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Abstrak :
This research is based on appearance of various change, generally in the society and specially in college. Faculty Social Science and Politics University Indonesia ( FISIP-UI) represent one of the faculty which under UI BRIAN ( Legal Body Public of Ownership) is not quit of these problems. To stay at emulation which progressively tighten, FISIP-UI is not only claimed to be able to give best service but it is also claimed to make a change up better continually. Some expert suggest in order can live in emulation era which progressively tighten require to master learning organization. In this bearing, Senge (1994:21) told that organization learning is organization which continually develop its ability to create better future. Later; than transform become organization learning. Senge, 1994 and Senge, et, al 1996 6) said organization must having five discipline, those are Personal Mastery, Mental Model, Shared Vision, Team Learning, System Thinking. This research is done to answer two questions of research, that is : First, How far the Non Academic Staff of organization either State servant or Non State Servant doing the learning organization in FISIP-UI ? Second; What obstacles influence the Non Academic either State servant or Non State Servant on learning organization in FISIP-UI This research represents descriptive research, using the quantitative and qualitative data. The population is non academic staff whether having state servant status or non state servant. According to the ability of researcher, this research is not include the staffs ruder non regular programs, but concentrate to the staffs of Dean/ faculty, which are the servants who are recruited by and get the salary from the faculty. This Research is done during the month of January, 2004 up to April month. 2004. The amount of population is 131 consists of 71 people of state servant and 60 of non state servant. Research use the sensus methods; therefore all of population is taken as sample of this research; using questionnaires as the tools in collecting quantitative data. From 71 of questionnaires we have distributed to all of non academic staff, we could gather 65 back only. Later, than for non state servant, from 60 questionnaires we have distributed, 57 peoples gave back and the rest, 3 did not give back them. For qualitative data, is done by the un structured interview method to 8 respondent which is assumed having competence or representative to non academic staff of FISIP-UT. After gathering quantitative data later; than processed them using computer by SPSS 10.00 program. Test appliance used the tables of frequency and cross tabulation. Based on analysis and data interpretation, obtained the result that just a few part of whether the state servant and non state servant of non academic staff is having high grade of learning. The factors of mastering the organization learning are : habit of waiting the order from superior staff or manager, self satisfaction sense, surrender with situation, poor of ability to accurate and investigate. Later; than the less of superior or manager support , in getting news ideas which appear bottom-up ; and also less opportunity to do wrongness in order have ability to develop and run new ideas. Formulation of mission and vision which is not be on down warded and socialized better. Besides, the non academic staff of FISIP-UI is also still less to attend the dialogue, discussion, seminar, meeting etc.

Abstrak :
Penelitian ini dilatarbelakangi karena Balai Besar Teknik Kesehatan Lingkungan Pemberantasan Penyakit Menular (BBTKL PPM) Jakarta didalam menyelenggarakan pelayanan laboratorium kesehatan, masih ditemukan keluhan-keluhan dari pelanggannya. Seperti hasil pemeriksaan laboratorium yang tidak tepat waktu, belum memadainya peralatan laboratorium yang berakibat tidak optimalnya kualitas pelayanan yang diberikan. Tujuan dari penelitian ini adalah untuk mengetahui persepsi/penilaian dan harapan pelanggan terhadap kualitas pelayanan yang diterapkan BBTKL PPM Jakarta, serta tingkat kesesuaian berdasarkan kesenjangan (gap) antara penilaian dan harapan pelanggan. Penelitian ini dirancang dengan menggunakan Model Servqual yang dikemukakan oleh Zeithaml, Parasuraman dan Berry, yaitu metode untuk mengukur kualitas pelayanan berdasarkan persepsi dan harapan pelanggan yang memiliki 5 dimensi yaitu Tangibles, Reliability, Responsiveness, Assurance, dan Empathy. Metode penelitian yang digunakan adalah deskriptif dengan jenis data kuantitatif. Data yang dikumpulkan terdiri atas data primer dan data sekunder. Data primer diperoleh dengan menggunakan kuesioner dan observasi di lokasi penelitian. Sedangkan data sekunder diperoleb melalui berbagai kepustakaan. Analisis data diperoleh dari pengisian kuesioner oleh responden yang dilakukan dengan program SPSS. Berdasarkan hasil dari tingkat kesesuaian terdapat 15 indikator yang tidak memenuhi atau tidak memuaskan responden yaiW 1. kelengkapan peralatan yang digunakan dalam menunjang pelayanan, 2. standar peralatan yang digunakan untuk pemeriksaan laboratorium, 3. kebersihan gedung, tempat parkin dan toilet yang tersedia, 4. Lokasi kantor, 5. kesiapan dan kecepatan pelayanan, 6. respon petugas pelayanan dalam menangani keluhan pelanggan, 7. ketentuan tarif atau biaya pemeriksaan, 8. kemampuan petugas dalam memberikan pelayanan yang dijanjikan, 9. kehandalan petugas dalam membantu menyelesaikan masalah, 10. jadwal pelayanan, 11. ketepatan waktu hasil pemeriksaan laboratorium, 12. pengetahuan atau wawasan petugas dalam memberikan solusi terhadap keluhan pelanggan, 13. jaminan dari hasil pemeriksaan laboratorium, 14. perhatian petugas pelayanan terhadap keinginan dan kebutuhan pelanggan dan 15. sikap profesionalisme petugas pelayanan dalam memenuhi keinginan dan kebutuhan pelanggan. Dari hasil temuan penelitian tersebut, dapat disimpulkan bahwa secara keseluruhan kualitas pelayanan yang diterapkan BBTKL PPM Jakarta tidak memenuhi harapan atau tidak memuaskan pelanggan karma sebagian besar indikator menunjukkan tingkat kesesuaiannya dibawah 100 %. Untuk dapat meningkatkan kualitas pelayanan disarankan : BBTKL PPM Jakarta harus berupaya memperbaiki kinerja pelayanan yang berorientasi kepada pelanggan, memberikan pendidikan dan pelatihan kepada petugas pelayanan agar dapat meningkatkan pengetahuan dan ketrampilan dalam menjalankan tugas sehari-hari terutama dalam menangani keluhan dan masalah yang dihadapi pelanggan.

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The background to do this research by Major Bureau on Environmental Health Technique on Contagious Disease Prevention (BBTKL PPM) Jakarta which is to carry out medical laboratory service, it still finds complaints from its customers. For example, non-timely results from laboratory examination, lack of laboratory equipment that causes less optimum on service quality. The objective of this research is to find customers perception / evaluation and expectation to service quality which has been applied by BBTKL PPM Jakarta and match level is based on gaps between customer's evaluation and expectation. The research is designed to use SERVQUAL Model which proposed by Teithaml, Parasurainan and Berry, the method to measure the service quality which based on customer's perception and expectation in five dimension which are Tangibles, Reliability, Responsiveness, Assurance, and Empathy. Used the research method is descriptive with quantitative data. Gathered data includes of primary and secondary. The primary data is gathered with using questionnaire and observation on study site. While, secondary data is gathered from certain references. Gathered data analysis of questionnaire which filled by respondents performed on SPSS program. Based on the extent of suitability, there are 15 indicators that do not meet or not satisfy the respondents, they are : 1. the completeness of equipments used in supporting the service, 2. standard of equipments used in the laboratory examination, 3. sanitation of the building, parking area and available toilets, 4. location of the office, 5. readiness and promptness of the service, 6. response of service personnel in handling the customer's complaints, 7. pricing and cost of examination, S. competence of personnel in providing the promised service, 9. reliability of personnel in supporting the problem solving, 10. schedule of service, 11- punctuality of laboratory examination result, 12. knowledge or insight possessed by the personnel in providing the solution to the customer's complaints, 13. guaranteed of the laboratory examination result, 14. attention paid by the service personnel to ward the customer's desire and need, and 15. professionalism attitude of service personnel in satisfying the customer's desire and need. Based on the results of the research, it can be concluded that as a whole, the quality of service, which applied at BBTKL PPM Jakarta, cannot meet or satisfy the customer's desire and need because most of indicators showed the extent of suitability below 100%. In order to improve the quality of service, it is recommended that: BBTKL PPM Jakarta should make various efforts to improve the customer-oriented performance of service, and to provide the education and training for the services personnel so their can improve their knowledge and skill in performing their daily duties, especially in handling the complaints and problems faced by the customers.

Abstrak :
Resistensi antimikroba adalah salah satu masalah utama yang dihadapi oleh berbagai sektor, dimana masalah ini mengancam efektivitas dari upaya pencegahan dan pengobatan dari penyakit yang disebabkan oleh infeksi mikroba sehingga diperlukan adanya strategi baru untuk mengatasi masalah ini. Salah satu molekul yang secara aktif dipelajari dan dipertimbangkan sebagai strategi alternatif adalah peptida antimikroba yang diproduksi secara alami oleh bakteri yang disebut bakteriosin, terutama yang dihasilkan oleh kelompok Bakteri Asam Laktat (BAL). Penelitian ini bertujuan untuk mengonfirmasi dan mengkarakterisasi bakteriosin dua peptida unik dalam kelas IIb yang diproduksi oleh Streptococcus macedonicus MBF10-2 dengan pendekatan in silico dan konfirmasi sekuens DNA penyandi nonlantibiotiknya. DNA genomik bakteri diesktraksi dari hasil kultur dan gen penyandi nonlantibiotik disekuens dengan metode Sanger. Hasil sekuens dibandingkan dengan sekuens gen penyandi nonlantibiotik hasil Whole Genome Sequencing (WGS) untuk mendeteksi keberadaan mutasi pada sekuens DNA dan asam amino yang dihasilkan. Sekuens asam amino dari kedua peptida kemudian dilakukan pemodelan menggunakan metode de novo, saling ditambatkan, dan divisualisasikan untuk melihat ikatan dan interaksi yang terbentuk. Hasil penambatan Sm1 dengan Sm2 menunjukkan terbentuknya interaksi pada motif A25xxxA29 dan A29xxxG33 dari Sm1, serta S11xxxA15 dan A38xxxA42­ dari Sm2. Penambatan kedua peptida dengan sesamanya menunjukkan terbentuknya interaksi di residu Ala-19, motif G8xxxG12, dan motif A25xxxA29 pada Sm1, serta residu Ala-42, Gly-16, dan motif S11xxxA15 pada Sm2 sehingga diprediksi peptida tunggal sudah memiliki aktivitas inhibisi. Prediksi ini perlu ditelusuri lebih lanjut dengan uji in vitro. ......Antimicrobial resistance is one of the urgent and growing problems that many sectors are facing which threatens the effectivity of preventive and curative effort on treating diseases caused by microbial infection, thus posing the need to discover a novel strategy in order to tackle the problem. One potential molecule currently being actively studied and considered to be an alternative strategy is an antimicrobial peptide naturally produced by bacteria called bacteriocin, especially those produced by the Lactic Acid Bacteria (LAB) group. This study aims to identify and characterize a unique two-peptide bacteriocin within the class IIb bacteriocin produced by Streptococcus macedonicus MBF10-2 through in silico approach and confirmation of its coding DNA. The bacteria’s genomic DNA was extracted from culture and its bacteriocin-coding DNA was sequenced with Sanger Sequencing method. The sequence result was then compared with the initial Whole Genome Sequencing result to detect any mutation in the DNA and its translated amino acid sequence. The amino acid sequence of the two peptides were then modeled with de novo method, docked with each other, and visualized to see the bonds and interactions formed. The docking result showed interactions within the A25xxxA29 and A­29xxxG33 motifs of Sm1 and the S11xxxA15 and A38xxxA42 motifs of Sm2. Docking of each peptide with its own showed interactions in Ala-19, the G8xxxG12 and A25xxxA29 motifs of Sm1 and Ala-42, Gly-16, and the S11xxxA15 motif of Sm2. These interactions pose the possibility that a single peptide might have an inhibition activity of some degree when working on its own. This possibility should be investigated further through an in vitro test.

Abstrak :
Dengan obat sebagai produknya, sebuah industri farmasi diharuskan untuk mengikuti Cara Pembuatan Obat yang Baik (CPOB) untuk memastikan keamanan pasien. Salah satu aspek pada CPOB adalah dokumentasi, yaitu bagian dari sistem manajemen informasi dan dokumentasi yang baik, serta penting diperhatikan dalam pemastian mutu. Proses dokumentasi bertujuan untuk memastikan tiap personil mendapatkan rincian pekerjaan yang jelas dan relevan untuk mengurangi misinterpretasi akibat komunikasi lisan. Implementasi dari aspek ini adalah catatan bets. Catatan bets yang lengkap dibutuhkan untuk memulai proses produksi sehingga beberapa faktor dapat memengaruhi waktu preparasinya dan berdampak terhadap proses produksi. Laporan ini bertujuan untuk menganalisis faktor yang memengaruhi waktu preparasi catatan bets dan dampaknya terhadap proses produksi. Dilakukan studi literatur mengenai catatan bets dan sistem dokumentasi pada industri farmasi. Standar prosedur operasional (SPO) persuahaan mengenai pembuatan catatan bets utama, sistem dokumentasi, dan manajemen catatan bets dikaji. Dilakukan juga wawancara bersama staf pemastian mutu dan produksi mengenai proses preparasi catatan bets dan aspek produksi mana yang mungkin terdampak oleh preparasi catatan bets. Notifikasi pembuatan catatan bets dari sistem Oracle® kemudian dikumpulkan. Data yang terkumpul dilakukan analisis dan identifikasi terkait faktor yang berpengaruh. Diagram fishbone dibuat sebagai visualisasi. Hasil analisis menunjukkan bahwa rentang waktu yang dibutuhkan untuk preparasi catatan bets adalah 1-8 hari. Beberapa aspek berperan dalam keterlambatan preparasi, seperti man (kurangnya tenaga kerja, kesalahan manusia), machine (kesalahan sistem dan proses printing), material (waktu tunggu dari material yang dibutuhkan, perubahan pada catatan bets utama), environment (kondisi penyimpanan catatan bets yang kurang baik), serta method (ketidakpatuhan terhadap SOP). Aspek-aspek ini berperan dalam keterlambatan pada proses produksi. ......With drugs and medicines as its product, a pharmaceutical industry is required to comply with the national current Good Manufacturing Practice (cGMP) to ensure patient safety. One of many aspects discussed in GMP is documentation, a part of information and document management system and paramount in quality assurance. Documentation process aims to ensure that each personnel receives a clear, detailed, and relevant job description to minimize misinterpretation due to verbal communication. An implementation of this aspect is batch record. A complete batch record is needed to commence the production process, thus several factors could affect its preparation time and in turn affect the production timeline. This report aims to analyze factors affecting batch record preparation time and its impact on the production process. Literature study about batch record and documentation system in pharmaceutical industry was conducted. The company’s existing standard operational procedure (SOP) about master batch record creation, documentation system, and batch record management were reviewed. A quality assurance (QA) and production staff were interviewed about the batch record preparation process and which production process might be affected by it, respectively. Batch record notification from the Oracle® system were collected. Several affecting factors were then identified and analyzed on their impact on the production process with a fishbone diagram as a visualization. Analysis results showed that the time interval needed for batch record preparation is 1-8 days. Several aspects contribute to preparation delay, which are man (lack of manpower, human error), machine (system and printing error), material (lead time of materials needed, changes in master batch record), environment (unfavorable storage conditions), and method (not following the applicable SOP). These aspects contribute to the delay in production process.