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"[ABSTRAKTanaman sambiloto (Andrographis Paniculata Nees ) memiliki banyak manfaat dalam pengobatan, salah satunya sebagai obat antikanker. Liposom merupakan salah satu perkembangan dari sistem penghantaran obat yang telah diteliti dapat digunakan sebagai pembawa obat-obat, protein, dan zat?zat molekuler lain. Penelitian ini bertujuan untuk mengembangkan obat dengan bahan dasar ekstrak herba sambiloto yang dienkapsulasi liposom dan diuji aktivitas antiproliferasinya terhadap sel kanker payudara T47D. Metode yang digunakan dalam pembuatan liposom ini adalah metode hidrasi lapis tipis. Pengecilan ukuran partikel dilakukan dengan cara ekstrusi. Evaluasi yang dilakukan dalam penelitian ini adalah distribusi ukuran partikel dan zeta potensial dengan alat DLS, efisiensi penjerapan dengan alat dialisis, morfologi ukuran dengan alat TEM. Uji antiproliferasi sel kanker menggunakan metode MTT. Hasil yang diperoleh pada TEM yang menggambarkan model liposom OLV dengan ukuran ±50 nm; distribusi ukuran partikel liposom sebesar 452,5 dan 43,82 nm serta zeta potensial sebesar -11,3 mV; efisiensi penjerapan sebesar 61,63 %. IC50 dari liposom ekstrak dan larutan ekstrak berturut-turut adalah 11,997 ppm dan 27,488 ppm. Hasil ini menunjukkan bahwa enkapsulasi ekstrak herba sambiloto dengan liposom memberikan pengaruh terhadap aktivitas antiproliferasi sel kanker payudara T47D.

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ABSTRACT

;A Sambiloto?s Plant (Andrographis paniculata Nees) has many benefits in the medicals treatment, one of them as an anticancer drug. Liposomes are one of the development of drug delivery systems that have been studied can be used as carriers of drugs, proteins, and other molecular substances. This research aims to develop drugs with a basis of extract of bitter herbs are encapsulated with liposomes for comparison their antiproliferation activity against T47D breast cancer cells. The method which used in the manufacture of liposomes is thin layer hydration method. Reduction of particle size liposomes is done by extrusion. Evaluations were performed in this study is the particle size distribution and zeta potential by DLS, entrapment efficiency by dialisis, morphology size by TEM. Antiproliferation cancer cells test using MTT method. Results obtained at the TEM depicting the model OLV liposomes with a size of about ±50 nm; liposome particle size distribution of 441 and 45.3 nm, and zeta potential of -11.3 mV; The entrapment efficiency of 61.69%. Showed IC50 of liposomes extract and extract solution are respectively 11,997 ppm and 27,488 ppm. This result showed that the extract of bitter herbs encapsulation with liposomes give effect to the antiploriferative activity of T47D breast cancer cells.

;A Sambiloto?s Plant (Andrographis paniculata Nees) has many benefits in the medicals treatment, one of them as an anticancer drug. Liposomes are one of the development of drug delivery systems that have been studied can be used as carriers of drugs, proteins, and other molecular substances. This research aims to develop drugs with a basis of extract of bitter herbs are encapsulated with liposomes for comparison their antiproliferation activity against T47D breast cancer cells. The method which used in the manufacture of liposomes is thin layer hydration method. Reduction of particle size liposomes is done by extrusion. Evaluations were performed in this study is the particle size distribution and zeta potential by DLS, entrapment efficiency by dialisis, morphology size by TEM. Antiproliferation cancer cells test using MTT method. Results obtained at the TEM depicting the model OLV liposomes with a size of about ±50 nm; liposome particle size distribution of 441 and 45.3 nm, and zeta potential of -11.3 mV; The entrapment efficiency of 61.69%. Showed IC50 of liposomes extract and extract solution are respectively 11,997 ppm and 27,488 ppm. This result showed that the extract of bitter herbs encapsulation with liposomes give effect to the antiploriferative activity of T47D breast cancer cells.

, A Sambiloto’s Plant (Andrographis paniculata Nees) has many benefits in the medicals treatment, one of them as an anticancer drug. Liposomes are one of the development of drug delivery systems that have been studied can be used as carriers of drugs, proteins, and other molecular substances. This research aims to develop drugs with a basis of extract of bitter herbs are encapsulated with liposomes for comparison their antiproliferation activity against T47D breast cancer cells. The method which used in the manufacture of liposomes is thin layer hydration method. Reduction of particle size liposomes is done by extrusion. Evaluations were performed in this study is the particle size distribution and zeta potential by DLS, entrapment efficiency by dialisis, morphology size by TEM. Antiproliferation cancer cells test using MTT method. Results obtained at the TEM depicting the model OLV liposomes with a size of about ±50 nm; liposome particle size distribution of 441 and 45.3 nm, and zeta potential of -11.3 mV; The entrapment efficiency of 61.69%. Showed IC50 of liposomes extract and extract solution are respectively 11,997 ppm and 27,488 ppm. This result showed that the extract of bitter herbs encapsulation with liposomes give effect to the antiploriferative activity of T47D breast cancer cells.

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"Praktek Kerja Profesi Apoteker di Apotek Kimia Farma No. 352 Margonda Periode Januari Tahun 2016 bertujuan untuk agar calon apoteker mampu memahami tugas dan tanggung jawab apoteker dalam pengelolaan apotek; mampu melakukan praktik pelayanan kefarmasian dengan baik dan benar sesuai dengan standar operasional dan peraturan yang berlaku; memiliki wawasan, pengetahuan, keterampilan, dan pengalaman untuk melakukan praktik kefarmasian di Apotek; memiliki gambaran nyata tentang permasalahan praktik kefarmasian dan cara mengatasinya serta mempelajari kegiatan-kegiatan yang dapat dilakukan dalam rangka pengembangan praktik kefarmasian. Tugas khusus yang diberikan berjudul Pengkajian Resep Pasien Typhoid. Tujuan dari tugas khusus ini adalah untuk mengetahui alur pelayanan resep yang sesuai dengan pelayanan farmasi klinik yang tertera pada standar pelayanan kefarmasian di apotek serta untuk menilai kerasionalan pengobatan dari resep yang diberikan.

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Profession Internship at Apotek Kimia Farma No. 352 Margonda on Period January 2016 aiming for that prospective pharmacists are able to understand the duties and responsibilities of pharmacists in the Apotek management; be able to practice pharmacy services properly and correctly in accordance with the standard operational procedures and regulations; have the insight, knowledge, skills and experience to do the practice of pharmacy in Apotek; and have a real picture of the issues pharmaceutical practice and learn the strategies and activities that can be done in the framework of the development of pharmacy practice. The special task that is given titled Analysis of Prescription Typhoid Patients. The purpose of this special task is to determine the appropriate prescription service flow in accordance with clinical pharmacy services listed on the standard of pharmacy services at Apotek and then to assess the rationality of prescriptions that given for treatment."

"Praktik Kerja Profesi Apoteker di Suku Dinas Kesehatan Kota Administrasi Jakarta Barat bertujuan untuk agar calon apoteker memiliki pengetahuan tentang tugas dan fungsi Suku Dinas Kesehatan Kota Administrasi Jakarta Barat dalam bidang kefarmasian; mampu memahami peranan, tugas dan tanggung jawab apoteker di Suku Dinas Kesehatan Kota Administrasi Jakarta Barat; serta memiliki wawasan, pengetahuan, keterampilan, dan pengalaman praktis untuk melakukan pekerjaan kefarmasiaan di Suku Dinas Kesehatan Kota Administrasi Jakarta Barat Tugas khusus yang dilaksanakan berjudul Kegiatan Binwasdal Sarana Apotek XYZ Yang Dilakukan Oleh Suku Dinas Kesehatan Kota Administrasi Jakarta Barat. Tujuan dari tugas khusus ini adalah untuk mengetahui pelaksanaan kegiatan Pembinaan, pengawasan, dan pengendalian sarana apotek XYZ oleh Suku Dinas Kesehatan Kora Administrasi Jakarta Barat.

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Profession Internship at Suku Dinas Kesehatan Kota Administrasi Jakarta Barat Periode Bulan April Tahun 2016 aiming for that prospective pharmacist has the knowledge of the duties and functions of Suku Dinas Kesehatan Kota Administrasi Jakarta Barat in the field of pharmacy; able to understand the role, duties and responsibilities of pharmacists in Suku Dinas Kesehatan Kota Administrasi Jakarta Barat; and have the insight, knowledge, skills, and practical experience to do the job at t Suku Dinas Kesehatan Kota Administrasi Jakarta Barat. The special task undertaken titled Binwasdal Activity in Apotek XYZ means ducted by Suku Dinas Kesehatan Kota Administrasi Jakarta Barat. The purpose of this special task is to investigate the implementation of the guidance, supervision, and control of the apotek XYZ means by Suku Dinas Kesehatan Kota Administrasi Jakarta Barat."