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"ABSTRAKProtein kedelai tersuksinilasi merupakan protein kedelai yang termodifikasi secara kimia dan berpotensi dimanfaatkan sebagai pembentuk matriks mikrosfer. Protein kedelai disuksinilasi dengan suksinat anhidrida 100% b/b dalam suasana basa. Protein kedelai tersuksinilasi yang diperoleh memiliki derajat suksinilasi 35,74±0,38%, menunjukkan peak pada bilangan gelombang 1653 cm-1 mengindikasikan gugus karbonil amida yang terbentuk, memiliki nilai uji daya larut pada pH 1,2 sebesar 0,21±0,010 gram/100 ml dan pada pH 7,5 sebesar 0,35±0,003 gram/100 ml, serta memiliki kemampuan mengembang pada pH 1,2 sebesar 33,21±2,04% dan pada pH 7,5 sebesar 66,36±2,12%. Mikrosfer lepas lambat propranolol hidroklorida dibuat dengan eksipien konsentrat protein kedelai dan protein kedelai tersuksinilasi sebagai matriks menggunakan alat spray dryer dan dihasilkan mikrosfer dengan ukuran partikel 11,54-16,79 µm, nilai presentase rendemen 36,46-58,91%, dan nilai efisiensi penjerapan 95,75-99,81%. Formula 2 menahan pelepasan obat paling baik dalam medium pH 1,2 dengan nilai pelepasan obat kumulatif 14,44±0,10% selama 1 jam dan 63,05±0,40% jika dilanjutkan dalam medium pH 7,5 hingga jam ke-12.

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ABSTRACTSuccinylated soybean protein was chemically-modified soybean protein that could be used as matrix for sustained release microspheres containing propranolol hydrochloride. Soybean protein was succinylated with anhydride succinic 100% w/w in basic condition. Succinylated soybean protein had degree of succinylation 35.74±0.38%, showed peak in wave numbers 1653 cm-1 on IR spectrum which was indicating formed amide carbonyl group, had solubility index 0.21±0.010 gram/100 ml in aqueous medium pH 1.2 and 0.35±0.003 gram/100 ml in aqueous medium pH 7.5, and had swelling index 33.21±2.04% in aqueous medium pH 1.2 and 66.36±2.12% in aqueous medium pH 7.5. Sustained release microspheres containing propranolol hydrochloride were made by using spray dryer and obtained microspheres had particle diameters 11.54-16.79 µm, had yield values 36.46-58.91%, and had encapsulation efficiency values 95.75-99.81%. Second formula was the best formula that could sustain drug release in the aqueousmedium pH 1.2 with the value of cumulative drug release 14.44±0.10% for 1 hour and 63.05±0.40% if it was continued in aqueous medium pH 7.5 up to 12 hours."

"[ABSTRAK Praktek Kerja Profesi PKP dilakukan di PT Kimia Farma Trading Distribution KFTD Jalan Budi Utomo No 1 Jakarta Pusat dan KFTD Cabang Jakarta 2 Jl Pulo Kambing Kav J No 15 Jakarta Timur Kegiatan PKP ini bertujuan agar mampu memahami peranan tugas dan tanggung jawab Apoteker di Pedagang Besar Farmasi memiliki wawasan pengetahuan keterampilan dan pengalaman praktis untuk melakukan pekerjaan kefarmasian di Pedagang Besar Farmasi memahami penerapan Cara Distribusi Obat yang Baik CDOB di Pedagang Besar Farmasi serta memiliki gambaran nyata tentang permasalahan pekerjaan kefarmasian di Pedagang Besar Farmasi Pada pelaksanaan Praktek Kerja Profesi dilakukan pembuatan tugas khusus oleh mahasiswa calon Apoteker yang memiliki judul rancangan penempatan perbekalan farmasi kuantitas besar dan alat kesehatan di gudang KFTD Cabang Jakarta 2 Tugas khusus ini bertujuan untuk mempermudah pencarian produk dan memanfaatkan seluruh ruang di gudang KFTD Cabang Jakarta 2 secara optimal ABSTRACT The profession internship was implemented at PT Kimia Farma Trading Distribution KFTD Jalan Budi Utomo No 1 Jakarta Pusat and KFTD Cabang Jakarta 2 Jl Pulo Kambing Kav J No 15 Jakarta Timur It was aimed to understand roles duties and responsibilities of a pharmacist in pharmaceutical distributor to get insights knowledges skills and experiences about how to do pharmaceutical work in pharmaceutical distributor to understand the implementation of Cara Pembuatan Obat yang Baik CDOB in Pharmaceutical Distributor and to get the real picture about troubles in Pharmaceutical Distributor When implementing the profession internship carried out the special task of designing the placement of large quantity pharmaceutical supplies and medical devices in the warehouse of KFTD Cabang Jakarta 2 That special task was aimed to ease product finding and to utilize the whole room in the warehouse of KFTD Cabang Jakarta 2 optimally ;The profession internship was implemented at PT Kimia Farma Trading Distribution KFTD Jalan Budi Utomo No 1 Jakarta Pusat and KFTD Cabang Jakarta 2 Jl Pulo Kambing Kav J No 15 Jakarta Timur It was aimed to understand roles duties and responsibilities of a pharmacist in pharmaceutical distributor to get insights knowledges skills and experiences about how to do pharmaceutical work in pharmaceutical distributor to understand the implementation of Cara Pembuatan Obat yang Baik CDOB in Pharmaceutical Distributor and to get the real picture about troubles in Pharmaceutical Distributor When implementing the profession internship carried out the special task of designing the placement of large quantity pharmaceutical supplies and medical devices in the warehouse of KFTD Cabang Jakarta 2 That special task was aimed to ease product finding and to utilize the whole room in the warehouse of KFTD Cabang Jakarta 2 optimally ;The profession internship was implemented at PT Kimia Farma Trading Distribution KFTD Jalan Budi Utomo No 1 Jakarta Pusat and KFTD Cabang Jakarta 2 Jl Pulo Kambing Kav J No 15 Jakarta Timur It was aimed to understand roles duties and responsibilities of a pharmacist in pharmaceutical distributor to get insights knowledges skills and experiences about how to do pharmaceutical work in pharmaceutical distributor to understand the implementation of Cara Pembuatan Obat yang Baik CDOB in Pharmaceutical Distributor and to get the real picture about troubles in Pharmaceutical Distributor When implementing the profession internship carried out the special task of designing the placement of large quantity pharmaceutical supplies and medical devices in the warehouse of KFTD Cabang Jakarta 2 That special task was aimed to ease product finding and to utilize the whole room in the warehouse of KFTD Cabang Jakarta 2 optimally ;The profession internship was implemented at PT Kimia Farma Trading Distribution KFTD Jalan Budi Utomo No 1 Jakarta Pusat and KFTD Cabang Jakarta 2 Jl Pulo Kambing Kav J No 15 Jakarta Timur It was aimed to understand roles duties and responsibilities of a pharmacist in pharmaceutical distributor to get insights knowledges skills and experiences about how to do pharmaceutical work in pharmaceutical distributor to understand the implementation of Cara Pembuatan Obat yang Baik CDOB in Pharmaceutical Distributor and to get the real picture about troubles in Pharmaceutical Distributor When implementing the profession internship carried out the special task of designing the placement of large quantity pharmaceutical supplies and medical devices in the warehouse of KFTD Cabang Jakarta 2 That special task was aimed to ease product finding and to utilize the whole room in the warehouse of KFTD Cabang Jakarta 2 optimally ;The profession internship was implemented at PT Kimia Farma Trading Distribution KFTD Jalan Budi Utomo No 1 Jakarta Pusat and KFTD Cabang Jakarta 2 Jl Pulo Kambing Kav J No 15 Jakarta Timur It was aimed to understand roles duties and responsibilities of a pharmacist in pharmaceutical distributor to get insights knowledges skills and experiences about how to do pharmaceutical work in pharmaceutical distributor to understand the implementation of Cara Pembuatan Obat yang Baik CDOB in Pharmaceutical Distributor and to get the real picture about troubles in Pharmaceutical Distributor When implementing the profession internship carried out the special task of designing the placement of large quantity pharmaceutical supplies and medical devices in the warehouse of KFTD Cabang Jakarta 2 That special task was aimed to ease product finding and to utilize the whole room in the warehouse of KFTD Cabang Jakarta 2 optimally , The profession internship was implemented at PT Kimia Farma Trading Distribution KFTD Jalan Budi Utomo No 1 Jakarta Pusat and KFTD Cabang Jakarta 2 Jl Pulo Kambing Kav J No 15 Jakarta Timur It was aimed to understand roles duties and responsibilities of a pharmacist in pharmaceutical distributor to get insights knowledges skills and experiences about how to do pharmaceutical work in pharmaceutical distributor to understand the implementation of Cara Pembuatan Obat yang Baik CDOB in Pharmaceutical Distributor and to get the real picture about troubles in Pharmaceutical Distributor When implementing the profession internship carried out the special task of designing the placement of large quantity pharmaceutical supplies and medical devices in the warehouse of KFTD Cabang Jakarta 2 That special task was aimed to ease product finding and to utilize the whole room in the warehouse of KFTD Cabang Jakarta 2 optimally ]"