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ABSTRAKDaun alpukat (Persea americana Mill) dan buah oyong (Luffa acutangula (L.)
Roxb.) merupakan tanaman yang secara empiris digunakan untuk berbagai
penyakit, salah satunya diabetes. Penelitian ini bertujuan untuk mengetahui efek
penurunan kadar glukosa darah kombinasi ekstrak etanol daun alpukat dan buah
oyong pada mencit. Dua puluh empat ekor mencit putih jantan galur ddY yang
dibagi dalam enam kelompok. Mencit dipuasakan ±16 jam, kemudian diukur
kadar glukosa darah puasa, lalu diberikan ekstrak daun alpukat, ekstrak buah
oyong, ekstrak kombinasi, metformin HCl, dan larutan CMC 0,5%. Tiga puluh
menit setelahnya, diukur kembali kadar glukosa, lalu diberikan glukosa 2 g/kg bb
peroral. Pengukuran dilakukan pada menit ke-30, 60, 90, 120 setelah pemberian
glukosa. Kadar glukosa darah diukur menggunakan glukometer Accu-Chek
Active®. Pemberian kombinasi ekstrak 1, daun alpukat 50 mg/kg bb dan buah
oyong 200 mg/kg bb dapat menurunkan kadar glukosa darah yang bermakna
secara statistik pada setengah jam setelah pemberian glukosa, sedangkan
kombinasi ekstrak 2, daun alpukat 100 mg/kg bb dan buah oyong 200 mg/kg bb
dapat menurunkan kadar glukosa darah yang bermakna pada satu jam setelah
pemberian glukosa.
AbstractAvocado leaves (Persea americana Mill ) and ridge gourd fruit (Luffa acutangula
(L.) Roxb) is a plant that empirically used for various diseases, one of them is
diabetes. The aim of this research was to know the blood glucose lowering effect
of combination extract ethanol avocado leaves and ridge gourd fruit on mice.
Twenty-four of ddY mice white male which was divided into six groups. Each
mice was fasted for ±16 hours, then measured blood glucose levels of fasting, and
administered extract avocado leaves, extract ridge gourd fruit, extract
combinations, metformin HCl, and CMC liquid 0,5%. Thirty minutes later,
measured back glucose levels, and administered glucose 2 g/ kg bw orally. Blood
glucose then was measured in 30, 60, 90, and 120 minutes after glucose
administration. Blood glucose was measured using Accu-Chek Active®
glucometer. Combination extract 1, avocado leaves 50 mg / kg bb and ridge gourd
fruit 200 mg/ kg bw was able to lower glucose levels in 30 minutes after glucose
administration, while combination extract 2, avocado leaves 100 mg / kg bw and
ridge gourd fruit 200 mg/ kg bw was able to lower blood glucose levels in one
hour after glucose administration."
