara mutasi thalassemia polimorfisme dan SNPs pada klaster gen globin
" Latar belakang: Thalassemia dan hemoglobinopati merupakan kelainan gen tunggal terbanyak di dunia, termasuk di Indonesia dengan frekuensi pembawa sifat thalassemia-~ 3-10% dan HbE 1-36%. Thalassemia-WIThE adalah bentuk heterozigot ganda paling sering ditemukan dengan gejala klinis bervariasi, dari asimtomatik sampai berat. Beberapa faktor pemodifikasi telah diketahui memengaruhi manifestasi klinis. Faktanya pasien dengan jenis mutasi sarna dapat memiliki manifestasi klinis berbeda. Hal itu menunjukkan ada faktor pemodifikasi lain yang memengaruhi derajat manifestasi klinis. Tujuan: Meneari faktor-faktor genetik ... "
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2009
D1765
UI - Disertasi Open  Universitas Indonesia Library
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Pustika Amalia Wahidiyat
Comparison of deferiprone to deferasirox and deferoxamine to cardiac and hepatic T2 MRI in thalassemia patients: evidence-based case report / Pustika Amalia Wahidiyat, Mikhael Yosia, Teny Tjitra Sari
" ABSTRACT
Background: there are currently three iron chelator readily available for patients Indonesia; deferiprone/DFP (branded as Ferriprox), deferasirox/DFX (branded as Exjade) and deferoxamine/DFO (branded as Desferal). This study aims to determine which iron chelator is the most efficient in reducing cardiac and hepatic iron overload (measured by means of T2 MRI). Methods: journal search with determined MeSH term was done in PubMed and Scopus. Studies that looked upon thalassemia major patient in all ages with usage ... "
Jakarta: University of Indonesia. Faculty of Medicine, 2018
JAK 3:2 (2017)
Artikel Jurnal  Universitas Indonesia Library
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Pustika Amalia Wahidiyat
Evaluation of iron overload between age groups using magnetic resonance imaging and its correlation with iron profile in transfusion dependent thalassemia
" ABSTRACT
Background: routine blood transfusion in transfusion-dependent-thalassemia (TDT) causes iron accumulation in various organ. Serum markers of iron overload, serum ferritin and transferrin saturation, are sensitive but not specific. MRI T2-star (T2*) is valuable for detecting iron level in organs. This study aimed to explore the degree of iron overload in various organs, iron deposition difference between children and adults, also its correlation with serum marker of iron overload. Methods: this was a cross-sectional study of ... "
Jakarta: University of Indonesia. Faculty of Medicine, 2018
610 UI-IJIM 50:3 (2018)
Artikel Jurnal  Universitas Indonesia Library