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Abstrak :
[ABSTRAK
Latar Belakang Delayed graft function (DGF) adalah komplikasi yang umum dijumpai pada transplantasi dari mayat. Berdasarkan studi terdahulu, DGF dan factor resikonya memiliki hasil yang bervariasi pada donor nefrektomi hidup Metode Peneliti melakukan analisis retrospektif dari rekam medic donor dan resipien transplantasi ginjal pada 100 kasus laparoskopi donor nefrektomi hidup di Rumah Sakit Cipto Mangunkusumo dari November 2011 hingga Februari 2014. Kriteria DGF adalah pasien didialisis pada 1 minggu post operasi dan/ atau kreatinin lebih dari 2.5 mg/dl pada hari ke 7 post operasi. Pasien yang tidak masuk dalam kriteria tersebut didefinisikan memiliki renal allograft yang berfungsi normal Hasil Prevalensi DGF pada penelitian ini adalah 14%. Indeks massa tubuh resipien, cold ischemia time, waktu anastomosis vaskular, dan total ischemia time lebih tinggi pada grup DGF, tetapi tidak ditemukan faktor resiko DGF yang signifikan secara statistic saat dilakukan analisis multivariat Kesimpulan Insidensi DGF pada studi ini masuk dalam rentang yang diamati pada studi-­‐ studi sebelumnya. Faktor resiko yang dilaporkan sebagai faktor resiko DGF pada laparoskopi donor nefrektomi hidup tidak signifikan secara statistik dengan DGF pada studi kali ini.

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ABSTRACT
Background Delayed graft function (DGF) is a common complication affecting deceased donor renal transplantation. Based on previous studies, DGF and its risk factors in live donor nephrectomy (LDN) have a various results. Methods We retrospectively analyzed the medical records of donor and recipient from our first 100 cases of laparoscopic LDN in Cipto Mangunkusumo Hospital from November 2011 to February 2014. The criteria used to define DGF were the requirement for dialysis in postoperative week 1 and/or serum creatinine greater than 2.5 mg/dl at postoperative day 7. Patients who did not match any of these criteria were define as having normal renal allograft function. Results The overall prevalence of DGF was 14%. Recipients body mass index, cold ischemia time, vascular anastomosis time, and total ischemia time were higher among the delayed graft function group, but no risk factors for DGF were significantly associated after multivariate analysis. Conclusions The incidence of DGF in our study was in the range of that observed in previous studies. The factors that previously reported and believed as risk factors of DGF in laparoscopic LDN were not significantly associated with the development of DGF in our study.;Background Delayed graft function (DGF) is a common complication affecting deceased donor renal transplantation. Based on previous studies, DGF and its risk factors in live donor nephrectomy (LDN) have a various results. Methods We retrospectively analyzed the medical records of donor and recipient from our first 100 cases of laparoscopic LDN in Cipto Mangunkusumo Hospital from November 2011 to February 2014. The criteria used to define DGF were the requirement for dialysis in postoperative week 1 and/or serum creatinine greater than 2.5 mg/dl at postoperative day 7. Patients who did not match any of these criteria were define as having normal renal allograft function. Results The overall prevalence of DGF was 14%. Recipients body mass index, cold ischemia time, vascular anastomosis time, and total ischemia time were higher among the delayed graft function group, but no risk factors for DGF were significantly associated after multivariate analysis. Conclusions The incidence of DGF in our study was in the range of that observed in previous studies. The factors that previously reported and believed as risk factors of DGF in laparoscopic LDN were not significantly associated with the development of DGF in our study.;Background Delayed graft function (DGF) is a common complication affecting deceased donor renal transplantation. Based on previous studies, DGF and its risk factors in live donor nephrectomy (LDN) have a various results. Methods We retrospectively analyzed the medical records of donor and recipient from our first 100 cases of laparoscopic LDN in Cipto Mangunkusumo Hospital from November 2011 to February 2014. The criteria used to define DGF were the requirement for dialysis in postoperative week 1 and/or serum creatinine greater than 2.5 mg/dl at postoperative day 7. Patients who did not match any of these criteria were define as having normal renal allograft function. Results The overall prevalence of DGF was 14%. Recipients body mass index, cold ischemia time, vascular anastomosis time, and total ischemia time were higher among the delayed graft function group, but no risk factors for DGF were significantly associated after multivariate analysis. Conclusions The incidence of DGF in our study was in the range of that observed in previous studies. The factors that previously reported and believed as risk factors of DGF in laparoscopic LDN were not significantly associated with the development of DGF in our study., Background Delayed graft function (DGF) is a common complication affecting deceased donor renal transplantation. Based on previous studies, DGF and its risk factors in live donor nephrectomy (LDN) have a various results. Methods We retrospectively analyzed the medical records of donor and recipient from our first 100 cases of laparoscopic LDN in Cipto Mangunkusumo Hospital from November 2011 to February 2014. The criteria used to define DGF were the requirement for dialysis in postoperative week 1 and/or serum creatinine greater than 2.5 mg/dl at postoperative day 7. Patients who did not match any of these criteria were define as having normal renal allograft function. Results The overall prevalence of DGF was 14%. Recipients body mass index, cold ischemia time, vascular anastomosis time, and total ischemia time were higher among the delayed graft function group, but no risk factors for DGF were significantly associated after multivariate analysis. Conclusions The incidence of DGF in our study was in the range of that observed in previous studies. The factors that previously reported and believed as risk factors of DGF in laparoscopic LDN were not significantly associated with the development of DGF in our study.]

Abstrak :
ABSTRACT
Background: resistive index (RI) is highly utilised to assess the graft function using Doppler ultrasonography. The RI has been shown as the best ultrasound parameter to assess kidney allograft dysfunction. Several studies have established the role of the RI as a predictor of transplant failure. However, these studies were using RI measurement in the later stages post transplantation. The present study has conducted to identify the association between early RI measurement and early graft function represented as delayed graft function (DGF) and immediate graft function (IGF), as well as long-term graft survival. Methods: an evidence based clinical review of studies published before May 2018 was conducted from Medline, Science Direct, EMBASE and Cochrane databases. Studies on early measurement of RI whereby the primary or secondary goals of the study related to graft function and/or graft survival were included. Studies using late RI measurement and without RI value groups were excluded. The Mantzel Haenzel method was used to analyse pooled risk ratio and 95% confidence interval, while the heterogeneity of the study was calculated through I2 value. Data analysis was performed using Review Manager 5.3. Results: nine studies with a total of 1802 patients who had undergone a kidney transplant were analysed. DGF was found in 19% (193/1015) of the low RI group and in 42.8% (337/787) of the high RI group (RR 2.04 (95% CI 1.72 - 2.41), p < 0.00001, I2 = 28%). IGF was found in 39.5% (62/157) of the low RI group and in 10.5% (28/268) of the high RI group (RR 0.26 (95% CI 0.17 0.40), p < 0.00001, I2 = 0%). Long term graft survival, with follow up between 60 144 months, was found in 83% (701/845) of the low RI group and in 69.4% (395/569) of the high RI group (RR 0.82 (95% CI 0.72 0.93), p = 0.002, I2 = 63%). Conclusion: the results of this study emphasise the association between early measurement of RI and early graft function, and longterm graft survival. An elevated RI provides the chance of recognizing the patients with poor longterm prognosis, from the first moment after kidney transplant.